Heterocyclic Building Blocks-Pyridazine

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 21778-81-4, is researched, Molecular C10H9NO2, about Development and Synthesis of DNA-Encoded Benzimidazole Library, the main research direction is preparation DNA conjugated benzimidazole library NK3 receptor antagonist; DNA tagged fluoronitrobenzamide amine aldehyde; DNA-encoded library technology; benzimidazole.Recommanded Product: 5-Methoxy-1H-indole-2-carbaldehyde.

Encoded library technol. (ELT) is an effective approach to the discovery of novel small-mol. ligands for biol. targets. A key factor for the success of the technol. is the chem. diversity of the libraries. Here we report the development of DNA-conjugated benzimidazoles. Using 4-fluoro-3-nitrobenzoic acid as a key synthon, we synthesized a 320 million-member DNA-encoded benzimidazole library using Fmoc-protected amino acids, amines and aldehydes as diversity elements. Affinity selection of the library led to the discovery of a novel, potent and specific antagonist of the NK3 receptor.

After consulting a lot of data, we found that this compound(21778-81-4)Recommanded Product: 5-Methoxy-1H-indole-2-carbaldehyde can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 21778-81-4, is researched, SMILESS is O=CC(N1)=CC2=C1C=CC(OC)=C2, Molecular C10H9NO2Journal, Organic Chemistry Frontiers called Asymmetric construction of polycyclic indole derivatives with different ring connectivities by an organocatalysis triggered two-step sequence, Author is Xie, Chao-Chao; Tan, Rui; Liu, Yan-Kai, the main research direction is polycyclic indole preparation regioselective stereoselective; hemiacetal indole nitroolefin tandem Michael addition alkylation organocatalysis.COA of Formula: C10H9NO2.

An organocatalysis triggered highly regio- and stereoselective two-step sequence between hemiacetals and indole-containing nitroolefins was developed. The key to the success of this sequence was the intramol. oxocarbenium ion induced collective alkylation at the C3, C2, or N1-position of the indole moiety, resp., providing biol. important polycyclic indole derivatives with different ring connectivities. An unexpected epimerization was observed during the C3-alkylation process, which generated products with different relative configurations compared with the C2- and N1-alkylation products.

After consulting a lot of data, we found that this compound(21778-81-4)COA of Formula: C10H9NO2 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 5-Methoxy-1H-indole-2-carbaldehyde(SMILESS: O=CC(N1)=CC2=C1C=CC(OC)=C2,cas:21778-81-4) is researched.Category: pyridazine. The article 《Development and Synthesis of DNA-Encoded Benzimidazole Library》 in relation to this compound, is published in ACS Combinatorial Science. Let’s take a look at the latest research on this compound (cas:21778-81-4).

Encoded library technol. (ELT) is an effective approach to the discovery of novel small-mol. ligands for biol. targets. A key factor for the success of the technol. is the chem. diversity of the libraries. Here we report the development of DNA-conjugated benzimidazoles. Using 4-fluoro-3-nitrobenzoic acid as a key synthon, we synthesized a 320 million-member DNA-encoded benzimidazole library using Fmoc-protected amino acids, amines and aldehydes as diversity elements. Affinity selection of the library led to the discovery of a novel, potent and specific antagonist of the NK3 receptor.

After consulting a lot of data, we found that this compound(21778-81-4)Electric Literature of C10H9NO2 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 5-Methoxy-1H-indole-2-carbaldehyde, is researched, Molecular C10H9NO2, CAS is 21778-81-4, about Rhodium(II)-catalyzed intramolecular annulation of 1-sulfonyl-1,2,3-triazoles with indoles: facile synthesis of functionalized tetrahydro-β-carbolines, the main research direction is indolyl sulfonyltriazole preparation rhodium catalyst intramol cyclization; tetrahydro carboline preparation.Category: pyridazine.

A novel rhodium(II)-catalyzed intramol. annulation of 1-sulfonyl-1,2,3-triazoles with indoles was developed, which enabled the facile synthesis of various 4-functionalized tetrahydro-β-carbolines as well as relevant scaffolds from readily available starting materials.

After consulting a lot of data, we found that this compound(21778-81-4)Category: pyridazine can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 21778-81-4, is researched, Molecular C10H9NO2, about Rapid Generation of Privileged Substructure-Based Compound Libraries with Structural Diversity and Drug-Likeness, the main research direction is indolecarboxaldehyde amine carboxylic acid isonitrile Ugi intramol arylation cyclization; heterocyclic compound library preparation structural diversity drug likeness.SDS of cas: 21778-81-4.

A library of privileged-substructure-based, heterocyclic compounds was constructed by a sequence of Ugi four-component reactions incorporating the indole motif and microwave-assisted cyclizations in branched pathways. Cheminformatic anal. confirmed that the library exhibited a high degree of structural diversity and good drug-likeness.

After consulting a lot of data, we found that this compound(21778-81-4)SDS of cas: 21778-81-4 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Computed Properties of C7H13BrO2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2-(2-Bromoethoxy)tetrahydro-2H-pyran, is researched, Molecular C7H13BrO2, CAS is 17739-45-6, about Development of high-affinity fluorinated ligands for cannabinoid subtype 2 receptor, and in vitro evaluation of a radioactive tracer for imaging. Author is Modemann, Daniel J.; Mahardhika, Andhika B.; Yamoune, Sabrina; Kreyenschmidt, Anne-Katrin; Maass, Frederike; Kremers, Sarah; Breunig, Christian; Sahlmann, Carsten-Oliver; Bucerius, Jan; Stalke, Dietmar; Wiltfang, Jens; Bouter, Yvonne; Mueller, Christa E.; Bouter, Caroline; Meller, Birgit.

The development of neurodegenerative diseases is associated with cerebral inflammation, which activates resident immune cells of the central nervous system (CNS), namely microglial cells that show an up-regulation of the cannabinoid subtype 2 receptor (CB2R) expression. Therefore our work aimed to design and synthesize a radiotracer for the detection of CB2R expression by positron emission tomog. (PET) allowing an early diagnosis of neurodegenerative diseases. For the development of such a PET tracer, N-alkyl-substituted indole-3-yl-tetramethylcyclopropylketones served as lead structures due to their high CB2R potency and selectivity, allowing radiolabeling on the N-alkyl chain. To this end, eight novel fluorinated N-alkyl-indole-3-yl-tetramethylcyclopropylketones were synthesized, investigated in radioligand binding studies, and structure-activity relationships were evaluated. The most promising candidate was (1-(4-fluoropropyl)-1H-indole-3-yl)(2,2,3,3-tetramethyl-cyclopropyl)methanone (Ki: 7.88 nM at the CB2R, 3430 nM at cannabinoid subtype 1 receptor (CB1R)). A precursor was synthesized, radiofluorinated with no-carrier-added [18F]F- by nucleophilic substitution of a tosyl group, and the resulting PET ligand was purified, all being performed on a fully automated synthesis module. The tracer was produced in 34 ± 6% radiochem. yield within 2 h and with molar activities of up to 1500 GBq/μmol. A first preclin. evaluation was carried out including determination of logP, metabolic stability by liver microsomes, and autoradiog. The novel PET tracer for imaging CB2R showed promising results warranting subsequent clin. evaluation.

After consulting a lot of data, we found that this compound(17739-45-6)Computed Properties of C7H13BrO2 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Nishiyama, Takashi; Hatae, Noriyuki; Yoshimura, Teruki; Takaki, Sawa; Abe, Takumi; Ishikura, Minoru; Hibino, Satoshi; Choshi, Tominari published the article 《Concise synthesis of carbazole-1,4-quinones and evaluation of their antiproliferative activity against HCT-116 and HL-60 cells》. Keywords: carbazolequinone preparation antiproliferative human; indole allyl alc tandem ring closing metathesis dehydrogenation; Antiproliferative activity; Carbazole-1,4-quinone; Koeniginequinone A; Koeniginequinone B.They researched the compound: 5-Methoxy-1H-indole-2-carbaldehyde( cas:21778-81-4 ).Reference of 5-Methoxy-1H-indole-2-carbaldehyde. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:21778-81-4) here.

A convenient synthesis of carbazole-1,4-quinone alkaloid koeniginequinones A and B using a tandem ring-closing metathesis with the dehydrogenation reaction sequence under an O2 atmosphere as an important step is reported. Using this method, carbazole-1,4-quinones substituted at the 5-, 6-, 7-, and/or 8-positions I (R1 = R2 = H, CH3; R3 = H, 6-OCH3, 5,6-(OCH3)2, 7-CH3, 6-NO2, etc.; R4 = H, MOM) have been synthesized. Moreover, 24 compounds, including koeniginequinones A and B, have been evaluated for their antiproliferative activity against HCT-116 and HL-60 cells, and the 6-nitro analog exhibited the most potent activity against both tumor cell types.

After consulting a lot of data, we found that this compound(21778-81-4)Reference of 5-Methoxy-1H-indole-2-carbaldehyde can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Mevissen, Christian; Kwamen, A. Carel N.; Himmel, Leonard; Chen, Xiaofei; Brueckner, Matthias; Huda, Saskia; Goeb, Christian; Jenniches, Judith; Oppel, Iris; Ward, Jas S.; Rissanen, Kari; Albrecht, Markus published the article 《Helicates with Ether-Substituted Catechol Esters as Ligands》. Keywords: titanium lithium catechol complex preparation; crystal structure titanium lithium catechol complex.They researched the compound: 2-(2-Bromoethoxy)tetrahydro-2H-pyran( cas:17739-45-6 ).SDS of cas: 17739-45-6. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:17739-45-6) here.

Mono- or biscatechol esters with ether-type substituents or spacers form either triple lithium bridged dimeric helicates or triple stranded helicates with the ability to bind three lithium cations in their interior. Hierarchical helicates with ether or thioether substituents show in solution a monomer-dimer equilibrium which is independent of the heteroatom in the ester substituent. However, dimerization constants are significantly lower than for corresponding alkyl derivatives Dinuclear helicates with oligoether spacers are well obtained in the presence of lithium cations. Upon removal of the cations the helicates expand and successive addition of LiCl results in compression again.

After consulting a lot of data, we found that this compound(17739-45-6)SDS of cas: 17739-45-6 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 5-Methoxy-1H-indole-2-carbaldehyde(SMILESS: O=CC(N1)=CC2=C1C=CC(OC)=C2,cas:21778-81-4) is researched.Product Details of 21778-81-4. The article 《Carbene-Catalyzed Enantioselective Aromatic N-Nucleophilic Addition of Heteroarenes to Ketones》 in relation to this compound, is published in Angewandte Chemie, International Edition. Let’s take a look at the latest research on this compound (cas:21778-81-4).

The aromatic nitrogen atoms of heteroarylaldehydes were activated by carbene catalysts to react with ketone electrophiles. Multi-functionalized cyclic N,O-acetal products I [R1 = H, 8′-Br, 7′-Cl, etc.; R2 = H, 4-Br, 5-Cl, etc.; R3 = Me, Bn, Trt], II [R1 = H, 8-Br, 7-F, etc.; R2 = H, 3-Me, 4-Cl, etc.; R3 = Me, Et, Ph, Bn, CHPh2] and III [R1 = H, 6;t-Bu, 7’Cl, etc.; R2 = H, 4-Cl, 5-Me, etc.] were afforded in good to excellent yields and optical purities. Reaction involved the formation of an unprecedented aza-fulvene-type acylazolium intermediate. A broad range of N-heteroaromatic aldehydes and electron-deficient ketone substrates works effectively in this transformation. Several of the chiral N,O-acetal products afforded through this protocol exhibited excellent antibacterial activities against Ralstonia solanacearum (Rs) and are valuable in the development of novel agrichems. for plant protection.

After consulting a lot of data, we found that this compound(21778-81-4)COA of Formula: C10H9NO2 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 5-Methoxy-1H-indole-2-carbaldehyde(SMILESS: O=CC(N1)=CC2=C1C=CC(OC)=C2,cas:21778-81-4) is researched.Application of 21778-81-4. The article 《Synthetic studies on mitomycins. Synthesis of aziridinopyrrolo[1,2-a]indoles》 in relation to this compound, is published in Tetrahedron Letters. Let’s take a look at the latest research on this compound (cas:21778-81-4).

Conversion of the nitro compounds 2,4,5-Me(R1O)R2C6H2NO2 (R1, R2 = Me, H; Me, Me; PhCH2O, H; PhCH2O, Me) by a modified Reissert indole synthesis gave the esters I (R3 = CO2Et), m. 155-6, – , – , 141-2°, resp., reduced by LiAlH4 to the alcs. I (R3 = CH2OH), m. 83.5-5.0, 139-40, 103-4, 100-3°, resp., oxidized in turn by KMnO4 in Me2CO with poor yields (10-20%) or with yields up to 90% by CrO3-C5H5N of the corresponding aldehydes I (R3 = CHO), m. 136-7, 172-3, 178-9, 172-5°, resp. The aldehydes treated with NaH and H2C:CHPPh3Br in tetrahydrofuran (THF) gave 80-8% yields of 9H-pyrrolo[1,2-a]indoles (II) (R1, R2 = Me, H; PhCH2O, H; PhCH2O, Me), m. 80-1, 88-9, 88-9°, resp., with structures supported by uv and N.M.R. spectra. Acylation of II with KOCMe3 and Me2CO3 afforded 60-80% 3H-pyrrolo-[1,2-a]indoles (III) (R4 = OMe), m. 121-3, 122-3, 139-41°, resp. Similarly acylation with HCO2Et gave III (R4 = H; R1, R2 = Me, H; PhCH2O, Me), m. 135-41 (decomposition), and 138-42°, with structures supported by ir, uv, and N.M.R. spectra. Functionalization of the vinylic double bond of III for attachment of the aziridine moiety was achieved by iodine-azide addition giving 74-5% yields of iodo-azides (IV, R1, R2 = Me, H; PhCH2O, Me), m. 93.8-4.5, and 171-9°, ir, uv, and N.M.R. spectral data given. Catalytic hydrogenation of IV over Pd-C in MeOH containing HCl gave 60-90% yields of the corresponding iodo-amine hydrochlorides, m. >300, >300°, yielding the expected iodoamines, m. indefinite, 135-41° (decomposition), resp., ir bands (Nujol) given. Protection of the amine group with ClCO2Me furnished the iodo carbamates (V) (R5 = H; R1, R2 = Me, H; PhCH2O, Me) (VI, VII), m. 160-2 and 183-4°, resp. Cyclization with NaOMe in (MeOCH2)2 or THF gave VIII (R5 = H; R1 = Me, R2 = H), m. 210.5-14.5°, with structure confirmed by spectroscopic data, and VIII (R5 = H, R1 = PhCH2O, R2 = Me), m. 219.5-21.5°. Nitration of VI and VII gave the 8-nitro derivatives V (R5 = NO2, R1, R2 = Me, H; PhCH2O, Me), m. indefinite and 192-9°, resp. The location of the NO2 group was elucidated by N.M.R. spectral anal. The ring closure of the 8-nitro derivatives similarly gave the corresponding aziridines, VIII (R5 = NO2; R1, R2 = Me, H; PhCH2O, Me), m. 242-6, and 232-3.5°.

After consulting a lot of data, we found that this compound(21778-81-4)Product Details of 21778-81-4 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem