Tag: 206.63

Saturated heterocycles. Part 226. Copper(II) chloride as an efficient reagent for the dehydrogenation of pyridazinone derivatives was written by Csende, Ferenc;Szabo, Zoltan;Bernath, Gabor;Stajer, Geza. And the article was included in Synthesis in 1995.HPLC of Formula: 2166-13-4 This article mentions the following:

A new procedure is described for the preparation of the pyridazinones I [R = H, Me, F, Cl, Br; R¹ = H; R¹₂ = (CH₂)₄] from the corresponding 4,5-dihydropyridazinones under mild conditions with CuCl₂ in MeCN via halogenation and spontaneous HCl elimination. For the trans-phthalazinone I [R = Me; R¹₂ = (CH₂)₄], the HCl elimination is 5 times faster than for its cis isomer. In the experiment, the researchers used many compounds, for example, 6-(4-Chlorophenyl)pyridazin-3(2H)-one (cas: 2166-13-4HPLC of Formula: 2166-13-4).

6-(4-Chlorophenyl)pyridazin-3(2H)-one (cas: 2166-13-4) belongs to pyridazine derivatives. The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. The unsubstituted pyridazines are more resistant to eletrophilic substitution due to the nature of withdrawal of electron density from the ring by two heteroatoms, while the related electron deficiency of the ring makes pyridazine more easily attacked by nucleophiles.HPLC of Formula: 2166-13-4

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Chromium(III) complex thiocyanates with pyridazone derivatives was written by Guran, Cornelia Jitaru Ioana;Jitaru, Ioana;Ciocoiu, Ioana. And the article was included in Revue Roumaine de Chimie in 1994.Recommanded Product: 6-(4-Chlorophenyl)pyridazin-3(2H)-one This article mentions the following:

K[CrL₂(NCS)₄] (L = p-chlorophenylpyridazone, p-bromophenylpyridazone and p-tolylpyridazone) were prepared and characterized. The compounds are characterized by elemental chem. anal., measurements of elec. conductivity and electronic, IR and x-ray spectra. In the experiment, the researchers used many compounds, for example, 6-(4-Chlorophenyl)pyridazin-3(2H)-one (cas: 2166-13-4Recommanded Product: 6-(4-Chlorophenyl)pyridazin-3(2H)-one).

6-(4-Chlorophenyl)pyridazin-3(2H)-one (cas: 2166-13-4) belongs to pyridazine derivatives. Pyridazines are rare in nature, possibly reflecting the scarcity of naturally occurring hydrazines, common building blocks for the synthesis of these heterocycles. In the past decade, X-ray data were reported with regard to the characterization and structural elucidation of a number of pyridazine-metal complexes, including pyridazine ligands with zinc, nickel, copper, cadmium and ruthenium.Recommanded Product: 6-(4-Chlorophenyl)pyridazin-3(2H)-one

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

The effect of solvent on the synthesis of pyridazinones and some reactions of the new compounds was written by Sayed, Galal Hosni;Radwan, Azza;Hamed, Ashraf Ahmed;Boraie, Waleed El Sayed. And the article was included in Bulletin of the Chemical Society of Japan in 1993.Application of 2166-13-4 This article mentions the following:

The reaction of 4-aryl-4-oxo-2-(5-oxo-1,3-diphenyl-2-pyrazolin-4-yl)butanoic acids with hydrazine hydrate in ethanol afforded (oxopyrazolinyl)pyridazinones I (R = p-ClC₆H₄, p-tolyl); in 1-butanol pyrazolo[3,4-c]pyridazino[4,3-e]pyridazine derivative II was obtained, while in acetic acid the 6-aryl-3(2H)-pyridazinone was the product. A probable mechanism has been proposed. The behavior of I toward di-Me sulfate, di-Et sulfate, Et bromoacetate, p-anisaldehyde, phosphoryl chloride and phosphorus pentasulfide has been studied. In the experiment, the researchers used many compounds, for example, 6-(4-Chlorophenyl)pyridazin-3(2H)-one (cas: 2166-13-4Application of 2166-13-4).

6-(4-Chlorophenyl)pyridazin-3(2H)-one (cas: 2166-13-4) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. The unsubstituted pyridazines are more resistant to eletrophilic substitution due to the nature of withdrawal of electron density from the ring by two heteroatoms, while the related electron deficiency of the ring makes pyridazine more easily attacked by nucleophiles.Application of 2166-13-4

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Production of 6-arylpyridazin-3-ones was written by Anonymous. And the article was included in Research Disclosure in 1990.Reference of 2166-13-4 This article mentions the following:

The cyclization of benzoylacrylic acid derivatives with NH₃ and hydrazine derivatives gave phenylpyridazinone derivatives I (R = H, Me, F, Cl, Br, OMe; R¹ = H, CH₂OH, Ph, CH(OH)Ph, CH(OH)CH₂OBu, CH₂CO₂H). In the experiment, the researchers used many compounds, for example, 6-(4-Chlorophenyl)pyridazin-3(2H)-one (cas: 2166-13-4Reference of 2166-13-4).

6-(4-Chlorophenyl)pyridazin-3(2H)-one (cas: 2166-13-4) belongs to pyridazine derivatives. Pyridazines is a six-membered nitrogen-containing significant heterocycle. It has received considerable interest because of its useful applications as natural products, pharmaceuticals, and various bioactive molecules. Pyridazine compounds have attracted interest in various fields like medicinal, industrial, and agricultural research as they are used for numerous biological activities and other applications.Reference of 2166-13-4

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Saturated heterocycles. Part 226. Copper(II) chloride as an efficient reagent for the dehydrogenation of pyridazinone derivatives was written by Csende, Ferenc;Szabo, Zoltan;Bernath, Gabor;Stajer, Geza. And the article was included in Synthesis in 1995.HPLC of Formula: 2166-13-4 This article mentions the following:

A new procedure is described for the preparation of the pyridazinones I [R = H, Me, F, Cl, Br; R¹ = H; R¹₂ = (CH₂)₄] from the corresponding 4,5-dihydropyridazinones under mild conditions with CuCl₂ in MeCN via halogenation and spontaneous HCl elimination. For the trans-phthalazinone I [R = Me; R¹₂ = (CH₂)₄], the HCl elimination is 5 times faster than for its cis isomer. In the experiment, the researchers used many compounds, for example, 6-(4-Chlorophenyl)pyridazin-3(2H)-one (cas: 2166-13-4HPLC of Formula: 2166-13-4).

6-(4-Chlorophenyl)pyridazin-3(2H)-one (cas: 2166-13-4) belongs to pyridazine derivatives. The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. The unsubstituted pyridazines are more resistant to eletrophilic substitution due to the nature of withdrawal of electron density from the ring by two heteroatoms, while the related electron deficiency of the ring makes pyridazine more easily attacked by nucleophiles.HPLC of Formula: 2166-13-4

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Saturated heterocycles. Part 226. Copper(II) chloride as an efficient reagent for the dehydrogenation of pyridazinone derivatives was written by Csende, Ferenc;Szabo, Zoltan;Bernath, Gabor;Stajer, Geza. And the article was included in Synthesis in 1995.HPLC of Formula: 2166-13-4 This article mentions the following:

A new procedure is described for the preparation of the pyridazinones I [R = H, Me, F, Cl, Br; R¹ = H; R¹₂ = (CH₂)₄] from the corresponding 4,5-dihydropyridazinones under mild conditions with CuCl₂ in MeCN via halogenation and spontaneous HCl elimination. For the trans-phthalazinone I [R = Me; R¹₂ = (CH₂)₄], the HCl elimination is 5 times faster than for its cis isomer. In the experiment, the researchers used many compounds, for example, 6-(4-Chlorophenyl)pyridazin-3(2H)-one (cas: 2166-13-4HPLC of Formula: 2166-13-4).

6-(4-Chlorophenyl)pyridazin-3(2H)-one (cas: 2166-13-4) belongs to pyridazine derivatives. The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. The unsubstituted pyridazines are more resistant to eletrophilic substitution due to the nature of withdrawal of electron density from the ring by two heteroatoms, while the related electron deficiency of the ring makes pyridazine more easily attacked by nucleophiles.HPLC of Formula: 2166-13-4

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

The effect of solvent on the synthesis of pyridazinones and some reactions of the new compounds was written by Sayed, Galal Hosni;Radwan, Azza;Hamed, Ashraf Ahmed;Boraie, Waleed El Sayed. And the article was included in Bulletin of the Chemical Society of Japan in 1993.Application of 2166-13-4 This article mentions the following:

The reaction of 4-aryl-4-oxo-2-(5-oxo-1,3-diphenyl-2-pyrazolin-4-yl)butanoic acids with hydrazine hydrate in ethanol afforded (oxopyrazolinyl)pyridazinones I (R = p-ClC₆H₄, p-tolyl); in 1-butanol pyrazolo[3,4-c]pyridazino[4,3-e]pyridazine derivative II was obtained, while in acetic acid the 6-aryl-3(2H)-pyridazinone was the product. A probable mechanism has been proposed. The behavior of I toward di-Me sulfate, di-Et sulfate, Et bromoacetate, p-anisaldehyde, phosphoryl chloride and phosphorus pentasulfide has been studied. In the experiment, the researchers used many compounds, for example, 6-(4-Chlorophenyl)pyridazin-3(2H)-one (cas: 2166-13-4Application of 2166-13-4).

6-(4-Chlorophenyl)pyridazin-3(2H)-one (cas: 2166-13-4) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. The unsubstituted pyridazines are more resistant to eletrophilic substitution due to the nature of withdrawal of electron density from the ring by two heteroatoms, while the related electron deficiency of the ring makes pyridazine more easily attacked by nucleophiles.Application of 2166-13-4

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Production of 6-arylpyridazin-3-ones was written by Anonymous. And the article was included in Research Disclosure in 1990.Reference of 2166-13-4 This article mentions the following:

The cyclization of benzoylacrylic acid derivatives with NH₃ and hydrazine derivatives gave phenylpyridazinone derivatives I (R = H, Me, F, Cl, Br, OMe; R¹ = H, CH₂OH, Ph, CH(OH)Ph, CH(OH)CH₂OBu, CH₂CO₂H). In the experiment, the researchers used many compounds, for example, 6-(4-Chlorophenyl)pyridazin-3(2H)-one (cas: 2166-13-4Reference of 2166-13-4).

6-(4-Chlorophenyl)pyridazin-3(2H)-one (cas: 2166-13-4) belongs to pyridazine derivatives. Pyridazines is a six-membered nitrogen-containing significant heterocycle. It has received considerable interest because of its useful applications as natural products, pharmaceuticals, and various bioactive molecules. Pyridazine compounds have attracted interest in various fields like medicinal, industrial, and agricultural research as they are used for numerous biological activities and other applications.Reference of 2166-13-4

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem