Tag: 65202-50-8

65202-50-8, Methyl 6-chloropyridazine-3-carboxylate is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

65202-50-8, 6-(3,6-Dihydro-2H-pyran-4-yl)pyridazin-3-carboxylic Acid Methyl 6-chloropyridazine-3-carboxylate (1.00 g, 5.79 mmol), 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-2H-pyran (1.22 g, 5.79 mmol), Pd(PPh3)4 (536 mg, 0.44 mmol) and Cs2CO3 (3.40 g, 10.4 mmol) were suspended in dioxane (8 mL) and water (8 mL) and heated in a microwave reactor at 125¡ã C. for 30 min. 1M aq HCl (10 mL) was added, the precipitate was removed by filtration and the filtrate was concentrated in vacuo. The residue was passed through a silica pad eluting with 30percent MeOH in DCM and concentrated in vacuo to give the title compound as a white solid (946 mg, 79.2percent). LCMS (ES+): 207.1 [MH]+. HPLC: Rt 3.30 min, 49.9percent purity.

The synthetic route of 65202-50-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Proximagen Limited; Espensen, Max; Patient, Lee; Evans, David; Savory, Edward; Simpson, Iain; US2014/275040; (2014); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

65202-50-8, Methyl 6-chloropyridazine-3-carboxylate is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Methyl 6-chloropyridazine-3-carboxylate (1.4 g), spiro[1-benzofuran-3,3′-pyrrolidine] (1.5 g), potassium carbonate (1.4 g) and tetrabutylammonium iodide (370 mg) were suspended in tetrahydrofuran (80 mL), and the suspension was stirred under reflux overnight. The reaction mixture was diluted with ethyl acetate, and washed with aqueous sodium carbonate solution. The organic layer was dried over sodium sulfate and the solvent was evaporated under reduced pressure. Ethyl acetate-hexane was added and the resulting precipitate was collected by filtration to give the object product (2.2 g, 88%). 1H NMR (300 MHz, DMSO-d6) delta ppm 2.21-2.41 (m, 2H) 3.52-4.04 (m, 7H) 4.43-4.54 (m, 2H) 6.80-7.02 (m, 3H) 7.13-7.25 (m, 1H) 7.32 (d, J=7.35 Hz, 1H) 7.87 (d, J=9.42 Hz, 1 H)

As the paragraph descriping shows that 65202-50-8 is playing an increasingly important role.

Reference£º
Patent; Taniguchi, Takahiko; Miyata, Kenichi; Kubo, Osamu; US2010/69351; (2010); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

65202-50-8, Methyl 6-chloropyridazine-3-carboxylate is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Methyl 6-chloropyridazine-3-carboxylate (1.4 g), spiro[1-benzofuran-3,3′-pyrrolidine] (1.5 g), potassium carbonate (1.4 g) and tetrabutylammonium iodide (370 mg) were suspended in tetrahydrofuran (80 mL), and the suspension was stirred under reflux overnight. The reaction mixture was diluted with ethyl acetate, and washed with aqueous sodium carbonate solution. The organic layer was dried over sodium sulfate and the solvent was evaporated under reduced pressure. Ethyl acetate-hexane was added and the resulting precipitate was collected by filtration to give the object product (2.2 g, 88%). 1H NMR (300 MHz, DMSO-d6) delta ppm 2.21-2.41 (m, 2H) 3.52-4.04 (m, 7H) 4.43-4.54 (m, 2H) 6.80-7.02 (m, 3H) 7.13-7.25 (m, 1H) 7.32 (d, J=7.35 Hz, 1H) 7.87 (d, J=9.42 Hz, 1 H)

As the paragraph descriping shows that 65202-50-8 is playing an increasingly important role.

Reference£º
Patent; Taniguchi, Takahiko; Miyata, Kenichi; Kubo, Osamu; US2010/69351; (2010); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem