Tag: 84956-71-8

84956-71-8, 2-(tert-Butyl)-4,5-dichloropyridazin-3(2H)-one is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,84956-71-8

REFERENCE EXAMPLE 1 Synthesis of 2-tert.-butyl-5-chloro-4-methyl-3(2H)-pyridazinone (starting material) To a solution of 6.0 g (0.25 mol) of magnesium in 50 ml of dry tetrahydrofuran was added dropwise 35.5 g (0.25 mol) of methyl iodide under stream of nitrogen to produce a Grignard reagent. After completion of adding the methyl iodide, 1000 ml of dry toluene was added thereto. The resulting solution was heated to 60 to 70 C. and added dropwise with methyl iodide until the magnesium was completely consumed. The resulting Grignard reagent was cooled to room temperature and was added dropwise over 20 minutes with 22.1 g (0.1 mol) of 2-tert.-butyl-4,5-dichloro-3(2H)-pyridazinone dissolved in 200 ml of dry toluene. After completion of adding, the reaction liquid was subjected to reaction for 1.5 hours at room temperature and then poured into a solution of 100 ml of conc. hydrochloric acid in 900 ml of ice-water to effect extraction. The resulting organic layer was then washed with 500 ml of 10% aqueous solution of sodium hydroxide and then with 500 ml of water, and dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure to give 17.2 g of a crude product. The crude product was subjected to distillation (boiling point: 60 to 62 C./0.22 mmHg) and then column chromatography (silica gel; hexane_acetone=15:1) for separation and purification to give 4.5 g of 2-tert.-butyl-5-chloro-4-methyl-3(2H)-pyridazinone. ND20 =1.5238. NMR (CDCl3, delta, TMS): 1.63 (9H, s), 2.23 (3H, s), 7.66 (1H, s).

The synthetic route of 84956-71-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Nissan Chemical Industries, Ltd.; US4874861; (1989); A;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.84956-71-8,2-(tert-Butyl)-4,5-dichloropyridazin-3(2H)-one,as a common compound, the synthetic route is as follows.

Example 6 Synthesis of 2-tert.-butyl-4-chloro-5-[4-(1,1,2-trifluoro-2-trifluoromethoxy-ethoxy)-alpha-methyl-benzyloxy]-3(2H)-pyridazinone [Compound (1)] 1.5 g of 4-(1,1,2-trifluoromethoxy-ethoxy)-alpha-methylbenzyl alcohol (Example 1) were added to a suspension of 0.24 g of sodium hydride (50% in 10 ml of formaldehyde) and 15 minutes later 1.1 g of 2-tert.-butyl-4,5-dichloro-3(2H)-pyridazinone were added to the resulting mixture. The reaction mixture was stirred for 1 hour at room temperature, diluted with ether and washed with diluted HCl and brine. The washed solution was thoroughly dried, the solvent was evaporated and the crude reaction product thus obtained was chromatographed on silica gel with 9/1 hexane/ethyl acetate. Thus 0.9 g of pure product were obtained.

The synthetic route of 84956-71-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MINISTERO DELL’ UNIVERSITA’ E DELLA RICERCA SCIENTIFICA E TECNOLOGICA; EP391390; (1990); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.84956-71-8,2-(tert-Butyl)-4,5-dichloropyridazin-3(2H)-one,as a common compound, the synthetic route is as follows.

Example 6 Synthesis of 2-tert.-butyl-4-chloro-5-[4-(1,1,2-trifluoro-2-trifluoromethoxy-ethoxy)-alpha-methyl-benzyloxy]-3(2H)-pyridazinone [Compound (1)] 1.5 g of 4-(1,1,2-trifluoromethoxy-ethoxy)-alpha-methylbenzyl alcohol (Example 1) were added to a suspension of 0.24 g of sodium hydride (50% in 10 ml of formaldehyde) and 15 minutes later 1.1 g of 2-tert.-butyl-4,5-dichloro-3(2H)-pyridazinone were added to the resulting mixture. The reaction mixture was stirred for 1 hour at room temperature, diluted with ether and washed with diluted HCl and brine. The washed solution was thoroughly dried, the solvent was evaporated and the crude reaction product thus obtained was chromatographed on silica gel with 9/1 hexane/ethyl acetate. Thus 0.9 g of pure product were obtained.

The synthetic route of 84956-71-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MINISTERO DELL’ UNIVERSITA’ E DELLA RICERCA SCIENTIFICA E TECNOLOGICA; EP391390; (1990); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.84956-71-8,2-(tert-Butyl)-4,5-dichloropyridazin-3(2H)-one,as a common compound, the synthetic route is as follows.

crude oil thus obtained in dry dimethylformamide (5.00 mL) then 2-(t-butyl)-4,5-dichloro-2-hydropyridazin-3-one (0.166 g, 0.750 mmol) and cesium carbonate (0.326,1.00mmol ) it was treated at ambient temperature, each one time. Then, the resulting suspension was immersed in an oil bath , with vigorous stirring, and maintained for 21 hours at 65 C.After cooling to ambient temperature, a funnel suspension is separated and transferred to the water and ethyl acetate (each 20 ml) divided into, a separating layer. Next, the washing and drying (2¡Á20mL) ethyl acetate, ethyl acetate aqueous layer in combination with magnesium sulfate, filtration, the amber color of the concentrated oil under reduced pressure. Subsequently, coarse material, 7:3 hydroxypentanoic/ethyl acetate is used, is purified by using silica chromatography (30¡Á180mm). 200-350mL peak elution of the collecting main product, pools, in reduced pressure to concentrate the white solid (0. 191g, 0. 400mmol; 79. 9%).1H NMR : (300MHz, CDCl3) delta7. 71 (1H, s), 7. 15 (1H, d, J = 1. 9Hz), 6. 92 (1H, d, J = 2. 0Hz), 5. 21 (2H, s), 4. 74 (2H, dt, J = 47. 1, 5. 9Hz), 4. 13 (2H, t, J = 6. 0Hz), 3. 86 (3H, s), 2. 17 (2H, dtt, J = 25. 5, 6. 0, 6. 0Hz), 1. 64 (9H, s).13C NMR : (75MHz, CDCl3) delta158. 9,154. 1,153. 4,145. 8,131. 9,125. 0,123. 2,118. 6,118. 0,110. 2, 81. 0 (d, JCF= 164Hz), 71. 0, 68. 9 (d, JCF= 5. 5Hz), 66. 5, 56. 1, 31. 3 (d, JCF= 20. 2Hz), 27. 8. HRMS C19H2379Br35ClN2O4to calculated value (M+H): 477. 0587 ; measured value: 477. 0589. TLC: Rf0. 15 (silica gel, 4:1 hydroxypentanoic/ethyl acetate, CAM).

84956-71-8 2-(tert-Butyl)-4,5-dichloropyridazin-3(2H)-one 2782225, apyridazine compound, is more and more widely used in various.

Reference£º
Patent; LANTHEUS MEDICAL IMAGING INCORPORATED; CESATI, RICHARD R; RADEKE, HEIKE S; PANDEY, SURESH K; PUROHIT, AJAY; ROBINSON, SIMON P; (297 pag.)JP2015/531760; (2015); A;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.84956-71-8,2-(tert-Butyl)-4,5-dichloropyridazin-3(2H)-one,as a common compound, the synthetic route is as follows.

Synthesis of 2-tert-Butyl-4-chloro-5-thio-3(2H)-pyridazinone To 0.5 g of 2-tert-Butyl-4,5-dichloro-3(2H)-pyridazinone was added 7 ml water and sodium sulfide (0.53 g, 6.81 mmol) and the mixture was heated to 80 C. until all the solid dissolved. The solution was then cooled to room temperature and concentrated HCl was carefully added to give a yellow precipitate, which was filtered and washed with cold water. Crystallization from hexanes afforded the product as a white solid (270 mg).

As the paragraph descriping shows that 84956-71-8 is playing an increasingly important role.

Reference£º
Patent; Casebier, David S.; Robinson, Simon P.; Purohit, Ajay; Radeke, Heike S.; Azure, Michael T.; Dischino, Douglas D.; US2005/191238; (2005); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.84956-71-8,2-(tert-Butyl)-4,5-dichloropyridazin-3(2H)-one,as a common compound, the synthetic route is as follows.

A solution of the product of part A (0.105 g, 0.300 mmol) in 2-fluoroethanol (1.75 mL) was treated with 11.4 mg p-toluenesulfonic acid hydrate (0.06 mmol; 20 mol %) in one portion at ambient temperature. After 24 h, all volatiles were removed in vacuo, and the residue directly purified by chromatography on silica (30*185 mm) using 4:1 hexanes/ethyl acetate. The main product peak eluting 360-450 mL was collected, pooled and concentrated in vacuo to a colorless oil (81.2 mg, 0.205 mmol; 68.3%). 1H NMR: (300 MHz, DMSO-d6) delta 8.28 (1H, s), 7.55-7.39 (4H, m), 5.44 (2H, s), 4.62-4.52 (1H, m), 4.47-4.36 (1H, m), 3.46-3.34 (1H, m), 3.36-3.25 (1H, m), 1.58 (9H, s), 1.49 (6H, s). 19F NMR: (282 MHz, DMSO-d6) delta -222.01 (1F, tt, J=47.8, 30.6 Hz). 13C NMR: (75 MHz, DMSO-d6) delta 157.8, 153.9, 146.3, 133.9, 127.7, 126.1, 125.8, 115.5, 83.17 (d, J=166.3 Hz), 76.3, 71.2, 65.3, 61.89 (d, J=19.2 Hz), 28.0, 27.4. HRMS Calcd. for C20H2635ClFN2O3 (M+H): 397.1689. found: 397.1695. TLC: Rf 0.51 (silica gel, 3:2 hexanes/ethyl acetate, uv).

84956-71-8 2-(tert-Butyl)-4,5-dichloropyridazin-3(2H)-one 2782225, apyridazine compound, is more and more widely used in various.

Reference£º
Patent; Lantheus Medical Imaging, Inc.; Cesati, Richard R.; Radeke, Heike S.; Pandey, Suresh K.; Purohit, Ajay; Robinson, Simon P.; US2015/196672; (2015); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem