Tag: 279.47

Kumar Rout, Saroj et al. published their research in Chemistry – A European Journal in 2022 | CAS: 923595-49-7

6-Chloro-3-iodoimidazo[1,2-b]pyridazine (cas: 923595-49-7) belongs to pyridazine derivatives. Pyridazines is a six-membered nitrogen-containing significant heterocycle. It has received considerable interest because of its useful applications as natural products, pharmaceuticals, and various bioactive molecules. The activity depends upon the changes of substituted groups in the pyridazine ring system resulting in different biological activities. In addition, the natural pyrimidine bases uracil, thymine, and cytosine, which are constituents of the nucleic acids, are found to be the most important naturally occurring diazines.COA of Formula: C6H3ClIN3

Reliable Functionalization of 5,6-Fused Bicyclic N-Heterocycles Pyrazolopyrimidines and Imidazopyridazines via Zinc and Magnesium Organometallics was written by Kumar Rout, Saroj;Kastrati, Agonist;Jangra, Harish;Schwarzer, Kuno;Sunagatullina, Alisa S.;Garny, Maximilien;Lima, Fabio;Brocklehurst, Cara E.;Karaghiosoff, Konstantin;Zipse, Hendrik;Knochel, Paul. And the article was included in Chemistry – A European Journal in 2022.COA of Formula: C6H3ClIN3 This article mentions the following:

DFT-calculations allow predictions of the reactivity of uncommon N-heterocyclic scaffolds of pyrazolo[1,5-a]pyrimidines and imidazo[1,2-b]pyridazines and considerably facilitate their functionalization. The derivatization of these N-heterocycles was realized using Grignard reagents for nucleophilic additions to 5-chloropyrazolo[1,5-a]pyrimidines; and TMP2Zn路2 MgCl2路2 LiCl allowed regioselective zincations. In the case of 6-chloroimidazo[1,2-b]pyridazine, bases such as TMP2Zn路MgCl2路2LiCl, in the presence or absence of BF3路OEt2, led to regioselective metalations at positions 3 or 8. Subsequent functionalizations were achieved with TMPMgCl路LiCl, producing various polysubstituted derivatives (up to penta-substitution). X-ray anal. confirmed the regioselectivity for key functional heterocycles. In the experiment, the researchers used many compounds, for example, 6-Chloro-3-iodoimidazo[1,2-b]pyridazine (cas: 923595-49-7COA of Formula: C6H3ClIN3).

6-Chloro-3-iodoimidazo[1,2-b]pyridazine (cas: 923595-49-7) belongs to pyridazine derivatives. Pyridazines is a six-membered nitrogen-containing significant heterocycle. It has received considerable interest because of its useful applications as natural products, pharmaceuticals, and various bioactive molecules. The activity depends upon the changes of substituted groups in the pyridazine ring system resulting in different biological activities. In addition, the natural pyrimidine bases uracil, thymine, and cytosine, which are constituents of the nucleic acids, are found to be the most important naturally occurring diazines.COA of Formula: C6H3ClIN3

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

 

Kumar Rout, Saroj et al. published their research in Chemistry – A European Journal in 2022 | CAS: 923595-49-7

6-Chloro-3-iodoimidazo[1,2-b]pyridazine (cas: 923595-49-7) belongs to pyridazine derivatives. Pyridazines is a six-membered nitrogen-containing significant heterocycle. It has received considerable interest because of its useful applications as natural products, pharmaceuticals, and various bioactive molecules. The activity depends upon the changes of substituted groups in the pyridazine ring system resulting in different biological activities. In addition, the natural pyrimidine bases uracil, thymine, and cytosine, which are constituents of the nucleic acids, are found to be the most important naturally occurring diazines.COA of Formula: C6H3ClIN3

Reliable Functionalization of 5,6-Fused Bicyclic N-Heterocycles Pyrazolopyrimidines and Imidazopyridazines via Zinc and Magnesium Organometallics was written by Kumar Rout, Saroj;Kastrati, Agonist;Jangra, Harish;Schwarzer, Kuno;Sunagatullina, Alisa S.;Garny, Maximilien;Lima, Fabio;Brocklehurst, Cara E.;Karaghiosoff, Konstantin;Zipse, Hendrik;Knochel, Paul. And the article was included in Chemistry – A European Journal in 2022.COA of Formula: C6H3ClIN3 This article mentions the following:

DFT-calculations allow predictions of the reactivity of uncommon N-heterocyclic scaffolds of pyrazolo[1,5-a]pyrimidines and imidazo[1,2-b]pyridazines and considerably facilitate their functionalization. The derivatization of these N-heterocycles was realized using Grignard reagents for nucleophilic additions to 5-chloropyrazolo[1,5-a]pyrimidines; and TMP2Zn·2 MgCl2·2 LiCl allowed regioselective zincations. In the case of 6-chloroimidazo[1,2-b]pyridazine, bases such as TMP2Zn·MgCl2·2LiCl, in the presence or absence of BF3·OEt2, led to regioselective metalations at positions 3 or 8. Subsequent functionalizations were achieved with TMPMgCl·LiCl, producing various polysubstituted derivatives (up to penta-substitution). X-ray anal. confirmed the regioselectivity for key functional heterocycles. In the experiment, the researchers used many compounds, for example, 6-Chloro-3-iodoimidazo[1,2-b]pyridazine (cas: 923595-49-7COA of Formula: C6H3ClIN3).

6-Chloro-3-iodoimidazo[1,2-b]pyridazine (cas: 923595-49-7) belongs to pyridazine derivatives. Pyridazines is a six-membered nitrogen-containing significant heterocycle. It has received considerable interest because of its useful applications as natural products, pharmaceuticals, and various bioactive molecules. The activity depends upon the changes of substituted groups in the pyridazine ring system resulting in different biological activities. In addition, the natural pyrimidine bases uracil, thymine, and cytosine, which are constituents of the nucleic acids, are found to be the most important naturally occurring diazines.COA of Formula: C6H3ClIN3

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem