Tag: M.W:0-100

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Product Details of 5469-70-5, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 5469-70-5, Name is 3-Aminopyridazine, molecular formula is C4H5N3

Aminoimidazoles as bioisosteres of acylguanidines: Novel, potent, selective and orally bioavailable inhibitors of the sodium hydrogen exchanger isoform-1

Inhibition of the sodium hydrogen exchanger isoform-1 (NHE-1) has been shown to limit damage to the myocardium under ischemic conditions in animals. While most known NHE-1 inhibitors are acylguanidines, this report describes the design and synthesis of a series of heterocyclic inhibitors of NHE-1 including aminoimidazoles with undiminished in vitro activity and oral bioavailability.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N56 – PubChem

 

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Quality Control of 3-Aminopyridazine. Introducing a new discovery about 5469-70-5, Name is 3-Aminopyridazine

MODULATORS OF THE GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-KB ACTIVITY AND USE THEREOF

A class of novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-?B activity including obesity, diabetes, inflammatory and immune diseases, and have the structure of formula (I) its stereoisomers thereof, or a solvate thereof, or a prodrug thereof, or a pharmaceutically acceptable salt thereof, where Z is CONR1R2 or CH2NR 1R2 and where at least one of X1-X8 is N, and R, Ra, Rb, Rc and Rd are defined herein. Also provided are pharmaceutical compositions and methods of treating obesity, diabetes and inflammatory or immune associated diseases comprising said compounds.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Quality Control of 3-Aminopyridazine, you can also check out more blogs about5469-70-5

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N17 – PubChem

 

Synthetic Route of 20744-39-2, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.20744-39-2, Name is Pyridazin-4-amine, molecular formula is C4H5N3. In a article，once mentioned of 20744-39-2

MORPHINAN DERIVATIVES FOR THE TREATMENT OF NEUROPATHIC PAIN

The present invention relates to compounds and their use as ligands for mu opioid receptors. Also included are methods for preparing the compounds and pharmaceutical compositions containing the compounds. In one or more embodiments of the invention, a compound according to Formula I is provided: and pharmaceutically acceptable salts thereof, wherein R1-R11 are as described herein.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 20744-39-2

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N104 – PubChem

 

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. SDS of cas: 20744-39-2, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 20744-39-2, name is Pyridazin-4-amine. In an article，Which mentioned a new discovery about 20744-39-2

VEGFR3 INHIBITORS

This invention relates to a compound of the formula (I): The invention also relates to processes for the preparation of the compound of the formula (I), pharmaceutical agents or compositions containing the compound or a method of using the compound for the treatment of proliferative diseases, such as cancer, as well as the treatment of diseases ameliorated by the control and/or inhibition of lymphangiogenesis.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N116 – PubChem

 

20744-39-2, Name is Pyridazin-4-amine, belongs to pyridazine compound, is a common compound. COA of Formula: C4H5N3In an article, once mentioned the new application about 20744-39-2.

NOVEL ULK1 INHIBITORS AND METHODS USING SAME

In certain aspects, the invention provides a method for treating a disease or condition in a subject, the method comprising co-administering to a subject in need thereof a therapeutically effective amount of at least one ULK1-inhibiting pyrimidine, and a therapeutically effective amount of an mTOR inhibitor.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N135 – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, COA of Formula: C4H5N3, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 5469-70-5, Name is 3-Aminopyridazine, molecular formula is C4H5N3

FUSED PYRIMIDINE-DIONE DERIVATIVES AS TRPA1 MODULATORS

The invention described herein relates to novel fused pyrimidinediones derivatives of formula (I) which are TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPAl (Transient Receptor Potential subfamily A, member 1). This invention also provides processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPAl. Formula (I)

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, COA of Formula: C4H5N3, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 5469-70-5

Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N9 – PubChem

 

Reference of 20744-39-2, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.20744-39-2, Name is Pyridazin-4-amine, molecular formula is C4H5N3. In a Patent£¬once mentioned of 20744-39-2

Pyridazinylurea plant regulators

Pyridazinylurea plant regulators of the formula STR1 and acid addition salts thereof; wherein R is alkyl or cycloalkyl, R1 is hydrogen or alkyl, each X independently is halogen, alkoxy, alkylthi or alkylsulfonyl, and p is 0, 1 or 2.

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Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N123 – PubChem

 

Chemistry is traditionally divided into organic and inorganic chemistry. COA of Formula: C4H5N3, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 5469-70-5

Flexible synthesis of pyrimidines with chiral monofluorinated and difluoromethyl side chains

(Chemical Equation Presented) Chiral pyrimidines with a fluorine atom in the benzylic position are easily accessible in high enantiomeric excesses from optically active propargylic intermediates by two complementary routes. Both the use of optically active propargylic fluorides and the fluorination of the chiral pyrimidine in the final stage give excellent results in terms of enantiocontrol. On the other hand, original pyrimidines with a difluoromethyl side chain are also obtained in a few steps from new propargylic ketones bearing a CHF2 substituent on the triple bond.

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Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N60 – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, COA of Formula: C4H5N3, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 20744-39-2, Name is Pyridazin-4-amine, molecular formula is C4H5N3

Design and synthesis of novel benzimidazole derivatives as phosphodiesterase 10A inhibitors with reduced CYP1A2 inhibition

A novel class of phosphodiesterase 10A (PDE10A) inhibitors with reduced CYP1A2 inhibition were designed and synthesized starting from 2-{[(1-phenyl-1H-benzimidazol-6-yl)oxy]methyl}quinoline (1). Introduction of an isopropyl group at the 2-position and a methoxy group at the 5-position of the benzimidazole ring of lead compound 1 resulted in the identification of 2-{[(2-isopropyl-5-methoxy-1-phenyl-1H-benzimidazol-6-yl)oxy]methyl}quinoline (25b), which exhibited potent PDE10A inhibitory activity with reduced CYP1A2 inhibitory activity compared to compound 1.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. COA of Formula: C4H5N3, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 20744-39-2, in my other articles.

Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N155 – PubChem

 

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Application In Synthesis of Pyridazin-4-amine, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 20744-39-2, name is Pyridazin-4-amine. In an article£¬Which mentioned a new discovery about 20744-39-2

Optimization of Physicochemical Properties for 4-Anilinoquinoline Inhibitors of Plasmodium falciparum Proliferation

We recently reported the medicinal chemistry reoptimization of a known human tyrosine kinase inhibitor, lapatinib, against a variety of parasites responsible for numerous tropical diseases, including human African trypanosomiasis (Trypanosoma brucei), Chagas disease (T. cruzi), Leishmaniasis (Leishmania spp.), and malaria (Plasmodium falciparum). Herein, we report our continuing efforts to optimize this series against P. falciparum. Through the design of a library of compounds focused on reducing the lipophilicity and molecular weight, followed by an SAR exploration, we have identified NEU-1953 (40). This compound is a potent inhibitor of P. falciparum with an improved ADME profile over the previously reported compound, NEU-961 (3).

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Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N161 – PubChem