Tag: 141-30-0

141-30-0, 3,6-Dichloropyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,141-30-0

22.47 g (150 mmoles) of 3, 6-dichloropyridazine are placed in 50 mL of acetic acid and agitated for 9h under reflux. The reaction medium is diluted in 50 mL of water and concentrated to dryness. The residue obtained is purified by silica gel flash chromatography (CH2Cl2-AcOEt, gradient 100:0 to 50:50 in 45 min) . 16.35 g of white solid are obtained (yield 82%) . TLC silic gel 60 F 254 Merck, CH2Cl2-AcOEt: 50:50, Rf=0.31.

The synthetic route of 141-30-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PIERRE FABRE MEDICAMENT; DUPONT-PASSELAIGUE, Elisabeth; MIALHE, Samuel; RIEU, Jean-Pierre; JUNQUERO, Didier; VALEILLE, Karine; WO2011/15629; (2011); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

141-30-0, 3,6-Dichloropyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2.70 kg (18.0 mol) of sodium iodide are added in portions at room temperature to a mixture of 5.0 l of water and 11.3 l of 57% aqueous hydroiodic acid (75.2 mol). 2.00 kg (13.4 mol) of 3,6-dichloropyridazine are subsequently added in portions to the solution held at 20 C. The reaction mixture is stirred at 20 C. for 18 hours. 10 l of tert-butyl methyl ether and 4 l of water are added to the reaction mixture. The organic phase is separated off and washed with water and aqueous sodium sulfite solution. The organic phase is concentrated, heptane is added, and the resultant solid is filtered off with suction and washed with heptane. The residue is dried in vacuo: 3-chloro-6-iodopyridazine as colourless leaf-shaped crystals; ESI 241.

141-30-0 3,6-Dichloropyridazine 67331, apyridazine compound, is more and more widely used in various.

Reference£º
Patent; MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG; US2011/257181; (2011); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem