With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.933-76-6,4,5-Dichloro-2-methylpyridazin-3(2H)-one,as a common compound, the synthetic route is as follows.,933-76-6
A mixture of 4,5-dichloro-2-methyl-pyridazin-3-one (551 mg, 3.08 mmol), 3-chloro- lH-indazole (1.17 g, 7.70 mmol), and caesium carbonate (1.48 g, 7.70 mmol) in DMF (15 ml) is heated to 110 C for 1 h. The reaction mixture is cooled then concentrated in vacuo. The reaction mixture is diluted with ethyl acetate (50 ml) and washed with water (50 mL) and brine (50 mL x 2). The organic extract is dried over magnesium sulphate, filtered and concentrated in vacuo. The crude product is purified by chromatography on silica eluting with 0-95% ethyl acetate in isohexane to give the product as a light orange oil (940 mg). 1H NMR (CDC13) delta (ppm) 8.36 (1 H, s) 7.45 – 7.62 (2 H, m) 7.34 (1 H, ddd) 7.08 – 7.20 (3 H, m) 7.04 (1 H, ddd) 6.68 (1 H, d) 3.97 (3 H, s).
As the paragraph descriping shows that 933-76-6 is playing an increasingly important role.
Reference£º
Patent; SYNGENTA LIMITED; BURTON, Paul; KOZAKIEWICZ, Anthony; MORRIS, James Alan; MATHEWS, Christopher John; SHANAHAN, Stephen; WO2013/160126; (2013); A1;,
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