Heinrich, Timo et al. published new experimental results with the assistance of cas: 65202-52-0

The pyridazine structure is a popular pharmacophore which is found within a number of herbicides such as credazine, pyridafol and pyridate.Synthetic Route of C6H5BrN2O2 It is also found within the structure of several drugs such as cefozopran, cadralazine, minaprine, pipofezine, and hydralazine.

Synthetic Route of C6H5BrN2O2In 2021, Heinrich, Timo;Sala-Hojman, Ada;Ferretti, Roberta;Petersson, Carl;Minguzzi, Stefano;Gondela, Andrzej;Ramaswamy, Shivapriya;Bartosik, Anna;Czauderna, Frank;Crowley, Lindsey;Wahra, Pamela;Schilke, Heike;Boepple, Pia;Dudek, Lukasz;Les, Marcin;Niedziejko, Paulina;Olech, Kamila;Pawlik, Henryk;Wloszczak, Lukasz;Zuchowicz, Karol;Suarez Alvarez, Jose Ramon;Martyka, Justyna;Sitek, Ewa;Mikulski, Maciej;Szczesniak, Joanna;Jaeckel, Sven;Krier, Mireille;Krol, Marcin;Wegener, Ansgar;Galezowski, Michal;Nowak, Mateusz;Becker, Frank;Herhaus, Christian published 《Discovery of 5-{2-[5-Chloro-2-(5-ethoxyquinoline-8-sulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic Acid, a Highly Selective in Vivo Useable Chemical Probe to Dissect MCT4 Biology》. 《Journal of Medicinal Chemistry》published the findings. The article contains the following contents:

Due to increased lactate production during glucose metabolism, tumor cells heavily rely on efficient lactate transport to avoid intracellular lactate accumulation and acidification. Monocarboxylate transporter 4 (MCT4/SLC16A3) is a lactate transporter that plays a central role in tumor pH modulation. The discovery and optimization of a novel class of MCT4 inhibitors (hit 9a), identified by a cellular screening in MDA-MB-231, is described. Direct target interaction of the optimized compound 18n with the cytosolic domain of MCT4 was shown after solubilization of the GFP-tagged transporter by fluorescence cross-correlation spectroscopy and microscopic studies. In vitro treatment with 18n resulted in lactate efflux inhibition and reduction of cellular viability in MCT4 high expressing cells. Moreover, pharmacokinetic properties of 18n allowed assessment of lactate modulation and antitumor activity in a mouse tumor model. Thus, 18n represents a valuable tool for investigating selective MCT4 inhibition and its effect on tumor biol. And Methyl 6-bromopyridazine-3-carboxylate (cas: 65202-52-0) was used in the research process.

The pyridazine structure is a popular pharmacophore which is found within a number of herbicides such as credazine, pyridafol and pyridate.Synthetic Route of C6H5BrN2O2 It is also found within the structure of several drugs such as cefozopran, cadralazine, minaprine, pipofezine, and hydralazine.

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

 

Cas: 65202-52-0 | Barlin, Gordon B. et al. made new progress in 1977

The pyridazine structure is a popular pharmacophore which is found within a number of herbicides such as credazine, pyridafol and pyridate.Application In Synthesis of Methyl 6-bromopyridazine-3-carboxylate It is also found within the structure of several drugs such as cefozopran, cadralazine, minaprine, pipofezine, and hydralazine.

Barlin, Gordon B.;Yap, C. Yoot published 《Some 3-halopyridazines》. The research results were published in《Australian Journal of Chemistry》 in 1977.Application In Synthesis of Methyl 6-bromopyridazine-3-carboxylate The article conveys some information:

3-Halogenopyridazines including 3-fluoro-6-methyl- and 3-iodo-pyridazines; Me 3-fluoro-, 3-bromo- and 3-iodopyridazine-6-carboxylates and some intermediates were prepared Thus, Me 3-hydroxypyridazine-6-carboxylate was treated with POCl3 to give Me 3-chloropyridazine-6-carboxylate. To complete the study, the researchers used Methyl 6-bromopyridazine-3-carboxylate (cas: 65202-52-0) .

The pyridazine structure is a popular pharmacophore which is found within a number of herbicides such as credazine, pyridafol and pyridate.Application In Synthesis of Methyl 6-bromopyridazine-3-carboxylate It is also found within the structure of several drugs such as cefozopran, cadralazine, minaprine, pipofezine, and hydralazine.

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

 

Application of cas: 65202-52-0 | Ohno, Hiroaki et al. published an article in 2016

The pyridazine structure is a popular pharmacophore which is found within a number of herbicides such as credazine, pyridafol and pyridate.HPLC of Formula: 65202-52-0 It is also found within the structure of several drugs such as cefozopran, cadralazine, minaprine, pipofezine, and hydralazine.

HPLC of Formula: 65202-52-0《Structure-activity relationship study of 4-(thiazol-5-yl)benzoic acid derivatives as potent protein kinase CK2 inhibitors》 was published in 2016. The authors were Ohno, Hiroaki;Minamiguchi, Daiki;Nakamura, Shinya;Shu, Keito;Okazaki, Shiho;Honda, Maho;Misu, Ryosuke;Moriwaki, Hirotomo;Nakanishi, Shinsuke;Oishi, Shinya;Kinoshita, Takayoshi;Nakanishi, Isao;Fujii, Nobutaka, and the article was included in《Bioorganic & Medicinal Chemistry》. The author mentioned the following in the article:

Two classes of modified analogs of 4-(thiazol-5-yl)benzoic acid-type CK2 inhibitors were designed. The azabenzene analogs, pyridine- and pyridazine-carboxylic acid derivatives, showed potent protein kinase CK2 inhibitory activities [IC50 (CK2α) = 0.014-0.017 μM; IC50 (CK2α’) = 0.0046-0.010 μM]. Introduction of a 2-halo- or 2-methoxy-benzyloxy group at the 3-position of the benzoic acid moiety maintained the potent CK2 inhibitory activities [IC50 (CK2α) = 0.014-0.016 μM; IC50 (CK2α’) = 0.0088-0.014 μM] and led to antiproliferative activities [CC50 (A549) = 1.5-3.3 μM] three to six times higher than those of the parent compound To complete the study, the researchers used Methyl 6-bromopyridazine-3-carboxylate (cas: 65202-52-0) .

The pyridazine structure is a popular pharmacophore which is found within a number of herbicides such as credazine, pyridafol and pyridate.HPLC of Formula: 65202-52-0 It is also found within the structure of several drugs such as cefozopran, cadralazine, minaprine, pipofezine, and hydralazine.

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

 

Heinrich, Timo et al. published new experimental results with the assistance of cas: 65202-52-0

The pyridazine structure is a popular pharmacophore which is found within a number of herbicides such as credazine, pyridafol and pyridate.Recommanded Product: Methyl 6-bromopyridazine-3-carboxylate It is also found within the structure of several drugs such as cefozopran, cadralazine, minaprine, pipofezine, and hydralazine.

Recommanded Product: Methyl 6-bromopyridazine-3-carboxylateIn 2021, Heinrich, Timo;Sala-Hojman, Ada;Ferretti, Roberta;Petersson, Carl;Minguzzi, Stefano;Gondela, Andrzej;Ramaswamy, Shivapriya;Bartosik, Anna;Czauderna, Frank;Crowley, Lindsey;Wahra, Pamela;Schilke, Heike;Boepple, Pia;Dudek, Lukasz;Les, Marcin;Niedziejko, Paulina;Olech, Kamila;Pawlik, Henryk;Wloszczak, Lukasz;Zuchowicz, Karol;Suarez Alvarez, Jose Ramon;Martyka, Justyna;Sitek, Ewa;Mikulski, Maciej;Szczesniak, Joanna;Jaeckel, Sven;Krier, Mireille;Krol, Marcin;Wegener, Ansgar;Galezowski, Michal;Nowak, Mateusz;Becker, Frank;Herhaus, Christian published 《Discovery of 5-{2-[5-Chloro-2-(5-ethoxyquinoline-8-sulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic Acid, a Highly Selective in Vivo Useable Chemical Probe to Dissect MCT4 Biology》. 《Journal of Medicinal Chemistry》published the findings. The article contains the following contents:

Due to increased lactate production during glucose metabolism, tumor cells heavily rely on efficient lactate transport to avoid intracellular lactate accumulation and acidification. Monocarboxylate transporter 4 (MCT4/SLC16A3) is a lactate transporter that plays a central role in tumor pH modulation. The discovery and optimization of a novel class of MCT4 inhibitors (hit 9a), identified by a cellular screening in MDA-MB-231, is described. Direct target interaction of the optimized compound 18n with the cytosolic domain of MCT4 was shown after solubilization of the GFP-tagged transporter by fluorescence cross-correlation spectroscopy and microscopic studies. In vitro treatment with 18n resulted in lactate efflux inhibition and reduction of cellular viability in MCT4 high expressing cells. Moreover, pharmacokinetic properties of 18n allowed assessment of lactate modulation and antitumor activity in a mouse tumor model. Thus, 18n represents a valuable tool for investigating selective MCT4 inhibition and its effect on tumor biol. And Methyl 6-bromopyridazine-3-carboxylate (cas: 65202-52-0) was used in the research process.

The pyridazine structure is a popular pharmacophore which is found within a number of herbicides such as credazine, pyridafol and pyridate.Recommanded Product: Methyl 6-bromopyridazine-3-carboxylate It is also found within the structure of several drugs such as cefozopran, cadralazine, minaprine, pipofezine, and hydralazine.

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

 

The influence of catalyst in reaction 21778-81-4

The article 《Copper-Catalyzed Annulation of 2-Formylazoles with o-Aminoiodoarenes》 also mentions many details about this compound(21778-81-4)Category: pyridazine, you can pay attention to it or contacet with the author([email protected]) to get more information.

Category: pyridazine. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 5-Methoxy-1H-indole-2-carbaldehyde, is researched, Molecular C10H9NO2, CAS is 21778-81-4, about Copper-Catalyzed Annulation of 2-Formylazoles with o-Aminoiodoarenes. Author is Reeves, Jonathan T.; Fandrick, Daniel R.; Tan, Zhulin; Song, Jinhua J.; Lee, Heewon; Yee, Nathan K.; Senanayake, Chris H..

In the presence of catalytic CuI and sparteine, 2-formylpyrroles can be annulated with o-aminoiodoarenes to give substituted pyrrolo[1,2-a]quinoxalines and related heterocycles. The reaction also works for annulation of 2-formylindoles, 2-formylimidazole, 2-formylbenzimidazole, and a 3-formylpyrazole.

The article 《Copper-Catalyzed Annulation of 2-Formylazoles with o-Aminoiodoarenes》 also mentions many details about this compound(21778-81-4)Category: pyridazine, you can pay attention to it or contacet with the author([email protected]) to get more information.

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

 

Downstream Synthetic Route Of 17739-45-6

The article 《Helicates with Ether-Substituted Catechol Esters as Ligands》 also mentions many details about this compound(17739-45-6)Application of 17739-45-6, you can pay attention to it, because details determine success or failure

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Mevissen, Christian; Kwamen, A. Carel N.; Himmel, Leonard; Chen, Xiaofei; Brueckner, Matthias; Huda, Saskia; Goeb, Christian; Jenniches, Judith; Oppel, Iris; Ward, Jas S.; Rissanen, Kari; Albrecht, Markus researched the compound: 2-(2-Bromoethoxy)tetrahydro-2H-pyran( cas:17739-45-6 ).Application of 17739-45-6.They published the article 《Helicates with Ether-Substituted Catechol Esters as Ligands》 about this compound( cas:17739-45-6 ) in European Journal of Organic Chemistry. Keywords: titanium lithium catechol complex preparation; crystal structure titanium lithium catechol complex. We’ll tell you more about this compound (cas:17739-45-6).

Mono- or biscatechol esters with ether-type substituents or spacers form either triple lithium bridged dimeric helicates or triple stranded helicates with the ability to bind three lithium cations in their interior. Hierarchical helicates with ether or thioether substituents show in solution a monomer-dimer equilibrium which is independent of the heteroatom in the ester substituent. However, dimerization constants are significantly lower than for corresponding alkyl derivatives Dinuclear helicates with oligoether spacers are well obtained in the presence of lithium cations. Upon removal of the cations the helicates expand and successive addition of LiCl results in compression again.

The article 《Helicates with Ether-Substituted Catechol Esters as Ligands》 also mentions many details about this compound(17739-45-6)Application of 17739-45-6, you can pay attention to it, because details determine success or failure

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

 

Derivation of elementary reaction about 21778-81-4

The article 《Synthesis of Indole- and Pyrrole-Fused Seven-Membered Nitrogen Heterocycles via Acid-Base Switchable Cyclization Involving Cleavage of Amide C-N Bonds》 also mentions many details about this compound(21778-81-4)SDS of cas: 21778-81-4, you can pay attention to it, because details determine success or failure

SDS of cas: 21778-81-4. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 5-Methoxy-1H-indole-2-carbaldehyde, is researched, Molecular C10H9NO2, CAS is 21778-81-4, about Synthesis of Indole- and Pyrrole-Fused Seven-Membered Nitrogen Heterocycles via Acid-Base Switchable Cyclization Involving Cleavage of Amide C-N Bonds. Author is Hao, Yanke; Zhou, Pan; Niu, Kaikai; Song, Hongjian; Liu, Yuxiu; Zhang, Jingjing; Wang, Qingmin.

The method for synthesis of indole- and pyrrole-fused seven-membered nitrogen heterocycles I [R = H, Br; R1 = H; RR1 = -CH=CHCH=CH-, -CH=C(OMe)CH=CH-, -CH=CHC(Br)=CH-, etc.; R2 = H, Me, 3-(trifluoromethyl)phenyl, ethyloxidanyl; R3 = H, Me; R4 = Me, 4-methylphenyl, thiophen-2-yl, etc.], 2-tosyl-1,2,3,4-tetrahydro-5H-[1,5]diazocino[3,2,1-hi]indol-5-one and II (R5 = H, OMe; R6 = Me, 2-fluorophenyl, thiophen-2-yl, etc.) by means of acid-base switchable cyclization reactions have been reported. The reactions involved cleavage of amide C-N bonds, chemoselective N-1 or C-3 acylation, and 1,4-Michael addition This method could be used to construct two different kinds of seven-membered rings in one step from the same starting material without the need for a transition-metal catalyst.

The article 《Synthesis of Indole- and Pyrrole-Fused Seven-Membered Nitrogen Heterocycles via Acid-Base Switchable Cyclization Involving Cleavage of Amide C-N Bonds》 also mentions many details about this compound(21778-81-4)SDS of cas: 21778-81-4, you can pay attention to it, because details determine success or failure

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

 

Flexible application of in synthetic route 21778-81-4

The article 《Asymmetric organocatalytic N-alkylation of indole-2-carbaldehydes with α,β-unsaturated aldehydes: one-pot synthesis of chiral pyrrolo[1,2-a]indole-2-carbaldehydes》 also mentions many details about this compound(21778-81-4)Synthetic Route of C10H9NO2, you can pay attention to it, because details determine success or failure

Synthetic Route of C10H9NO2. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 5-Methoxy-1H-indole-2-carbaldehyde, is researched, Molecular C10H9NO2, CAS is 21778-81-4, about Asymmetric organocatalytic N-alkylation of indole-2-carbaldehydes with α,β-unsaturated aldehydes: one-pot synthesis of chiral pyrrolo[1,2-a]indole-2-carbaldehydes. Author is Hong, Liang; Sun, Wangsheng; Liu, Chunxia; Wang, Lei; Wang, Rui.

Diphenylprolinol trimethylsilyl ether-catalyzed asym. aza-Michael addition/aldol addition of indole-2-carboxaldehyde with unsaturated aldehydes is described. A series of chiral pyrrolo[1,2-a]indole-2-carbaldehydes were obtained in good yields with excellent stereoselectivities.

The article 《Asymmetric organocatalytic N-alkylation of indole-2-carbaldehydes with α,β-unsaturated aldehydes: one-pot synthesis of chiral pyrrolo[1,2-a]indole-2-carbaldehydes》 also mentions many details about this compound(21778-81-4)Synthetic Route of C10H9NO2, you can pay attention to it, because details determine success or failure

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

 

Properties and Exciting Facts About 136725-55-8

The article 《Fluorine Substitution Induced High Tc of Enantiomeric Perovskite Ferroelectrics: (R)- and (S)-3-(Fluoropyrrolidinium)MnCl3》 also mentions many details about this compound(136725-55-8)Application of 136725-55-8, you can pay attention to it, because details determine success or failure

Application of 136725-55-8. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: (R)-(-)-3-Fluoropyrrolidine Hydrochloride, is researched, Molecular C4H9ClFN, CAS is 136725-55-8, about Fluorine Substitution Induced High Tc of Enantiomeric Perovskite Ferroelectrics: (R)- and (S)-3-(Fluoropyrrolidinium)MnCl3. Author is Ai, Yong; Chen, Xiao-Gang; Shi, Ping-Ping; Tang, Yuan-Yuan; Li, Peng-Fei; Liao, Wei-Qiang; Xiong, Ren-Gen.

The past decade has witnessed much progress in designing mol. ferroelecs., whose intrinsic mech. flexibility, structural tunability, and easy processability are desirable for next-generation flexible and wearable electronic devices. However, an obstacle in expanding their promising applications in nonvolatile memory elements, capacitors, and sensors is effectively modulating the Curie temperature (Tc). Here, taking advantage of fluorine substitution on the reported mol. ferroelec., (pyrrolidinium)MnCl3, we present enantiomeric perovskite ferroelecs., namely, (R)- and (S)-3-(fluoropyrrolidinium)MnCl3. The close van der Waal’s radii and the similar steric parameters between H and F atoms ensure the min. disruption of the crystal structure, while their different electronegativity and polarizability can trigger significant changes in the phys. and chem. properties. As expected, the Tc gets successfully increased from 295 K in (pyrrolidinium)MnCl3 to 333 K in these two homochiral compounds Such a dramatic enhancement of 38 K signifies an important step toward designing high-Tc mol. ferroelecs. In the light of the conceptually new idea of fluorine substitution, one could look forward to a continuous succession of new mol. ferroelec. materials and technol. developments.

The article 《Fluorine Substitution Induced High Tc of Enantiomeric Perovskite Ferroelectrics: (R)- and (S)-3-(Fluoropyrrolidinium)MnCl3》 also mentions many details about this compound(136725-55-8)Application of 136725-55-8, you can pay attention to it, because details determine success or failure

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

 

Chemistry Milestones Of 21778-81-4

After consulting a lot of data, we found that this compound(21778-81-4)COA of Formula: C10H9NO2 can be used in many types of reactions. And in most cases, this compound has more advantages.

COA of Formula: C10H9NO2. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 5-Methoxy-1H-indole-2-carbaldehyde, is researched, Molecular C10H9NO2, CAS is 21778-81-4, about Catalytic Asymmetric [3 + 2] Annulation via Indolyl Copper-Allenylidene Intermediates: Diastereo- and Enantioselective Assembly of Pyrrolo[1,2-a]indoles. Author is Zhang, Jian; Ni, Tao; Yang, Wu-Lin; Deng, Wei-Ping.

A catalytic asym. decarboxylative [3 + 2] annulation via indolyl copper-allenylidene amphiphilic intermediates has been developed. This protocol offers a straightforward method for the synthesis of biol. important pyrrolo[1,2-a]indoles bearing contiguous quaternary and tertiary stereogenic centers with excellent diastereo- and enantioselectivities (up to >20:1 dr and >99% ee). In addition, the diversity-oriented synthesis of pyrrolo[1,2-a]indoles was achieved via versatile transformations of the alkyne-containing cycloadducts.

After consulting a lot of data, we found that this compound(21778-81-4)COA of Formula: C10H9NO2 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem