Tag: 88497-27-2

88497-27-2, 3-Amino-6-bromopyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 6-bromopyridazin-3-amine (3.48 g, 20 mmol) in EtOH/H2O (5/1, 180 mL) was added 2-bromo-1,1-diethoxyethane (11.8 g, 60 mmol), followed by p-toluenesulphonic acid (20.6 mg, 0.12 mmol). The mixture was stirred at 80 C. for 16 hours and then concentrated in vacuo. The resulted solid was washed with H2O (4 mL), collected by filtration, and dried in a vacuum oven overnight at 40 C. to give the title compound as a gray solid (3.9 g, 100%). MS (ESI, pos. ion) m/z: 198.1 [M+H]+; 1H NMR (400 MHz, CDCl3): delta 8.71 (d, J=9.6 Hz, 1H), 8.44 (d, J=1.6 Hz, 1H), 8.33 (d, J=1.9 Hz, 1H), 7.97 (d, J=9.6 Hz, 1H).

As the paragraph descriping shows that 88497-27-2 is playing an increasingly important role.

Reference£º
Patent; Calitor Sciences, LLC; Xi, Ning; US2014/134133; (2014); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

88497-27-2, 3-Amino-6-bromopyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 6-bromopyridazin-3-amine (10.75 g, 57.5 mmol) in ethyl acetate (150 ml) was added trimethylsilyl 2,2,2-trifluoroacetate (16.88 ml, 98 mmol). After the mixture was stirred for 5 mi triethoxymethane (17.21 ml, 103 mmol) was added. The resulting mixture wasstirred for another five mm, and this was followed by addition of azidotrimethylsilane (12.09 ml,92 mmol). Stirring continued at rt for 2 days, and the mixture was concentrated under reduced pressure. Recrystallization of the residue from ethyl acetate afforded 3-bromo-6-(1H-tetrazol-1- yl)pyridazine. LCMS [M+2+1] = 228.9.

As the paragraph descriping shows that 88497-27-2 is playing an increasingly important role.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; BISWAS, Dipshikha; DING, Fa-Xiang; DONG, Shuzhi; GU, Xin; JIANG, Jinlong; PASTERNAK, Alexander; SUZUKI, Takao; VACCA, Joseph; XU, Shouning; WO2015/103756; (2015); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

88497-27-2, 3-Amino-6-bromopyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[00268] To a solution of amino-heterocycle derivative (1 eq.) in nBuOH under argon are added successively the aldehyde RzCHO (2.5 eq.), MgC^ (0.04 eq.) and 1,1,3,3-tetramethylbutyl isocyanide (1.15 eq.). The reaction mixture is heated at 130 C from between 3.5 h to overnight, and then concentrated in vacuo. The residue is partitioned between heptane and water, stirred for 15 to 40 min, the biphasic solution is filtered on Celpure P65, and the cake is washed with heptane. The two layers of the filtrate are separated, the organic layer is washed successively with water, an aqueous 1M NaOH and brine, then dried over Na2S04 and concentrated in vacuo to afford the expected amine which is used directly in the next step.

The synthetic route of 88497-27-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GALAPAGOS NV; DESROY, Nicolas; HECKMANN, Bertrand; BRYS, Reginald Christophe Xavier; JONCOUR, Agnes Marie; PEIXOTO, Christophe; BOCK, Xavier Marie; HOUSSEMAN, Christopher Gaetan; WO2014/202458; (2014); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem