Tag: 202.6

Stevens, Marcus A. et al. published their research in Journal of the American Chemical Society in 1959 | CAS: 61404-41-9

Ethyl 6-chloro-3-hydroxypyridazine-4-carboxylate (cas: 61404-41-9) belongs to pyridazine derivatives. The pyridazine structure is also found within the structure of several drugs such as cefozopran, cadralazine, minaprine, pipofezine, and hydralazine. The unsubstituted pyridazines are more resistant to eletrophilic substitution due to the nature of withdrawal of electron density from the ring by two heteroatoms, while the related electron deficiency of the ring makes pyridazine more easily attacked by nucleophiles.Application of 61404-41-9

Purine N-oxides. V. Oxides of adenine nucleotides was written by Stevens, Marcus A.;Smith, Herman W.;Brown, Geo. Bosworth. And the article was included in Journal of the American Chemical Society in 1959.Application of 61404-41-9 This article mentions the following:

The parent nucleotides (AMP-2′), (AMP-3′), and (AMP-5′) oxidized with H2O2-AcOH mixtures gave the 1-(N-oxides) of adenosine 2′-, 3′-, and 5′-phosphates and adenosine 5′-diphosphate (ADP), resp. The nucleotides oxidized with H2O2 alone gave chromatographic amounts of the 1-(N-oxides) of AMP-5′ and deoxyadenylic acid. These nucleotide oxides were characterized by hydrogenation to the parent nucleotide and by acid hydrolysis to 4-amino-5 imidazolecarboxamide oxime. Adenosine 1-(N-oxide) and the AMP-2′, AMP-3′-and AMP-5′ 1-(N-oxides) hydrolyzed with alkali gave the 1-ribosyl and 1-phosphoribosyl derivatives of 5-amino-4-imidazolecarboxamide oxime, resp. The nucleotide oxides in the solid state and in aqueous solution showed an instability which was not observed with adenosine 1-(N-oxide) or adenine 1-(N-oxide). AMP-3′ (500 mg.) in 25 ml. AcOH and 5 ml. 30% H2O2 kept 9 days, the solution treated 2 days with 10% Pd-C, evaporated to dryness in vacuo at room temperature, the residue in 6 l. H2O2 chromatographed on Dowex-1 formate, and eluted with 0.1M formate yielded AMP-2′, AMP-2′ 1-(N-oxide), AMP-3′, and AMP-3′ 1-(N-oxide). AMP-5′.2H2O (333 mg.) kept 16 days in 2.6 ml. 30% H2O2, 0.7 ml. H2O, and 3.3 ml. AcOH and the product chromatographed yielded 120 mg. AMP-5′ and 121 mg. AMP-5′ 1-(N-oxide), m. 183-5°. In the experiment, the researchers used many compounds, for example, Ethyl 6-chloro-3-hydroxypyridazine-4-carboxylate (cas: 61404-41-9Application of 61404-41-9).

Ethyl 6-chloro-3-hydroxypyridazine-4-carboxylate (cas: 61404-41-9) belongs to pyridazine derivatives. The pyridazine structure is also found within the structure of several drugs such as cefozopran, cadralazine, minaprine, pipofezine, and hydralazine. The unsubstituted pyridazines are more resistant to eletrophilic substitution due to the nature of withdrawal of electron density from the ring by two heteroatoms, while the related electron deficiency of the ring makes pyridazine more easily attacked by nucleophiles.Application of 61404-41-9

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

 

Yanai, Mitsuji et al. published their research in Heterocycles in 1976 | CAS: 61404-41-9

Ethyl 6-chloro-3-hydroxypyridazine-4-carboxylate (cas: 61404-41-9) belongs to pyridazine derivatives. Pyridazines are rare in nature, possibly reflecting the scarcity of naturally occurring hydrazines, common building blocks for the synthesis of these heterocycles. Pyridazine is bioavailable (especially in the CNS) and can reduce toxicity. Pyridazine is a component of several drug molecules, and the pyridazine pharmacophore has contributed to a variety of pharmacologically active compounds.Category: pyridazine

A new alkylation of pyridazines with nitromethane and nitroethane was written by Yanai, Mitsuji;Takeda, Shigeko;Nishikawa, Makoto. And the article was included in Heterocycles in 1976.Category: pyridazine This article mentions the following:

The pyridazinecarboxylate I (R = 4-CO2Et) was alkylated by R1NO2 (R1 = Me, Et) to give II. I (R = 5-CO2Et) was similarly alkylated, whereas I (R = 4-CO2H, 5-CO2H) and 3-hydroxy-4-pyridazinecarboxylic acid were alkylated with decarboxylation. Me2SO was the best solvent and K2CO3 and NEt3 were suitable catalysts. In the experiment, the researchers used many compounds, for example, Ethyl 6-chloro-3-hydroxypyridazine-4-carboxylate (cas: 61404-41-9Category: pyridazine).

Ethyl 6-chloro-3-hydroxypyridazine-4-carboxylate (cas: 61404-41-9) belongs to pyridazine derivatives. Pyridazines are rare in nature, possibly reflecting the scarcity of naturally occurring hydrazines, common building blocks for the synthesis of these heterocycles. Pyridazine is bioavailable (especially in the CNS) and can reduce toxicity. Pyridazine is a component of several drug molecules, and the pyridazine pharmacophore has contributed to a variety of pharmacologically active compounds.Category: pyridazine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

 

Yanai, Mitsuji et al. published their research in Heterocycles in 1976 | CAS: 61404-41-9

Ethyl 6-chloro-3-hydroxypyridazine-4-carboxylate (cas: 61404-41-9) belongs to pyridazine derivatives. Pyridazines are rare in nature, possibly reflecting the scarcity of naturally occurring hydrazines, common building blocks for the synthesis of these heterocycles. Pyridazine is bioavailable (especially in the CNS) and can reduce toxicity. Pyridazine is a component of several drug molecules, and the pyridazine pharmacophore has contributed to a variety of pharmacologically active compounds.Category: pyridazine

A new alkylation of pyridazines with nitromethane and nitroethane was written by Yanai, Mitsuji;Takeda, Shigeko;Nishikawa, Makoto. And the article was included in Heterocycles in 1976.Category: pyridazine This article mentions the following:

The pyridazinecarboxylate I (R = 4-CO2Et) was alkylated by R1NO2 (R1 = Me, Et) to give II. I (R = 5-CO2Et) was similarly alkylated, whereas I (R = 4-CO2H, 5-CO2H) and 3-hydroxy-4-pyridazinecarboxylic acid were alkylated with decarboxylation. Me2SO was the best solvent and K2CO3 and NEt3 were suitable catalysts. In the experiment, the researchers used many compounds, for example, Ethyl 6-chloro-3-hydroxypyridazine-4-carboxylate (cas: 61404-41-9Category: pyridazine).

Ethyl 6-chloro-3-hydroxypyridazine-4-carboxylate (cas: 61404-41-9) belongs to pyridazine derivatives. Pyridazines are rare in nature, possibly reflecting the scarcity of naturally occurring hydrazines, common building blocks for the synthesis of these heterocycles. Pyridazine is bioavailable (especially in the CNS) and can reduce toxicity. Pyridazine is a component of several drug molecules, and the pyridazine pharmacophore has contributed to a variety of pharmacologically active compounds.Category: pyridazine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem