Tag: 119.124

Synthesis and structure-activity relationship of a series of analgesic imidazo[1,2-b]pyridazine acidic derivatives was written by Luraschi, Elena;Arena, Francesca;Sacchi, Antonia;Laneri, Sonia;Abignente, Enrico. And the article was included in Trends in Heterocyclic Chemistry in 1995.Formula: C6H5N3 This article mentions the following:

Four series of imidazo[1,2-b]pyridazine acidic derivatives, namely 2-phenylimidazo[1,2-b]pyridazine-3-carboxylic acids, 2-methylimidazo[1,2-b]pyridazine-3-carboxylic acids, imidazo[1,2-b]pyridazine-2-acetic acids and imidazo[1,2-b]pyridazine-2-carboxylic acids, were synthesized via a common synthetic method. Their antiinflammatory, analgesic and ulcerogenic activities were evaluated. Pharmacol. results were examined and discussed in order to find structure-activity relationships. A review with 10 references In the experiment, the researchers used many compounds, for example, Imidazo[1,2-b]pyridazine (cas: 766-55-2Formula: C6H5N3).

Imidazo[1,2-b]pyridazine (cas: 766-55-2) belongs to pyridazine derivatives. Pyridazine and phthalazine have quite different spectroscopic properties compared with their isomers, pyrazine and quinoxaline. Pyridazine and derivatives coordinate readily with transition metals to form complexes and catalysts with synthetic utility.Formula: C6H5N3

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Pyridazines. XXXI. A facile synthesis of 3-pyridazinecarbonitriles via 2-(4-toluenesulfonyl)-2,3-dihydro-3-pyridazinecarbonitriles was written by Dostal, Wolfgang;Heinisch, Gottfried. And the article was included in Heterocycles in 1986.Category: pyridazine This article mentions the following:

Pyridazines I(R = R¹ = R² = H; R = R² = H, R¹ = Me; R = R¹ = H, R² = Me) reacted with Me₃SiCN/4-MeC₆H₄SO₂Cl to give dihydropyridazines II (R³ = tosyl) in 63-84% yields. II were converted to pyridazines I (R = cyano) in 71-99% yields by the action of DBU. In the experiment, the researchers used many compounds, for example, 4-Methylpyridazine-3-carbonitrile (cas: 106861-17-0Category: pyridazine).

4-Methylpyridazine-3-carbonitrile (cas: 106861-17-0) belongs to pyridazine derivatives. Pyridazines is a six-membered nitrogen-containing significant heterocycle. It has received considerable interest because of its useful applications as natural products, pharmaceuticals, and various bioactive molecules. In the past decade, X-ray data were reported with regard to the characterization and structural elucidation of a number of pyridazine-metal complexes, including pyridazine ligands with zinc, nickel, copper, cadmium and ruthenium.Category: pyridazine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Synthesis and biological activity of 2-cyanoacrylamide derivatives tethered to imidazopyridine as TAK1 inhibitors was written by Kang, Seok Jong;Lee, Jung Wuk;Song, Jiho;Park, Jiwon;Choi, Jaeyul;Suh, Kwee Hyun;Min, Kyung Hoon. And the article was included in Journal of Enzyme Inhibition and Medicinal Chemistry in 2020.Reference of 766-55-2 This article mentions the following:

The importance of transforming growth factor beta-activated kinase 1 (TAK1) to cell survival has been demonstrated in many studies. TAK1 regulates signaling cascades, the NF-κB pathway and the mitogen-activated protein kinase (MAPK) pathway. TAK1 inhibitors can induce the apoptosis of cancerous cells, and irreversible inhibitors such as (5Z)-7-oxozeaenol are highly potent. However, they can react non-specifically with cysteine residues in proteins, which may have serious adverse effects. Reversible covalent inhibitors have been suggested as alternatives. We synthesized imidazopyridine derivatives as novel TAK1 inhibitors, which have 2-cyanoacrylamide moiety that can form reversible covalent bonding. A derivative with 2-cyano-3-(6-methylpyridin-2-yl)acrylamide exhibited potent TAK1 inhibitory activity with an IC₅₀ of 27 nM. It showed a reversible reaction with β-mercaptoethanol, which supports its potential as a reversible covalent inhibitor. In the experiment, the researchers used many compounds, for example, Imidazo[1,2-b]pyridazine (cas: 766-55-2Reference of 766-55-2).

Imidazo[1,2-b]pyridazine (cas: 766-55-2) belongs to pyridazine derivatives. The pyridazine structure is also found within the structure of several drugs such as cefozopran, cadralazine, minaprine, pipofezine, and hydralazine. The activity depends upon the changes of substituted groups in the pyridazine ring system resulting in different biological activities. In addition, the natural pyrimidine bases uracil, thymine, and cytosine, which are constituents of the nucleic acids, are found to be the most important naturally occurring diazines.Reference of 766-55-2

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Electrophotocatalytic C-H Azolation of Arenes was written by Hou, Zhong-Wei;Xu, Hai-Chao. And the article was included in ChemElectroChem in 2021.COA of Formula: C6H5N3 This article mentions the following:

An electrophotocatalytic method was developed for the dehydrogenative cross coupling of arenes with azoles employing a bicatalytic system consisting of acridinium dye and (2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO). The reactions were conducted in a simple undivided cell with visible-light irradiation and requires no external chem. oxidant. In the experiment, the researchers used many compounds, for example, Imidazo[1,2-b]pyridazine (cas: 766-55-2COA of Formula: C6H5N3).

Imidazo[1,2-b]pyridazine (cas: 766-55-2) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. The activity depends upon the changes of substituted groups in the pyridazine ring system resulting in different biological activities. In addition, the natural pyrimidine bases uracil, thymine, and cytosine, which are constituents of the nucleic acids, are found to be the most important naturally occurring diazines.COA of Formula: C6H5N3

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Sonogashira Couplings Catalyzed by Fe Nanoparticles Containing ppm Levels of Reusable Pd, under Mild Aqueous Micellar Conditions was written by Handa, Sachin;Jin, Bo;Bora, Pranjal P.;Wang, Ye;Zhang, Xiaohua;Gallou, Fabrice;Reilly, John;Lipshutz, Bruce H.. And the article was included in ACS Catalysis in 2019.Related Products of 766-55-2 This article mentions the following:

Nanoparticles derived from FeCl₃ containing the ligand XPhos and only 500 ppm Pd effect Sonogashira couplings in water between rt and 45°. The entire aqueous reaction medium can be easily recycled using an “in-flask” extraction Several tandem processes in one pot are illustrated, including a sequence involving five steps (10 reactions) in good overall yield. In the experiment, the researchers used many compounds, for example, Imidazo[1,2-b]pyridazine (cas: 766-55-2Related Products of 766-55-2).

Imidazo[1,2-b]pyridazine (cas: 766-55-2) belongs to pyridazine derivatives. Pyridazines is a six-membered nitrogen-containing significant heterocycle. It has received considerable interest because of its useful applications as natural products, pharmaceuticals, and various bioactive molecules. Pyridazine is bioavailable (especially in the CNS) and can reduce toxicity. Pyridazine is a component of several drug molecules, and the pyridazine pharmacophore has contributed to a variety of pharmacologically active compounds.Related Products of 766-55-2

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Synthesis and structure-activity relationship of a series of analgesic imidazo[1,2-b]pyridazine acidic derivatives was written by Luraschi, Elena;Arena, Francesca;Sacchi, Antonia;Laneri, Sonia;Abignente, Enrico. And the article was included in Trends in Heterocyclic Chemistry in 1995.Formula: C6H5N3 This article mentions the following:

Four series of imidazo[1,2-b]pyridazine acidic derivatives, namely 2-phenylimidazo[1,2-b]pyridazine-3-carboxylic acids, 2-methylimidazo[1,2-b]pyridazine-3-carboxylic acids, imidazo[1,2-b]pyridazine-2-acetic acids and imidazo[1,2-b]pyridazine-2-carboxylic acids, were synthesized via a common synthetic method. Their antiinflammatory, analgesic and ulcerogenic activities were evaluated. Pharmacol. results were examined and discussed in order to find structure-activity relationships. A review with 10 references In the experiment, the researchers used many compounds, for example, Imidazo[1,2-b]pyridazine (cas: 766-55-2Formula: C6H5N3).

Imidazo[1,2-b]pyridazine (cas: 766-55-2) belongs to pyridazine derivatives. Pyridazine and phthalazine have quite different spectroscopic properties compared with their isomers, pyrazine and quinoxaline. Pyridazine and derivatives coordinate readily with transition metals to form complexes and catalysts with synthetic utility.Formula: C6H5N3

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Scalable Photoelectrochemical Dehydrogenative Cross-Coupling of Heteroarenes with Aliphatic C-H Bonds was written by Xu, Pin;Chen, Peng-Yu;Xu, Hai-Chao. And the article was included in Angewandte Chemie, International Edition in 2020.Formula: C6H5N3 This article mentions the following:

Heteroarenes are structural motifs found in many bioactive compounds and functional materials. Dehydrogenative cross-coupling of heteroarenes with aliphatic C-H bonds provides straightforward access to functionalized heteroarenes from readily available materials. Established methods employ stoichiometric chem. oxidants under conditions of heating or light irradiation By merging electrochem. and photochem., we have achieved efficient photoelectrochem. dehydrogenative cross-coupling of heteroarenes and C(sp³)-H donors through H₂ evolution, without the addition of metal catalysts or chem. oxidants. Mechanistically, the C(sp³)-H donor is converted to a nucleophilic carbon radical through H-atom transfer with chlorine atom, which is produced by light irradiation of anodically generated Cl₂ from Cl^–. The carbon radical then undergoes radical substitution to the heteroarene to afford alkylated heteroarene products. In the experiment, the researchers used many compounds, for example, Imidazo[1,2-b]pyridazine (cas: 766-55-2Formula: C6H5N3).

Imidazo[1,2-b]pyridazine (cas: 766-55-2) belongs to pyridazine derivatives. The pyridazine structure is also found within the structure of several drugs such as cefozopran, cadralazine, minaprine, pipofezine, and hydralazine. Pyridazine can act as a hydrogen bond acceptor to improve the physicochemical properties of drug molecules by increasing their water solubility, and has a high affinity for complexing with targets due to its dipole moment.Formula: C6H5N3

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Pyridazines. XXXI. A facile synthesis of 3-pyridazinecarbonitriles via 2-(4-toluenesulfonyl)-2,3-dihydro-3-pyridazinecarbonitriles was written by Dostal, Wolfgang;Heinisch, Gottfried. And the article was included in Heterocycles in 1986.Category: pyridazine This article mentions the following:

Pyridazines I(R = R¹ = R² = H; R = R² = H, R¹ = Me; R = R¹ = H, R² = Me) reacted with Me₃SiCN/4-MeC₆H₄SO₂Cl to give dihydropyridazines II (R³ = tosyl) in 63-84% yields. II were converted to pyridazines I (R = cyano) in 71-99% yields by the action of DBU. In the experiment, the researchers used many compounds, for example, 4-Methylpyridazine-3-carbonitrile (cas: 106861-17-0Category: pyridazine).

4-Methylpyridazine-3-carbonitrile (cas: 106861-17-0) belongs to pyridazine derivatives. Pyridazines is a six-membered nitrogen-containing significant heterocycle. It has received considerable interest because of its useful applications as natural products, pharmaceuticals, and various bioactive molecules. In the past decade, X-ray data were reported with regard to the characterization and structural elucidation of a number of pyridazine-metal complexes, including pyridazine ligands with zinc, nickel, copper, cadmium and ruthenium.Category: pyridazine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Scalable Photoelectrochemical Dehydrogenative Cross-Coupling of Heteroarenes with Aliphatic C-H Bonds was written by Xu, Pin;Chen, Peng-Yu;Xu, Hai-Chao. And the article was included in Angewandte Chemie, International Edition in 2020.Formula: C6H5N3 This article mentions the following:

Heteroarenes are structural motifs found in many bioactive compounds and functional materials. Dehydrogenative cross-coupling of heteroarenes with aliphatic C-H bonds provides straightforward access to functionalized heteroarenes from readily available materials. Established methods employ stoichiometric chem. oxidants under conditions of heating or light irradiation By merging electrochem. and photochem., we have achieved efficient photoelectrochem. dehydrogenative cross-coupling of heteroarenes and C(sp³)-H donors through H₂ evolution, without the addition of metal catalysts or chem. oxidants. Mechanistically, the C(sp³)-H donor is converted to a nucleophilic carbon radical through H-atom transfer with chlorine atom, which is produced by light irradiation of anodically generated Cl₂ from Cl^–. The carbon radical then undergoes radical substitution to the heteroarene to afford alkylated heteroarene products. In the experiment, the researchers used many compounds, for example, Imidazo[1,2-b]pyridazine (cas: 766-55-2Formula: C6H5N3).

Imidazo[1,2-b]pyridazine (cas: 766-55-2) belongs to pyridazine derivatives. The pyridazine structure is also found within the structure of several drugs such as cefozopran, cadralazine, minaprine, pipofezine, and hydralazine. Pyridazine can act as a hydrogen bond acceptor to improve the physicochemical properties of drug molecules by increasing their water solubility, and has a high affinity for complexing with targets due to its dipole moment.Formula: C6H5N3

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Pyridazines. XXXI. A facile synthesis of 3-pyridazinecarbonitriles via 2-(4-toluenesulfonyl)-2,3-dihydro-3-pyridazinecarbonitriles was written by Dostal, Wolfgang;Heinisch, Gottfried. And the article was included in Heterocycles in 1986.Category: pyridazine This article mentions the following:

Pyridazines I(R = R¹ = R² = H; R = R² = H, R¹ = Me; R = R¹ = H, R² = Me) reacted with Me₃SiCN/4-MeC₆H₄SO₂Cl to give dihydropyridazines II (R³ = tosyl) in 63-84% yields. II were converted to pyridazines I (R = cyano) in 71-99% yields by the action of DBU. In the experiment, the researchers used many compounds, for example, 4-Methylpyridazine-3-carbonitrile (cas: 106861-17-0Category: pyridazine).

4-Methylpyridazine-3-carbonitrile (cas: 106861-17-0) belongs to pyridazine derivatives. Pyridazines is a six-membered nitrogen-containing significant heterocycle. It has received considerable interest because of its useful applications as natural products, pharmaceuticals, and various bioactive molecules. In the past decade, X-ray data were reported with regard to the characterization and structural elucidation of a number of pyridazine-metal complexes, including pyridazine ligands with zinc, nickel, copper, cadmium and ruthenium.Category: pyridazine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem