Heterocyclic Building Blocks-Pyridazine

Amination of 4-nitropyridazine 1-oxides by liquid ammonia-potassium permanganate was written by Tondys, Hanna;Van der Plas, Henk C.. And the article was included in Journal of Heterocyclic Chemistry in 1986.COA of Formula: C5H6N2O This article mentions the following:

Treatment of 4-nitropyridazine 1-oxide, 3-methoxy-6-chloro-4-nitropyridazine 1-oxide or 3,6-dimethoxy-4-nitropyridazine 1-oxide with a solution of KMnO₄ in NH₃(l) gives in reasonable-to-good yields the corresponding 5-amino-4-nitropyridazine 1-oxides (75%, 54%, and 62%, resp.). 3,6-Dimethoxypyridazine and 3-methoxypyridazine are converted into the corresponding 4-aminopyridazines I [R = R¹ = MeO; R = H, R¹ = MeO (II)] on treatment with KNH₂/NH₂(l)/KMnO₄ (yield 50 and 22% resp.). In the last-mentioned reaction besides II 3,3′-dimethoxy 4,4′-bipyridazine (23%) was obtained. In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4COA of Formula: C5H6N2O).

3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazine compounds have attracted interest in various fields like medicinal, industrial, and agricultural research as they are used for numerous biological activities and other applications.COA of Formula: C5H6N2O

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Electron impact studies. XVIII. Mass spectra of pyridazines, phthalazines, and related compounds was written by Bowie, John H.;Cooks, R. Graham;Donaghue, P. F.;Halleday, J. A.;Rodda, Harold J.. And the article was included in Australian Journal of Chemistry in 1967.Recommanded Product: 3-Methoxypyridazine This article mentions the following:

The mass spectra of substituted pyridazines, phthalazines, and related compounds are reported and discussed. Mol. ions are a prominent feature of all the spectra, and fragmentation modes may be usefully correlated with both the type of heterocycle and its substitution pattern. Fragmentation patterns were substantiated by extensive high resolution studies and appropriate metastable ions. 31 references. In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4Recommanded Product: 3-Methoxypyridazine).

3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. Pyridazine and phthalazine have quite different spectroscopic properties compared with their isomers, pyrazine and quinoxaline. Pyridazine and derivatives coordinate readily with transition metals to form complexes and catalysts with synthetic utility.Recommanded Product: 3-Methoxypyridazine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

The oxidation of s-triazolo[4,3-b]pyridazines with selenium dioxide was written by Iwao, Masatomo;Kuraishi, Tsukasa. And the article was included in Journal of Heterocyclic Chemistry in 1976.COA of Formula: C5H3ClN4O This article mentions the following:

The s-triazolo[4,3-b]pyridazines I (R = Me, MeO, Cl, H, R1 = H; R = Cl, R1 = AcNH) were oxidized to the s-triazolo[4,3-b]pyridazin-3-ones II with SeO2 in PhNO2 at 160-165° for 1-2 hr in 30-40% yields. In the experiment, the researchers used many compounds, for example, 6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one (cas: 33050-32-7COA of Formula: C5H3ClN4O).

6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one (cas: 33050-32-7) belongs to pyridazine derivatives. The pyridazine structure is a popular pharmacophore which is found within a number of herbicides such as credazine, pyridafol and pyridate. Pyridazine is bioavailable (especially in the CNS) and can reduce toxicity. Pyridazine is a component of several drug molecules, and the pyridazine pharmacophore has contributed to a variety of pharmacologically active compounds.COA of Formula: C5H3ClN4O

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Halogen-exchange fluorination of aromatic halides with HF or HF-base was written by Fukuhara, Tsuyoshi;Yondea, Norihiko. And the article was included in Chemistry Letters in 1993.Product Details of 33097-39-1 This article mentions the following:

Heteroaromatic halides such as 2-chloropyrimidines and 2-chloropyridines, and 2,4-dinitrochlorobenzene underwent halogen-exchange fluorination with the treatment of HF or HF-base solutions to afford the corresponding fluorides in good yields. In the experiment, the researchers used many compounds, for example, 3,6-Difluoropyridazine (cas: 33097-39-1Product Details of 33097-39-1).

3,6-Difluoropyridazine (cas: 33097-39-1) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. Specifically, the pyridazine moiety is an important structural feature of various pharmacologically important compounds with activities like antimicrobial, analgesic, anti-inflammatory, antiplatelet, anticancer, antisecretory, antiulcer, antidepressant, cardiotonic, vasodilator, antiarrhythmic, and hypocholesterolaemic.Product Details of 33097-39-1

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

The tautomerism of N-heteroaromatic hydroxy compounds. I. Infrared spectra was written by Mason, S. F.. And the article was included in Journal of the Chemical Society in 1957.Application of 19064-65-4 This article mentions the following:

The IR spectra of 37 N-heterocyclic hydroxy compounds have been measured in the O-H, N-H, and double-bond stretching-vibration regions by use of a Perkin-Elmer model 12C spectrometer with a LiF or NaCl prism. The compounds were examined at concentrations of 10^-2 to 10^-3M in cells of 5 cm. (CCl₄) or 1 cm. (CHCl₃) thickness in the O-H and N-H regions, and 1 mm. in the double-bond region, and as solids included in pressed KBr disks. The compounds with a OH group α or γ to a ring-N atom absorb in the N-H and C:O stretching vibration regions both in the solid state and in CHCl₃ solution, and so possess principally amide structures under these conditions. The remaining compounds have mainly enolic structures in solution, showing absorption due to a free or an intramolecularly H-bonded O-H group. The IR evidence for the zwitterionic structure of the latter group of compounds in the solid state is discussed. The compounds which tautomerize to an amide with a quasi ο-quinonoid structure show an N-H stretching vibration absorption in the range 3360-3420 cm.^-1, while their quasi p-quinonoid isomers absorb in the range 3415-45 cm.^-1, and their analogs with 5-membered rings in the range 3440-85 cm.^-1 The position of the C:O band of such compounds depends upon the structural type and the number of N atoms in the ring carrying the potentially tautomeric OH group. For nuclei similarly substituted, the C:O band of the quasiο-quinonoid amides lies at a higher frequency than that of the quasi p-quinonoid isomers. The structures of some dihydroxy and polyaza compounds are elucidated by means of these correlations. In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4Application of 19064-65-4).

3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Specifically, the pyridazine moiety is an important structural feature of various pharmacologically important compounds with activities like antimicrobial, analgesic, anti-inflammatory, antiplatelet, anticancer, antisecretory, antiulcer, antidepressant, cardiotonic, vasodilator, antiarrhythmic, and hypocholesterolaemic.Application of 19064-65-4

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Electronic spectra of N-heteroaromatic systems. III. π → π transitions of the monocyclic hydroxyazines was written by Mason, S. F.. And the article was included in Journal of the Chemical Society in 1959.Recommanded Product: 3-Methoxypyridazine This article mentions the following:

The ultraviolet absorption spectra of the enolic, cationic, anionic, and zwitterionic forms of the monocyclic hydroxyazines have been measured in aqueous solution, and the spectra of the enols and zwitterions, fixed as the O- and the N-Me derivatives, resp., have been obtained in nonpolar solvents. The first absorption band in the spectra of the different charged forms of a given compound lies at wave lengths in the sequence, zwitterion > anion > cation > enol, and the spectrum of the zwitterion shifts considerably towards the red region on changing from aqueous to nonpolar solvents. The solvent effect is inconsistent with the valence-bond theory of the spectra, and a mol.-orbital theory is developed to account for the solvent shifts and the spectral differences between the compounds studied and their various charged forms. The electronic absorption spectra of the 4 forms and the oscillator strength of the π → π absorption band of longest wave length in the spectra of the enolic and zwitterionic forms are given for 2-hydroxy-, 2-methoxy-, 3-hydroxy-, 3-methoxy-, 4-hydroxy-, and 4-methoxypyridine, 1-methyl-2- and 1-methyl-4-pyridone, 3-hydroxypyridine 1-methochloride, 2-hydroxy- and 2-methoxypyrazine, 1-methyl-2-pyrazone, 3-hydroxy-, 3-methoxy-, 4-hydroxy-, and 4-methoxypyridazine, 2-hydroxy-, 2-methoxy-, 4-hydroxy-, 4-methoxy-, and 5-hydroxypyrimidine, 1- and 3-methyl-4-pyrimidone, in various solvents, at different pH values. In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4Recommanded Product: 3-Methoxypyridazine).

3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. Pyridazine is bioavailable (especially in the CNS) and can reduce toxicity. Pyridazine is a component of several drug molecules, and the pyridazine pharmacophore has contributed to a variety of pharmacologically active compounds.Recommanded Product: 3-Methoxypyridazine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Vicarious nucleophilic substitution of pyridazinium N-dicyanomethylides was written by Itoh, Takashi;Matsuya, Yuji;Nagata, Kazuhiro;Miyazaki, Michiko;Tsutsumi, Nozomi;Ohsawa, Akio. And the article was included in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry in 1998.Related Products of 19064-65-4 This article mentions the following:

Pyridazines have been allowed to react with tetracyanoethylene oxide to give pyridazinium N-dicyanomethylides, which are subjected to vicarious nucleophilic substitution to afford the corresponding 4-substituted derivatives in moderate to good yields. The dicyanomethylene group is readily eliminated by a radical reaction, and 4-substituted pyridazines are obtained. In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4Related Products of 19064-65-4).

3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. Pyridazines is a six-membered nitrogen-containing significant heterocycle. It has received considerable interest because of its useful applications as natural products, pharmaceuticals, and various bioactive molecules. Pyridazine is bioavailable (especially in the CNS) and can reduce toxicity. Pyridazine is a component of several drug molecules, and the pyridazine pharmacophore has contributed to a variety of pharmacologically active compounds.Related Products of 19064-65-4

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Studies in the field of pyridazine compounds. 20. 6H-1,2,4-Triazino[4,3-b]1,2,4-triazolo[3,4-f]pyridazine, a novel angular ring system was written by Kosary, Judit;Jerkovich, Gyula;Polos, Katalin;Kasztreiner, Endre. And the article was included in Monatshefte fuer Chemie in 1986.Safety of 6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one This article mentions the following:

The novel ring system, the title triazinotriazolopyridazine I (R = H, Ph; R¹ = Me, CH:CHCO₂Et, CH:CMeCO₂Et) was prepared either by ring closure of ethoxycarbonylethylenetriazolopyridazinylhydrazines II (R² = H, Me) in polyphosphoric acid or a hydrazine III under the action of tri-Et orthoformate. Compound I (R = H; R¹ = CH:CMeCO₂Et) showed a pos. inotropic effect. In the experiment, the researchers used many compounds, for example, 6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one (cas: 33050-32-7Safety of 6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one).

6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one (cas: 33050-32-7) belongs to pyridazine derivatives. Pyridazine and phthalazine have quite different spectroscopic properties compared with their isomers, pyrazine and quinoxaline. Pyridazine can act as a hydrogen bond acceptor to improve the physicochemical properties of drug molecules by increasing their water solubility, and has a high affinity for complexing with targets due to its dipole moment.Safety of 6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Ag-catalyzed decarboxylative acylation of pyridazines using α-keto acids in aqueous media was written by Wang, Shengqiang;Xu, Xiaobo;Zou, Dapeng;Xu, Qijie. And the article was included in Tetrahedron Letters in 2021.Safety of 3-Methoxypyridazine This article mentions the following:

An efficient and general protocol for Ag-Catalyzed decarboxylative acylation of pyridazines using α-keto acids as acylation reagent in aqueous media has been described. This method provides a new avenue for the synthesis of diverse array of acylated pyridazines with different substitution patterns. The reaction proceeds smoothly in water under mild conditions and exhibits a good functional group tolerance. In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4Safety of 3-Methoxypyridazine).

3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. The pyridazine structure is a popular pharmacophore which is found within a number of herbicides such as credazine, pyridafol and pyridate. Pyridazine and derivatives coordinate readily with transition metals to form complexes and catalysts with synthetic utility.Safety of 3-Methoxypyridazine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity was written by Steadman, David;Atkinson, Benjamin N.;Zhao, Yuguang;Willis, Nicky J.;Frew, Sarah;Monaghan, Amy;Patel, Chandni;Armstrong, Emma;Costelloe, Kathryn;Magno, Lorenza;Bictash, Magda;Jones, E. Yvonne;Fish, Paul V.;Svensson, Fredrik. And the article was included in Journal of Medicinal Chemistry in 2022.Formula: C5H3ClN4O This article mentions the following:

Notum is a neg. regulator of Wnt signaling acting through the hydrolysis of a palmitoleoylate ester, which is required for Wnt activity. Inhibitors of Notum could be of use in diseases where dysfunctional Notum activity is an underlying cause. A docking-based virtual screen (VS) of a large com. library was used to short-list 952 compounds for exptl. validation as inhibitors of Notum. The VS was successful with 31 compounds having an IC₅₀ < 500 nM. A critical selection process was then applied with two clusters and two singletons selected for hit validation. Optimization of I guided by structural biol. identified potent inhibitors of Notum activity that restored Wnt/β-catenin signaling in cell-based models. The [1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one series represent a new chem. class of Notum inhibitors and the first to be discovered by a VS campaign. These results demonstrate the value of VS with well-designed docking models based on X-ray structures. In the experiment, the researchers used many compounds, for example, 6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one (cas: 33050-32-7Formula: C5H3ClN4O).

6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one (cas: 33050-32-7) belongs to pyridazine derivatives. Pyridazines is a six-membered nitrogen-containing significant heterocycle. It has received considerable interest because of its useful applications as natural products, pharmaceuticals, and various bioactive molecules. Pyridazine compounds have attracted interest in various fields like medicinal, industrial, and agricultural research as they are used for numerous biological activities and other applications.Formula: C5H3ClN4O

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem