Tag: 100-200

Product class 8: pyridazines was written by Haider, N.;Holzer, W.. And the article was included in Science of Synthesis in 2004.Quality Control of 5-Phenylpyridazin-3-amine The following contents are mentioned in the article:

A review. Methods of preparing pyridazines are reviewed including cyclization, ring transformation, aromatization, and substituent modification. This study involved multiple reactions and reactants, such as 5-Phenylpyridazin-3-amine (cas: 105537-97-1Quality Control of 5-Phenylpyridazin-3-amine).

5-Phenylpyridazin-3-amine (cas: 105537-97-1) belongs to pyridazine derivatives. Pyridazines are rare in nature, possibly reflecting the scarcity of naturally occurring hydrazines, common building blocks for the synthesis of these heterocycles. Pyridazine is bioavailable (especially in the CNS) and can reduce toxicity. Pyridazine is a component of several drug molecules, and the pyridazine pharmacophore has contributed to a variety of pharmacologically active compounds.Quality Control of 5-Phenylpyridazin-3-amine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

In 1998,Molecules [Electronic Publication] included an article by Fulep, Gunther; Haider, Norbert. Synthetic Route of C5H2ClN3. The article was titled 《Synthesis and intramolecular [4+2] cycloaddition reactions of 4-pyridazinecarbonitriles with alkyne side chains》. The information in the text is summarized as follows:

Title compounds I (X = O, R = H, Me; X = NH, R = H) were prepared I underwent thermally induced intramol. Diels-Alder reactions with inverse electron demand, affording fused benzonitriles (II). Incorporation of a 1,2-phenylene unit into the side chain, as in III (X = O, NAc), resulted in a more favorable conformation of the dienophilic substructure and thus in a pronounced acceleration of the [4+2] cycloaddition reaction. In the experiment, the researchers used 3-Chloropyridazine-4-carbonitrile(cas: 1445-56-3Synthetic Route of C5H2ClN3)

3-Chloropyridazine-4-carbonitrile(cas: 1445-56-3) belongs to pyridazine derivatives.The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazines are also important because of their utility in synthetic organic chemistry and in physical organic chemistry.There are reports available for the synthesis of pyridazine and their derivatives by using 2-oxoaldehyes.Synthetic Route of C5H2ClN3

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

In 1977,Chemical & Pharmaceutical Bulletin included an article by Yanai, Mitsuji; Takeda, Shigeko; Mitsuoka, Tamao. Category: pyridazine. The article was titled 《Studies on heterocyclic compounds. XX. The reaction of 4-cyano-3,6-dichloropyridazine with amines》. The information in the text is summarized as follows:

4-Cyano-3,6-dichloropyridazine (I) was treated with primary amines in MeOH under mild conditions (stirring at 0-5°) to give the corresponding 5-amino derivatives II (R = NHCH2CH2OH, NH2, PhCH2NH, NHMe, etc.) resulting from nuclear amination. When I was treated with secondary amines, the corresponding 3- or 6-amino derivatives were obtained.3-Chloropyridazine-4-carbonitrile(cas: 1445-56-3Category: pyridazine) was used in this study.

3-Chloropyridazine-4-carbonitrile(cas: 1445-56-3) belongs to pyridazine derivatives.The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazines are also important because of their utility in synthetic organic chemistry and in physical organic chemistry.There are reports available for the synthesis of pyridazine and their derivatives by using 2-oxoaldehyes.Category: pyridazine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

In 1970,Journal of Heterocyclic Chemistry included an article by Yanai, Mitsuji; Kuraishi, Tsukasa; Kinoshita, Toshio; Nishimura, Masakuni. Formula: C5H3Cl2N3O. The article was titled 《Recyclization of 3-amino-6-chloroimidazo[4,5-c]pyridazine》. The information in the text is summarized as follows:

3-Benzylideneamino-6-chloroimidazo[4,5-c]pyridazine refluxed with HCl or AcOH gave 5-chloro-8-amino-s-triazolo-[4,5-b]pyridazine and 3-benzylid enehydrazino-4-amino-6-chloropyridazine.3,6-Dichloropyridazine-4-carboxamide(cas: 27427-66-3Formula: C5H3Cl2N3O) was used in this study.

3,6-Dichloropyridazine-4-carboxamide(cas: 27427-66-3) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Formula: C5H3Cl2N3O

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Haider, Norbert; Heinisch, Gottfried; Lassnigg, Doris published their research in Journal of Heterocyclic Chemistry on February 29 ,1988. The article was titled 《Pyridazines. XXXV. Preparation of some novel pyrimido[4,5-c]pyridazine derivatives from 3-(alkylamino)- and 3-(arylamino)-4-pyridazinecarboxamides》.Product Details of 1445-56-3 The article contains the following contents:

Pyrimido[4,5-c]pyridazinediones I (R = Ph, PhCH2; R1R2 = O), pyrimido[4,5-c]pyridazinones II (R = Ph, PhCH2; R3 = H, Me, Et), and dihydropyrimido[4,5-c]pyridazinones I (R = Ph, PhCH2, Me2CH; R1 = H, R2 = Ph, 3-pyridyl) were prepared from 3-chloro-4-pyridazinecarbonitrile III (R4 = Cl) via amino carbonitriles III (R4 = NHR) and amino carboxamides. In addition, III (R4 = NH2) was prepared from III (R4 = Cl), via the tetrazolo[1,5-b]pyridazine IV as the key intermediate.3-Chloropyridazine-4-carbonitrile(cas: 1445-56-3Product Details of 1445-56-3) was used in this study.

3-Chloropyridazine-4-carbonitrile(cas: 1445-56-3) belongs to pyridazine derivatives.The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazines are also important because of their utility in synthetic organic chemistry and in physical organic chemistry.There are reports available for the synthesis of pyridazine and their derivatives by using 2-oxoaldehyes.Product Details of 1445-56-3

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Reference of 5-(Trifluoromethyl)pyridazin-3(2H)-oneOn March 6, 2020, Trofymchuk, Serhii; Bugera, Maksym Ya.; Klipkov, Anton A.; Razhyk, Bohdan; Semenov, Sergey; Tarasenko, Karen; Starova, Viktoriia S.; Zaporozhets, Olga A.; Tananaiko, Oksana Yu.; Alekseenko, Anatoliy N.; Pustovit, Yurii; Kiriakov, Oleksandr; Gerus, Igor I.; Tolmachev, Andrei A.; Mykhailiuk, Pavel K. published an article in Journal of Organic Chemistry. The article was 《Deoxofluorination of (Hetero)aromatic Acids》. The article mentions the following:

Diverse trifluoromethyl-substituted compounds were synthesized by deoxofluorination of cinnamic and (hetero)aromatic carboxylic acids with sulfur tetrafluoride. The obtained products were used as starting materials in the preparation of novel fluorinated amino acids, anilines, and aliphatic amines – valuable building blocks for medicinal chem. and agrochem. Of note, sulfur tetrafluoride (SF4) and hydrogen fluoride (HF) are toxic, therefore, safety and addnl. tech. training must be taken before working with them. The experimental part of the paper was very detailed, including the reaction process of 5-(Trifluoromethyl)pyridazin-3(2H)-one(cas: 244268-34-6Reference of 5-(Trifluoromethyl)pyridazin-3(2H)-one)

5-(Trifluoromethyl)pyridazin-3(2H)-one(cas: 244268-34-6) belongs to pyridazine derivatives.The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazines are also important because of their utility in synthetic organic chemistry and in physical organic chemistry.There are reports available for the synthesis of pyridazine and their derivatives by using 2-oxoaldehyes.Reference of 5-(Trifluoromethyl)pyridazin-3(2H)-one

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Siegrist, Romain; Pozzi, Davide; Jacob, Gael; Torrisi, Caterina; Colas, Kilian; Braibant, Bertrand; Mawet, Jacques; Pfeifer, Thomas; de Kanter, Ruben; Roch, Catherine; Kessler, Melanie; Corminboeuf, Olivier; Bezencon, Olivier published their research in Journal of Medicinal Chemistry on December 8 ,2016. The article was titled 《Structure-Activity Relationship, Drug Metabolism and Pharmacokinetics Properties Optimization, and in Vivo Studies of New Brain Penetrant Triple T-Type Calcium Channel Blockers》.Computed Properties of C5H2ClN3 The article contains the following contents:

Despite the availability of numerous antiepileptic drugs, 20-30% of epileptic patients are pharmacoresistant with seizures not appropriately controlled. Consequently, new strategies to address this unmet medical need are required. T-type calcium channels play a key role in neuronal excitability and burst firing and selective triple T-type calcium channel blockers could offer a new way to treat various CNS disorders, in particular epilepsy. Herein the authors describe the identification of new 1,4-benzodiazepines as brain penetrant and selective triple T-type calcium channel blockers. From racemic hit 4 ((±)-N,1-dibenzyl-3,5-cis-dimethyl-1,2,3,5-tetrahydro-4H-benzo[e][1,4]diazepine-4-carboxamide), optimization work led to the preparation of pyridodiazepine 31c with improved physicochem. properties, solubility and metabolic stability. The racemic mixture was separated by chiral preparative HPLC and the resulting lead compound (3R,5S)-31c ((3R,5S)-N,1-dibenzyld-3,5-dimethyl-1,2,3,5-tetrahydro-4,5-pyrido[3,4-e][1,4]diazepine-4-carboxamide) showed promising efficacy in the WAG/Rij-rat model of generalized non-convulsive absence-like epilepsy. In the experiment, the researchers used many compounds, for example, 3-Chloropyridazine-4-carbonitrile(cas: 1445-56-3Computed Properties of C5H2ClN3)

3-Chloropyridazine-4-carbonitrile(cas: 1445-56-3) belongs to pyridazine derivatives.The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazines are also important because of their utility in synthetic organic chemistry and in physical organic chemistry.There are reports available for the synthesis of pyridazine and their derivatives by using 2-oxoaldehyes.Computed Properties of C5H2ClN3

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Product Details of 5788-60-3On May 31, 2015, Kim, Chaewon; Lee, Jihee; Park, Myung-Sook published an article in Archives of Pharmacal Research. The article was 《Synthesis of new diorganodiselenides from organic halides: their antiproliferative effects against human breast cancer MCF-7 cells》. The article mentions the following:

A new series of bis(aryl or aralkyl) diselenides was synthesized by selenylation from aryl halide (or aralkyl halide) for development of new anticancer agents. The process involves the reaction of aryl halides (or aralkyl halides) with selenium, hydrazine hydrate under atm. pressure in the presence of sodium hydroxide, to afford diorganodiselenides. These new compounds showed antiproliferative activities against breast cancer (MCF-7) cells in CCK-8 assays, and could be promising candidates for chemotherapy of carcinomas. Among 17 synthesized compounds for inhibiting the growth of these cell lines, 1,2-bis(chloropyridazinyl) diselenide I showed the highest potency. This result suggests the potential anticancer activity of compound I. The experimental process involved the reaction of 3-Chloro-6-propoxypyridazine(cas: 5788-60-3Product Details of 5788-60-3)

3-Chloro-6-propoxypyridazine(cas: 5788-60-3) belongs to pyridazine derivatives.The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazines are also important because of their utility in synthetic organic chemistry and in physical organic chemistry.There are reports available for the synthesis of pyridazine and their derivatives by using 2-oxoaldehyes.Product Details of 5788-60-3

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Dostal, Wolfgang; Heinisch, Gottfried; Loetsch, Gerhard published an article in Monatshefte fuer Chemie. The title of the article was 《Chemistry of pyridazines. XXXVI. Novel diaza-analogs of 10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-one》.Name: 3-Chloropyridazine-4-carbonitrile The author mentioned the following in the article:

Procedures for the preparation of the novel tricyclic ketones 10,11-dihydro-5H-benzo[4,5]cyclohepta[1,2-d]pyridazin-5-one (I), 5,6-dihydro-11H-benzo[4,5]cyclohepta[2,1-c]pyridazin-11-one, and 10,11-dihydro-5H-benzo[4,5]cyclohepta[1,2-c]pyridazin-5-one starting from a preformed 1,2-diazine system are proposed. The key intermediates, e.g., II (R = CO2Et) are prepared from (2-phenylethyl)pyridazines, e.g., II (R = H) by introduction of a carboxylic functionality via homolytic alkoxycarbonylation or via a sulfonyl Reissert-type reaction. The experimental process involved the reaction of 3-Chloropyridazine-4-carbonitrile(cas: 1445-56-3Name: 3-Chloropyridazine-4-carbonitrile)

3-Chloropyridazine-4-carbonitrile(cas: 1445-56-3) belongs to pyridazine derivatives.The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazines are also important because of their utility in synthetic organic chemistry and in physical organic chemistry.There are reports available for the synthesis of pyridazine and their derivatives by using 2-oxoaldehyes.Name: 3-Chloropyridazine-4-carbonitrile

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Safety of 3-Chloropyridazine-4-carbonitrileOn May 31, 1991, Czech, Karin; Haider, Norbert; Heinisch, Gottfried published an article in Monatshefte fuer Chemie. The article was 《Pyridazines. LIV. The synthesis of pyridazine-fused S-heterocycles: thieno[2,3-c]pyridazine, pyrimido[4′,5′:4,5]thieno[2,3-c]pyridazine, and pyridazino[3,4-b][1,4]benzothiazine》. The article mentions the following:

Starting from 3-chloro-4-pyridazinecarbonitrile (I), the thienopyridazine derivatives II (R = OMe; R1 = OMe, NH2) were prepared Condensation of II (R = NH2) with (EtO3)CH afforded the novel tricyclic system III. Reaction of I (R = R1 = NH2) with 2-H2NC6H4SH, followed by treatment with NaH/DMSO gave pyridazinobenzothiazine IV instead of the expected condensed thiazepine. In the experiment, the researchers used many compounds, for example, 3-Chloropyridazine-4-carbonitrile(cas: 1445-56-3Safety of 3-Chloropyridazine-4-carbonitrile)

3-Chloropyridazine-4-carbonitrile(cas: 1445-56-3) belongs to pyridazine derivatives.The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazines are also important because of their utility in synthetic organic chemistry and in physical organic chemistry.There are reports available for the synthesis of pyridazine and their derivatives by using 2-oxoaldehyes.Safety of 3-Chloropyridazine-4-carbonitrile

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem