Tag: 95.1026

Reactions of N-heteroarylformamide oximes and N-heteroarylacetamide oximes with N,N-dimethylformamide dimethyl acetal. Synthesis of 2-methyl-s-triazolo[1,5-x]azines and N-methylcyanoaminoazines was written by Stanovnik, Branko;Stimac, Anton;Tisler, Miha;Vercek, Bojan. And the article was included in Journal of Heterocyclic Chemistry in 1982.Category: pyridazine This article mentions the following:

N-Heteroarylformamide oximes RNHCH:NOH (R = diazinyl, triazinyl) were converted with Me₂NCH(OMe)₂ into MeNRCN, as the main products. In some instances, RNHCN and some other products were also formed. On the other hand, RNMeCH:NOH were cyclized under the same reaction conditions into 2-methyl-s-triazolo[1,5-x]azines. RNHCMe:NOMe and RNMeCMe:NOMe were prepared from RN:CHNMe₂ or RN:CMeNMe₂ and MeONH₂. In the experiment, the researchers used many compounds, for example, 3-Aminopyridazine (cas: 5469-70-5Category: pyridazine).

3-Aminopyridazine (cas: 5469-70-5) belongs to pyridazine derivatives. The pyridazine structure is also found within the structure of several drugs such as cefozopran, cadralazine, minaprine, pipofezine, and hydralazine. Pyridazine can act as a hydrogen bond acceptor to improve the physicochemical properties of drug molecules by increasing their water solubility, and has a high affinity for complexing with targets due to its dipole moment.Category: pyridazine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Syntheses, structures, and properties of dipyridazino-fused 1,3,4,6-tetraazapentalenes was written by Pereira, David E.;Petric, Andrej;Leonard, Nelson J.. And the article was included in Tetrahedron in 1988.Formula: C4H5N3 This article mentions the following:

The fluorescent 2,9-dichloro[2”,3”:1′,2′]imidazo[4′,5′:4,5]imidazo[1,2-b]pyridazine (I, R = Cl) and the unsubstituted parent I (R = H) have been synthesized. The chloro groups of I (R = Cl) were easily displaced by a variety of nucleophiles to provide the 2,9-disubstituted compounds I (R = MeO, N₃, NH₂, NHNH₂, OH). A single crystal x-ray structure determination of the 2,9-dimethoxy compound I (R = MeO) revealed two crystallog. independent structures in the unit cell. I (R = H) forms a 2:1 complex with cobalt(II). In the experiment, the researchers used many compounds, for example, 3-Aminopyridazine (cas: 5469-70-5Formula: C4H5N3).

3-Aminopyridazine (cas: 5469-70-5) belongs to pyridazine derivatives. Pyridazines is a six-membered nitrogen-containing significant heterocycle. It has received considerable interest because of its useful applications as natural products, pharmaceuticals, and various bioactive molecules. The activity depends upon the changes of substituted groups in the pyridazine ring system resulting in different biological activities. In addition, the natural pyrimidine bases uracil, thymine, and cytosine, which are constituents of the nucleic acids, are found to be the most important naturally occurring diazines.Formula: C4H5N3

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Lead identification of novel and selective TYK2 inhibitors was written by Liang, Jun;Tsui, Vickie;Van Abbema, Anne;Bao, Liang;Barrett, Kathy;Beresini, Maureen;Berezhkovskiy, Leo;Blair, Wade S.;Chang, Christine;Driscoll, James;Eigenbrot, Charles;Ghilardi, Nico;Gibbons, Paul;Halladay, Jason;Johnson, Adam;Kohli, Pawan Bir;Lai, Yingjie;Liimatta, Marya;Mantik, Priscilla;Menghrajani, Kapil;Murray, Jeremy;Sambrone, Amy;Xiao, Yisong;Shia, Steven;Shin, Young;Smith, Jan;Sohn, Sue;Stanley, Mark;Ultsch, Mark;Zhang, Birong;Wu, Lawren C.;Magnuson, Steven. And the article was included in European Journal of Medicinal Chemistry in 2013.Quality Control of 3-Aminopyridazine This article mentions the following:

A therapeutic rationale is proposed for the treatment of inflammatory diseases, such as psoriasis and inflammatory bowel diseases (IBD), by selective targeting of TYK2. Hit triage, following a high-throughput screen for TYK2 inhibitors, revealed pyridine (I) as a promising starting point for lead identification. Initial expansion of 3 sep. regions of the mol. led to eventual identification of cyclopropyl amide (II), a potent lead analog with good kinase selectivity, physicochem. properties, and pharmacokinetic profile. Anal. of the binding modes of the series in TYK2 and JAK2 crystal structures revealed key interactions leading to good TYK2 potency and design options for future optimization of selectivity. In the experiment, the researchers used many compounds, for example, 3-Aminopyridazine (cas: 5469-70-5Quality Control of 3-Aminopyridazine).

3-Aminopyridazine (cas: 5469-70-5) belongs to pyridazine derivatives. The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. In the past decade, X-ray data were reported with regard to the characterization and structural elucidation of a number of pyridazine-metal complexes, including pyridazine ligands with zinc, nickel, copper, cadmium and ruthenium.Quality Control of 3-Aminopyridazine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Pyridazine doped g-C₃N₄ with nitrogen defects and spongy structure for efficient tetracycline photodegradation and photocatalytic H₂ evolution was written by Zhan, Xiaohui;Zhao, Yue;Sun, Yanping;Lei, Chen;Wang, He;Shi, Huixiang. And the article was included in Chemosphere in 2022.Recommanded Product: 5469-70-5 This article mentions the following:

In this study, with thiourea and 3-aminopyridazine as precursors, the graphite-phase carbon nitride (ACN-x) with nitrogen defects and sponge structure is prepared via the introduction of the benzene-like ring structure of pyridazine replacing a “melem” group through hydrothermal procedure combined with calcination. It is made possible by the attraction of three hydrogen bond receptors for 3-aminopyrazine to lone pair electrons on the “melem” mol. The remarkable extensively photocatalytic activity can be attributed to three effects of the introduction of 3-aminopyridazine: (i)formation of nitrogen defects between adjacent tri-s-triazine groups; (ii)formation of effective charge transfer channels within the tri-s-triazine group; (iii)the spongy structure exposed abundant amino groups(-NH₃) at edge sites, combining with the internal amino group and as hole stabilizer to prolong the excited state life of photocatalyst. The photogenerated carrier migration and separation efficiency improved effectively through the tuning synergy. As a result, ACN-x exhibits excellent photocatalytic activity, with hydrogen production efficiency of up to 11331.74μmol g^-1 h^-1, which is approx. 94.5 times that of the pristine g-C₃N₄ (119.88μmol g^-1 h^-1). The degradation constants of TC and RhB are 0.0498 min^-1 and 0.129min^-1, which are 3.32 and 6.35 times of the pristine g-C₃N₄, resp. The TC degradation in different initial concentrations, pH, dissolved organic matter concentrations, and water sources is conducted to prove the environmental adaptability of the ACN-x system. The mechanism of the system indicates that ·O^–₂ plays an important role, and the ·OH and h⁺ play a minor role in the TC photocatalytic degradation Finally, the TC degradation possible pathway is proposed. In the experiment, the researchers used many compounds, for example, 3-Aminopyridazine (cas: 5469-70-5Recommanded Product: 5469-70-5).

3-Aminopyridazine (cas: 5469-70-5) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. Pyridazine and derivatives coordinate readily with transition metals to form complexes and catalysts with synthetic utility.Recommanded Product: 5469-70-5

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Discovery of new chemical classes of synthetic ligands that suppress neuroinflammatory responses was written by Watterson, D. Martin;Haiech, Jacques;Van Eldik, Linda J.. And the article was included in Journal of Molecular Neuroscience in 2002.Product Details of 5469-70-5 This article mentions the following:

The authors used a chem. genomics approach that includes follow up in parallel syntheses to discover a new class of compounds that selectively suppress glial activation. While the mechanism of action remains to be determined, available data and the exptl. approach for discovery indicate that the mechanism includes inhibition of gene regulating protein kinases. Specifically, the increased production of IL-1β and iNOS in response to various activating stimuli, including Aβ1-42, is suppressed while the production of potentially beneficial responses, such as ApoE production, is not inhibited. The increased production of COX-2 and p38 MAPK activation are also not altered, demonstrating the novel nature of potential therapeutic targets compared to currently available drugs. The chem. scaffold is 3-aminopyridazine (3-AP). This is an attractive scaffold because of its potential for diversification by established, facile chemistries and the prior use of a 3-AP scaffold in other central nervous system targeted therapeutics. Therefore, the potential bioavailability of 3-AP derivatives and the demonstrated cellular selectivity demand that future research address the potential efficacy of selective 3-AP derivatives in animal models of disease. In the experiment, the researchers used many compounds, for example, 3-Aminopyridazine (cas: 5469-70-5Product Details of 5469-70-5).

3-Aminopyridazine (cas: 5469-70-5) belongs to pyridazine derivatives. The pyridazine structure is a popular pharmacophore which is found within a number of herbicides such as credazine, pyridafol and pyridate. The unsubstituted pyridazines are more resistant to eletrophilic substitution due to the nature of withdrawal of electron density from the ring by two heteroatoms, while the related electron deficiency of the ring makes pyridazine more easily attacked by nucleophiles.Product Details of 5469-70-5

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Reexamination of the application of linear free energy relationships to the azaheterocyclic systems. I. Substituent effects on the basicity of monocyclic azines was written by Tomasik, P.;Zalewski, R.. And the article was included in Chemicke Zvesti in 1977.Safety of 3-Aminopyridazine This article mentions the following:

The basicities of pyridines, pyrimidines, pyridazines, and pyrazines (180 compounds) were correlated with substituent effects by Hammett and Taft equations. Limitations of the LFER are discussed. In the experiment, the researchers used many compounds, for example, 3-Aminopyridazine (cas: 5469-70-5Safety of 3-Aminopyridazine).

3-Aminopyridazine (cas: 5469-70-5) belongs to pyridazine derivatives. The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazine can act as a hydrogen bond acceptor to improve the physicochemical properties of drug molecules by increasing their water solubility, and has a high affinity for complexing with targets due to its dipole moment.Safety of 3-Aminopyridazine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Optimization of physicochemical properties for 4-anilinoquinazoline inhibitors of trypanosome proliferation was written by Woodring, Jennifer L.;Bachovchin, Kelly A.;Brady, Kimberly G.;Gallerstein, Mitchell F.;Erath, Jessey;Tanghe, Scott;Leed, Susan E.;Rodriguez, Ana;Mensa-Wilmot, Kojo;Sciotti, Richard J.;Pollastri, Michael P.. And the article was included in European Journal of Medicinal Chemistry in 2017.Related Products of 5469-70-5 This article mentions the following:

Human African trypanosomiasis (HAT) is a deadly disease in need of new chemotherapeutics that can cross into the central nervous system. The authors previously reported the discovery of (NEU-617), a small mol. with activity against T. brucei bloodstream proliferation. Further optimization of NEU-617 to improve the physicochem. properties (LogP, LLE, [1], and MPO score) [2] have led us to twelve sub-micromolar compounds, most importantly the headgroup variants I and II, and the linker variant III. Although these 3 compounds had reduced potency compared to NEU-617, they all had improved LogP, LLE and MPO scores. Cross-screening these analogs against other protozoan parasites uncovered IV with potent activity towards T. brucei, T. cruzi and L. major, while four others compounds showed activity towards P. falciparum D6. This reinforces the effectiveness of lead repurposing for the discovery of new protozoan disease therapeutics. In the experiment, the researchers used many compounds, for example, 3-Aminopyridazine (cas: 5469-70-5Related Products of 5469-70-5).

3-Aminopyridazine (cas: 5469-70-5) belongs to pyridazine derivatives. Pyridazines are rare in nature, possibly reflecting the scarcity of naturally occurring hydrazines, common building blocks for the synthesis of these heterocycles. Pyridazine is bioavailable (especially in the CNS) and can reduce toxicity. Pyridazine is a component of several drug molecules, and the pyridazine pharmacophore has contributed to a variety of pharmacologically active compounds.Related Products of 5469-70-5

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Optimization of physicochemical properties for 4-anilinoquinazoline inhibitors of trypanosome proliferation was written by Woodring, Jennifer L.;Bachovchin, Kelly A.;Brady, Kimberly G.;Gallerstein, Mitchell F.;Erath, Jessey;Tanghe, Scott;Leed, Susan E.;Rodriguez, Ana;Mensa-Wilmot, Kojo;Sciotti, Richard J.;Pollastri, Michael P.. And the article was included in European Journal of Medicinal Chemistry in 2017.Related Products of 5469-70-5 This article mentions the following:

Human African trypanosomiasis (HAT) is a deadly disease in need of new chemotherapeutics that can cross into the central nervous system. The authors previously reported the discovery of (NEU-617), a small mol. with activity against T. brucei bloodstream proliferation. Further optimization of NEU-617 to improve the physicochem. properties (LogP, LLE, [1], and MPO score) [2] have led us to twelve sub-micromolar compounds, most importantly the headgroup variants I and II, and the linker variant III. Although these 3 compounds had reduced potency compared to NEU-617, they all had improved LogP, LLE and MPO scores. Cross-screening these analogs against other protozoan parasites uncovered IV with potent activity towards T. brucei, T. cruzi and L. major, while four others compounds showed activity towards P. falciparum D6. This reinforces the effectiveness of lead repurposing for the discovery of new protozoan disease therapeutics. In the experiment, the researchers used many compounds, for example, 3-Aminopyridazine (cas: 5469-70-5Related Products of 5469-70-5).

3-Aminopyridazine (cas: 5469-70-5) belongs to pyridazine derivatives. Pyridazines are rare in nature, possibly reflecting the scarcity of naturally occurring hydrazines, common building blocks for the synthesis of these heterocycles. Pyridazine is bioavailable (especially in the CNS) and can reduce toxicity. Pyridazine is a component of several drug molecules, and the pyridazine pharmacophore has contributed to a variety of pharmacologically active compounds.Related Products of 5469-70-5

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Optimization of physicochemical properties for 4-anilinoquinazoline inhibitors of trypanosome proliferation was written by Woodring, Jennifer L.;Bachovchin, Kelly A.;Brady, Kimberly G.;Gallerstein, Mitchell F.;Erath, Jessey;Tanghe, Scott;Leed, Susan E.;Rodriguez, Ana;Mensa-Wilmot, Kojo;Sciotti, Richard J.;Pollastri, Michael P.. And the article was included in European Journal of Medicinal Chemistry in 2017.Related Products of 5469-70-5 This article mentions the following:

Human African trypanosomiasis (HAT) is a deadly disease in need of new chemotherapeutics that can cross into the central nervous system. The authors previously reported the discovery of (NEU-617), a small mol. with activity against T. brucei bloodstream proliferation. Further optimization of NEU-617 to improve the physicochem. properties (LogP, LLE, [1], and MPO score) [2] have led us to twelve sub-micromolar compounds, most importantly the headgroup variants I and II, and the linker variant III. Although these 3 compounds had reduced potency compared to NEU-617, they all had improved LogP, LLE and MPO scores. Cross-screening these analogs against other protozoan parasites uncovered IV with potent activity towards T. brucei, T. cruzi and L. major, while four others compounds showed activity towards P. falciparum D6. This reinforces the effectiveness of lead repurposing for the discovery of new protozoan disease therapeutics. In the experiment, the researchers used many compounds, for example, 3-Aminopyridazine (cas: 5469-70-5Related Products of 5469-70-5).

3-Aminopyridazine (cas: 5469-70-5) belongs to pyridazine derivatives. Pyridazines are rare in nature, possibly reflecting the scarcity of naturally occurring hydrazines, common building blocks for the synthesis of these heterocycles. Pyridazine is bioavailable (especially in the CNS) and can reduce toxicity. Pyridazine is a component of several drug molecules, and the pyridazine pharmacophore has contributed to a variety of pharmacologically active compounds.Related Products of 5469-70-5

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem