Heterocyclic Building Blocks-Pyridazine

Hydrophobicity parameters determined by reversed-phase liquid chromatography. IX. Relationship between capacity factor and water-octanol partition coefficient of monosubstituted pyrimidines was written by Yamagami, Chisako;Yokota, Miho;Takao, Narao. And the article was included in Chemical & Pharmaceutical Bulletin in 1994.Electric Literature of C5H6N2O This article mentions the following:

The capacity factors, k’, of 2- and 5-substituted pyrimidines were determined by reversed-phase high performance liquid chromatog. (RPLC). The log k’ values were correlated with log P by using correction terms for the hydrogen-bond effects of the aza functions of the diazine ring and the substituent. By analogy with the case of the pyrazine series previously studied, a correlation equation with indicator variables categorizing the type and strength of the substituent hydrogen-bonding, and the elec. constant of substituents as addnl. parameters was obtained to describe the correlation between log k’ and log P. Suitable mobile-phase conditions to predict reliable log P values are proposed. In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4Electric Literature of C5H6N2O).

3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. The pyridazine structure is also found within the structure of several drugs such as cefozopran, cadralazine, minaprine, pipofezine, and hydralazine. Pyridazine and derivatives coordinate readily with transition metals to form complexes and catalysts with synthetic utility.Electric Literature of C5H6N2O

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Probing ¹J(C-F) and ⁿJ(F-F) Spin-Spin Coupling Constants for Fluoroazines: An Ab Initio Theoretical Investigation was written by Del Bene, Janet E.;Alkorta, Ibon;Elguero, Jose. And the article was included in Journal of Physical Chemistry A in 2010.HPLC of Formula: 33097-39-1 This article mentions the following:

Ab initio equation-of-motion coupled cluster singles and doubles calculations have been carried out to evaluate one-bond C-F coupling constants ¹J(C-F) and three-, four-, and five-bond F-F coupling constants ⁿJ(F-F) for a series of mono-, di-, and trifluoroazines. The computed ¹J(C-F) and ⁿJ(F-F) values for these are in good agreement with available exptl. coupling constants The values of ¹J(C-F) vary as the number and positions of N atoms and the number and relative positions of C-F bonds change, but it is difficult to discern general patterns for these changes due to opposing effects of the Fermi contact and paramagnetic spin-orbit terms. The majority of ¹J(C-F) values lie in a range that includes the three monosubstituted pyridines. For trifluoroazines, ¹J(C-F) for a C-F bond that is ortho to two other C-F bonds is greater than ¹J(C-F) for the other two bonds. F-F coupling constants arise in these mols. when the two C-F bonds are ortho, meta, or para. Values of ³J(F-F) are relatively large and neg., whereas values of ⁵J(F-F) are relatively large and pos. ⁴J(F-F) may be pos. or neg. and large or small. The value of this coupling constant depends on the nature of the atom that links the two C-F bonds and the number and positions of N atoms in the ring. The calculations carried out in this study at a reliable level of theory give values for one-bond C-F and n-bond F-F spin-spin coupling constants for the fluoroazines that are not available exptl. In addition, the patterns that describe the changes that occur in these mols. provide a basis for predicting their values in larger, related systems in the absence of exptl. data and direct calculations In the experiment, the researchers used many compounds, for example, 3,6-Difluoropyridazine (cas: 33097-39-1HPLC of Formula: 33097-39-1).

3,6-Difluoropyridazine (cas: 33097-39-1) belongs to pyridazine derivatives. Pyridazine and phthalazine have quite different spectroscopic properties compared with their isomers, pyrazine and quinoxaline. Pyridazine and derivatives coordinate readily with transition metals to form complexes and catalysts with synthetic utility.HPLC of Formula: 33097-39-1

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

The structures of diazine N-oxides. II. Dipole moments of some alkoxy derivatives of pyrimidine, pyridazine, and their N-oxides was written by Otomasu, Hirotaka;Takahashi, Hiroshi;Ogata, Michihiko. And the article was included in Chemical & Pharmaceutical Bulletin in 1964.Product Details of 19064-65-4 This article mentions the following:

The dipole moments of some diazines and their N-oxides was measured in C₆H₆ at 25°. [Compound and μ (D.) given]: 4-ethoxy-6-methylpyrimidine (I), 2.20; I N-oxide, 3.95; 3-methoxypyridazine (II), 2.87; II N-oxide (III), 4.80; 3-ethoxypyridazine (IV), (b₁₄ 91-3°), 3.17; IV N-oxide (V), (m. 65-7°), 4.76; 3-ethoxy-6-methylpyridazine (VI), 2.86; VI N-oxide, 5.11. The dipole moments were consistent with the moment of cis configuration. The conclusions of Hayashi, et al. (CA 58, 3425c) concerning the position of the N-oxide with respect to the alkoxyl group were confirmed. In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4Product Details of 19064-65-4).

3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. The pyridazine structure is also found within the structure of several drugs such as cefozopran, cadralazine, minaprine, pipofezine, and hydralazine. Pyridazine is bioavailable (especially in the CNS) and can reduce toxicity. Pyridazine is a component of several drug molecules, and the pyridazine pharmacophore has contributed to a variety of pharmacologically active compounds.Product Details of 19064-65-4

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Selective acid-catalyzed hydrolyses of methoxysulfanilamidodiazines was written by Venturella, Vincent S.. And the article was included in Journal of Pharmaceutical Sciences in 1968.Name: 3-Methoxypyridazine This article mentions the following:

The dilute acid hydrolysis of 3-methoxy-6-sulfanilamidopyridazine and several methoxysulfanilamidopyrimidines was studied. Experiments show that in cases where an intermediate 2-pyrimidone is a possible postulation, further hydrolysis usually leads to the formation of sulfanilamide and the corresponding hydroxypyrimidine. A multistage route for the acidic degradation of 3-methoxy-6-sulfanilamidopyridazine, 2,4-dimethoxy-6-sulfanilamidopyrimidine, and 2-methylthio-4-methoxy-6-sulfanilamidopyrimidine is proposed. 26 references. In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4Name: 3-Methoxypyridazine).

3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. The pyridazine structure is also found within the structure of several drugs such as cefozopran, cadralazine, minaprine, pipofezine, and hydralazine. Pyridazine compounds have attracted interest in various fields like medicinal, industrial, and agricultural research as they are used for numerous biological activities and other applications.Name: 3-Methoxypyridazine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Study of the simultaneous analytical method for residual veterinary drugs by LC/MS/MS was written by Kageyama, Tomoko;Maeda, Tomoyuki;Shirai, Miki;Ogo, Sayaka;Nakashima, Miho;Maeda, Yumie;Takahashi, Kazunori. And the article was included in Shizuoka-ken Kankyo Eisei Kagaku Kenkyusho Hokoku in 2009.Computed Properties of C5H6N2O This article mentions the following:

Due to the higher frequency of use or incidents of violations in the past, a method of collective anal. of residual veterinary drugs which were highly required to analyze in the inspection was investigated. Using LC/MS/MS in which anal. of high sensitivity and high selectivity is possible, the measurement conditions were established for 73 items. As regards the pre-processing method, the acetonitrile-methanol (7:3) is used in the extraction solvent and study regarding the extraction of veterinary drugs with wide range of phys. properties was conducted. As a result, the recovery rate in all studied items was 70-120% and among 73 items 53 items were below RSD 20%. This method is thought to be quick, simple and collective anal. method for the residual veterinary drugs with a wide range of phys. properties. In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4Computed Properties of C5H6N2O).

3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. Pyridazine and phthalazine have quite different spectroscopic properties compared with their isomers, pyrazine and quinoxaline. The activity depends upon the changes of substituted groups in the pyridazine ring system resulting in different biological activities. In addition, the natural pyrimidine bases uracil, thymine, and cytosine, which are constituents of the nucleic acids, are found to be the most important naturally occurring diazines.Computed Properties of C5H6N2O

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Ionization constants of heterocyclic substances. II. Hydroxy-derivatives of nitrogenous six-membered ring-compounds was written by Albert, Adrien;Phillips, J. N.. And the article was included in Journal of the Chemical Society in 1956.Related Products of 19064-65-4 This article mentions the following:

Acidic and basic ionization constants were determined potentiometrically and in some cases spectrometrically for 87 hydroxy (and related) derivatives of pyridine, quinoline, isoquinoline, acridine, phenanthridine, pyridazine, pyrimidine, pyrazine, cinnoline, phthalazine, quinazoline, quinoxaline, phenazine, triazine, 1,4,5-triazanaphthalene, and 1,4,6-triazanaphthalene. The tautomeric equilibrium between enol and amide in α and γ-hydroxy derivatives greatly favor the amide form. The preparation of 2-methoxypyrazine, b₂₉ 60-1°, and 3-hydroxypyridine methochloride were described. A m.p. of 57° was reported for 2-methyl-1-isoquinolone. In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4Related Products of 19064-65-4).

3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. The pyridazine structure is also found within the structure of several drugs such as cefozopran, cadralazine, minaprine, pipofezine, and hydralazine. In the past decade, X-ray data were reported with regard to the characterization and structural elucidation of a number of pyridazine-metal complexes, including pyridazine ligands with zinc, nickel, copper, cadmium and ruthenium.Related Products of 19064-65-4

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Kinetics of reactions in heterocycles. XIV. Reactions of 2- and 4-amino-, -methylamino-, and -dimethylaminopyridine methiodides and 2-methylthiopyrimidine methiodide with hydroxide ions in water was written by Barlin, Gordon B.;Benbow, John A.. And the article was included in Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) in 1975.Name: 3-Methoxypyridazine This article mentions the following:

The kinetics of the title reactions were studied. The reactions were second order and resulted in the formation of quant. yields of N-methylpyridones. At 20°C 2-dimethylaminopyridine methiodide reacted 8.5 × 103 times faster than the 4-NMe2 analog and these compounds were 2.3 × 10-4 and 3.1 × 10-6 resp., times less reactive than the corresponding 2- and 4-chloropyridine methiodides. 2-Methylthiopyridine methiodide with NaOH gave 1-methylpyrimidin-2-one by a step process. In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4Name: 3-Methoxypyridazine).

3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. Pyridazines is a six-membered nitrogen-containing significant heterocycle. It has received considerable interest because of its useful applications as natural products, pharmaceuticals, and various bioactive molecules. The unsubstituted pyridazines are more resistant to eletrophilic substitution due to the nature of withdrawal of electron density from the ring by two heteroatoms, while the related electron deficiency of the ring makes pyridazine more easily attacked by nucleophiles.Name: 3-Methoxypyridazine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Tautomerism of N-heterocycles. II. 3-Hydroxypyridazin-6-one and 3-mercaptopyridazine-6-thione was written by Barlin, Gordon B.. And the article was included in Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) in 1974.Synthetic Route of C5H6N2O This article mentions the following:

The ionization constants and uv of 3,6-dimercaptopyridazine and its N-Me and S-Me derivatives indicated that the parent compound existed as 3-mercaptopyridazine-6-thione in aqueous solution; 3,6-dihydroxypyridazine, its N,N-di-Me derivative, and 3-hydroxypyridazine behaved abnormally on protonation, owing to the existence of 2 overlapping ionization constants In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4Synthetic Route of C5H6N2O).

3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. The unsubstituted pyridazines are more resistant to eletrophilic substitution due to the nature of withdrawal of electron density from the ring by two heteroatoms, while the related electron deficiency of the ring makes pyridazine more easily attacked by nucleophiles.Synthetic Route of C5H6N2O

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Mild and Highly Selective Palladium-Catalyzed Monoarylation of Ammonia Enabled by the Use of Bulky Biarylphosphine Ligands and Palladacycle Precatalysts was written by Cheung, Chi Wai;Surry, David S.;Buchwald, Stephen L.. And the article was included in Organic Letters in 2013.SDS of cas: 13493-79-3 This article mentions the following:

A method for the Pd-catalyzed arylation of ammonia with a wide range of aryl and heteroaryl halides, including challenging five-membered heterocyclic substrates, is described. Excellent selectivity for monoarylation of ammonia to primary arylamines was achieved under mild conditions or at rt by the use of bulky biarylphosphine ligands as well as their corresponding aminobiphenyl palladacycle precatalysts. As this process requires neither the use of a glove box nor high pressures of ammonia, it should be widely applicable. In the experiment, the researchers used many compounds, for example, 6-Chloroimidazo[1,2-b]pyridazine hydrochloride (cas: 13493-79-3SDS of cas: 13493-79-3).

6-Chloroimidazo[1,2-b]pyridazine hydrochloride (cas: 13493-79-3) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. Pyridazine and derivatives coordinate readily with transition metals to form complexes and catalysts with synthetic utility.SDS of cas: 13493-79-3

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Synthesis of pyridazine derivatives. II. The reactivity of chlorine atom in 3- or 6-position of chloropyridazine 1-oxide was written by Sako, Shigeru. And the article was included in Chemical & Pharmaceutical Bulletin in 1963.Recommanded Product: 3-Methoxypyridazine This article mentions the following:

The 6-NH₂ derivative of pyridazine 1-oxide (I) diazotized in HCl, followed by addition of powd. Cu, yielded 61% 6-Cl derivative (II) of I, m. 157-8°. II and its 3-Cl isomer (III) sep. kept 1 hr. at 30° with MeONa in MeOH yielded, resp., 84% 6-MeO derivative (IV) of I, m. 126-7°, and 77% 3-MeO derivative of I, m. 79-80°. Similar treatment of 3-chloropyridazine (V) yielded only 33% 3-methoxypyridazine even after 1 hr. heating (picrate m. 109-11°). Heating II and III 1 hr. in a sealed tube on a steam bath with 70% EtNH₂ in EtOH yielded, resp., 79% 6-EtNH derivative (VI) of I, m. 113-14°, and 70% 3-EtNH derivative (VII) of I, m. 79-80° (picrate m. 131-2°), whereas similar treatment of V gave 97% starting material. However, heating V 3 hrs. at 120-30° with EtNH₂ in a sealed tube yielded 40% 3-ethylaminopyridazine (VIII), m. 93-4° (picrate m. 157-8°), formed also in confirmation of its structure (750% yield) by catalytic reduction (Pd-C) of 3-ethylamino-6-chloropyridazine. II and III yielded, resp., 4% VI and 3.5% VII when heated with EtNH₂ in a sealed tube 5 hrs. at 28°. Oxidation of VIII with H₂O₂ in AcOH yielded 20% VI. Hydrolysis of 301.6 mg. IV by heating 1 hr. on a steam bath with 5% NaOH yielded 83.2 mg. 2-hydroxy-3(2H)-pyridazinone, m. 167-8°, identified by both infrared and ultraviolet absorption spectra. These results showed almost the same reactivity for the Cl atom in the 3- and 6-positions of I, contrary to the case of the 3,6-Cl₂ derivative of I. In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4Recommanded Product: 3-Methoxypyridazine).

3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. Pyridazines is a six-membered nitrogen-containing significant heterocycle. It has received considerable interest because of its useful applications as natural products, pharmaceuticals, and various bioactive molecules. Pyridazine is bioavailable (especially in the CNS) and can reduce toxicity. Pyridazine is a component of several drug molecules, and the pyridazine pharmacophore has contributed to a variety of pharmacologically active compounds.Recommanded Product: 3-Methoxypyridazine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem