Tag: M.W:0-100

504-30-3, Pyridazin-3(2H)-one is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 40A tert-butyl 4-(6-oxo-1(6H)-pyridazinyl)-1-piperidinecarboxylate tert-Butyl 4-bromo-1-piperidinecarboxylate (1.00 g, 3.78 mmol) in DMF (20 mL) was treated with K2CO3 (523 mg, 3.78 mmol) and 3(2H)-pyridazinone (340 mg, 3.78 mmol) and then heated at 45 C. for 60 hours. The reaction mixture was allowed to cool to room temperature, poured into water (80 mL) and extracted with ethyl acetate (80 mL). The organic layer was washed with brine (3*50 mL), dried over MgSO4, filtered, and the filtrate concentrated under reduced pressure. The residue was purified by flash chromatography on silica gel (elution with hexanes:ethyl acetate, 3:1) to provide the title compound (180 mg, 17% yield). 1H NMR (300 MHz, DMSO-d6) delta1.41 (s, 9H), 1.66 (m, 4H), 2.91 (m, 2H), 4.05 (m, 2H), 4.96 (m, 1H), 6.93 (dd, 1H, J=1.5, 9.0 Hz), 7.39 (dd, 1H, J=3.0, 9.0 Hz), 7.95 (dd, 1H, J=3.0, 9.0 Hz); (MS (DCI/NH3) m/e 280 (M+H)+., 504-30-3

As the paragraph descriping shows that 504-30-3 is playing an increasingly important role.

Reference£º
Patent; Bhatia, Pramila A.; Daanen, Jerome F.; Hakeem, Ahmed A.; Kolasa, Teodozyj; Matulenko, Mark A.; Mortell, Kathleen H.; Patel, Meena V.; Stewart, Andrew O.; Wang, Xueqing; Xia, Zhiren; Zhang, Henry Q.; US2004/29887; (2004); A1;,
Pyridazine – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5469-70-5,3-Aminopyridazine,as a common compound, the synthetic route is as follows.

A RBF was charged with (P)-perfluorophenyl 2-oxo-1-(2,3′,4′-trifluoro-5-methoxy-[1,1′-biphenyl]-4-yl)-1,2-dihydroquinoline-6-sulfonate (151.1 mg, 0.241 mmol) and pyridazin-3-amine (34.4 mg, 0.361 mmol). DMSO (602 mul) was added to give a solution which was then diluted with THF (1806 mul). The flask was cooled in an ice-water bath for 10 min, then lithium bis(trimethylsilyl)amide (1M in THF) (530 mul, 0.530 mmol) was added dropwise. After 15 min total, the mixture was diluted with 1N aq. HCl and EtOAc. The layers were separated, and the aq. layer was extracted with EtOAc (1*). The combined organic extracts were dried over sodium sulfate, filtered, and concentrated. The residue was taken up in MeOH and filtered through a 0.2 micron filter. The resulting solution was purified by reverse-phase HPLC (25-70% CH3CN/H2O with 0.1% TFA). Fractions containing the desired product were combined and lyophilized to give (P)-2-oxo-N-3-pyridazinyl-1-(2,3′,4′-trifluoro-5-methoxy-4-biphenylyl)-1,2-dihydro-6-quinolinesulfonamide (55 mg, 0.102 mmol, 42.4% yield) as a white solid. 1H NMR (400 MHz, DMSO-d6) delta=14.5 (br. s, 1H), 8.52-8.06 (m, 3H), 8.01-7.76 (m, 3H), 7.76-7.30 (m, 5H), 6.91-6.62 (m, 2H), 3.73 (br. s., 3H). m/z (ESI) 539.0 (M+H)+., 5469-70-5

As the paragraph descriping shows that 5469-70-5 is playing an increasingly important role.

Reference£º
Patent; Amgen Inc.; Weiss, Matthew; Boezio, Alessandro; Boezio, Christiane; Butler, John R.; Chu-Moyer, Margaret Yuhua; Dimauro, Erin F.; Dineen, Thomas; Graceffa, Russell; Guzman-Perez, Angel; Huang, Hongbing; Kreiman, Charles; La, Daniel; Marx, Isaac E.; Milgrim, Benjamin Charles; Nguyen, Hanh Nho; Peterson, Emily; Romero, Karina; Sparling, Brian; US9212182; (2015); B2;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1632-76-4,3-Methylpyridazine,as a common compound, the synthetic route is as follows.

1632-76-4, General procedure: K2[M'(CN)4].H2O was prepared by mixing the stoichiometric amounts of nickel(II) chloride hexahydrate (1 mmol, 0.238 g) or palladium(II) chloride (1 mmol, 0.177 g) or platinum(II) chloride(1 mmol, 0.266 g) in water (10 mL) solutions with potassiumcyanide (4 mmol, 0.260 g) in water (10 mL) solutions. These solutions were filtered and allowed to evaporate at room temperature in order to crystallize. The K2[M'(CN)4]H2O (1 mmol) complexes(M’ , 0.259 g for Ni(II), 0.306 g for Pd(II), 0.395 g for Pt(II)) were dissolved in water (50 mL). To these solutions, 1 mmol of zinc(II) chloride or 1 mmol of cadmium(II) chloride hemi(pentahydrate)dissolved in water (10 mL) were added with continuous stirring approximately for 4h at 50¡ãC in a temperature-controlled bath.The M[M'(CN)4]H2O compounds obtained were filtered and dried in air. The complexes were prepared by mixing together with the50 mL of water solution of 1 mmol of Zn[Ni(CN)4]H2O = 0.246 g,Zn[Pd(CN)4]H2O = 0.293 g or Zn[Pt(CN)4]H2O = 0.382 g, separately.To M[M'(CN)4]H2O solutions, 3-mpdz (2 mmol, 0.188 g) dissolved in ethanol (10 mL) was added with continuous stirring and after afew minutes ammonia (5 mL, 28percent) was added a few drops to resulting solution with continuous stirring approximately for 5h at 60¡ãCin a temperature-controlled bath and then filtered. The resulting clear solutions were kept for crystallization at room temperature. In the meantime, the ammonia was moved away from the solutions itself. Within about a week bright crystals were obtained. The procedure for the syntheses of cadmium complexes was similar to that used for zinc complexes, except that the Zn[M'(CN)4]H2Owas used instead of Cd[M'(CN)4]H2O [Cd[Ni(CN)4]H2O = 0.246 g,Cd[Pd(CN)4]H2O = 0.340 g or Cd[Pt(CN)4]H2O = 0.429 g]. The C, H,N analyses were carried out for the complexes and were found tofit the proposed formulae well.

The synthetic route of 1632-76-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Goer, Kansu; Kuerkcueo?lu, Guene? Sueheyla; Ye?ilel, Okan Zafer; Bueyuekguengoer, Orhan; Inorganica Chimica Acta; vol. 414; (2014); p. 15 – 20;,
Pyridazine – Wikipedia
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1120-88-3, 4-Methylpyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred mixture of 4-Methyl-pyridazine (11) (0.500 g, 5.312 mmol) and Benzaldehyde (12) (1.1 g, 10.625 mmol) was added zinc chloride (1.44 g, 10.625 mmol) and the resultant reaction mixture was heated at 150C for 16h. The reaction mixture was quenched with 2M NaOH solution and DCM was added. The layers were partitioned and the aqs part was further extracted with DCM (2 times). The combined organic layers were dried over sodium sulfate and concentrated. Portioned between 2M NaOH and DCM and extracted the aqueous layer with DCM. Combined all organic layers and dried over Sodium sulphate. The crude was purified by column chromatography in 100-200 silica using Hexane/EtOAc (4: 1) as eluent to afford Intermediate 13 (290mg, 29.9%) as brown oil.

1120-88-3, 1120-88-3 4-Methylpyridazine 136882, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; THE BROAD INSTITUTE, INC.; THE GENERAL HOSPITAL CORPORATION; INSTITUTO CARLOS SLIM DE LA SALUD; BURNS, Sean, M.; WAGNER, Bridget, K.; VETERE, Amedeo; (189 pag.)WO2018/175324; (2018); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20744-39-2,Pyridazin-4-amine,as a common compound, the synthetic route is as follows.

). A solution of 28b (68 mg, 0.141 mmol), pyridazin-4-amine (20.06 mg, 0.211 mmol), HATU (107 mg, 0.281 mmol) and DIPEA (0.098 mL, 0.563 mmol) in DMF (7 mL) was stirred at 60 C for 4 hr. After cooled to room temperature, the mixture was diluted with EA, washed with water and brine, dried over Na2SO4 and concentrated. The residue was re-dissolved in DMF and purified by flash chromatography on C18 (5~95% MeCN in H2O, 0.05% NH4OH) to give the title compound (28.3 mg, 0.061 mmol, 43.3 % yield) as a white solid. LCMS: 447 [M+H]+. 1H NMR (400 MHz, DMSO-d6): delta 10.75 (s, 1H), 9.21 (dd, J= 2.8, 1.2 Hz, 1H), 9.00-9.08 (m, 1H), 8.02 (dd, J= 6.0, 2.8 Hz, 1H), 7.46-7.54 (m, 3 H), 7.40-7.46 (m, 1H), 7.27-7.39 (m, 3H), 7.23 (d, J= 8.8 Hz, 1H), 5.18-5.25 (m, 2H), 3.44 (t, J= 6.0 Hz, 2H), 3.24 (s, 3H), 2.96 (br., 2 H), 2.45-2.49 (m, 2H), 1.99-2.12 (m, 2 H), 1.69-1.78 (m, 2H), 1.55-1.69 (m, 2H). 13C NMR (101 MHz, CDCl3): delta 164.5, 155.3, 151.5, 143.5, 140.5, 137.5, 134.8, 132.6, 131.3, 129.9, 129.5, 128.8, 119.9, 114.1, 113.0, 72.4, 70.3, 58.9, 58.3, 54.6, 41.6, 33.3.

20744-39-2, As the paragraph descriping shows that 20744-39-2 is playing an increasingly important role.

Reference£º
Article; Ding, Xiao; Stasi, Luigi Piero; Dai, Xuedong; Long, Kai; Peng, Cheng; Zhao, Baowei; Wang, Hailong; Sun, Changhui; Hu, Huan; Wan, Zehong; Jandu, Karamjit S.; Philps, Oliver J.; Chen, Yan; Wang, Lizhen; Liu, Qian; Edge, Colin; Li, Yi; Dong, Kelly; Guan, Xiaoming; Tattersall, F. David; Reith, Alastair D.; Ren, Feng; Bioorganic and Medicinal Chemistry Letters; vol. 29; 2; (2019); p. 212 – 215;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1120-88-3,4-Methylpyridazine,as a common compound, the synthetic route is as follows.

1120-88-3, 3-(2,6-difluorophenyl)-2-fluorobenzoate (9.0 g, 0.026 mol) was dissolved in dry tetrahydrofuran (5 mL), the reaction flask was placed in a dry ice bath, cooling to -20C .Under nitrogen, was added dropwise LiHMDS (50 mL, 0.050 mol) was stirred for half an hour, the reaction flask moved to 0C ice bath, was slowly added dropwise 4-methyl pyridazine (2.5g, 0.027 mol), dropwise reactions were complete in 2 hours under ice-cooling, warmed to room temperature, saturated ammonium chloride solution (30 mL), (100 mL) and extracted with ethyl acetate, the organic phase was washed with water (30 mL) and saturated sodium chloride solution ( 30 mL), dried over anhydrous sodium sulfate, and the solvent removed by rotary evaporation, chromatographed to give the product (6.5 g, 61% yield) by silica gel column.

1120-88-3 4-Methylpyridazine 136882, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; Tonghua Jida Pharmaceutical Co., Ltd.; Wu, yongqian; (22 pag.)CN103936728; (2016); B;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20744-39-2,Pyridazin-4-amine,as a common compound, the synthetic route is as follows.

General procedure: To a flame-dried flask was added 8 (0.046g, 0.142mmol), xantphos (0.016g, 0.028mmol), potassium carbonate (0.392g, 2.83mmol), palladium(II) acetate (0.003g, 0.014mmol), and the respective amine (0.170mmol). The flask was purged with nitrogen three times and then anhydrous dioxane (1.5mL) was added under nitrogen. The reaction was refluxed at 105C for 12h while under nitrogen, maintaining a positive pressure. The mixture was concentrated under reduced pressure, separated by silica column chromatography (dichloromethane/isopropanol), and purified by reverse phase chromatography (water/acetonitrile).

20744-39-2, As the paragraph descriping shows that 20744-39-2 is playing an increasingly important role.

Reference£º
Article; Woodring, Jennifer L.; Bachovchin, Kelly A.; Brady, Kimberly G.; Gallerstein, Mitchell F.; Erath, Jessey; Tanghe, Scott; Leed, Susan E.; Rodriguez, Ana; Mensa-Wilmot, Kojo; Sciotti, Richard J.; Pollastri, Michael P.; European Journal of Medicinal Chemistry; vol. 141; (2017); p. 446 – 459;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

5469-70-5, 3-Aminopyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,5469-70-5

General procedure: To a slurry of 6?-bromo-8?-methyl-2?H-spiro[cyclohexane-1,3?-imidazo[1,5-a]pyridine]-1?,5?-dione (12) and aromatic aminederivatives (1.2 eq) in 1,4-dioxane was added Cs2CO3 (3 eq). Themixture was stirred at room temperature for 20 min under nitrogen.To the mixture was then added Pd(OAc)2 (0.1 eq) and Xantphos(0.2 eq). After stirred at room temperature for additional 20 minunder nitrogen, the mixture was heated at 95 C for 12 h undernitrogen. The mixture was concentrated in vacuo, added with water,stirred and filtered. The filter cake was dried and purified by flashcolumn chromatography.

5469-70-5 3-Aminopyridazine 230373, apyridazine compound, is more and more widely used in various fields.

Reference£º
Article; Yuan, Xinrui; Wu, Hanshu; Bu, Hong; Zheng, Peiyuan; Zhou, Jinpei; Zhang, Huibin; Bioorganic and Medicinal Chemistry; vol. 27; 7; (2019); p. 1211 – 1225;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

20744-39-2, Pyridazin-4-amine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a mixture of 27 (500 mg, 1.39 mmol), 4-aminopyridazine (159 mg, 1.67 mmol) and K3PO4 (355 mg, 1.67 mmol) in DMSO (8 mL) were added CuI (318 mg, 1.67 mmol) and N,N’-dimethylethylenediamine (0.18 mL, 1.67 mmol), and the mixture was stirred at 110 C for 30 min under an argon gas atmosphere. After cooling atroom temperature, the mixture was diluted with water and 28% aqueous ammonia solution, and extracted with EtOAc. The organic layer was washed with brine, dried over MgSO4, filtered and concentrated in vacuo. The residue was purified by silica gel column chromatography (0-5% MeOH in CHCl3) to give 30f (138 mg, 27%) as a yellow solid. 1H NMR (CDCl3) delta 5.47 (s,2H), 6.80 (dd, 1H, J = 9.4, 2.6 Hz), 6.90 (dd, 1H, J = 5.9, 2.9 Hz), 7.07 (d, 1H, J = 2.6 Hz), 7.57-7.64 (m, 2H), 7.78-7.84 (m, 1H), 7.87 (d, 1H, J = 8.1 Hz), 8.05 (d, 1H, J = 8.6 Hz), 8.22-8.27 (m, 2H), 8.59 (br s, 1H), 9.08 (br s, 1H), 9.58 (s, 1H); MS (ESI) m/z 374 [M+H]+., 20744-39-2

As the paragraph descriping shows that 20744-39-2 is playing an increasingly important role.

Reference£º
Article; Hamaguchi, Wataru; Masuda, Naoyuki; Isomura, Mai; Miyamoto, Satoshi; Kikuchi, Shigetoshi; Amano, Yasushi; Honbou, Kazuya; Mihara, Takuma; Watanabe, Toshihiro; Bioorganic and Medicinal Chemistry; vol. 21; 24; (2013); p. 7612 – 7623;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

1632-76-4, 3-Methylpyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(i) 1-(2,4-Difluorophenyl)-2-(pyridazin-3-yl)ethanone Treatment of 3-methylpyridazine (4.70 g) with lithium diisopropylamide (0.05 mole) in dry tetrahydrofuran followed by methyl 2,4-difluorobenzoate (8.60 g) according to the method of Example 11(i) gave the title compound, (3.40 g), m.p. 115.5¡ã-117.5¡ã (from ether).

1632-76-4, As the paragraph descriping shows that 1632-76-4 is playing an increasingly important role.

Reference£º
Patent; Pfizer Inc.; US5116844; (1992); A;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem