Tag: 14161-11-6

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14161-11-6,3,4,5-Trichloropyridazine,as a common compound, the synthetic route is as follows.

A mixture of 3,4,5-trichloropyridazine (17.79 g, 96.99 mmol) and a solution of NH3 in THF ( 250 mL, 750 mmol, 3 M) was stirred at 125 C in a sealed tube for 5 h. The reaction mixture was concentrated in vacuo and the residue was purified by silica gel column chromatography (EtOAc/PE (v/v) = 1/2) to give the title compound as a white solid (4.01 g, yield 25%).MS (ESI, pos. ion) m/z: 164.1 [M+H]+;1H NMR (600 MHz, CDCb) d (ppm): 8.60 (s, 1H), 4.89 (s, 2H).

14161-11-6, As the paragraph descriping shows that 14161-11-6 is playing an increasingly important role.

Reference£º
Patent; SUNSHINE LAKE PHARMA CO., LTD.; CALITOR SCIENCES, LLC; XI, Ning; LI, Minxiong; PENG, Ju; LI, Xiaobo; ZHANG, Tao; HU, Haiyang; CHEN, Wuhong; BAI, Changlin; KE, Donghua; CHEN, Peng; (281 pag.)WO2019/99311; (2019); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

14161-11-6, 3,4,5-Trichloropyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,14161-11-6

A mixture of 3,4,5-trichloro- pyridazine (200 mg, 0.0011 mol), intermediate 2 (see Example Al/b) (273 mg, 0.0011 mol) and diisopropylamine (0.38 ml, 0.0011 mol) was stirred in 2-propanol (4.0 ml) at 800C for 1 hour. The solvent was evaporated, and the crude mixture was taken back in EtOAc. The organic layer was washed with a saturated solution of sodium bicarbonate and with brine, dried (MgSO4), filtered, and the solvent was evaporated. The residue was purified by column chromatography over silica gel (40-63 mum) (eluent: EtOAc/cyclohexane 50/50). The pure fractions were collected and the solvent was evaporated, yielding 179 mg (41%) of intermediate 86 and intermediate 87 as a 1/1 mixture of two pyridazine compounds.

The synthetic route of 14161-11-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; JANSSEN PHARMACEUTICA N.V.; WO2006/32631; (2006); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

14161-11-6, 3,4,5-Trichloropyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,14161-11-6

A mixture of 3,4,5-trichloropyridazine (0.5 g, 2.73 mmol), 4-(2,5- dimethoxyphenyl)piperidine hydrochloride (0.703 g, 2.73 mmol), and potassium carbonate (0.79 1 g, 5.72 mmol) in dioxane (10 ml) was heated to reflux for 1 h. Themixture was cooled and 35% hydrazine in water (2.469 ml, 27.3 mmol) was added and the mixture was heated to reflux for 16 h. The reaction was diluted with ethyl acetate and water. The ethyl acetate layer was washed with water, dried over magnesium sulfate, and concentrated to give 4-chloro-5-(4-(2,5- dimethoxyphenyl)piperidin- 1 -yl)-3 -hydrazinylpyridazine as a brown oil. (M+H) =364.2.

The synthetic route of 14161-11-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; MATTSON, Ronald J.; MENG, Zhaoxing; GUERNON, Leatte R.; WO2013/192306; (2013); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

14161-11-6, 3,4,5-Trichloropyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 3,4,5-trichloropyridazine (1 eq) in eOH (1 mUmmol) was added dropwise a solution of the appropiate aminoalcohol (ex: 2-methylamino-ethanol) (3 eq) in MeOH (1 mUmmol)(acetonitrile can be also used). The reaction mixture was stirred at room temperature from 1 h to 2 days depending on the amine. The solvent was removed under vacuum to give a brown oil which was purified by biotage flash column chromatography (70% EtOAc in cyclohexane to 100% EtOAc) to give the desired product (ex: 2-[(5,6-dichloro-pyridazin-4-yl)-methyl- amino]-ethanol).The appropiate dichloropyridazine (ex: 2-[(5,6-dichloro-pyridazin-4-yl)-methyl- amino]-ethanol) (1 eq) was dissolved in THF (20 mL/mmol). When the solution started refluxing, potassium tert-butoxide (1.2 eq) was added portionwise. The reaction mixture was refluxed for 2 h. On cooling, a saturated aqueous solution of amonium chloride was added and the layers were separated. The aqueous phase was extracted with EtOAc (x2). The combined organic layers were dried (sodium sulphate), filtered and evaporated. The residue was triturated with Et20-DCM 9: 1 and filtered off to afford the desired product (ex: 8-chloro-4-methyl-3,4-dihydro- 2H-pyridazino[4,5-b]-1 ,4-oxazine).Intermediate 98-Chloro-4-methyl-3,4-dihydro-2H-p ,5-b]-1 ,4-oxazine:HPLC- S (method 4): Rt =0.98 min, [ +H]* 186.1.1H NMR (300 MHz, CDCI3) delta 8.47 (s, 1 H), 4.42 (m, 2H), 3.46 (m, 2H), 3.06 (s, 3H).Yield: 77% for two steps

14161-11-6 3,4,5-Trichloropyridazine 70111, apyridazine compound, is more and more widely used in various.

Reference£º
Patent; CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO); GARCIA COLLAZO, Ana Maria; PASTOR FERNANDEZ, Joaquin; BLANCO APARICIO, Carmen; RODRIGUEZ HERGUETA, Antonio; MARTIN HERNANDO, Jose Ignacio; RAMOS LIMA, Francisco Javier; HERNANDEZ HIGUERAS, Ana Isabel; SALUSTE, Carl-Gustave Pierre; GONZALEZ CANTALAPIEDRA, Esther; MARTINEZ GONZALEZ, Sonia; SALGADO SERRANO, Antonio; NOYA MARINO, Beatriz; WO2011/80510; (2011); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14161-11-6,3,4,5-Trichloropyridazine,as a common compound, the synthetic route is as follows.

A mixture of 3,4,5-trichloropyridazine (1 g, 5.45mmol), 4-phenylpiperidine (0.9 g, 5.58 mmol) and potassium carbonate (1.5 g, 10.85mmol) in acetonitrile (25 ml) was stirred for 4 days. The mixture was diluted withethyl acetate and water. The ethyl acetate layer was separated, washed with water, dried with brine, and concentrated to a red-brown solid. The solid was dissolved in dioxane (25 ml) and 35% hydrazine (10 ml, 110 mmol) was added. The mixture was heated to reflux for 16 hr overnight. The mixture was diluted with ethyl acetate andwater. The ethyl acetate layer was separated, washed twice with water, dried with brine, and separated. The ethyl acetate layer was placed into a 250 ml flask with saturated sodium carbonate (15 ml). A solution of 2-cyclopropylacetyl chloride (freshly prepared from 2-cyclopropylacetic acid (0.600 g, 6.00 mmol) and thionyl chloride) in ethyl acetate (25 ml) was added and the mixture was stirred for 16 h.

As the paragraph descriping shows that 14161-11-6 is playing an increasingly important role.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; MATTSON, Ronald J.; MENG, Zhaoxing; GUERNON, Leatte R.; WO2013/192306; (2013); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14161-11-6,3,4,5-Trichloropyridazine,as a common compound, the synthetic route is as follows.

To 3,4,5-trichloropyridazine (1.624 g, 8.85 mmol) and N-ethyl-N-isopropylpropan-2-amine (2.289 g, 17.71 mmol) in 50 mL N,N-dimethylformamide at 0 C. was added tert-butyl 4-(4-(azetidine-3-carboxamido)phenylsulfonyl)piperidine-1-carboxylate (2.5 g, 5.90 mmol) in ml N,N-dimethylformamide, dropwise. The reaction mixture was stirred from 0 C. to room temperature overnight, diluted with water and extracted with ethyl acetate. The organic layer was dried with magnesium sulfate, filtered, concentrated and purified by flash chromatography to give the title compound.

As the paragraph descriping shows that 14161-11-6 is playing an increasingly important role.

Reference£º
Patent; ABBVIE INCORPORATED; HANSEN, TODD M; LONGENECKER, KENTON; HEYMAN, HOWARD R; CURTIN, MICHAEL L; CLARK, RICHARD F; SORENSEN, BRYAN; JI, ZHIQIN; DOHERTY, GEORGE; FREY, ROBIN; WOLLER, KEVIN; (600 pag.)JP2015/520752; (2015); A;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14161-11-6,3,4,5-Trichloropyridazine,as a common compound, the synthetic route is as follows.

PREPARATION 31 3,5-Dichloro-4-(1-methylethylamino)pyridazine A solution of 3,4,5-trichloropyridazine (9.2 g) and isopropylamine (16.5 g) in toluene (25 ml) is refluxed for 18 hr. Excess isopropylamine is removed by atmospheric distillation. The residual solution is cooled and diluted with dichloromethane and aqueous sodium hydroxide solution (5%). The phases are separated. The organic phase is washed with water and then with saline. The organic phase is dried over sodium sulfate and concentrated under reduced pressure to give a liquid which contains a mixture of isomeric products. The isomers are separated by flash chromatography on silica gel eluding with ether/hexane (30/70). The appropriate fractions are pooled and concentrated to give the desired isomer, NMR (CDCl3) 1.33, 4.59, 4.87 and 8.60 delta; CMR (CDCl3) 24.2, 46.4, 117.1, 139.3, 145.5 and 151.3 delta. Further elution gives 3,4-dichloro-5-(1-methylethylamino)pyridazine which is recrystallized from ether hexane, NMR (CDCl3) 1.35, 387, 4.80, and 8.55 delta; CMR (CDCl3) 22.6, 44.7, 116.5, 136.3, 142.5 and 153.4 delta.

The synthetic route of 14161-11-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; The Upjohn Company; US5489593; (1996); A;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14161-11-6,3,4,5-Trichloropyridazine,as a common compound, the synthetic route is as follows.

2-(l-(5-Chloro-6-hydrazinylpyridazin-4-yl)piperidin-4-yl)benzonitrile. A mixture of 3,4,5-trichloropyridazine (0.50 g, 2.73 mmol), 2-(piperidin-4-yl)benzonitrile hydrochloride (0.607 g, 2.73 mmol), and potassium carbonate (0.791 g, 5.72 mmol) in dioxane (9.1 ml) and water (1 ml) was heated to reflux for 1 h. The mixture was cooled and 35% hydrazine (4.94 ml, 54.5 mmol) was added. The mixture was heated to reflux for 16 h. The reaction was diluted with ethyl acetate and water. The ethyl acetate layer was washed with water and concentrated to give 2-(l-(5-chloro-6- hydrazinylpyridazin-4-yl)piperidin-4-yl)benzonitrile as a brown oil. Rt = 0.71 min, (M+H)+ = 329.1. The material was used without purification

The synthetic route of 14161-11-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; MATTSON, Ronald J.; MENG, Zhaoxing; GUERNON, Leatte R.; WO2013/192306; (2013); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

14161-11-6, 3,4,5-Trichloropyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 3,4,5-trichloropyridazine (0.50 g, 2.73 mmol), 1-(4- fluorophenyl)piperazine (0.511 g, 2.83 mmol), and potassium carbonate (0.79 1 g, 5.72 mmol) in dioxane (10 ml) was heated to reflux for 1 h. The mixture was cooledand 35% hydrazine (4.94 ml, 54.5 mmol) was added. The mixture was heated to reflux for 16 h overnight. The reaction was diluted with ethyl acetate and water. The ethyl acetate layer was washed with water, dried over magnesium sulfate, and concentrated to give 4-chloro-5-(4-(4-fluorophenyl)piperazin- 1 -yl)-3 – hydrazinylpyridazine (0.880 g, 100%), which was used without purification. LCMS:

The synthetic route of 14161-11-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; MATTSON, Ronald J.; MENG, Zhaoxing; GUERNON, Leatte R.; WO2013/192306; (2013); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem