Category: pyridazines

Synthetic Route of 1538-08-5, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 1538-08-5, Name is 2,2,2-Trifluoroacetohydrazide, SMILES is NNC(=O)C(F)(F)F, belongs to pyridazines compound. In a article, author is Yan, Tengfei, introduce new discover of the category.

Supramolecular nanochannels self-assembled by helical pyridine-pyridazine oligomers

Herein, we demonstrate a supramolecular nanochannel formed by intermolecular pi stacking of pyridine-pyridazine helical oligomers, wherein alkali ions could be easily recognized and transported. Importantly, this nanochannel also revealed reversible collection and triggered-release behaviors via modulating the folded and unfolded states of helical pyridine-pyridazine oligomers.

Synthetic Route of 1538-08-5, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 1538-08-5 is helpful to your research.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 110-03-2, Name is 2,5-Dimethyl-2,5-hexanediol, molecular formula is C8H18O2, belongs to pyridazines compound. In a document, author is Wu, Wei, introduce the new discover, Application In Synthesis of 2,5-Dimethyl-2,5-hexanediol.

Synthesis of pertrifluoromethyl pyridazine derivatives via a tandem reaction of aryldiazonium salts with hexafluoroacetylacetone

A new strategy for the construction of pertrifluoromethyl pyridazine derivatives is presented. The tandem reaction starts from the condensation of arenediazonium salts with hexafluoroacetylacetone leading to the formation of pertrifluoromethyl pyridazinols, which readily undergo electrophilic substitution reactions with phenols to afford benzo[5,6]chromeno[3,4-c]pyridazine products in the presence of concd H2SO4.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 110-03-2. Application In Synthesis of 2,5-Dimethyl-2,5-hexanediol.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, Name: 3-Bromobenzotrifluoride401-78-5, Name is 3-Bromobenzotrifluoride, SMILES is FC(F)(F)C1=CC=CC(Br)=C1, belongs to pyridazines compound. In a article, author is Hu, Zilun, introduce new discover of the category.

Pyridazine and pyridazinone derivatives as potent and selective factor XIa inhibitors

Pyridazine and pyridazinone derivatives were designed and synthesized as coagulation factor XIa inhibitors. Potent and selective inhibitors with single digit nanomolar affinity for factor XIa were discovered. Selected inhibitors demonstrated moderate oral bioavailability. (C) 2018 Elsevier Ltd. All rights reserved.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 401-78-5. Name: 3-Bromobenzotrifluoride.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Reference of 50681-25-9, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 50681-25-9, Name is 4-Pyridazinecarboxylic Acid, SMILES is N1=NC=C(C=C1)C(=O)O, belongs to pyridazines compound. In a article, author is Flaig, Kim S., introduce new discover of the category.

Generation of Annelated Dicarbenes and Their Alkali-Metal Chelate Complexes in Solution: Equilibrium between Hetero- and Homoleptic NHC Lithium Complexes

Attempts to generate the free bis(N-heterocyclic carbene) vegi(R) (R = nPr, tBu; vegi(R) = 2,L7-dihydro-2,7-dialkyldiimidazo[1,5-b:5′,1′-f]pyridazine-1,8-diylidene) from its imidazolium salts 1 with alkali-metal bases resulted exclusively in the formation of the respective lithium, sodium, and potassium complexes 2-4 due to the strongly chelating properties of the dicarbene. DFT calculations reveal pronounced dispersion interactions in the case of N-tertbutyl substituents as the reason for the formation of the homoleptic lithium species 2b-H in solution. The dynamic behavior of the lithium complexes in equilibrium was studied by NMR techniques. Attempts to liberate the free carbenes by addition of the respective crown ethers failed for the lithium and sodium complexes. Deprotonation of the imidazolium salts 1a,b with the strong metal-free phosphazene base P4-tBu ({(Me2N)(3)PN}(3)PNtBu) generated successfully the free dicarbenes vegi(R) (5) and monocarbene 6b in solution.

Reference of 50681-25-9, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 50681-25-9.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Recommanded Product: 88-17-5, 88-17-5, Name is 2-(Trifluoromethyl)aniline, molecular formula is C7H6F3N, belongs to pyridazines compound. In a document, author is Zhao, Menghao, introduce the new discover.

Synthesis of Pyrimidopyrrolopyridazines via a Tandem Reaction of Heterocyclic Ketene Aminals with 1,2-Diaza-1,3-dienes

A tandem reaction of heterocyclic ketene aminals and 1,2-diaza-1,3-dienes was developed for the expedient synthesis of pyrimidopyrrolopyridazine derivatives. This process involved an intramolecular conjugate addition followed by CuCl2-catalyzed hydrazone formation.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 88-17-5. Recommanded Product: 88-17-5.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Chemistry, like all the natural sciences, Application In Synthesis of N,N’-Diphenylthiourea, begins with the direct observation of nature¡ª in this case, of matter.102-08-9, Name is N,N’-Diphenylthiourea, SMILES is S=C(NC1=CC=CC=C1)NC2=CC=CC=C2, belongs to pyridazines compound. In a document, author is Swarup, Hassan. A., introduce the new discover.

Effective and Transition-Metal-Free Construction of Disubstituted, Trisubstituted 1,2,3-NH-Triazoles and Triazolo Pyridazine via Intermolecular 1,3-Dipolar Cycloaddition Reaction

An interesting approach for synthesis of disubstituted-1,2,3-(NH) triazoles from easily available raw materials and reagents like substituted acetophenones, iodine, DMSO and NaN3 via intermolecular 1,3-dipolar cycloaddition reaction. Trisubstituted triazoles and its corresponding triazolo pyridazine could be made easily using this method. These are key intermediates for poly benzodithiophene triazole (PBnDT-TAZ) for solar cells and 1-benzyl-1H-4,5-dibenzoyl-1,2,3-triazole (BDBT) for corrosion inhibition.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 102-08-9. Application In Synthesis of N,N’-Diphenylthiourea.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 103-85-5, Name is 1-Phenylthiourea, SMILES is S=C(N)NC1=CC=CC=C1, in an article , author is Moine, Esperance, once mentioned of 103-85-5, Category: pyridazines.

Imidazo[1,2-b]pyridazines targeting Toxoplasma gondii calcium-dependent protein kinase 1 decrease the parasite burden in mice with acute toxoplasmosis

The current therapeutic arsenal for toxoplasmosis is restricted to drugs non-specific to the parasite which cause important side effects. Development of more efficient and specific anti-Toxoplasma compounds is urgently needed. Imidazo[1,2-b]pyridazines designed to inhibit the calcium-dependent protein kinase 1 of Toxoplasma gondii (TgCDPK1) and effective against tachyzoite growth in vitro at submicromolar ranges were modified into hydrochloride salts to be administered in vivo in a mouse model of acute toxoplasmosis. All protonated imidazo[1,2-b]pyridazine salts (SP230, SP231 and SP232) maintained their activity on TgCDPK1 and T. gondii tachyzoites. Rat and mouse liver microsomes were used to predict half-life and intrinsic clearance, and the pharmacokinetic profile of the most rapidly degraded imidazo [1,2b]pyridazine salt (SP230) was determined in serum, brain and lungs of mice after a single administration of 50 mg/kg. Compounds were then tested in vivo in a murine model of acute toxoplasmosis. Mice infected with tachyzoites of the ME49 strain of T. gondii were treated for 4, 7 or 8 days with 25 or 50 mg/kg/day of SP230, SP231 or SP232. The parasite burdens were strongly diminished (>90% reduction under some conditions) in the spleen and the lungs of mice treated with imidazo[1,2-b]pyridazine salts compared with untreated mice, without the need for pre-treatment. Moreover, no increases in the levels of hepatic and renal toxicity markers were observed, demonstrating no significant signs of short-term toxicity. To conclude, imidazo[1,2-b]pyridazine salts have strong efficacy in vivo on acute toxoplasmosis and should be further tested in a model of mouse congenital toxoplasmosis. (C) 2018 Australian Society for Parasitology. Published by Elsevier Ltd. All rights reserved.

Interested yet? Read on for other articles about 103-85-5, you can contact me at any time and look forward to more communication. Category: pyridazines.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Application of 375395-33-8, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 375395-33-8, Name is N-Methyl-N,N-dioctyloctan-1-aminium bis((trifluoromethyl)sulfonyl)amide, SMILES is CCCCCCCC[N+](CCCCCCCC)(C)CCCCCCCC.O=S([N-]S(=O)(C(F)(F)F)=O)(C(F)(F)F)=O, belongs to pyridazines compound. In a article, author is El-Ahwany, M. F., introduce new discover of the category.

Synthesis, heterocyclization and anti-tumour activity evaluation of some benzimidazole derivatives

Methylbenzimidazole 1 is converted to imidazole acrylic acid 3 via cyclo condensation with chloral followed by hydrolysis. Compound 3 also obtained from the reaction of o-phenylenediamine with maleic anhydride. Treatment of 1 with SeO2 yielded the oxidized product 4 (Aldehyde 4) which undergoes Wittig reaction using ester and Ph3P to furnish the acrylates 5. Compound 5 is also obtained by cyclocondensation of o-phenylenediamine and the corresponding maleate. Cyclization of 3 using Ac2O provides pyrroloimidazole 6. Imidazole 6 undergoes several transformations using HCI, ammonium hydroxide in neutral medium, o-phenylene diamine/HCI to provide acrylic acid 3, amide 7 and/or bicompound 8 respectively. Anilide 9 is obtained as a result of condensation of 3 with amines. Ester 5 undergoes 1,4-addition to benzimidazole ring to give the corresponding anilino derivative 10. Pyridazine cyclization is acheived by treatment of 5 with NH2OH in acidic medium. In vitro cytotoxicity is evaluated using SRB (sulphorhodamine-B) assay against two human cell lines, breast and liver carcinoma cell lines. The results show that compound 11 has strong activity against all cell lines tested.

Application of 375395-33-8, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 375395-33-8 is helpful to your research.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Chemistry is an experimental science, Quality Control of Carbonothioic dihydrazide, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 2231-57-4, Name is Carbonothioic dihydrazide, molecular formula is CH6N4S, belongs to pyridazines compound. In a document, author is Li Bu-Tong.

Looking for High Energy Density Molecules in the Nitro-substituted Derivatives of Pyridazine

A series of derivatives of pyridazine were designed through substituting hydrogens on the pyridazine ring with nitro groups. To explore the thermal stability of the title molecules, heats of formation, bond dissociation energies, and bond orders were calculated at the B3PW91/6-311+G(d,p) level. To confirm the potential usage as high energy density compounds, the detonation pressure and detonation velocity were predicted by using the empirical Kamlet-Jacobs (K-J) equation. Based on our calculated results, both thermal and kinetic stabilities of the title molecules are confirmed with good detonation characters. Especially, 3,4,5-trinitropyridazide and 3,4,6-trinitropyridazide represent excellent detonation parameters better than 1,3,5-trinitro-1,3,5-triazacyclohexane (RDX) and are screened out as potential high energy density compounds.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 2231-57-4. Quality Control of Carbonothioic dihydrazide.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Synthetic Route of 103-85-5, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 103-85-5, Name is 1-Phenylthiourea, SMILES is S=C(N)NC1=CC=CC=C1, belongs to pyridazines compound. In a article, author is Song, Yao-Dong, introduce new discover of the category.

Constructing a novel nonlinear optical materials: substituents and heteroatoms in pi-pi systems effect on the first hyperpolarizability

By doping pi-pi systems with Li atom, a series of Li@sandwich configuration and Li@T-shaped configuration compounds have been theoretically designed and investigated using density functional theory. It is revealed that energy gaps (E (gap)) between highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) of all compounds are in a range of 0.4-0.9 ev. When Li atom is introduced into different sandwich configuration pi-pi systems (C-60-toluene, C-60-fluorobenzene, C-60-phenol, C-60-benzonitrile), Li@C-60-benzonitrile exhibits considerable first hyperpolarizability as large as 19,759 au, which is larger by about 18,372-18,664 au than those of other compounds. When Li atom is introduced into different T-shaped configuration pi-pi systems (C-60-pyridine, C-60-pyrazine, C-60-1, 3, 5-triazine, C-60-pyridazine), Li@C-60-pyridazine is found to present largest first hyperpolarizability up to 67,945 au in all compounds. All compounds are transparency in the deep ultraviolet spectrum range. We hope that this study could provide a new idea for designing nonlinear optical materials using pi-pi systems as building blocks.

Synthetic Route of 103-85-5, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 103-85-5.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem