Heterocyclic Building Blocks-Pyridazine

Model Studies toward the Total Synthesis of Thebaine by an Intramolecular Cycloaddition Strategy was written by Koukal, Petr;Hajicek, Josef;Gupta, Setu;Hudlicky, Tomas. And the article was included in ChemistrySelect in 2017.Related Products of 19064-65-4 This article mentions the following:

Three model compounds required for an approach to thebaine by intramol. [4+2] cycloaddition were prepared In the first two cases the anticipated cycloaddition products were obtained under thermal conditions. Thermolysis of the third, more advanced model compound, afforded products resulting from rearrangements and/or elimination. A study of analogous intra- and intermol. reactions using benzofuran as dienophile and various electron-poor and electron-rich dienes (pyridazines, pyranones, Danishefsky diene) was undertaken. In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4Related Products of 19064-65-4).

3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. Pyridazine can act as a hydrogen bond acceptor to improve the physicochemical properties of drug molecules by increasing their water solubility, and has a high affinity for complexing with targets due to its dipole moment.Related Products of 19064-65-4

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Synthesis and evaluation of pyrazolo[1,5-b]pyridazines as selective cyclin dependent kinase inhibitors was written by Stevens, Kirk L.;Reno, Michael J.;Alberti, Jennifer B.;Price, Daniel J.;Kane-Carson, Laurie S.;Knick, Victoria B.;Shewchuk, Lisa M.;Hassell, Anne M.;Veal, James M.;Davis, Stephen T.;Griffin, Robert J.;Peel, Michael R.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2008.Recommanded Product: 19064-65-4 This article mentions the following:

A novel series of pyrazolo[1,5-b]pyridazines have been synthesized and identified as cyclin dependent kinase inhibitors potentially useful for the treatment of solid tumors. Modification of the hinge-binding amine or the C(2)- and C(6)-substitutions on the pyrazolopyridazine core provided potent inhibitors of CDK4 and demonstrated enzyme selectivity against VEGFR-2 and GSK3β. In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4Recommanded Product: 19064-65-4).

3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. Pyridazine and derivatives coordinate readily with transition metals to form complexes and catalysts with synthetic utility.Recommanded Product: 19064-65-4

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Selective fluorination by halogen exchange of chlorodiazines and chloropyridines promoted by the ‘proton sponge’-triethylamine tris(hydrogen fluoride) system was written by Darabantu, M.;Lequeux, T.;Pommelet, J.-C.;Ple, N.;Turck, A.. And the article was included in Tetrahedron in 2001.Name: 3,6-Difluoropyridazine This article mentions the following:

The ‘proton sponge’-triethylamine tris(hydrogen fluoride) mixtures provide a mild and efficient fluorinating reagent to introduce selectively fluorine atoms by halogen exchange into chlorodiazines and chloronitropyridine series. The PS/Et₃N.3HF mixtures provide an efficient reagent to realize a selective fluorination of various π-deficient chlorinated heterocycles: (benzo)diazines and pyridines. In the experiment, the researchers used many compounds, for example, 3,6-Difluoropyridazine (cas: 33097-39-1Name: 3,6-Difluoropyridazine).

3,6-Difluoropyridazine (cas: 33097-39-1) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. Pyridazine and derivatives coordinate readily with transition metals to form complexes and catalysts with synthetic utility.Name: 3,6-Difluoropyridazine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Pyridazines. XXIII. Synthesis of N-substituted 1,4-dihydropyridazines was written by Kaneko, Chisato;Tsuchiya, Takashi;Igeta, Hiroshi. And the article was included in Chemical & Pharmaceutical Bulletin in 1974.Recommanded Product: 3-Methoxypyridazine This article mentions the following:

1-Methylpyridazinium salts, derived from pyridazines I to VI, were reduced with NaBH4 to give the corresponding 1-methyl-1,6-dihydropyridazines VII in 40-60% yields. Pyridazines I to VI were reduced with NaBH4 in the presence of MeO2CCl to afford 1-methoxycarbonyl-1,6-dihydropyridazines VIII and their 1,4-isomers IX, in total 35-65% yields, ratio of which depended on the kinds of the substituents. Thus, I gave little of the corresponding IX, while V gave little VIII. In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4Recommanded Product: 3-Methoxypyridazine).

3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. The activity depends upon the changes of substituted groups in the pyridazine ring system resulting in different biological activities. In addition, the natural pyrimidine bases uracil, thymine, and cytosine, which are constituents of the nucleic acids, are found to be the most important naturally occurring diazines.Recommanded Product: 3-Methoxypyridazine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

3-Benzyloxy-6-fluoropyridazine was written by Hu, Fang Zhong;Zhang, Min;Song, Hai Bin;Zou, Xiao Mao;Yang, Hua Zheng. And the article was included in Acta Crystallographica, Section E: Structure Reports Online in 2005.Name: 3,6-Difluoropyridazine This article mentions the following:

The title mol., C₁₁H₉FN₂O, was synthesized from 3,6-difluoropyridazine, benzyl alc. and NaOH in MeCN under reflux. Crystallog. data are given. The asym. unit contains two independent mols. with nearly identical geometry. In the crystal structure, the mols. are linked by weak intermol. C-H···F H bonds and C-H···π interactions. In the experiment, the researchers used many compounds, for example, 3,6-Difluoropyridazine (cas: 33097-39-1Name: 3,6-Difluoropyridazine).

3,6-Difluoropyridazine (cas: 33097-39-1) belongs to pyridazine derivatives. The pyridazine structure is also found within the structure of several drugs such as cefozopran, cadralazine, minaprine, pipofezine, and hydralazine. Pyridazine is bioavailable (especially in the CNS) and can reduce toxicity. Pyridazine is a component of several drug molecules, and the pyridazine pharmacophore has contributed to a variety of pharmacologically active compounds.Name: 3,6-Difluoropyridazine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Reaction of methoxy-N-heteroaromatics with phenylacetonitrile under basic conditions was written by Yamanaka, Hiroshi;Ohba, Setsuya. And the article was included in Heterocycles in 1990.COA of Formula: C5H6N2O This article mentions the following:

The monomethoxy derivatives (I) of various π-electron deficient N-heteroaromatics reacted with PhCH₂CN in THF in the presence of NaH to give α-phenyl-N-heteroareneacetonitriles in 45-78% yields. Other active methylene compounds, e.g., NCCH₂CO₂Et or NCCH₂CN were less reactive towards (I) under similar conditions. The synthesis of benzoyl-N-heteroaromatics by the air oxidation of α-phenyl-N-heteroareneacetonitriles is also described. In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4COA of Formula: C5H6N2O).

3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. The activity depends upon the changes of substituted groups in the pyridazine ring system resulting in different biological activities. In addition, the natural pyrimidine bases uracil, thymine, and cytosine, which are constituents of the nucleic acids, are found to be the most important naturally occurring diazines.COA of Formula: C5H6N2O

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Incorporation of Hydrogen-Bonding Functionalities into the Second Coordination Sphere of Iron-Based Water-Oxidation Catalysts was written by Hoffert, Wesley A.;Mock, Michael T.;Appel, Aaron M.;Yang, Jenny Y.. And the article was included in European Journal of Inorganic Chemistry in 2013.Recommanded Product: 27349-66-2 This article mentions the following:

Energy storage and conversion schemes based on environmentally benign chem. fuels will require the discovery of faster, cheaper, and more robust catalysts for the oxygen-evolution reaction (OER). Although the incorporation of pendant bases into mol. catalysts for hydrogen production and use led to enhanced turnover frequencies, the analogous incorporation of pendant bases into mol. catalysts for water oxidation has received little attention. Herein, the syntheses, structures, and catalytic activities of new iron complexes with pendant bases are reported. Of these new complexes, [Fe(L¹)]²⁺ {L¹ = N,N’-dimethyl-N,N’-bis(pyridazin-3-ylmethyl)ethane-1,2-diamine} is the most active catalyst. Initial turnover frequencies of 141 and 24 h^-1 were measured by using ceric ammonium nitrate at pH 0.7 and sodium periodate at pH 4.7, resp. These results suggest that the incorporation of pendant bases into mol. catalysts for water oxidation might be an effective strategy that can be considered in the development of new catalysts for the OER, but will require the careful balance of many factors. In the experiment, the researchers used many compounds, for example, 3-(Chloromethyl)pyridazine hydrochloride (cas: 27349-66-2Recommanded Product: 27349-66-2).

3-(Chloromethyl)pyridazine hydrochloride (cas: 27349-66-2) belongs to pyridazine derivatives. The pyridazine structure is a popular pharmacophore which is found within a number of herbicides such as credazine, pyridafol and pyridate. Pyridazine is bioavailable (especially in the CNS) and can reduce toxicity. Pyridazine is a component of several drug molecules, and the pyridazine pharmacophore has contributed to a variety of pharmacologically active compounds.Recommanded Product: 27349-66-2

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Selectivity and Physicochemical Optimization of Repurposed Pyrazolo[1,5-b]pyridazines for the Treatment of Human African Trypanosomiasis was written by Tear, Westley F.;Bag, Seema;Diaz-Gonzalez, Rosario;Ceballos-Perez, Gloria;Rojas-Barros, Domingo I.;Cordon-Obras, Carlos;Perez-Moreno, Guiomar;Garcia-Hernandez, Raquel;Martinez-Martinez, Maria Santos;Ruiz-Perez, Luis Miguel;Gamarro, Francisco;Gonzalez Pacanowska, Dolores;Caffrey, Conor R.;Ferrins, Lori;Manzano, Pilar;Navarro, Miguel;Pollastri, Michael P.. And the article was included in Journal of Medicinal Chemistry in 2020.Related Products of 19064-65-4 This article mentions the following:

From a high-throughput screen of 42 444 known human kinases inhibitors, a pyrazolo[1,5-b]pyridazine scaffold was identified to begin optimization for the treatment of human African trypanosomiasis. Previously reported data for analogous compounds against human kinases GSK-3β, CDK-2, and CDK-4 were leveraged to try to improve the selectivity of the series, resulting in 23a which showed selectivity for T. b. brucei over these three human enzymes. In parallel, properties known to influence the absorption, distribution, metabolism, and excretion (ADME) profile of the series were optimized resulting in 20g being progressed into an efficacy study in mice. Though 20g showed toxicity in mice, it also demonstrated CNS penetration in a PK study and significant reduction of parasitemia in four out of the six mice. In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4Related Products of 19064-65-4).

3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. Pyridazines is a six-membered nitrogen-containing significant heterocycle. It has received considerable interest because of its useful applications as natural products, pharmaceuticals, and various bioactive molecules. Pyridazine can act as a hydrogen bond acceptor to improve the physicochemical properties of drug molecules by increasing their water solubility, and has a high affinity for complexing with targets due to its dipole moment.Related Products of 19064-65-4

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

NMR studies on σ-adducts of heterocyclic systems with nucleophiles. (Part VIII). Carbon-13-NMR data of pyridazines and some of their covalent amination products. (Part IV) was written by Klinge, D. E.;Van der Plas, H. C.;Van Veldhuizen, A.. And the article was included in Recueil des Travaux Chimiques des Pays-Bas in 1976.Product Details of 19064-65-4 This article mentions the following:

13C NMR data of several 3-mono- and 3,6-disubstituted pyridazines, 3-, 4-, and 6-mono- and 3,6-disubstituted pyridazine 1-oxides, and 4-nitro-3,6-disubstituted pyridazine 1-oxides are reported. 13C substituent effects of some substituents in the 3-, 4-, and 6-position of the pyridazine ring and that of the N-oxide function are calculated The 13C NMR spectra of the σ-adducts of 4-nitro-3,6-disubstituted pyridazine 1-oxides with liquid NH3 are described. In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4Product Details of 19064-65-4).

3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. In the past decade, X-ray data were reported with regard to the characterization and structural elucidation of a number of pyridazine-metal complexes, including pyridazine ligands with zinc, nickel, copper, cadmium and ruthenium.Product Details of 19064-65-4

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Pyridazines. LXXV. Quaternary and mesoionic s-triazolo[4,3-b]pyridazines was written by Langof, I.;Stanovnik, B.;Tisler, M.. And the article was included in Croatica Chemica Acta in 1975.Application In Synthesis of 6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one This article mentions the following:

The triazolopyridazine I (R1 = MeO) was prepared from I (R1 = Cl) and MeONa. II (R = Ph, R1 = Cl, OH, OMe, R2 = H, X = ClO4; R = H, R1 = OMe, R2 = H, X = iodo; R = Ph, Cl, R1 = R2 = H,; X = ClO4; R = R1 = R2 = Cl, X = ClO4) and III were prepared by quaternization of the triazolopyridazines. II (R = Ph, R1 = Cl, R2 = H, X = iodo) and KOH gave IV. In the experiment, the researchers used many compounds, for example, 6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one (cas: 33050-32-7Application In Synthesis of 6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one).

6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one (cas: 33050-32-7) belongs to pyridazine derivatives. Pyridazines is a six-membered nitrogen-containing significant heterocycle. It has received considerable interest because of its useful applications as natural products, pharmaceuticals, and various bioactive molecules. Specifically, the pyridazine moiety is an important structural feature of various pharmacologically important compounds with activities like antimicrobial, analgesic, anti-inflammatory, antiplatelet, anticancer, antisecretory, antiulcer, antidepressant, cardiotonic, vasodilator, antiarrhythmic, and hypocholesterolaemic.Application In Synthesis of 6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem