Category: pyridazines

Chemistry, like all the natural sciences, Application In Synthesis of 3-Amino-6-chloropyridazine, begins with the direct observation of nature¡ª in this case, of matter.5469-69-2, Name is 3-Amino-6-chloropyridazine, SMILES is C1=C(N=NC(=C1)Cl)N, belongs to pyridazines compound. In a document, author is Kandasamy, Palanivel, introduce the new discover.

Amino acid transporters revisited: New views in health and disease

Amino acid transporters (AATs) are membrane-bound transport proteins that mediate transfer of amino acids into and out of cells or cellular organelles. AATs have diverse functional roles ranging from neurotransmission to acid-base balance, intracellular energy metabolism, and anabolic and catabolic reactions. In cancer cells and diabetes, dysregulation of AATs leads to metabolic reprogramming, which changes intracellular amino acid levels, contributing to the pathogenesis of cancer, obesity and diabetes. Indeed, the neutral amino acid transporters (NATs) SLC7A5/LAT1 and SLC1A5/ASCT2 are likely involved in several human malignancies. However, a clinical therapy that directly targets AATs has not yet been developed. The purpose of this review is to highlight the structural and functional diversity of AATs, their diverse physiological roles in different tissues and organs, their wide-ranging implications in human diseases and the emerging strategies and tools that will be necessary to target AATs therapeutically.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 5469-69-2. Application In Synthesis of 3-Amino-6-chloropyridazine.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Reference of 73963-42-5, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 73963-42-5, Name is 5-(4-Chlorobutyl)-1-cyclohexyl-1H-tetrazole, SMILES is ClCCCCC1=NN=NN1C2CCCCC2, belongs to pyridazines compound. In a article, author is Lv, Lina, introduce new discover of the category.

A structural and thermodynamic study of the complexes of U(vi) with azinecarboxylates

Complexation of U(vi) with pyridazine-3-carboxylate (PDZ) and pyrazine-2-carboxylate (PAZ) was studied by spectrophotometry, potentiometry and microcalorimetry in 1.0 mol dm(-3) NaClO4. Three complexes, [UO2L](+), UO2L2(aq) and [UO2L3](-), were identified and their stability constants (log) and the corresponding formation enthalpies were determined. The thermodynamic parameters indicate that the formation of the three complexes is endothermic and driven exclusively by entropy. H-1 and C-13-NMR data provide insight into the coordination modes of the complexes which corroborate with the thermodynamic data. Ligands chelate to U(vi) via (2)(N,O) coordination mode in complexes [UO2L](+) and UO2L2(aq). The crystal structures of four U(vi) complexes, [(UO2)(PAZ)(2)(H2O)]H2O(i), [(UO2)(PDZ)(2)(H2O)](ii), [(UO2)(PDZ)(3)Na2ClO4]2H(2)O(iii), and [(UO2)(2)(PDZ)(4)(H2O)(2)]2H(2)O(iv), were determined by single-crystal X-ray diffraction and compared with the U(vi) complex with picolinate (PA) (CH6N3)[UO2(PA)(3)] in the literature. The structure data suggest that the carboxylates coordinate with uranium in O?C-O-U mode. The strengths of the U-O-C-C-N chelate cycles in the U(vi)/L complexes decrease with the trend of PA > PDZ > PAZ, which is in great agreement with the trend of thermodynamic parameters in aqueous solutions. It is interesting that in compound II two PDZ molecules coordinate with U(vi) in cis-planar positions via (2)(N,O) mode, but in other metal complexes of the three ligands having the same (2)(N,O) coordination mode the two ligand molecules are all in trans-arrangement. In the dimeric complex IV, one ligand coordinate with U(vi) in (2)(N,O) mode, while the other does it in (2)-L-(2)(O:O) mode respectively.

Reference of 73963-42-5, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 73963-42-5.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Chemistry, like all the natural sciences, Category: pyridazines, begins with the direct observation of nature¡ª in this case, of matter.102-08-9, Name is N,N’-Diphenylthiourea, SMILES is S=C(NC1=CC=CC=C1)NC2=CC=CC=C2, belongs to pyridazines compound. In a document, author is Javed, Athar, introduce the new discover.

Synthesis, antimicrobial activity, and docking study of some N-3, N-6-diphenylpyridazine-3,6-diamine derivatives as dihydrofolate reductase inhibitors

Objective: The present study focussed on the synthesis of pyridazine analogs to explore broad-spectrum antimicrobial study. Since pyridazine analogs are not conventionally found in nature, and hence, its analogs are studied later. Materials and Methods: All the synthesized compounds were characterized by spectroscopic techniques, namely, UV, IR,(HNMR)-H-1, and mass spectrometry. Antimicrobial activity was screened by serial dilution method and absorbance was recorded using ELISA reader, subsequently minimum inhibitory concentrations were determined. Docking study was done into the active site of dihydrofolate reductase using Auto Dock 4.2. Results: The present investigation about synthesis, characterization, and biological studies of some new pyridazine analogs were carried out to obtain potent and pharmacologically active compounds. The free energy of binding was in the range of 5.12 to 8.97 kcal/mole. In silico study report was in good tune with laboratory experiments. Conclusions: Most of the compounds were moderate-to-good toward the antimicrobial activity. Compound AJ27 was found to be most active. Results of anti-microbial activity establishes the importance of N-3, N-6-diphenylpyridazine-3,6-diamine as the basic skeleton required for the antimicrobial activity.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 102-08-9. Category: pyridazines.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 455-24-3, Name is 4-(Trifluoromethyl)benzoic acid, SMILES is C1=C(C=CC(=C1)C(O)=O)C(F)(F)F, in an article , author is Axundova, F. N., once mentioned of 455-24-3, Application In Synthesis of 4-(Trifluoromethyl)benzoic acid.

Synthesis of New Iminosugar Derivatives Based on (S)-(1,2,3,6-Tetrahydropyridazin-3-yl)methanol

(S)-(1,2,3,6-Tetrahydropyridazin-3-yl)methanol was synthesized in two steps by the Diels-Alder reaction of penta-2,4-dien-1-ol with diethyl azodicarboxylate in the presence of (S)-BINOL as chiral catalyst. The subsequent Boc-protection of the 2-position of the pyridazine ring, ring-closing carbonylation of the hydroxy group, and deprotection afforded a bicyclic iminosugar analog. The structure of the isolated compounds was proved by NMR, IR, and mass spectra and elemental analyses.

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Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 50681-25-9, Name is 4-Pyridazinecarboxylic Acid, SMILES is N1=NC=C(C=C1)C(=O)O, belongs to pyridazines compound. In a document, author is El Kali, Fouad, introduce the new discover, Name: 4-Pyridazinecarboxylic Acid.

Crystal structure and Hirshfeld surface analysis of 4-(2,6-dichlorobenzyl)-6-phenylpyridazin-3(2H)-one

The asymmetric unit of the title compound, C17H12Cl2N2O, contains one independent molecule. The molecule is not planar, the phenyl and pyridazine rings are twisted with respect to each other, making a dihedral angle of 29.96 (2)degrees and the dichlorophenyl ring is nearly perpendicular to the pyridazine ring, with a dihedral angle of 82.38 (11)degrees. In the crystal, pairs of N-H center dot center dot center dot O hydrogen bonds link the molecules to form inversion dimers with an R-2(2)(8) ring motif. The dimers are linked by C-H center dot center dot center dot O interactions, forming layers parallel to the bc plane. The intermolecular interactions were investigated using Hirshfeld surface analysis and two-dimensional fingerprint plots, and the molecular electrostatic potential surface was also analysed. The Hirshfeld surface analysis of the title compound suggests that the most significant contributions to the crystal packing are by H center dot center dot center dot H (31.4%), Cl center dot center dot center dot H/H center dot center dot center dot Cl (19.9%) and C center dot center dot center dot H/H center dot center dot center dot C (19%) contacts.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 50681-25-9 is helpful to your research. Name: 4-Pyridazinecarboxylic Acid.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 39825-33-7, Name is H-Ala-OiPr, formurla is C6H13NO2. In a document, author is Salghi, R., introducing its new discovery. Safety of H-Ala-OiPr.

6-phenylpyridazin-3(2H) one as New Corrosion Inhibitor for C38 Steel in 1 M HCl

The corrosion behavior of C38 steel in HCl solutions and its inhibition by 6-phenylpyridazin-3(2H) one (PPO) has been studied in different temperature using polarization and electrochemical impedance spectroscopy (EIS) techniques as well as weight loss measurements. The 6-phenylpyridazin-3(2H) one has shown good inhibitive properties and acts as mixed inhibitor as observed in polarization method. The EIS results confirmed the efficiency of tested inhibitor and showed that the charge transfer resistance increase with the rise in the concentration following the same trend of the inhibition efficiency. The effect of the temperature, Langmuir adsorption isotherm and their parameters are discussed to examine the mechanism of the interactions between metal surface and tested compound. A chemisorption mechanism is proposed.

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Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

In an article, author is Dong, Jun-Liang, once mentioned the application of 4949-44-4, Name is Ethyl 3-oxopentanoate, molecular formula is C7H12O3, molecular weight is 144.17, MDL number is MFCD00009317, category is pyridazines. Now introduce a scientific discovery about this category, Quality Control of Ethyl 3-oxopentanoate.

Cobalt MOTs base on benzimidazoi and varied carboxylate ligands with higher capacitance for supercapacitors and magnetic properties

Five new three-dimensional (3D) cobalt-based metal-organic frameworks (MOFs), [Co(L)(0.5)(1,4-BDC)](n), (1), [Co-3(L)(1,2,4-TBC)(2)(H2O)(4)](n) (2), [Co-1.5(L)(1,2,4,5-FIBTC)(H2O)(2)](n) (3), [Co(L)(5-AIPC)(n) (4), and [Co(L)(1,4NDC)](n) (5), (L = 3,6-bis(benzimidazol-1-yl)Pyridazine; 1,4-H2BDC = terephthalic acid; 1,2,4-H3BTC = benzene-1,2,4-tricarboxylic acid; 1,2,4,5-H4BTC = benzene-1,2,4,5-tetracarboxylic acid; 5-H(2)AIPC = aminoisophthalic acid; 1,4-H2NDC = naphthalene-1,4-dicarboxylic acid) have been synthesized, and then characterized by IR spectroscopy, thermogravimetric analysis, elemental analysis, powder X-ray diffraction, and single-crystal X-ray diffraction. The structure analysis displays that complexes 1-5 have a 3D network, which 1 displays a 2-fold interpenetrating 3D framework structure with the point symbol of (4(12).6(3)), 2 have a 8-connected 3D framework structure with the point symbol of (3(6).4(14) 5(7).6) and 3 displays a 2,6-connected 3D new topological structure with the point symbol of (4(4).6(10).10)(6). Co-MOFs were evaluated as an electrode material for supercapacitors. Complex 1 displayed a higher specific capacitance of 281 F g(-1) in 6 M KOH solution at a current density of 1 A g(-1) and remained at 195 Fri after 2000 cycles at 2 A g(-1). In addition, the magnetic properties of complexes 1-5 have been investigated and discussed.

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Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Electric Literature of 1538-08-5, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 1538-08-5, Name is 2,2,2-Trifluoroacetohydrazide, SMILES is NNC(=O)C(F)(F)F, belongs to pyridazines compound. In a article, author is Moir, M., introduce new discover of the category.

Ring-opened aminothienopyridazines as novel tau aggregation inhibitors

Aminothienopyridazines (ATPZs) have demonstrated efficacy, in vitro, as tau protein aggregation inhibitors. Modifications were made to the ATPZ scaffold to determine the importance of certain structural features for activity. More specifically, ring-opened analogues detached at the nitrogen-nitrogen bond of the pyridazine, were synthesized and their inhibitory activity evaluated. Preliminary data suggests that the ring-opened structures retain inhibitory activity, independent of tau oxidation. The structures detailed represent the beginnings of a deconstruction-reconstruction-elaboration study, with the aim of identifying simpler scaffolds, which retain activity and can be optimized in terms of physiochemical properties.

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Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , SDS of cas: 110-03-2, 110-03-2, Name is 2,5-Dimethyl-2,5-hexanediol, molecular formula is C8H18O2, belongs to pyridazines compound. In a document, author is Maione, Francesco, introduce the new discover.

New insights on the arylpiperazinylalkyl pyridazinone ET1 as potent antinociceptive and anti-inflammatory agent

Pyridazine derivatives, such as arylpiperazinylalkyl pyridazinones, display antinociceptive effects to thermal and chemical stimuli. Here, we extended our previous knowledge on the pharmacological profile of 4-amino-6-methyl-2-(3-(4-(4-methylcyclohexa-1,3-dien-1-yl)piperazin-1-yl)propyl)-5-vinylpyridazin-3(2H)-one, here referred as ET1, paving the way for the comprehension of its complete mechanism of action. To this aim, we have evaluated the mouse behavioural responses in several animal models of pain, the effect of ET1 in the murine model of zymosan-induced paw oedema and air-pouch, assessing the cytokines and the cellular phenotype and finally, an in vitro radioligand binding study was performed on a panel of 30 different receptors. In the formalin test, ET1 reduced both neurogenic and inflammatory phase of nociception induced by the aldehyde. Similarly, ET1 strongly reduced paw licking response in the capsaicin test, the abdominal stretching in the writhing test and the carrageenan-induced thermal hyperalgesia. ET1 also evoked a long-lasting reduction of thermal hyperalgesia. Furthermore, ET1 produced a long-lasting anti-inflammatory effect in the zymosan-induced mouse paw oedema and air-pouch through the selective inhibition of inflammatory monocytes recruitment and the modulation of IL-1 beta, IL-6, TNF-alpha and MCP-1. Binding experiments confirmed an inhibitory effect on adrenergic alpha(1A), alpha(1B) and alpha(2A) receptors subtypes and, for the first time, a moderate affinity was observed for the following receptors: histamine H-1, imidazoline I-2, sigma non-opioid intracellular receptor 1 and sigma(2). These results prompt ET1 as a potent analgesic and anti-inflammatory agent, and support the possibility that it may be suitable for clinical applications in a wide-range of inflammatory-based diseases.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 110-03-2. SDS of cas: 110-03-2.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Category: pyridazines, 5469-69-2, Name is 3-Amino-6-chloropyridazine, SMILES is C1=C(N=NC(=C1)Cl)N, belongs to pyridazines compound. In a document, author is Howes, Timothy R. L., introduce the new discover.

Structure-activity relationships among DNA ligase inhibitors: Characterization of a selective uncompetitive DNA ligase I inhibitor

In human cells, there are three genes that encode DNA ligase polypeptides with distinct but overlapping functions. Previously small molecule inhibitors of human DNA ligases were identified using a structure-based approach. Three of these inhibitors, L82, a DNA ligase I (Ligl)-selective inhibitor, and L67, an inhibitor of LigI and DNA ligases III (LigIII), and L189, an inhibitor of all three human DNA ligases, have related structures that are composed of two 6-member aromatic rings separated by different linkers. Here we have performed a structure activity analysis to identify determinants of activity and selectivity. The majority of the LigI-selective inhibitors had a pyridazine ring whereas the LigI/III- and LigIII-selective inhibitors did not. In addition, the aromatic rings in LigI-selective inhibitors had either arylhydrazone or acylhydrazone, but not vinyl linkers. Among the LigIselective inhibitors, L82-G17 exhibited increased activity against and selectivity for LigI compared with L82. Notably. L82-G17 is an uncompetitive inhibitor of the third step of the ligation reaction, phosphodiester bond formation. Cells expressing LigI were more sensitive to L82-G17 than isogenic LIG1 null cells. Furthermore, cells lacking nuclear LigIfict, which can substitute for LigI in DNA replication, were also more sensitive to L82-G17 than isogenic parental cells. Together, our results demonstrate that L82-G17 is a LigI-selective inhibitor with utility as a probe of the catalytic activity and cellular functions of LigI and provide a framework for the future design of DNA ligase inhibitors.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 5469-69-2. Category: pyridazines.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem