SAR of the arylpiperazine moiety of obeline somatostatin sst1 receptor antagonists was written by Hurth, Konstanze;Enz, Albert;Floersheim, Philipp;Gentsch, Conrad;Hoyer, Daniel;Langenegger, Daniel;Neumann, Peter;Pfaeffli, Paul;Sorg, Dieter;Swoboda, Robert;Vassout, Annick;Troxler, Thomas. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2007.Electric Literature of C8H12N4 This article mentions the following:
The SAR of over 50 derivatives of octahydrobenzo[g]quinoline (obeline)-type somatostatin sst1 receptor antagonist 1 is presented, focusing on the modification of its arylpiperazine moiety. Sst1 affinities in this series cover a range of five orders of magnitude with the best derivatives displaying subnanomolar sst1 affinities and >10,000-fold selectivities over the sst2 receptor subtype as well as promising pharmacokinetic properties. In the experiment, the researchers used many compounds, for example, 3-Piperazin-1-yl-pyridazine (cas: 51047-56-4Electric Literature of C8H12N4).
3-Piperazin-1-yl-pyridazine (cas: 51047-56-4) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. Pyridazine is bioavailable (especially in the CNS) and can reduce toxicity. Pyridazine is a component of several drug molecules, and the pyridazine pharmacophore has contributed to a variety of pharmacologically active compounds.Electric Literature of C8H12N4
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem