Heterocyclic Building Blocks-Pyridazine

90008-50-7, Name is 6-Propoxypyridazin-3-amine, belongs to pyridazine compound, is a common compound. Formula: C7H11N3OIn an article, once mentioned the new application about 90008-50-7.

Syntheses, pharmacological evaluation and molecular modelling of substituted 6-alkoxyimidazo<1,2-b>pyridazines as new ligands for the benzodiazepine receptor

A series of 2,3-disubstituted-6-alkoxyimidazo<1,2-b>pyridazines has been synthesized and evaluated for in vitro affinity for the benzodiazepine receptor (BZR). 3-(Benzamidomethyl or substituted benzamidomethyl)-6-methoxy-2-(3,4-methylenedioxyphenyl)imidazo<1,2-b>pyridazines were found to be the most potent BZR ligands (eg, 4a, IC50 7 nM; 4e, IC50 14 nM; 4v, IC50 8 nM).Imidazo<1,2-b>pyridazines unsubstituted in the 3-position, or containing bulkier alkoxy groups in the 6-position, were found to bind less strongly to the BZR.Selected compounds from the series wereidentified from in vitro GABA-shift experiments as BZR agonists.Molecular modelling has been employed to identify the common pharmacophoric points of lipophilic and hydrogen bonding, ligand-receptor interaction and areas of steric hindrance for these substituted imidazo<1,2-b>pyridazines at the BZR. – Keywords: imidazo<1,2-b>pyridazine; benzodiazepine receptor; structure-activity relationship; molecullar modelling

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1987 – PubChem

 

Reference of 91063-19-3, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.91063-19-3, Name is 3-(Benzyloxy)-6-chloropyridazine, molecular formula is C11H9ClN2O. In a Patent，once mentioned of 91063-19-3

Sulfonyl pyridazinone compounds useful as aldose reductase inhibitors

This invention relates to novel sulfonyl pyridazinone compounds useful as aldose reductase inhibitors in the treatment or prevention of certain complications arising from diabetes mellitus, pharmaceutical compositions comprising the sulfonyl pyridazinone, pharmaceutical compositions comprising a combination of the sulfonyl pyridazinone together with a second pharmaceutical agent, therapeutic methods comprising the administration of the sulfonyl pyridazinone compounds, therapeutic methods comprising the administration of the sulfonyl pyridazinone compounds in combination with a second pharmaceutical agent and compounds useful as intermediates for preparing the sulfonyl pyridazinone compounds of this invention.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 91063-19-3

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2919 – PubChem

 

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Application In Synthesis of 3-Aminopyridazine, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 5469-70-5, name is 3-Aminopyridazine. In an article，Which mentioned a new discovery about 5469-70-5

2-Aminoimidazole-based antagonists of the 5-HT6 receptor ? A new concept in aminergic GPCR ligand design

A new strategy in the design of aminergic GPCR ligands is proposed ? the use of aromatic, heterocyclic basic moieties in place of the evergreen piperazine or alicyclic and aliphatic amines. This hypothesis has been tested using a benchmark series of 5-HT6R antagonists obtained by coupling variously substituted 2-aminoimidazole moieties to the well established 1-benzenesulfonyl-1H-indoles, which served as the ligands cores. The crystallographic studies revealed that upon protonation, the 2-aminoimidazole fragment triggers a resonance driven conformational change leading to a form of higher affinity. This molecular switch may be responsible for the observed differences in 5-HT6R activity of the studied chemotypes with different amine-like fragments. Considering the multiple functionalization sites of the embedded guanidine fragment, diverse libraries were constructed, and the relationships between the structure and activity, metabolic stability, and solubility were established. Compounds from the N-(1H-imidazol-2-yl)acylamide chemotype (10a?z) exhibited high affinity for 5-HT6R and very high selectivity over 5-HT1A, 5-HT2A, 5-HT7 and D2 receptors (negligible binding), which was attributed to their very weak basicity. The lead compound in the series 4-methyl-5-[1-(naphthalene-1-sulfonyl)-1H-indol-3-yl]-1H-imidazol-2-amine (9i) was shown to reverse the cognitive impairment caused by the administration of scopolamine in rats indicating procognitive potential.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N76 – PubChem

 

Electric Literature of 2164-61-6, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 2164-61-6, molcular formula is C5H4N2O2, introducing its new discovery.

NOVEL 2-HETEROARYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVE

A glucokinase activator is provided; and a remedy and/or a preventive for diabetes, or a remedy and/or a preventive for diabetes such as retinopathy, nephropathy, neurosis, ischemic cardiopathy, arteriosclerosis, and further a remedy and/or a preventive for obesity are provided. A glucokinase activator characterized by containing a 2-heteroaryl-substituted benzimidazole derivative of a general formula (I-0) or its pharmaceutically-acceptable salt: [in the formula, X represents a carbon atom or a nitrogen atom; X1, X2, X3 and X4 each independently represent a carbon atom or a nitrogen atom; the ring A represents a 5- or 6-membered nitrogen-containing aromatic hetero ring of a formula (II): (in the formula, X represents a carbon atom or a nitrogen atom); R1 represents an aryl, etc.; R2 represents a hydroxy, etc.; R3 represents a -C1-6 alkyl, etc.; R4 represents a -C1-6 alkyl, etc.; X5 represents -O-, etc.; a indicates an integer of 1, 2 or 3; q indicates an integer of from 0 to 2; m indicates an integer of from 0 to 2].

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 2164-61-6 is helpful to your research. Electric Literature of 2164-61-6

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N469 – PubChem

 

Electric Literature of 27349-66-2, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.27349-66-2, Name is 3-(Chloromethyl)pyridazine hydrochloride, molecular formula is C5H6Cl2N2. In a Patent，once mentioned of 27349-66-2

Alkyl- or aryl-aminoalkoxy-benzene-sulfonyl indoles

The present invention relates to aminoalkoxyphenyl derivatives of formula: STR1 and its N-oxide and pharmaceutically acceptable salts, in which: B represents a–S–, –SO– or –SO2 — group, R1 and R2, which are identical or different, each denote hydrogen, a methyl or ethyl radial or a halogen atom, A denotes a straight-or branched-alkylene radical having from 2 to 5 carbon atoms or a 2-hydroxypropylene radial in which the hydroxy is optionally substituted by a lower alkyl radical, R3 denotes an alkkyl radical or a radical of formula: in which Alk denotes a single bond or a linear- or branched-alkylene radical having from 1 to 5 carbon atoms and Ar denotes a pyridyl, phenyl, 2,3-methylenedioxyphenyl or 3,4-methylenedioxyphenyl radical or a phenyl group substituted with one or more substituents, which may be identical or different, selected from halogen atoms, lower alkyl group or lower alkoxy groups, R11 denotes hydrogen or a lower alkyl, phenyl, diphenylmethyl, benzyl or halogenobenzyl radical, R4 denotes hydrogen or an alkyl radical, or R3 and R4 when taken together denote an alkylene or alkenylene radical having from 3 to 6 carbon atoms and optionally substituted with a phenyl radical or optionally interrupted by STR2 R represent hydrogen, an alkyl radical, a cycloalkyl radical, a benzyl radical or a phenyl radical optionally substituted with one or more substituents, which may be identical or different, selected from halogen atoms and from lower alkyl, lower alkoxy or nitro groups, are described. The compounds of the invention possess exceptional pharmacological properties, especially calcium transport inhibitory properties, as well as bradycardic, hypotensive and antiadrenergic properties.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 27349-66-2

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2392 – PubChem

 

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Product Details of 5788-58-9. Introducing a new discovery about 5788-58-9, Name is 4,5-Dibromopyridazin-3(2H)-one

ANTIMICROBIAL AGENTS AND SCREENING METHODS

Disclosed herein are antibacterial and antimicrobial compositions and methods of use. Also disclosed are screening assays for identification of an agent that specifically inhibits DsbB or bVKOR. Such methods are useful, for example, in identifying antibacterial and antimicrobial agents and compositions.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Product Details of 5788-58-9, you can also check out more blogs about5788-58-9

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N3145 – PubChem

 

Chemistry is traditionally divided into organic and inorganic chemistry. Recommanded Product: 1120-95-2, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 1120-95-2

Efficient synthesis of pyrazine boronic esters via palladium-catalyzed Miyaura borylation

A facile and efficient protocol for palladium-catalyzed Miyaura borylation reaction of chloropyrazines with B2pin2has been developed. A certain range of difficult-to-access pyrazine boronic esters can be easily prepared from the corresponding chloropyrazines in moderate to good yields.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N422 – PubChem

 

35857-89-7, Name is 6-Chloropyridazine-3-carbonitrile, belongs to pyridazine compound, is a common compound. Formula: C5H2ClN3In an article, once mentioned the new application about 35857-89-7.

Synthesis of substituted 4-(5-Alkyl-thiazol-2-ylmethyl)-3,4-dihydro-2H-1,4- benzoxazines and 5-(2,3-Dihydro-1,4-benzoxazin-4-ylmethyl)-4-methyl-1-phenyl-1H- pyrazol-3-ylamine

Substituted 4-(5-alkyl-thiazol-2-ylmethyl)-3,4-dihydro-2H-1,4-benzoxazines and 5-(2,3-dihydro-1,4-benzoxazin-4-ylmethyl)-4-methyl-1-phenyl-1H-pyrazol-3- ylamines were prepared by the reaction of (2,3-dihydro-1,4-benzoxazin-4-yl)- acetic acid methyl ester and some common reagents to provide the product in satisfactory yields.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N952 – PubChem

 

Chemistry is traditionally divided into organic and inorganic chemistry. SDS of cas: 89640-81-3, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 89640-81-3

Process for manufacturing 1,6-dihydro-6-oxo-4-pyridazine carboxylic acid

The present invention provides a process for manufacturing 6-oxo-1 H-pyridazine-4-carboxylic acid 5 comprising – (a) reacting dimethyl 2-methylenebutanedioate with hydrazine to obtain methyl 6- oxohexahydropyridazine-4-carboxylate 11; – (b) oxidizing methyl 6-oxohexahydropyridazine-4-carboxylate 11 with a suitable oxidizing agent to methyl 6-oxo-1 H-pyridazine-4-carboxylate 4a; – (c) isolating methyl 6-oxo-1 H-pyridazine-4-carboxylate 4a; – (d) hydrolyzing methyl 6-oxo-1 H-pyridazine-4-carboxylate 4a in the presence of an aqueous base or acid to the 6-oxo-1 H-pyridazine-4-carboxylic acid 5.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2005 – PubChem

 

Application of 5788-60-3, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 5788-60-3, 3-Chloro-6-propoxypyridazine, introducing its new discovery.

Allylthiopyridazine derivatives and process for preparing the same

The, present invention relates to a novel allylthiopyridazine derivative represented by formula (I) which exhibits a superior effect for prevention and treatment or hepatic diseases induced by toxic substances and for protection of human tissues from radiation: STR1 or a pharmaceutically acceptable salt thereof, in which R1 represents halogen atom, lower alkoxy, dialkylaminoalkoxy, hydroxyalkoxy, phenoxy substituted or unsubstituted with lower alkyl, benzyloxy, or phenyl, and R2 and R3 independently of one another represent hydrogen or lower alkyl, or R2 and R3 together with carbon atom to which they are attached can form a saturated or unsaturated 6-membered ring, provided that R2 and R3 are other than hydrogen when R1 is chloro; and to a process for preparing thereof and a pharmaceutical composition containing the same as an effective component.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application of 5788-60-3. In my other articles, you can also check out more blogs about 5788-60-3

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2445 – PubChem