Heterocyclic Building Blocks-Pyridazine

Proton spin-lattice relaxation on acetic acid was written by Hrynkiewicz, A. Z.;Krynicki, K.;Waluga, I.. And the article was included in Archives des Sciences in 1961.Recommanded Product: 3-Methoxypyridazine This article mentions the following:

By measuring the nuclear resonance absorption at a resonance frequency of 28 Mc., a non-exponential increase of magnetization of protons in liquid AcOH is observed with time of storage at temperatures of 20, 30, 50, and 80°. An explanation for these results is possible on the assumption of different spin-lattice relaxation times for the protons in the CH₃ and in the COOH groups. In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4Recommanded Product: 3-Methoxypyridazine).

3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. Pyridazines are rare in nature, possibly reflecting the scarcity of naturally occurring hydrazines, common building blocks for the synthesis of these heterocycles. The unsubstituted pyridazines are more resistant to eletrophilic substitution due to the nature of withdrawal of electron density from the ring by two heteroatoms, while the related electron deficiency of the ring makes pyridazine more easily attacked by nucleophiles.Recommanded Product: 3-Methoxypyridazine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

3,6-Bis(4-methoxybenzyloxy)pyridazine was written by Hu, Fang Zhong;Zhang, Min;Song, Hai Bin;Zou, Xiao Mao;Yang, Hua Zheng. And the article was included in Acta Crystallographica, Section E: Structure Reports Online in 2005.COA of Formula: C4H2F2N2 This article mentions the following:

In the crystal structure of the title compound, C₂₀H₂₀N₂O₄, the mols. are linked by a weak intermol. C-H···N H bond. The mol. has crystallog. 2-fold rotation symmetry. Crystallog. data are given. In the experiment, the researchers used many compounds, for example, 3,6-Difluoropyridazine (cas: 33097-39-1COA of Formula: C4H2F2N2).

3,6-Difluoropyridazine (cas: 33097-39-1) belongs to pyridazine derivatives. The pyridazine structure is a popular pharmacophore which is found within a number of herbicides such as credazine, pyridafol and pyridate. The activity depends upon the changes of substituted groups in the pyridazine ring system resulting in different biological activities. In addition, the natural pyrimidine bases uracil, thymine, and cytosine, which are constituents of the nucleic acids, are found to be the most important naturally occurring diazines.COA of Formula: C4H2F2N2

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Scaffold-hopping strategy: synthesis and biological evaluation of 5,6-fused bicyclic heteroaromatics to identify orally bioavailable anticancer agents was written by Tung, Yen-Shih;Coumar, Mohane Selvaraj;Wu, Yu-Shan;Shiao, Hui-Yi;Chang, Jang-Yang;Liou, Jing-Ping;Shukla, Paritosh;Chang, Chun-Wei;Chang, Chi-Yen;Kuo, Ching-Chuan;Yeh, Teng-Kuang;Lin, Chin-Yu;Wu, Jian-Sung;Wu, Su-Ying;Liao, Chun-Chen;Hsieh, Hsing-Pang. And the article was included in Journal of Medicinal Chemistry in 2011.Application of 19064-65-4 This article mentions the following:

Utilizing scaffold-hopping drug-design strategy, we sought to identify a backup drug candidate for BPR0L075 I, an indole-based anticancer agent. For this purpose, 5,6-fused bicyclic heteroaromatic scaffolds were designed and synthesized through shuffling of the nitrogen from the N-1 position or by insertion of one or two nitrogen atoms into the indole core of I. Among these, 7-azaindole core II showed potent in vitro anticancer activity and improved oral bioavailability (F = 35%) compared with I (F < 10%). In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4Application of 19064-65-4).

3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazine and derivatives coordinate readily with transition metals to form complexes and catalysts with synthetic utility.Application of 19064-65-4

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Synthesis of new s-triazolo[4,3-b]pyridazines was written by Francavilla, P.;Lauria, F.. And the article was included in Journal of Heterocyclic Chemistry in 1971.Synthetic Route of C5H3ClN4O This article mentions the following:

A new synthesis of s-triazolo[4,3-b]pyridazine (I) derivatives was achieved starting from 3,6-dichloropyridazine. The method opens the way to substitutions in the 2- or 3-positions. A tricyclo derivative, 3-chloro-6-methyl-(bis-s-triazolo[4,3-b;3′,4′-f]pyridazine) (II), was also synthesized. In the experiment, the researchers used many compounds, for example, 6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one (cas: 33050-32-7Synthetic Route of C5H3ClN4O).

6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one (cas: 33050-32-7) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. The activity depends upon the changes of substituted groups in the pyridazine ring system resulting in different biological activities. In addition, the natural pyrimidine bases uracil, thymine, and cytosine, which are constituents of the nucleic acids, are found to be the most important naturally occurring diazines.Synthetic Route of C5H3ClN4O

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Preparation of 3,6-difluoro- and 3-chlorofluoropyridazines and their nucleophilic reactions was written by Ishikawa, Nobuo;Kuroda, Katsuhiko;Onodera, Nobuo. And the article was included in Kogyo Kagaku Zasshi in 1971.Related Products of 33097-39-1 This article mentions the following:

3,6-Dichloropyridazine was treated with KF in DMF to give 3-fluoro-6-chloropyridazine (I) which was further treated with KF in Me2SO to give 3,6-difluoropyridazine (II). Treatment of II with 1 mole of various phenols (PhOH, o-, m-, p-ClC6H4OH, o-, m-, p-MeC6H4OH, etc.) in MeCN gave the corresponding 3-aryloxy-6-fluoropyridazines in 64-89% yields. 3,6-Diphenoxy- and 3-(dimethylamino)-6-fluoropyridazines were also prepared, and treatment of I with PhOK in MeCN gave 3-chloro-6-phenoxypyridazine. The 3-aryloxy-6-fluoropyridazines showed herbicidal activities (barnyard grass). In the experiment, the researchers used many compounds, for example, 3,6-Difluoropyridazine (cas: 33097-39-1Related Products of 33097-39-1).

3,6-Difluoropyridazine (cas: 33097-39-1) belongs to pyridazine derivatives. Pyridazines are rare in nature, possibly reflecting the scarcity of naturally occurring hydrazines, common building blocks for the synthesis of these heterocycles. Pyridazine can act as a hydrogen bond acceptor to improve the physicochemical properties of drug molecules by increasing their water solubility, and has a high affinity for complexing with targets due to its dipole moment.Related Products of 33097-39-1

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Studies on pyridazines. XXVI. The reaction of substituted N-acetyliminopyridazinium ylides with benzyne was written by Hasegawa, Hiroshi;Arai, Heihachiro;Igeta, Hiroshi. And the article was included in Chemical & Pharmaceutical Bulletin in 1977.Electric Literature of C5H6N2O This article mentions the following:

Reaction of N-acetyliminopyridazinium ylides I (R = Me, MeO, EtO, Ph, piperidino; R1 = R2 = H; R = MeO, R1 = Me, R2 = H; R = MeO, R1 = H, R2 = Me) with benzyne gave 1,3-dipolar cycloadducts II. Photolysis of II (R = MeO, EtO; R1 = R2 = H) gave α-alkoxynaphthalene and 3-(2-acetamidophenyl)pyridazines. Photolysis of II (R = Me, R1 = R2 = H) gave the indazolo[2,3-b]pyridazine (III). Reaction of II (R = MeO, Ph; R1 = R2 = H) with base gave 3-vinylindazole and the dihydroindazolopyridazine IV (R3 = MeO, Ph). Reaction of 3-pyridazinol 1-oxide with benzyne gave a 1,3-cycloadduct, which underwent N-O bond fission to give the pyridazinone V. In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4Electric Literature of C5H6N2O).

3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. Pyridazine and derivatives coordinate readily with transition metals to form complexes and catalysts with synthetic utility.Electric Literature of C5H6N2O

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

The tautomerism of N-heteroaromatic hydroxy compounds. II. Ultraviolet spectra was written by Mason, S. F.. And the article was included in Journal of the Chemical Society in 1957.Synthetic Route of C5H6N2O This article mentions the following:

The UV spectra of 68 N-heteroaromatic hydroxy compounds and their O- and N-Me derivatives with fixed structures have been measured. These were measured with a Hilger Uvispek H700/305 quartz spectrophotometer in buffered aqueous solutions The buffer solutions were 0.01M acetate for pH 3.8-5.7; 0.01M phosphate for pH 6.0-7.9, and 10.3-11.3; and 0.01M borate for pH 8.2-10.0. The variations of the spectra with temperature were measured by means of a water-jacketed cell-holder maintained at a constant temperature (±0.05°) with H₂O circulated from a thermostat. By comparing spectra, it was found that tautomerism from O-H to N-H forms in general among the monoaza and some diaza heterocyclic hydroxy compounds Equilibrium constants (K_t = [N-H form]/[O-H form] have been estimated from the spectra, and they have been found to increase with conjugation between the O and N atom, and with the addition of fused benzene rings, and to decrease with aza substitution, with a rise in temperature, and with a fall in the dielec. constant of the solvent. In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4Synthetic Route of C5H6N2O).

3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. Pyridazine and phthalazine have quite different spectroscopic properties compared with their isomers, pyrazine and quinoxaline. Specifically, the pyridazine moiety is an important structural feature of various pharmacologically important compounds with activities like antimicrobial, analgesic, anti-inflammatory, antiplatelet, anticancer, antisecretory, antiulcer, antidepressant, cardiotonic, vasodilator, antiarrhythmic, and hypocholesterolaemic.Synthetic Route of C5H6N2O

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

The proton sponge-triethylamine tris(hydrogen fluoride) system as a selective nucleophilic fluorinating reagent for chlorodiazines was written by Darabantu, M.;Lequeux, T.;Pommelet, J.-C.;Ple, N.;Turck, A.;Toupet, L.. And the article was included in Tetrahedron Letters in 2000.Reference of 33097-39-1 This article mentions the following:

The proton sponge-triethylamine tris(hydrogen fluoride) mixture provides a mild and efficient fluorinating reagent for the selective introduction of a fluorine atom, by halogen exchange, into dichlorodiazines. In the experiment, the researchers used many compounds, for example, 3,6-Difluoropyridazine (cas: 33097-39-1Reference of 33097-39-1).

3,6-Difluoropyridazine (cas: 33097-39-1) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. In the past decade, X-ray data were reported with regard to the characterization and structural elucidation of a number of pyridazine-metal complexes, including pyridazine ligands with zinc, nickel, copper, cadmium and ruthenium.Reference of 33097-39-1

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

The tautomeric properties of 6-(2-pyrrolyl)pyridazin-3-one and 6-(2-pyrrolyl)pyridazin-3-thione was written by Jones, R. Alan;Whitmore, Alexander. And the article was included in ARKIVOC (Gainesville, FL, United States) in 2007.Recommanded Product: 19064-65-4 This article mentions the following:

The pyrrolyl substituent enhances the electron densities on the pyridazine ring and has the effect of shifting the positions of the tautomeric equilibrium for 1c,d ⇌ 2c,d, which exist predominantly as the pyridazin-3-one and -3-thione forms, towards the hydroxyl (thiol) structures, compared with those of those for the parent unsubstituted systems. In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4Recommanded Product: 19064-65-4).

3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. The unsubstituted pyridazines are more resistant to eletrophilic substitution due to the nature of withdrawal of electron density from the ring by two heteroatoms, while the related electron deficiency of the ring makes pyridazine more easily attacked by nucleophiles.Recommanded Product: 19064-65-4

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Synthesis and herbicidal activity of 3-aryloxy-6-substituted pyridazines was written by Yang, Hua-Zheng;Wang, Xiang;Hu, Fang-Zhong;Yang, Xiu-Feng. And the article was included in Gaodeng Xuexiao Huaxue Xuebao in 2002.Safety of 3,6-Difluoropyridazine This article mentions the following:

A series of 3-aryloxy-6-substituted pyridazines have been synthesized and their herbicidal activity have been studied. All of above pyridazines have been confirmed by ¹H NMR and elemental analyses, and some of them have been characterized by IR and MS. The bioassay result indicated that some of the title compounds have a high herbicidal activity. In addition, the structure-activity relationship was discussed. In the experiment, the researchers used many compounds, for example, 3,6-Difluoropyridazine (cas: 33097-39-1Safety of 3,6-Difluoropyridazine).

3,6-Difluoropyridazine (cas: 33097-39-1) belongs to pyridazine derivatives. The pyridazine structure is also found within the structure of several drugs such as cefozopran, cadralazine, minaprine, pipofezine, and hydralazine. Pyridazine is bioavailable (especially in the CNS) and can reduce toxicity. Pyridazine is a component of several drug molecules, and the pyridazine pharmacophore has contributed to a variety of pharmacologically active compounds.Safety of 3,6-Difluoropyridazine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem