Heterocyclic Building Blocks-Pyridazine

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 932-22-9, name is 4,5-Dichloro-3(2H)-pyridazinone, introducing its new discovery. Recommanded Product: 932-22-9

The functionalization of 4,5-dichloropyridazin-3(2H)-one and 4,5-dichloro-2-methyl-6-nitropyridazin-3(2H)-one was reported. A mixture of 4,5-dichloropyridazin-3(2H)-one, potassium nitrate and conc-sulfuric acid was stirred for 5 hours at 110-120C. After cooling to room temperature, the solution was slowly poured into ice-water. The resulting yellow crystals was filtered, washed with water and dried in air to give the product. A mixture of 4,5-dichloro-6- nitropyridazin-3(2H)-one and POCl3 was refluxed for 24 hours. After cooling to room temperature, the solution was evaporated under reduced pressure. The resulting residue was slowly poured into ice-water (300 mL). Chlorination of compound 4,5-dichloro-6- nitropyridazin-3(2H)-one with phosphorus oxychloride also gave 3,4,5-trichloro-6-nitropyridazine in 72% yield. Three proton signals were also detected at d 9.0 (1H), 8.64 (1H) and 6.20 (2H) ppm in the spectrum of 1H NMR.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2365 – PubChem

Reference of 35857-89-7, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.35857-89-7, Name is 6-Chloropyridazine-3-carbonitrile, molecular formula is C5H2ClN3. In a Article，once mentioned of 35857-89-7

An efficient and halogen-free catalytic methodology for the synthesis of beta-amino alcohols from aromatic amines and biomass-derived carbohydrates is demonstrated for the first time. The activation of C5/C6 sugars by a ruthenium catalyst selectively generates the C2 alkylating reagent glycolaldehyde. The transformation involves metal-catalyzed hydrogen borrowing for the reduction of the imine intermediate. A series of arylamines bearing various substituents were successfully transformed into the desired products in good to excellent yields.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N933 – PubChem

Electric Literature of 20375-65-9, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 20375-65-9, Name is 3-Phenyl-6-chloropyridazine,introducing its new discovery.

A variety of phosphonopeptides, shown in 2 as a general formula, containg natural and/or unnatural amino acids were synthesized, and their in vitro antibacterial activities were examined.N-Protected amino acids were condensed with 1-amino-ethylphosphonic acid or its ester followed by deprotection and hydrolysis to give the requisite phosphonopeptides.Several compounds showed higher levels of activity against certain members of Gram-negative bacteria than those of Alafosfalin (1) as the standard phosphonopeptide.A brief discussion on structure-activity relationships is also described.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2665 – PubChem

Electric Literature of 34231-77-1, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 34231-77-1, Name is Methyl pyridazine-4-carboxylate,introducing its new discovery.

Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as pesticides, especially as herbicides.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N779 – PubChem

Synthetic Route of 141-30-0, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 141-30-0, Name is 3,6-Dichloropyridazine,introducing its new discovery.

The present invention relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I:wherein W1, W2, W3, R1, Q, X1, X2 and X3 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N1262 – PubChem

Related Products of 88491-61-6, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.88491-61-6, Name is 3-Bromopyridazine, molecular formula is C4H3BrN2. In a article，once mentioned of 88491-61-6

Analogs of compound 1 with a variety of azacycles and heteroaryl groups were synthesized. These analogs exhibited K(i) values ranging from 0.15 to > 10,000 nM when tested in vitro for cholinergic channel receptor binding activity (displacement of [3H](-) cytisine from whole rat brain synaptic membranes).

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2144 – PubChem

Related Products of 89089-18-9, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 89089-18-9, Name is 3-Bromo-6-chloropyridazine, molecular formula is C4H2BrClN2. In a Article，once mentioned of 89089-18-9

A monoprotected aminoethyl amine chiral ligand based on an ethylenediamine backbone was developed to achieve Pd-catalyzed enantioselective C(sp3)-H arylation of cyclopropanecarboxylic and 2-aminoisobutyric acids without using exogenous directing groups. This new chiral catalyst affords new disconnection for preparing diverse chiral carboxylic acids from simple starting materials that are complementary to the various ring forming approaches.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2873 – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, SDS of cas: 65202-50-8, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 65202-50-8, Name is Methyl 6-chloropyridazine-3-carboxylate, molecular formula is C6H5ClN2O2

The invention provides a series of -alpha ketoheterocyclic compounds, for example, compounds of formula (I). The compounds can inhibit fatty acid amide hydrolase and can be useful for treatment of malconditions modulated by fatty acid amide hydrolase. The invention further provides methods of making compounds of formula (I), useful intermediates for the preparation of compounds of formula (I), and methods of using compounds of formula (I) and compositions thereof.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2404 – PubChem

Application of 35857-89-7, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 35857-89-7, 6-Chloropyridazine-3-carbonitrile, introducing its new discovery.

Air-stable P,N-bidentate ligands L1-L7 with cyclic secondary amine moieties linked to the benzene rings of triphenylphosphine were designed and prepared. The chelating coordination mode of the P,N-bidentate ligands to the Pd(II) center was confirmed by determining the X-ray structures of the Pd(II) complexes C1 and C2 derived from ligands L1 and L2, respectively. The ligands were used for the selective synthesis of delta-lactone through the palladium (Pd)-catalyzed telomerization of 1,3-butadiene with carbon dioxide. The highest yield (60% with 79% selectivity) was observed using the Pd2(dba) 3/4-(2-(diphenylphosphino)phenyl)morpholine (L2) catalyst system.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N914 – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. name: 6-Chloropyridazine-3-carboxamide, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 66346-83-6

There is provided a compound of formula (I): or a pharmaceutically acceptable salt thereof. There are also provided processes for the manufacture of a compound of Formula 1, and the use of a compound of Formula 1 as a medicament and in the treatment of cancer.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2019 – PubChem