Heterocyclic Building Blocks-Pyridazine

Application of 21778-81-4. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 5-Methoxy-1H-indole-2-carbaldehyde, is researched, Molecular C10H9NO2, CAS is 21778-81-4, about Rapid and selective access to three distinct sets of indole-based heterocycles from a single set of Ugi-adducts under microwave heating. Author is Zhang, Lei; Zhao, Fei; Zheng, Mingyue; Zhai, Yun; Liu, Hong.

Three distinct sets of indole-based heterocycles, e.g. I, II and III, were rapidly and selectively synthesized from the same set of Ugi-adducts, e.g. IV, under microwave heating in a reaction-condition-controlled manner. Notably, an unprecedented metal-free intramol. sp3-hybridized C-H arylation using only cesium carbonate was discovered.

After consulting a lot of data, we found that this compound(21778-81-4)Application of 21778-81-4 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 21778-81-4, is researched, Molecular C10H9NO2, about Coupling Catalytic Alkene Hydroacylation and α-Arylation: Enantioselective Synthesis of Heterocyclic Ketones with α-Chiral Quaternary Stereocenters, the main research direction is alkene intramol hydroacylation enantioselective arylation nickel NHC catalyst; heterocyclic ketone chiral quaternary stereocenter stereoselective preparation.Quality Control of 5-Methoxy-1H-indole-2-carbaldehyde.

We report a strategy that combines alkene hydroacylation and enantioselective α-(hetero)arylation reactions to form a wide variety of nitrogen-containing heterocyclic ketones bearing α-chiral quaternary stereogenic centers. Exo-selective, intramol. Ni-catalyzed hydroacylations of N-homoallylindole- and N-homoallylpyrrole-2-carboxaldehydes form α-substituted six-membered heterocyclic ketones in up to 95% yield, while N-heterocyclic carbene (NHC) catalyzed hydroacylations of N-allylindole- and N-allylpyrrole-2-carboxaldehydes form α-substituted five-membered heterocyclic ketones in up to 99% yield. The racemic five- and six-membered products of Ni- and NHC-catalyzed hydroacylation reactions are readily transformed into heterocyclic ketones containing an α-chiral quaternary stereogenic center by enantioselective Ni-catalyzed α-arylation and α-heteroarylation reactions. The chiral, nonracemic products formed through a combination of alkene hydroacylation and α-(hetero)arylation reactions are formed in moderate to high yields (44-99%) with excellent enantioselectivities (typically >95% ee). The identity of the precatalyst for Ni-catalyzed α-(hetero)arylation is dictated by the identity of the α-substituted heterocyclic ketone starting material. α-(Hetero)arylations of six-membered heterocyclic ketones occur at 65-85 °C in the presence of a catalyst generated in situ from Ni(COD)2 and (R)-BINAP or (R)-DIFLUORPHOS. α-(Hetero)arylation of five-membered heterocyclic ketones must be conducted at room temperature in the presence of an [((R)-BINAP)Ni(η2-NC-Ph)] precatalyst or a catalyst generated in situ from Ni(COD)2, (R)-DIFLUORPHOS, and benzonitrile.

After consulting a lot of data, we found that this compound(21778-81-4)Quality Control of 5-Methoxy-1H-indole-2-carbaldehyde can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Safety of 5-Methoxy-1H-indole-2-carbaldehyde. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 5-Methoxy-1H-indole-2-carbaldehyde, is researched, Molecular C10H9NO2, CAS is 21778-81-4, about Synthesis of carbazole derivatives. III. Synthesis of new pyrrolidino[3,4-c]carbazoles by intramolecular Michael addition. Author is Mahboobi, Sioavosh; Kuhr, Sabine; Koller, Markus.

The authors have reported on the synthesis of carbazoles by inter- and intramol. Michael addition Ellipticine derivatives are related to these compounds, and especially those with 9-methoxy- and 9-hydroxy substituents exhibit appreciable antitumor and antileukemic activity. Therefore, the authors have prepared the tetrahydrocarbazoles I (R1 = OMe, R2 = H; R1 = H, R2 = OMe), starting from N-benzyl-2-formyl-5-methoxyindole and N-benzyl-2-formyl-7-methoxyindole, resp.

After consulting a lot of data, we found that this compound(21778-81-4)Safety of 5-Methoxy-1H-indole-2-carbaldehyde can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Mechanistic study of reversible solid-state melt isomerization of 2-oxindoles to 2-quinolinones and its occurrence in a mass spectrometer, published in 2019-01-05, which mentions a compound: 885272-25-3, mainly applied to oxindole solid state melt isomerization mechanism green chem, Safety of 2-(5-Methoxy-2-oxoindolin-3-yl)acetic acid.

An eco-friendly equilibrated rearrangement of a series of 2-oxo-3-indolyl acetic acids (1) with 2-oxo-1,2,3,4-tetrahydroquinoline-4-carboxylic acid derivatives (2) was investigated through a solid state melt reaction (SSMR). Mechanistic insight into the thermal rearrangement is provided by 13C-isotopic labeling. The standard mass spectra of 1 and 2 were virtually identical preventing their reliable identification. Reversible interconversion of 1 and 2 was evidenced to occur in the inlet system of a mass spectrometer under electron impact conditions. Relative abundances of fragment ions were found to be a function of temperature

After consulting a lot of data, we found that this compound(885272-25-3)Safety of 2-(5-Methoxy-2-oxoindolin-3-yl)acetic acid can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Name: (R)-(-)-3-Fluoropyrrolidine Hydrochloride. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (R)-(-)-3-Fluoropyrrolidine Hydrochloride, is researched, Molecular C4H9ClFN, CAS is 136725-55-8, about Facile and efficient syntheses of novel (S)- and (R)-3-fluoropyrrolidines and 3,3-difluoropyrrolidine. Author is Giardina, Giuseppe; Dondio, Giulio; Grugni, Mario.

Novel enantiomeric 3-fluoropyrrolidines and 3,3-difluoropyrrolidine were obtained in high yield starting from the enantiomerically pure and com. available (2S,4R)-4-hydroxyproline. Spray-dried potassium fluoride and diethylaminosulfur trifluoride were used to introduce one or two fluorine atoms, resp.

After consulting a lot of data, we found that this compound(136725-55-8)Name: (R)-(-)-3-Fluoropyrrolidine Hydrochloride can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called A combinatory approach towards the design of organic polymer luminescent materials, published in 2019, which mentions a compound: 17739-45-6, mainly applied to luminescent polylactide preparation property cell imaging, HPLC of Formula: 17739-45-6.

Room-temperature phosphorescent (RTP) materials have been widely used in sensing, imaging and display technol. The ability to predict and modulate RTP properties, such as emission color and lifetime, is particularly important for the design of rational materials. Here, we show that by incorporating three different types of acceptor moieties into a polylactide (PLA)-substituted carbazole donor, RTP with different emission colors and lifetimes (with an absolute quantum yield of up to 39.4%) could be generated. Specifically, the chem. conjugation between an n-π* type of luminophore and a π-π* one most likely results in dual RTP while the conjugation between two π-π* types of luminophores produces fluorescence-RTP (F-RTP) dual emission. The consistency between the exptl. results and theor. calculations further validates the observation. To demonstrate the versatility and application potential of these purely organic, biocompatible materials, aqueous nanoparticles were fabricated and used as high-contrast cell imaging agents, given the large Stokes shift of RTP materials.

After consulting a lot of data, we found that this compound(17739-45-6)HPLC of Formula: 17739-45-6 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Discovery of 4-Amino and 4-Hydroxy-1-aroylindoles as Potent Tubulin Polymerization Inhibitors, published in 2008-07-24, which mentions a compound: 21778-81-4, mainly applied to indole trimethoxybenzoyl chloride aroylation; trimethoxybenzoic anhydride indole acylation; indoline trimethoxybenzoyl chloride aroylation; tetrahydroquinoline trimethoxybenzoyl chloride acylation; aroylindole derivative preparation antitubulin anticancer activity; aroylindoline derivative preparation antitubulin anticancer activity; aroyltetrahydroquinoline derivative preparation antitubulin anticancer activity, Quality Control of 5-Methoxy-1H-indole-2-carbaldehyde.

1-Aroylindoline, 1-aroyl-1,2,3,4-tetrahydroquinoline, and 1-aroylindole derivatives, e.g., I and II, were synthesized and evaluated for anticancer activity. The 4-amino and 4-hydroxy-1-aroylindoles I and II, with IC50 of 0.9 and 0.6 μM, resp., exhibited antitubulin activity superior or comparable to that of colchicine and combretastatin A-4. They also showed antiproliferative activity with IC50 of 0.3-5.4 nM in a set of human cancer cell lines.

After consulting a lot of data, we found that this compound(21778-81-4)Quality Control of 5-Methoxy-1H-indole-2-carbaldehyde can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, ACS Catalysis called Enantioselective Synthesis of Polycyclic Indole Derivatives Based on aza-Morita-Baylis-Hillman Reaction, Author is Gao, Yuning; Xu, Qin; Shi, Min, which mentions a compound: 21778-81-4, SMILESS is O=CC(N1)=CC2=C1C=CC(OC)=C2, Molecular C10H9NO2, Category: pyridazine.

A chiral phosphine-catalyzed asym. aza-Morita-Baylis-Hillman reaction between indole-derived sulfonyl imines and bis(3-chlorophenyl)methyl acrylate has been developed, giving the desired adducts in good yields and enantiomeric excess values along with the further transformations to polycyclic indoles such as dihydropyrido[1,2-a]indole and dihydropyrazino[1,2-a]indole skeleton.

After consulting a lot of data, we found that this compound(21778-81-4)Category: pyridazine can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Hao, Yanke; Zhou, Pan; Niu, Kaikai; Song, Hongjian; Liu, Yuxiu; Zhang, Jingjing; Wang, Qingmin published the article 《Synthesis of Indole- and Pyrrole-Fused Seven-Membered Nitrogen Heterocycles via Acid-Base Switchable Cyclization Involving Cleavage of Amide C-N Bonds》. Keywords: tetrahydro diazepinoindolone sulfonyl preparation chemoselective; sulfonyl tetrahydroazepinoindolone preparation chemoselective; indolyl methyl sulfonyl acrylamide switchable heterocyclization acid base catalyst.They researched the compound: 5-Methoxy-1H-indole-2-carbaldehyde( cas:21778-81-4 ).Application In Synthesis of 5-Methoxy-1H-indole-2-carbaldehyde. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:21778-81-4) here.

The method for synthesis of indole- and pyrrole-fused seven-membered nitrogen heterocycles I [R = H, Br; R1 = H; RR1 = -CH=CHCH=CH-, -CH=C(OMe)CH=CH-, -CH=CHC(Br)=CH-, etc.; R2 = H, Me, 3-(trifluoromethyl)phenyl, ethyloxidanyl; R3 = H, Me; R4 = Me, 4-methylphenyl, thiophen-2-yl, etc.], 2-tosyl-1,2,3,4-tetrahydro-5H-[1,5]diazocino[3,2,1-hi]indol-5-one and II (R5 = H, OMe; R6 = Me, 2-fluorophenyl, thiophen-2-yl, etc.) by means of acid-base switchable cyclization reactions have been reported. The reactions involved cleavage of amide C-N bonds, chemoselective N-1 or C-3 acylation, and 1,4-Michael addition This method could be used to construct two different kinds of seven-membered rings in one step from the same starting material without the need for a transition-metal catalyst.

After consulting a lot of data, we found that this compound(21778-81-4)Application In Synthesis of 5-Methoxy-1H-indole-2-carbaldehyde can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 5-Methoxy-1H-indole-2-carbaldehyde, is researched, Molecular C10H9NO2, CAS is 21778-81-4, about Selective Synthesis of 5,6-Dihydroindolo-[1,2-a]quinoxalines and 6,7-Dihydroindolo-[2,3-c]quinolines by Orthogonal Copper and Palladium Catalysis, the main research direction is dihydroindoloquinoxaline dihydroindoloquinoline preparation copper palladium catalyst; Ugi four component reaction.Safety of 5-Methoxy-1H-indole-2-carbaldehyde.

In combination with the Ugi four-component reaction, two important indole-fused heterocycles were prepared in two steps from readily accessible starting materials. From the same set of Ugi adducts 5, 5,6-dihydroindolo[1,2-a]quinoxalines were rapidly generated in excellent yields by a copper-catalyzed N-H arylation pathway, whereas 6,7-dihydroindolo[2,3-c]quinolones were obtained by palladium-catalyzed C-H arylations in good yields without the protection of the indole N1 moiety. Microwave heating was used to accelerate these intramol. C-N and C-C bond-forming reactions performed under controlled reaction conditions.

After consulting a lot of data, we found that this compound(21778-81-4)Safety of 5-Methoxy-1H-indole-2-carbaldehyde can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem