Heterocyclic Building Blocks-Pyridazine

Electric Literature of 5469-70-5, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.5469-70-5, Name is 3-Aminopyridazine, molecular formula is C4H5N3. In a Article£¬once mentioned of 5469-70-5

Non-charged thiamine analogs as inhibitors of enzyme transketolase

Inhibition of the thiamine-utilizing enzyme transketolase (TK) has been linked with diminished tumor cell proliferation. Most thiamine antagonists have a permanent positive charge on the B-ring, and it has been suggested that this charge is required for diphosphorylation by thiamine pyrophosphokinase (TPPK) and binding to TK. We sought to make neutral thiazolium replacements that would be substrates for TPPK, while not necessarily needing thiamine transporters (ThTr1 and ThTr2) for cell penetration. The synthesis, SAR, and structure-based rationale for highly potent non-thiazolium TK antagonists are presented.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N97 – PubChem

 

Application of 1698-53-9, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.1698-53-9, Name is 4,5-Dichloro-2-phenylpyridazin-3(2H)-one, molecular formula is C10H6Cl2N2O. In a Article£¬once mentioned of 1698-53-9

One-pot three component synthesis of heteroarylated arylacetates via VNSAr-SN reaction using N-methylpyrrolidone as general solvent

An efficient three component one-pot method was developed to assemble 2-heteroaryl-2-aryl acetates via VNSAr-SNAr and VNS Ar-SN reaction by using N-methylpyrrolidone (NMP) as general solvent. This journal is The Royal Society of Chemistry.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N3093 – PubChem

 

Application of 141-30-0, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.141-30-0, Name is 3,6-Dichloropyridazine, molecular formula is C4H2Cl2N2. In a article£¬once mentioned of 141-30-0

Fungicidal (+)-2-(2,4-difluorophenyl)-3-methyl-1-(1H-1,2,4-triazol-1-yl)3-(6-(1H-1,2,4-triazol-1-yl)pyridazin-3-ylthio) butan-2-ol

(+)-2-(2,4-Difluorophenyl)-3-methyl-1-(1H-1,2,4-triazol-1-yl)-3-(6-(1H-1,2,4-triazol-1-yl)pyridazin-3-ylthio)butan-2-ol and a pharmaceutically acceptable salt thereof useful as an antifungal agent are disclosed. An inclusion complex of the compound with cyclodextrin can be given either orally or intravenously and has increased absorption when administered orally.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1536 – PubChem

 

20375-65-9, Name is 3-Phenyl-6-chloropyridazine, belongs to pyridazine compound, is a common compound. Quality Control of 3-Phenyl-6-chloropyridazineIn an article, once mentioned the new application about 20375-65-9.

Stereoselective micellar catalysis. Reactions of amino-acid ester derivatives with N-acyl-L-histidine in micelles

Mixed micelles of the N-acyl-L-histidines (I) and cetyltrimethylammonium bromide (CTABr) are effective stereoselective catalysts for cleavage of the enantiomeric amino-acid ester derivatives (II). The rate enhancements and stereoselective effects depend on the hydrophobicity of (I) in micelles, and an increase in the chain length of the acyl part of (I) increases both the reaction rates and the enantiomer rate ratio. Mixed micelles with anionic and nonionic surfactants are relatively less effective stereoselective catalysts. Kinetic analysis indicates that the stereoselectivity in mixed micelles is mainly determined by catalytic acyl transfer to the optically active imidazole group of (I).

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2652 – PubChem

 

Synthetic Route of 935777-24-5, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 935777-24-5, Name is 6-(Trifluoromethyl)pyridazin-3-amine, molecular formula is C5H4F3N3. In a Patent£¬once mentioned of 935777-24-5

HETERCYCLIC COMPOUNDS FOR THE TREATMENT OF DISEASE

Described herein are heterocyclic compounds, compositions, and methods for their use for treatment of disease.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2208 – PubChem

 

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 89089-18-9, name is 3-Bromo-6-chloropyridazine, introducing its new discovery. HPLC of Formula: C4H2BrClN2

N-[3-(2-CARBOXYETHYL)PHENYL]PIPERIDIN-1-YLACETAMIDE DERIVATIVES AND USE THEREOF AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE

The present application relates to novel substituted 2-(piperidin-1-yl)acetamide derivatives, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of cardiovascular diseases.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2845 – PubChem

 

Synthetic Route of 20733-11-3, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.20733-11-3, Name is 4-Methoxypyridazine, molecular formula is C5H6N2O. In a article£¬once mentioned of 20733-11-3

AMIDO-BENZYL SULFONE AND SULFONAMIDE DERIVATIVES

Disclosed are certain amido-benzyl sulfone and sulfonamide compounds, pharmaceutical compositions comprising such compounds, land methods of treatment using such compounds.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N274 – PubChem

 

187973-60-0, Name is 6-Iodopyridazin-3-amine, belongs to pyridazine compound, is a common compound. COA of Formula: C4H4IN3In an article, once mentioned the new application about 187973-60-0.

Preparation of differentially substituted 3,6-diaminopyridazines under mild conditions

Although desirable from a medicinal chemistry perspective, the differentially substituted 3,6-diaminopyridazine moiety is a highly challenging target using current literature approaches. Recent methods of Ullmann-type couplings are evaluated and a mild route to prepare these structures from iodide precursors is presented.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2941 – PubChem

 

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 66346-87-0, name is 6-Chloro-5-methylpyridazin-3-amine, introducing its new discovery. Application In Synthesis of 6-Chloro-5-methylpyridazin-3-amine

2-Phenylimidazo[1,2-b]pyridazine derivatives highly active against Haemonchus contortus

A series of 2-phenylimidazo[1,2-b]pyridazine derivatives were synthesized and evaluated for their in vitro anthelmintic activity against Haemonchus contortus. The most active compounds had in vitro LD99 values of 30 nM, which is comparable to that of the benchmark commercial nematocide, Ivermectin.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1096 – PubChem

 

Electric Literature of 64068-00-4, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.64068-00-4, Name is 6-Chloro-4-methylpyridazin-3-amine, molecular formula is C5H6ClN3. In a Article£¬once mentioned of 64068-00-4

New non-peptide endothelin-a receptor antagonists: Synthesis, biological properties, and structure-activity relationships of 5-(dimethylamino)-N- pyridyl-, -N-pyrimidinyl-, -N-pyridazinyl-, and -N-pyrazinyl-1- naphthalenesulfonamides

Use of automated synthesis led to the discovery of several 6-membered nitrogen heterocycles as replacements for the N-isoxazolyl substituent present in the 1-naphthalenesulfonamide endothelin-A (ETA) antagonist 5- (dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide (BMS 182874). In each of these heterocycles, a small substituent such as halogen para to the position of attachment to the sulfonamide nitrogen atom was found to be advantageous for ETA receptor affinity. Of these heterocycles, 2- pyrazines offered the greatest scope for improving receptor affinity. Optimization of the substituents at the 3- and 5-positions in the pyrazine ring led to potent, ET(A)-selective compounds such as 5-(dimethylamino)-N- (5-chloro-3-methoxy-2-pyrazinyl)-1-naphthalenesulfonamide (7m, ET(A) pIC50 8.1). When dosed orally at 10 mg/kg to conscious, normotensive rats infused with big ET-1, compounds such as 7m showed significant inhibition of the pressor response with a duration of effect lasting for the 5-h course of the experiment.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1059 – PubChem