Category: pyridazines

Synthetic Route of 73963-42-5, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 73963-42-5, Name is 5-(4-Chlorobutyl)-1-cyclohexyl-1H-tetrazole, SMILES is ClCCCCC1=NN=NN1C2CCCCC2, belongs to pyridazines compound. In a article, author is Porter, Jacob D., introduce new discover of the category.

An anthrone-based Kv7.2/7.3 channel blocker with improved properties for the investigation of psychiatric and neurodegenerative disorders

A set of novel Kv7.2/7.3 (KCNQ2/3) channel blockers was synthesized to address several liabilities of the known compounds XE991 (metabolic instability and CYP inhibition) and the clinical compound DMP 543 (acid instability, insolubility, and lipophilicity). Using the anthrone scaffold of the prior channel blockers, alternative heteroarylmethyl substituents were installed via enolate alkylation reactions. Incorporation of a pyridazine and a fluorinated pyridine gave an analog (compound 18, JDP-107) with a promising combination of potency (IC50=0.16 mu M in a Kv7.2 thallium flux assay), efficacy in a Kv7.2/7.3 patch clamp assay, and drug-like properties.

Synthetic Route of 73963-42-5, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 73963-42-5.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

In an article, author is Samir, B., once mentioned the application of 375395-33-8, Recommanded Product: 375395-33-8, Name is N-Methyl-N,N-dioctyloctan-1-aminium bis((trifluoromethyl)sulfonyl)amide, molecular formula is C27H54F6N2O4S2, molecular weight is 648.85, MDL number is MFCD08275364, category is pyridazines. Now introduce a scientific discovery about this category.

Gas-phase UV absorption spectra of pyrazine, pyrimidine and pyridazine

The gas phase UV absorption spectra of pyrazine, pyrimidine and pyridazine were determined by using a D2-lamp coupled to a monochromator-PM system between 200 and 380 nm, at 353 +/- 3 K and at pressures lower than their vapor pressure (0.08-0.5 torr). The obtained spectra consist of a broad continuum with low intense absorption bands at 200-380 nm. Absorption of the investigated compounds at wavelengths > 290 nm is non-negligible (sigma(lambda) > 290 nm in the order of 10(-20) cm(2) molecule(-1)). These results indicate that, pyrazine, pyrimidine and pyridazine could be removed from the troposphere via photolysis reactions.

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Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 401-78-5, Name is 3-Bromobenzotrifluoride, SMILES is FC(F)(F)C1=CC=CC(Br)=C1, in an article , author is Dong, Jun-Liang, once mentioned of 401-78-5, Product Details of 401-78-5.

Syntheses, structures, and magnetic properties of mixed-ligand complexes based on 3,6-bis(benzimidazol-1-yl)pyridazine

Six new metal-organic coordination polymers (CPs) [Ni(L)(2,5-TDC)(H2O)](n)(1), [Ni(L)(1,3-BDC)(H2O)](n) (2), [Ni(L)(1,4-BDC)(H2O)](n) (3), [Mn(L)(2,5-TDC)(H2O)](n) (4), [Mn(L)(2,6-PYDC)(H2O)](n) (5) and [Mn(L)(1,4-NDC)](n) (6) were achieved by reactions of the corresponding metal salt with mixed organic ligands (L = 3,6-bis(benzimidazol-1-yl)pyridazine, 2,5-H2TDC = thiophene-2,5-dicarboxylic acid, 1,3-H2BDC = isophthalic acid, 1,4-H2BDC = terephthalic acid, 2,6-H2PYDC = pyridine-2,6-dicarboxylic acid, 1,4-H2NDC = naphthalene-1,4-dicarboxylic acid) under solvothermal condition. CPs 1-6 were characterized by single-crystal X-ray diffraction, IR, TG, XRD and elemental analyses. Their structures range from the intricate 3D CPs 1, 3, 4 and 6 to the 2D coordination polymer 2 and the infinite 1D chain 5. The CPs 1-4 and 6 underlying networks were classified from the topological viewpoint, disclosing the distinct sql (in 1), pcu (in 3 and 6), new topology (in 2), and dia (in 4) topological nets. Moreover, analysis of thermal stability shows that they had good thermal stability. Finally, magnetic properties of CPs 1-6 have been studied, the results showed that complex 2 had ferromagnetic coupling and complexes 1, 3-6 were antiferromagnetic.

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Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Chemistry is an experimental science, Category: pyridazines, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 103-85-5, Name is 1-Phenylthiourea, molecular formula is C7H8N2S, belongs to pyridazines compound. In a document, author is Cetin, Adnan.

A study on synthesis and antimicrobial activity of 4-acyl-pyrazoles

4-Acyl-pyrazole-3-carboxylic acids (1) were synthesized via the reaction of 4-acyl-2,3-furandiones (F) with hydrazone (1-benzylidene-2-(2,5-dimethyl-phenyl)-hydrazine) by heating under solid phase and their acid chlorides (2) were obtained. Then these derivatives were easily converted into the corresponding derivatives such as ester, amide, ureide, pyrazolo-pyridazine, etc. Totally 62 new compounds were synthesized. The structures of these new synthesized compounds were determined by spectroscopic methods and the in vitro antibacterial activity of newly synthesized compounds were carried out against some gram-positive and gram-negative bacteria by well diffusion method (zone inhibition). Our results have showed that these new synthesized compounds have much potent of antibacterial activity owing to containing of pyrazole and/or pyridazine, chromone, oxazine, furane, and pyrrole rings. Some of the new pyrazole derivatives exhibited higher activities than reference drugs against the representative bacteria. (C) 2016 King Saud University. Production and hosting by Elsevier B.V.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 103-85-5, in my other articles. Category: pyridazines.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Reference of 73963-42-5, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 73963-42-5, Name is 5-(4-Chlorobutyl)-1-cyclohexyl-1H-tetrazole, SMILES is ClCCCCC1=NN=NN1C2CCCCC2, belongs to pyridazines compound. In a article, author is Chmovzh, Timofey N., introduce new discover of the category.

Safe Synthesis of 4,7-Dibromo[1,2,5]thiadiazolo[3,4-d]pyridazine and Its SNAr Reactions

A safe and efficient synthesis of 4,7-dibromo[1,2,5]thiadiazolo[3,4-d]pyridazine from the commercial diaminomaleonitrile is reported. Conditions for selective aromatic nucleophilic substitution of one or two bromine atoms by oxygen and nitrogen nucleophiles are found, whereas thiols formed the bis-derivatives only. Buchwald-Hartwig or Ullmann techniques are successful for incorporation of a weak nitrogen base, such as carbazole, into the [1,2,5]thiadiazolo[3,4-d]pyridazine core. The formation of rather stable S … eta(2)-(N=N) bound chains in 4,7-bis(alkylthio)-[1,2,5]thiadiazolo[3,4-d]pyridines makes these compounds promising for the design of liquid crystals.

Reference of 73963-42-5, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 73963-42-5.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 102-08-9, Name is N,N’-Diphenylthiourea, molecular formula is C13H12N2S. In an article, author is Silva, Charles Biral,once mentioned of 102-08-9, Recommanded Product: 102-08-9.

A Microwave Step for the Synthesis of 4,5-Dicyanopyridazine: A Great Forerunner to Phthalocyanines

4,5-Dicyanopyridazine (DCP) shows unexpected reactivity with dienophiles via Hetero Diels-Alder. Reactions involving this compound and alkynes or enamines was already described, and open possibilities to synthesize precursors for important macromolecules, like phthalonitriles used in phthalocyanines synthesis. Herein, we present a microwave synthetic step in the DCP synthetic route in order to minimize the time to synthesize this compound.

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Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 2605-67-6, Name is Methyl 2-(triphenylphosphoranylidene)acetate, molecular formula is C21H19O2P. In an article, author is Zhang, Yiwen,once mentioned of 2605-67-6, Application In Synthesis of Methyl 2-(triphenylphosphoranylidene)acetate.

Facile syntheses of ionic polymers for efficient catalytic conversion of CO2 to cyclic carbonates

The development of sustainable heterogeneous catalysts in converting carbon dioxide (CO2) into value-added chemicals is a promising way to alleviate the environmental pressure caused by global warming. Here, two novel ionic polymers (IPs, namely IP-1 and IP-2) with high yield and excellent physiochemical stability have been synthesized facilely from the direct reaction of 1,3,5-tris(bromomethyl)benzene with 1,4-diazabicyclo [2.2.2]octane and 3,6-di(1H-imidazol-1-yl)pyridazine, respectively. Their catalytic abilities to convert CO2 into cyclic carbonates have been explored, and both IP-1 and IP-2 show excellent catalytic activity under solvent free, cocatalyst-free, and mild reaction conditions, and can be recycled and reused six times without decreasing their catalytic abilities. These materials are easily synthesized, and there are no metals and other additives during the catalytic process, which provides a possibility for the industrial immobilization of CO2 to carbonate over heterogeneous catalysts.

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Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 2605-67-6, Name is Methyl 2-(triphenylphosphoranylidene)acetate, molecular formula is C21H19O2P. In an article, author is Ning, Xiaowen,once mentioned of 2605-67-6, Quality Control of Methyl 2-(triphenylphosphoranylidene)acetate.

Green and yellow pyridazine-based phosphorescent Iridium(III) complexes for high-efficiency and low-cost organic light-emitting diodes

Despite efficient electroluminescence performance, the high fabrication cost due to the utilization of noble metals impedes the commercialization of phosphorescent organic light-emitting diodes (PHOLEDs) based on iridium(III) complexes. In this paper, we designed and synthesized a series of green and yellow phosphorescent iridium(III) complexes with 3-(2,4-difluorophenyl)-6-methylpyridazine as the cyclometalating ligand to fabricate high-performance and low-cost PHOLEDs. By the introduction of a pyridazine moiety to enhance the coordination bond between iridium(III) ion and cyclometalating ligands, these iridium(III) complexes were obtained in high yields and exhibit good thermal stabilities and volatilities, which are beneficial to reduce the device manufacturing cost. Besides, high photoluminescence quantum yields (PLQYs) and short phosphorescent lifetimes of these pyridazine-based iridium(III) complexes endow their PHOLEDs with excellent device performance, which can be promising for practical applications. Particularly, the green emitter (fpdz)(2)Irpic exhibited a high PLQY of 0.89 in solid doped thin-film; PHOLED based on (fpdz)(2)Irpic achieved an outstanding maximum external quantum efficiency (EQE(max)) of 28.7% with ultralow efficiency roll-off of 2% at the high luminance of 1000 cd m(-2), which was superior to the commercial green phosphor bis(phenylpyridineyl)iridium(acetylacetonate) [(ppy)(2)Ir(acac), EQE(max) = 24.2%].

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Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Electric Literature of 375-72-4, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 375-72-4, Name is 1,1,2,2,3,3,4,4,4-Nonafluorobutane-1-sulfonyl fluoride, SMILES is O=S(C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)(F)=O, belongs to pyridazines compound. In a article, author is Komendantova, Anna S., introduce new discover of the category.

Cyclization of beta-Chlorovinyl Thiohydrazones into Pyridazines: A Mechanistic Study

Extensive experimental and theoretical investigations on the isomerization and heterocyclizations of -chlorovinyl thiohydrazones derived from oxamic acid thiohydrazides and -chlorovinyl aldehydes were performed to elucidate the reaction mechanism of pyridazine formation. We showed that model -chlorovinyl thiohydrazone undergoes multiple isomerization reactions in solution induced by thione-thiol tautomerism and Z/E-isomerization at the C=N bond. Mechanistic rationalization along with computational studies demonstrated that pyridazine is predominantly generated from the Z-thiol isomers by 6-electrocyclization of the thiohydrazone-derived 2,3-diazatriene intermediate. The autocatalytic character of cyclization accelerated by the formation of acid was demonstrated by means of H-1 NMR monitoring.

Electric Literature of 375-72-4, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 375-72-4 is helpful to your research.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Electric Literature of 103-85-5, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 103-85-5, Name is 1-Phenylthiourea, SMILES is S=C(N)NC1=CC=CC=C1, belongs to pyridazines compound. In a article, author is Noonan, Terence J., introduce new discover of the category.

Five Solid Forms of a Potent Imidazopyridazine Antimalarial Drug Lead: A Preformulation Study

A novel antimalarial drug lead, 6-(3-(methylsulfonyl)phenyl)-3-(4-(methylsulfonyl)phenyl)-imidazo[1,2-b]pyridazine (MMV652103), with good in vitro and in vivo antiplasmodial effects but poor aqueous solubility was investigated for preformulation beneficiation by supramolecular methods. Three polymorphs (Forms 1-3), an amorphous phase (Form 4), and a monohydrate (Form 5) were discovered and characterized by thermal analytical methods including hot stage microscopy, differential scanning calorimetry, and thermogravimetric analysis, complemented by variable-temperature powder X-ray diffraction. Single crystals of polymorphic Form 1, Form 2, and a monohydrate of the drug lead were isolated, and their structures were elucidated by X-ray diffraction, which enabled the respective molecular conformations, inter- and intramolecular interactions, and packing arrangements to be determined. A schematic energy-temperature diagram incorporating the polymorphic forms and the amorphous form of the drug lead was constructed using data gleaned from thermal analysis, kinetic solubility experiments, and observations of solvent-mediated transitions. The amorphous form of the drug lead displayed a significant increase in dissolution rate, yielding a maximum concentration of 3-4 times those of the crystalline forms after 1 h.

Electric Literature of 103-85-5, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 103-85-5 is helpful to your research.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem