Category: pyridazine

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 136725-55-8, is researched, Molecular C4H9ClFN, about Fluorine Substitution Induced High Tc of Enantiomeric Perovskite Ferroelectrics: (R)- and (S)-3-(Fluoropyrrolidinium)MnCl3, the main research direction is manganese chloride fluoropyrrolidinium fluorine substitution enantiomeric perovskite ferroelec.Synthetic Route of C4H9ClFN.

The past decade has witnessed much progress in designing mol. ferroelecs., whose intrinsic mech. flexibility, structural tunability, and easy processability are desirable for next-generation flexible and wearable electronic devices. However, an obstacle in expanding their promising applications in nonvolatile memory elements, capacitors, and sensors is effectively modulating the Curie temperature (Tc). Here, taking advantage of fluorine substitution on the reported mol. ferroelec., (pyrrolidinium)MnCl3, we present enantiomeric perovskite ferroelecs., namely, (R)- and (S)-3-(fluoropyrrolidinium)MnCl3. The close van der Waal’s radii and the similar steric parameters between H and F atoms ensure the min. disruption of the crystal structure, while their different electronegativity and polarizability can trigger significant changes in the phys. and chem. properties. As expected, the Tc gets successfully increased from 295 K in (pyrrolidinium)MnCl3 to 333 K in these two homochiral compounds Such a dramatic enhancement of 38 K signifies an important step toward designing high-Tc mol. ferroelecs. In the light of the conceptually new idea of fluorine substitution, one could look forward to a continuous succession of new mol. ferroelec. materials and technol. developments.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 5-Methoxy-1H-indole-2-carbaldehyde, is researched, Molecular C10H9NO2, CAS is 21778-81-4, about Selective Synthesis of 5,6-Dihydroindolo-[1,2-a]quinoxalines and 6,7-Dihydroindolo-[2,3-c]quinolines by Orthogonal Copper and Palladium Catalysis.Reference of 5-Methoxy-1H-indole-2-carbaldehyde.

In combination with the Ugi four-component reaction, two important indole-fused heterocycles were prepared in two steps from readily accessible starting materials. From the same set of Ugi adducts 5, 5,6-dihydroindolo[1,2-a]quinoxalines were rapidly generated in excellent yields by a copper-catalyzed N-H arylation pathway, whereas 6,7-dihydroindolo[2,3-c]quinolones were obtained by palladium-catalyzed C-H arylations in good yields without the protection of the indole N1 moiety. Microwave heating was used to accelerate these intramol. C-N and C-C bond-forming reactions performed under controlled reaction conditions.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Related Products of 21778-81-4. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 5-Methoxy-1H-indole-2-carbaldehyde, is researched, Molecular C10H9NO2, CAS is 21778-81-4, about Synthesis of Indole- and Pyrrole-Fused Seven-Membered Nitrogen Heterocycles via Acid-Base Switchable Cyclization Involving Cleavage of Amide C-N Bonds. Author is Hao, Yanke; Zhou, Pan; Niu, Kaikai; Song, Hongjian; Liu, Yuxiu; Zhang, Jingjing; Wang, Qingmin.

The method for synthesis of indole- and pyrrole-fused seven-membered nitrogen heterocycles I [R = H, Br; R1 = H; RR1 = -CH=CHCH=CH-, -CH=C(OMe)CH=CH-, -CH=CHC(Br)=CH-, etc.; R2 = H, Me, 3-(trifluoromethyl)phenyl, ethyloxidanyl; R3 = H, Me; R4 = Me, 4-methylphenyl, thiophen-2-yl, etc.], 2-tosyl-1,2,3,4-tetrahydro-5H-[1,5]diazocino[3,2,1-hi]indol-5-one and II (R5 = H, OMe; R6 = Me, 2-fluorophenyl, thiophen-2-yl, etc.) by means of acid-base switchable cyclization reactions have been reported. The reactions involved cleavage of amide C-N bonds, chemoselective N-1 or C-3 acylation, and 1,4-Michael addition This method could be used to construct two different kinds of seven-membered rings in one step from the same starting material without the need for a transition-metal catalyst.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Synthesis and biological evaluation of indoles, published in 2015, which mentions a compound: 21778-81-4, Name is 5-Methoxy-1H-indole-2-carbaldehyde, Molecular C10H9NO2, Computed Properties of C10H9NO2.

Objective of this research was to synthesize and characterize indole derivatives Indole nucleus has antimicrobial activities. Different kind of indole ring derivatives were synthesized such as 3-((E)-2-nitrovinyl)-1H-indole, 2-(1H-indol-3-yl)ethanamine, N-(2-(1H-indol-3-yl)ethyl)benzamide, Me 2-(3-(2-(benzamido)ethyl)-1H-indol-1-yl)acetate, 2-(3-(2-(benzamido)ethyl)-1H-indol-1-yl)acetic acid, N-(2-(1-((2,3-dihydro-1H-inden-5-yl-carbamoyl)methyl)-1H-indol-3-yl)ethyl)benzamide, e.g., I [R = 4-indanyl, 5-indanyl]. Antifungal activity of compounds I [R = 4-indanyl, 5-indanyl] were also studied.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Tetrahedron Letters called A solid-phase synthetic route to N-acylated α-alkyl-D,L-homoserine lactones, Author is Ali, Ahmed I. M.; O’Donnell, Martin J.; Scott, William L.; Samaritoni, J. Geno, which mentions a compound: 17739-45-6, SMILESS is BrCCOC1CCCCO1, Molecular C7H13BrO2, Formula: C7H13BrO2.

A synthetic route to N-acylated α-alkyl-D,L-homoserine lactones was established using solid-phase unnatural peptide synthesis (UPS) and combinatorial chem. The application of UPS methodol. allowed access to racemic N-acylated homoserine lactones (D,L-AHLs) and their α-alkyl structural analogs (α-D,L-AHLs). The synthesis and characterization of a library of five D,L-AHLs and ten α-R1-D,L-AHLs prepared from resin-bound amino acids is reported.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Name: 5-Methoxy-1H-indole-2-carbaldehyde. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 5-Methoxy-1H-indole-2-carbaldehyde, is researched, Molecular C10H9NO2, CAS is 21778-81-4, about Convenient synthesis of tetrahydro-γ-carbolines and tetrahydroquinolines through a chemo- and regioselectivity switch by a Bronsted acid catalyzed, one-pot, multicomponent reaction. Author is Cheng, Hong-Gang; Chen, Cai-Bao; Tan, Fen; Chang, Ning-Jie; Chen, Jia-Rong; Xiao, Wen-Jing.

An efficient, one-pot, multicomponent reaction of aldehydes, p-methoxyaniline, and 2-vinylindoles was developed. This approach provides a practical approach to synthetically and biol. significant tetrahydro-γ-carboline and tetrahydroquinoline derivatives in good yields through a chemo- and regioselectivity switch, which can be tuned by simply changing the substituent on the indole component under identical reaction conditions.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-(2-Bromoethoxy)tetrahydro-2H-pyran, is researched, Molecular C7H13BrO2, CAS is 17739-45-6, about New GSH-responsive amphiphilic zinc(II) phthalocyanine micelles as efficient drug carriers for combinatorial cancer therapy, the main research direction is glutathione zinc phthalocyanine micelle drug carrier cancer therapy.Related Products of 17739-45-6.

Combination therapies for the treatment of cancer have attracted wide attention. The poor selectivity and biocompatibility of photosensitizers (PS) limit the use of combination therapies in chemotherapy and photodynamic therapy (PDT) for cancer. In this work, the Gender PS (mPEG-b-PLA-S-S-ZnPC), asym. zinc(II) phthalocyanine (ZnPC) and mono-methoxy oxygen-based polyethylene glycol-polylactic acid (mPEG-b-PLA) were designed and synthesized for PDT through disulfide bond (-S-S-). The amphipathic PS could be self-assembled into a micelle in aqueous solution, and paclitaxel (PTX) was encapsulated in the core of the micelle for chemotherapy (PTX/mPEG-b-PLA-S-S-ZnPc). The PTX/mPEG-b-PLA-S-S-ZnPc micelle was spherical with a uniform diameter of about 184 nm. At the first 48 h, the release behaviors of ZnPC and PTX at 10 mmol / L GSH were 30% and 75.2%, resp. These results suggested that GSH-responsive PTX/mPEG-b-PLA-S-S-ZnPc micelle was an active ingredient in combination therapies for cancer.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Application In Synthesis of 2-(2-Bromoethoxy)tetrahydro-2H-pyran. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2-(2-Bromoethoxy)tetrahydro-2H-pyran, is researched, Molecular C7H13BrO2, CAS is 17739-45-6, about Pontimicrobium aquaticum gen. nov., sp. nov., a bacterium in the family Flavobacteriaceae isolated from seawater. Author is Janthra, Thidarat; Baek, Jihye; Kim, Jong-Hwa; Yoon, Jung-Hoon; Sukhoom, Ampaitip; Kim, Wonyong.

A Gram-stain-neg., yellow-pigmented, non-spore-forming, non-motile, rod-shaped, catalase-pos., strictly aerobic bacterial strain, designated CAU 1491T, was isolated from seawater and its taxonomic position was examined using a polyphasic approach. Cells of strain CAU 1491T grew optimally at 30°C, pH 7.5 and in 2.0% (w/v) NaCl. Phylogenetic anal. based on the 16S rRNA gene sequence of CAU 1491T showed that it formed a distinct lineage within the family Flavobacteriaceae as a sep. deep branch, with 97.0% or lower sequence similarity to representatives of the genera Lacinutrix, Gaetbulibacter and Aquibacter. The major cellular fatty acids of strain CAU 1491T were iso-C15:0, iso-C15:1 G, iso-C17:0 3-OH and summed feature 3. The polar lipid pattern consisted of diphosphatidylglycerol, phosphatidylserine, phosphatidylethanolamine and an unidentified phospholipid. The strain contained MK-6 as the sole respiratory quinone. Genome sequencing revealed that strain CAU 1491T has a genome size of 3.13 Mbp and a G + C content of 32.4 mol%. On the basis of the phenotypic, chemotaxonomic and genomic data, strain CAU 1491T represents a new genus and species in the family Flavobacteriaceae for which the name Pontimicrobium aquaticum gen. nov., sp. nov. is proposed. The type strain of Pontimicrobium aquaticum is CAU 1491T (= KCTC 72003T = NBRC 113695T).

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-(2-Bromoethoxy)tetrahydro-2H-pyran(SMILESS: BrCCOC1CCCCO1,cas:17739-45-6) is researched.Application In Synthesis of 2-(2-Bromoethoxy)tetrahydro-2H-pyran. The article 《Towards an Improved Design of MRI Contrast Agents: Synthesis and Relaxometric Characterisation of Gd-HPDO3A Analogues》 in relation to this compound, is published in Chemistry – A European Journal. Let’s take a look at the latest research on this compound (cas:17739-45-6).

The properties of LnIII-HPDO3A complexes as relaxation enhancers and paraCEST agents are essentially related to the hydroxylpropyl moiety. A series of three HPDO3A derivatives, with small modifications to the hydroxyl arm, were herein studied to understand how heightened control can be gained over the parameters involved in the design of these agents. A full 1H and 17O-NMR relaxometric anal. was conducted and demonstrated that increasing the length of the OH group from the lanthanide center significantly enhanced the water exchange rate of the gadolinium complex, but with a subsequent reduction in kinetic stability. Alternatively, the introduction of an addnl. Me group, which increased the steric bulk around the OH moiety, gave almost exclusively the TSAP isomer (95 %) as identified by 1H-NMR of the europium complex. The gadolinium analog of this complex also exhibited a very fast water exchange rate, but with no detectable loss of kinetic stability. This complex therefore demonstrates a notable improvement over Gd-HPDO3A.

There are many compounds similar to this compound(17739-45-6)COA of Formula: C7H13BrO2. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (R)-(-)-3-Fluoropyrrolidine Hydrochloride, is researched, Molecular C4H9ClFN, CAS is 136725-55-8, about Facile and efficient syntheses of novel (S)- and (R)-3-fluoropyrrolidines and 3,3-difluoropyrrolidine, the main research direction is fluoropyrrolidine enantiomeric synthesis; difluoropyrrolidine enantiomeric; pyrrolidine fluoro difluoro.Quality Control of (R)-(-)-3-Fluoropyrrolidine Hydrochloride.

Novel enantiomeric 3-fluoropyrrolidines and 3,3-difluoropyrrolidine were obtained in high yield starting from the enantiomerically pure and com. available (2S,4R)-4-hydroxyproline. Spray-dried potassium fluoride and diethylaminosulfur trifluoride were used to introduce one or two fluorine atoms, resp.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem