Tag: 1632-76-4

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1632-76-4,3-Methylpyridazine,as a common compound, the synthetic route is as follows.,1632-76-4

General procedure: Methyldiazine derivative (1mmol) and compound 3 (1.1equiv per methyl group) were dissolved in THF (20mL). tBuOK (1.5equiv per methyl group) was slowly added at room temperature. The solution, which immediately turned brown, was then refluxed overnight. After cooling, water was added, THF was evaporated and the mixture extracted with CH2Cl2, dried over MgSO4 and the solvent removed under vacuum.

The synthetic route of 1632-76-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Achelle, Sylvain; Kahlal, Samia; Saillard, Jean-Yves; Cabon, Nolwenn; Caro, Bertrand; Robin-Le Guen, Franc?oise; Tetrahedron; vol. 70; 17; (2014); p. 2804 – 2815;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1632-76-4,3-Methylpyridazine,as a common compound, the synthetic route is as follows.

A solution of 3-Methylpyridazine 15 (5.0 g, 53.0 mmol) in THF (10 mL) was added to potassium tert-butoxide (8.9 g, 80.0 mmol) in THF (50 mL) at 0 C. After stirring at room temperature for 1.5 hours, tert-butyl nitrite (12.6 mL, 106 mmol) in THF (10 mL) was added to the reaction mixture at 0 C. After stirring at room temperature for 19 hours, the solvent was removed in vacuo and the residue was added to 4 M HCl solution (20 mL). The resulting mixture was concentrated in vacuo and filtered a colorless powder of aldoxime 16a (1.8 g). The residue was extracted with ethylacetate (50 mL 3). The organic layer was dried over MgSO4. The solvent was removed in vacuo, then triturated with n-hexane to yield aldoxime 16a (2.8 g). The combined aldoxime 16a (4.6 g, 71%) was E, Z mixture of isomer. N-Chlorosuccimide (4.0g, 30 mmol) was added to a suspension of 16a (3.7 g, 30 mmol), ethynyl tri-n-butylstannane (9.3 g, 20 mmol), NaHCO3 (6.3 g, 75 mmol), ethyacetate (100 mL) and distilled water (5 mL). After stirring at room temperature for 16 hours, distilled water (5 mL) was added to the reaction mixture. After stirring at room temperature for 4 hours, the reaction mixture was washed with saturated NaHCO3 (100 mL), and the aqueous layer was extracted with ethylacetate (100 mL). The combined organic layer was dried over MgSO4. The solvent was removed in vacuo and the residue was used in the next reaction without further purification. The crude 17a was dissolved in THF (100 mL). Iodine (3.2 g, 25.2 mmol) was added to the solution at room temperature. After stirring at room temperature for 35 minutes, the reaction mixture was diluted with 6% sodium thiosulfate solution (100 mL) and extracted with ethylacetate (100 ml). The organic layer was washed with brine and dried over MgSO4. The solvent was removed in vacuo and the residue was recrystallized from n-hexane to yield compound 14a (2.9 g, 35% for two steps) as a brown powder

1632-76-4 3-Methylpyridazine 74208, apyridazine compound, is more and more widely used in various.

Reference£º
Article; Sugimoto, Tomohiro; Shimazaki, Yoichi; Manaka, Akira; Tanikawa, Tetsuya; Suzuki, Keiko; Nanaumi, Kayoko; Kaneda, Yoshie; Yamasaki, Yukiko; Sugiyama, Hiroyuki; Bioorganic and Medicinal Chemistry Letters; vol. 22; 17; (2012); p. 5739 – 5743;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

1632-76-4, 3-Methylpyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Synthesis of 6-methylpyridazine 1-oxideTo a solution of 3-methylpyridazine (4.60 g, 48.9 mmol) in acetic acid (30.0 mL) was added H202 (29.4 g,259 mmol, 29.4 mL, 30percent (w/w) in water). The mixture was heated at 120 ¡ãC for 6 h. The mixture wasallowed to cool to RT and poured in aqueous saturated NaHCO3 (500 mL) and extracted with DCM (5x 50 mL). The combined organic layer was dried over Na2SO4 and concentrated in vacuo to afford 6- methylpyridazine 1-oxide (2.22 g, 20.2 mmol, 41percent). LCMS: caic. for [M+H] = 111.05, found 111.2. 1H- NMR shows a 1:1 mixture of both possible N-oxides.

1632-76-4 3-Methylpyridazine 74208, apyridazine compound, is more and more widely used in various.

Reference£º
Patent; GRUeNENTHAL GMBH; NARDI, Antonio; RATCLIFFE, Paul; CRAAN, Tobias; HERTRAMPF, Thorsten; LESCH, Bernhard; KIME, Robert; STEINHAGEN, Henning; WO2015/161928; (2015); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem