Category: pyridazine

19064-67-6, 6-Chloro-3-hydroxypyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6-Chloro-2H-pyridazin-3-one (944 mg, 7.23 mmol) and difluoro(fluorosulfonyl)acetic acid (1.42 g, 7.96 mmol) were dissolved in acetonitrile (19 ml) in a vessel with stirrer bar and stirred at room temperature for 40 h. The reaction solution was then diluted with ethyl acetate (150 ml) and washed successively with water, saturated sodium hydrogencarbonate solution and again with water. The organic phase was dried using sodium sulfate, filtered and evaporated to dryness in a rotary evaporator. The residue was taken up in cyclohexane, re-filtered, and the solvent was removed in a rotary evaporator. The residue obtained was purified by means of flash column chromatography (gradient cyclohexane/0-50% by vol. of ethyl acetate, CombiFlash Rf 200). The suitable product fractions were combined, and the solvents were removed in a rotary evaporator, giving 3-chloro-6-(difluoromethoxy)pyridazine (285 mg, 1.58 mmol, MS: 181.0/183.1[M+H+]), 22% yield) as colourless liquid.

As the paragraph descriping shows that 19064-67-6 is playing an increasingly important role.

Reference£º
Patent; Merck Patent GmbH; FUCHSS, Thomas; EMDE, Ulrich; BUCHSTALLER, Hans-Peter; MEDERSKI, Werner; (224 pag.)US2016/83401; (2016); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34584-69-5,3,6-Dichloro-4,5-dimethylpyridazine,as a common compound, the synthetic route is as follows.

Preparation 8 Synthesis of 3-ethoxy-4,5-dimethyl-6-chloropyridazine 0.69g(0.03mol) of metallic sodium was dissolved in 100mlitre of absolute ethanol and then 5.31g(0.03mol) of 3,6-dichloro-4,5-dimethylpyridazine was added thereto and completely dissolved. The reaction solution was stirred for 4 hours at room temperature and then treated according to the same manner as Preparation 5 to obtain the title compound as a pale white crystal. Yield: 4.22g (75.4percent) Melting Point: 60-62¡ãC Recrystallizing solvent: ethanol NMR(CDCl3, delta): 1.42(t, 3H, CH3), 2.20((s, 3H, CH3), 2.32(s, 3H, CH3), 4.52(q, 2H, OCH2)

As the paragraph descriping shows that 34584-69-5 is playing an increasingly important role.

Reference£º
Patent; Seoul Pharm. Co., Ltd.; Kwon, Soon Kyoung; EP1058681; (2003); B1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1121-79-5,3-Chloro-6-methylpyridazine,as a common compound, the synthetic route is as follows.

To a refluxing solution of 3-chloro-6-methylpyridazine (5.0 g, 39 mmol) in chloroform (75 mL) was added trichloroisocyanuric acid (3.6 g, 16 mmol) portionwise. The solution was allowed to reflux overnight, after which the crude reaction mixture was filtered, washed with 1 M sodium hydroxide (NaOH), and the organic phase was dried over magnesium sulfate. The crude product was concentrated under reduced pressure and purified by silica gel chromatography to furnish 3-chloro-6-chloromethyl-pyridazine (D) as a yellow oil which upon sitting became a brown solid=2.9 g (46%).

1121-79-5 3-Chloro-6-methylpyridazine 227254, apyridazine compound, is more and more widely used in various.

Reference£º
Patent; DOW AGROSCIENCES LLC; US2010/56534; (2010); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20698-04-8,3,6-Diiodopyridazine,as a common compound, the synthetic route is as follows.

3-Iodo-6-dimethylaminopyridazine can be prepared by stirring, at a temperature of 20 C for 48 hours, a solution of 3,6-diiodopyridazine (203.7 g) and of dimethylamine (276 g) in methanol (1500 cc). After evaporation to dryness under reduced pressure, the residue obtained is stirred for 15 minutes with distilled water (1500 cc). The insoluble product is filtered off and washed with distilled water (2 * 200 cc) to give 3-iodo-6-dimethylaminopyridazine (113.7 g) melting at 135 C.

As the paragraph descriping shows that 20698-04-8 is playing an increasingly important role.

Reference£º
Patent; Rhone-Poulenc Industries; US4104386; (1978); A;,
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1121-79-5, 3-Chloro-6-methylpyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Add trichloroisocyanuric acid (0.189 g) to a solution of 3-chloro-6-methylpyridazine (0.208 g) in chloroform (10 mL). Heat the oil bath to 60 C, lasts for 12 hours. Cool to room temperature, the filtrate was collected by filtration. Concentrated and purified by column chromatography (PE/EA=10/1). 0.201 g of 3-chloro-6-(chloromethyl)pyridazine was obtained.

As the paragraph descriping shows that 1121-79-5 is playing an increasingly important role.

Reference£º
Patent; BetaEpsilonTauTauAlpha PHARMACEUTICALS CO., LTD; WANG, YIQIAN; WANG, JIABING; DING, LIEMING; (80 pag.)TW2018/29406; (2018); A;,
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34584-69-5, 3,6-Dichloro-4,5-dimethylpyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1-(5-Trifluoromethyl-pyridin-2-yl)-piperazine (10 g, 43.3 mmol) is combined with 3,6-dichloro-4,5-dimethyl-pyridazine (14.4 g, 84.3 mmol), triethylamine (8.25 mL), and NMP (40 mL). The reaction mixture is heated to a temperature of 180¡ã C. for 25 min, and then concentrated in vacuo. The residue is purified by flash chromatography on silica gel (0-8percent MeOH/CH2Cl2) to afford the title compound (13.2 g, 82percent). 1H NMR (400 MHz, DMSO-d6) delta=8.48-8.41 (m, 1H) 7.84 (dd, J=9.1 Hz, 2.4 Hz, 1H) 7.03 (d, J=9.1 Hz, 1H) 3.88-3.76 (m, 4H) 3.28-3.20 (m, 4H) 2.31 (s, 6H).

The synthetic route of 34584-69-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Novartis AG; US2010/41663; (2010); A1;,
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867130-58-3, 6-Oxo-1,6-dihydropyridazine-4-carboxylic acid is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6-Oxo-l,6-dihydro-pyridazine-4-carboxylic acid ethyl esterThe title compound from Example 18.3 (1.0 g, 7.13 mmol) was added to a solution of ethanol (16 mL) and acetyl chloride (4 mL) and the resulting suspension was heated to 75 C and stirred overnight. The reaction mixture was concentrated, diluted with water and extracted with dichloromethane. The organic phase was dried over sodium sulfate, filtered and concentrated to give the title compound.1H NMR (300 MHz, CDCl3) delta 10.91 (br, IH), 8.26 (s, IH), 7.53 (s, IH), 4.43 (q, 2H), 1.40 (t, 3H).

The synthetic route of 867130-58-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTRAZENECA AB; ISAAC, Methvin; SLASSI, Abdelmalik; EDWARDS, Louise; DOVE, Peter; XIN, Tao; STEFANAC, Tomislav; WO2008/41075; (2008); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19064-67-6,6-Chloro-3-hydroxypyridazine,as a common compound, the synthetic route is as follows.

Step 1: 6-(2,4-Dichloro-phenylsulfanyl)-2H-pyridazin-3-one. Potassium t-butoxide (1.1 g) was added to a solution of 2,4-dichlorothiophenol (1.8 g) in N,N-dimethylformamide (DM F) (5 mL). The mixture was stirred at room temperature for 10 minutes and then 6-chloro 2H-pyridazin-3-one (1.31 g) was added. The reaction mixture was stirred at 100 C. for five hours. The mixture was then cooled to room temperature, poured into water (20 mL) and 20% potassium hydroxide (5 mL) was added. The resulting dark solution was extracted with ethyl acetate (2*10 mL). The aqueous layer was collected and the pH was adjusted to 3 with concentrated hydrochloric acid. The solution was then extracted with ethyl acetate (3*10 mL). The ethyl acetate layer was collected, dried over anhydrous sodium sulfate, filtered and evaporated to obtain a crude product, which was purified by silica gel chromatography (1:1 ethyl acetate/hexane as eluent) to afford 6-(2,4-dichloro-phenylsulfanyl)-2H-pyridazin-3-one (418 mg, 15%); NMR 6.88 (d, 1H), 7.10 (d, 1H), 7.24 (dd, 1H), 7.48 (d, 11H), 7.52 (d, 1H).

19064-67-6 6-Chloro-3-hydroxypyridazine 252828, apyridazine compound, is more and more widely used in various.

Reference£º
Patent; Martin, William H.; Mylari, Banavara L.; US2003/4139; (2003); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.75680-92-1,Ethyl 6-chloro-3-pyridazinecarboxylate,as a common compound, the synthetic route is as follows.

General procedure: To a suspension of ethyl 6-chloropyridazine-3-carboxylate 16 (534 mg, 2.87 mmol) in distilled water (9 mL), isobutyric acid (60 muL, 0.65 mmol), conc. H2SO4 (230 muL, 4.31 mmol) and AgNO3 (48.75 mg, 0.29 mmol) were added at room temperature. The mixture was heated at 65-75 C and a solution of NH4S2O8 (982.40 mg, 4.31 mmol) in distilled water (5 mL) was added dropwise in 10-15 min. The reaction was stirred for an additional 30 min at 70-75 C, then poured over ice, then neutralized with a 30% aqueous solution of NH4OH and immediately extracted twice with dichloromethane. The collected organic layers were dried over anhydrous MgSO4, and evaporated in vacuo. The residue was purified by flash chromatography on silica gel (200-300 mesh, hexane: ethyl acetate = 5:1) to obtain the regioisomer 17a (29.4 mg, yield 4.5%) and regioisomer 17b (294.0 mg, 44.9%). 5.1.8.1 Ethyl 6-chloro-4-isopropylpyridazine-3-carboxylate (17a) Yellow liquid. 1H NMR (CDCl3, 500 MHz): delta 7.51 (s, 1H), 0.4.54-4.49 (q, 2H), 3.47-3.41 (m, 1H), 1.46 (t, J = 7 Hz, 3H), 1.31 (s, 3H), 1.29 (s, 3H). MS (ESI), m/z: 229.11 [M+H]+.

As the paragraph descriping shows that 75680-92-1 is playing an increasingly important role.

Reference£º
Article; Qian, Hai-Yan; Wang, Zhi-Long; Xie, Xiao-Yu; Pan, You-Lu; Li, Gang-Jian; Xie, Xin; Chen, Jian-Zhong; European Journal of Medicinal Chemistry; vol. 137; (2017); p. 598 – 611;,
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88497-27-2, 3-Amino-6-bromopyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 6-bromopyridazin-3-amine (3.48 g, 20 mmol) in EtOH/H2O (5/1, 180 mL) was added 2-bromo-1,1-diethoxyethane (11.8 g, 60 mmol), followed by p-toluenesulphonic acid (20.6 mg, 0.12 mmol). The mixture was stirred at 80 C. for 16 hours and then concentrated in vacuo. The resulted solid was washed with H2O (4 mL), collected by filtration, and dried in a vacuum oven overnight at 40 C. to give the title compound as a gray solid (3.9 g, 100%). MS (ESI, pos. ion) m/z: 198.1 [M+H]+; 1H NMR (400 MHz, CDCl3): delta 8.71 (d, J=9.6 Hz, 1H), 8.44 (d, J=1.6 Hz, 1H), 8.33 (d, J=1.9 Hz, 1H), 7.97 (d, J=9.6 Hz, 1H).

As the paragraph descriping shows that 88497-27-2 is playing an increasingly important role.

Reference£º
Patent; Calitor Sciences, LLC; Xi, Ning; US2014/134133; (2014); A1;,
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Pyridazine | C4H4N2 – PubChem