Category: pyridazine

5788-58-9, 4,5-Dibromopyridazin-3(2H)-one is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5788-58-9, To a stirred solution of (3S)-3-methyl-1-[(2-methylphenyl)methyl]piperazine (500 mg, 2.45 mmol, 1 equiv.) and DIEA(632.6 mg, 4.89 mmol, 2 equiv.) in DMA(5 mL) was added 4,5- dibromo-2,3-dihydropyridazin-3-one (745.6 mg, 2.94 mmol, 1.2 equiv.) in portions at 100 degrees C overnight

The synthetic route of 5788-58-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GOLDFINCH BIO, INC.; YU, Maolin; DANIELS, Matthew, H.; HARMANGE, Jean-christophe, P.; TIBBITTS, Thomas, T.; LEDEBOER, Mark, W.; WALSH, Liron; MUNDEL, Peter, H.; MALOJCIC, Goran; (860 pag.)WO2019/55966; (2019); A2;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19064-67-6,6-Chloro-3-hydroxypyridazine,as a common compound, the synthetic route is as follows.

To a 1000-mL round-bottom flask purged and maintained with an inert atmosphere of nitrogen was placed a solution of 6-chloro-2,3- dihydropyridazin-3-one (5 g, 38.30 mmol) and (3-methoxyphenyl)boronic acid (7.6 g, 50.01 mmol) in dioxane (300 mL)/water (15 mL) then Pd(dppf)Cl2 (1.41 g) and K2C03 (15.9 g, 115.04 mmol) were added. The reaction was stirred at 110C for 15 h, quenched by the addition of 100 mL of water, and extracted with EtOAc (3×150 mL). The organic extracts were combined, washed with brine (3×200 mL), dried over anhydrous Na2S04, and concentrated under reduced pressure. The residue was purified by column chromatography eluting with EtO Ac/petroleum ether (9: 1) affording 5.6 g (72%) of the title compound as a white solid. Mass Spectrum (LCMS, ESI pos): Calcd. for CnHnN202+: 203.1 (M+H); Found: 203.1., 19064-67-6

As the paragraph descriping shows that 19064-67-6 is playing an increasingly important role.

Reference£º
Patent; PROTEOSTASIS THERAPEUTICS, INC.; PARKS, Daniel; MUNOZ, Benito; (66 pag.)WO2018/81378; (2018); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

372118-01-9, Methyl 4,6-dichloropyridazine-3-carboxylate is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 4 6-Chloro-4-(5,6-dimethoxy-pyridin-2-ylamino)-pyridazine-3-carboxylic acid methyl ester A mixture of 4,6-dichloro-pyridazine-3-carboxylic acid methyl ester (1.0 g, 4.83 mmol) and 5,6-dimethoxypyridin-2-amine (968 mg, 6.28 mmol) was dissolved in acetonitrile (5 mL) and heated at 70 C. for 16 h. The mixture was concentrated in vacuo and the crude mass obtained was purified by chromatography (silica, 100-200 mesh, 10-70% ethyl acetate in hexane) to give 6-chloro-4-(5,6-dimethoxy-pyridin-2-ylamino)-pyridazine-3-carboxylic acid methyl ester (830 mg, 53%) as a yellow solid. LC-MS: 325.2 [M+H]+., 372118-01-9

As the paragraph descriping shows that 372118-01-9 is playing an increasingly important role.

Reference£º
Patent; Hoffman-La Roche Inc.; Hermann, Johannes Cornelius; Kennedy-Smith, Joshua; Lucas, Matthew C.; Padilla, Fernando; Soth, Michael; US2013/178478; (2013); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

35857-89-7, 6-Chloropyridazine-3-carbonitrile is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 30 6-(5-((5-chloro-2-((l -methyl- lH-pyrazol-4-yl)amino)pyrimidin-4-yl)amino) hexahvdrocvclopentarc1pyrrol-2(lH)-yl)pyridazine-3-carbonitrile [0458] To a solution of 5-chloro-N2-(l -methyl- lH-pyrazol^-y -N4- (octahydrocyclopenta[c]pyrrol-5-yl)pyrimidine-2,4-diamine (85.8 mg, 0.26 mmol) and Et3N (80.4 mg, 0.80 mmol) in EtOH (10 mL) was added 6-chloropyridazine-3-carbonitrile (72.8 mg, 0.52 mmol). The reaction mixture was stirred at rt overnight, quenched with water (30 mL), and extracted with DCM (100 mL chi 3). The combined organic phases were washed with brine (100 mL), dried over anhydrous Na2S04, filtered and concentrated in vacuo. The residue was purified by silica gel column chromatography (MeOH/DCM (v/v) = 1/50) to give the title compound as a beige solid (109.6 mg, yield 97.6%). LC-MS (ESI, pos. ion) m/z: 437.4 [M+H]+; NMR (600 MHz, OMSO-d6) delta (ppm): 9.03 (s, 1H), 7.85 (m, 2H), 7.75 (s, 1H), 7.45 (s, 1H), 7.02 (d, J = 9.6 Hz, 1H), 6.93 (d, J = 7.8 Hz, 1H), 4.59 (m, 1H), 3.79 (s, 3H), 3.72 (m, 4H), 2.84 (s, 2H), 2.33 (m, 2H), 1.62 (m, 2H); 13C NMR (150 MHz, CDCb) delta (ppm): 158.2, 157.5, 131.1, 130.1, 128.2, 124.2, 118.2, 111.8, 72.7, 60.7, 52.9, 40.8, 39.1, 37.6., 35857-89-7

35857-89-7 6-Chloropyridazine-3-carbonitrile 13382871, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; SUNSHINE LAKE PHARMA CO., LTD.; CALITOR SCIENCES, LLC; XI, Ning; LI, Minxiong; LI, Xiaobo; CHEN, Wuhong; ZHANG, Tao; HU, Haiyang; DAI, Weilong; WU, Yanjun; (192 pag.)WO2017/44434; (2017); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

88497-27-2,88497-27-2, 3-Amino-6-bromopyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Reference example 197 4- ( (4-Chlorobenzyl) oxy) -1- ( 2-cyclopropyl-3-methylimidazo [1, 2- b] pyridazin-6-yl ) pyridin-2 ( 1H) -one A) 6-Bromo-2-cyclopropyl-3-methylimidazo [1, 2-b] pyridazine To a solution of 6-bromopyridazin-3-amine (1.0 g) in DMA (10 ml) were added 2-bromo-l-cyclopropylpropan-l-one (2.04 g) and NaHCC>3 (0.966 g) at room temperature, and the mixture was stirred at 80C for 16 h. The mixture was partitioned between EtOAc and water, and the organic layer was washed with brine, dried over MgS04, concentrated – in vacuo, and purified by silica gel column chromatography (hexane/EtOAc) to give the title compound (1.10 g) as yellow crystals. MS (ESI+) : [M+H]+ 252.0.

88497-27-2 3-Amino-6-bromopyridazine 2794779, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; KASAI, Shizuo; IGAWA, Hideyuki; TAKAHASHI, Masashi; MAEKAWA, Tsuyoshi; KAKEGAWA, Keiko; YASUMA, Tsuneo; KINA, Asato; AIDA, Jumpei; KHAMRAI, Uttam; KUNDU, Mrinalkanti; WO2013/105676; (2013); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

932-22-9, 4,5-Dichloro-3(2H)-pyridazinone is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,932-22-9

4.5- dichloro-2-methyl-pyridazin-3-one To a stirred solution of 4,5-dichloro-lH-pyridazin-6-one (25.0 g, 152 mmol) in N,N-dimethylformamide (152 ml) was added potassium carbonate (25.4 g, 182 mmol) and iodomethane (25.8 g, 182 mmol, 11.3 ml). The resulting mixture was stirred at room temperature overnight. The reaction mixture was then poured onto ice-water (300ml) and the mixture stirred for 15 mins. The resulting precipitate was collected by filtration, then dissolved in dichloromethane and passed through a phase separation cartridge. The organics were concentrated in vacuo to give 19.7 g of a pale brown solid. 1H NMR (400 MHz, Chloroform) d ppm 3.83 (s, 3 H) 7.77 (s, 1 H)

932-22-9 4,5-Dichloro-3(2H)-pyridazinone 73247, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; SYNGENTA LIMITED; BHONOAH, Yunas; ELLIOTT, Alison Clare; GAULIER, Steven; LING, Kenneth; MITCHELL, Glynn; MORRIS, James Alan; RZEPA, Paula Rocha; VINER, Russell Colin; WO2013/50421; (2013); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

5469-70-5, 3-Aminopyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Under an atmosphere of nitrogen, a 25 mL dry Schlenk flask was placed with Cu(acac)2 (1.6 mg, 0.01 mmol) and ligand A (2.6 mg, 0.012 mmol). Anhydrous MeOH (1.0 mL) was added, and the mixture was magnetically stirred at 20 C for 15 min. Then a solution of 1-phenylprop-2-yn-1-yl acetate 2a (0.24 mmol), 2-aminopyridine 1a (0.2 mmol) and diisopropylethylamine (0.07 mL, 0.4 mmol) in MeOH (0.5 mL) were added dropwise. The reaction flask was kept at room temperature for 6 h. After 1a was completely consumed as monitored by TLC, H2O (10 mL) was added to quench the reaction. The resulting mixture was then extracted three times with diethyl ether (10 mL*3). The combined organic layer was dried over Na2SO4. After evaporation of the volatile solvent under reduced pressure, the residue was purified by flash chromatography on silica gel to afford pure 3a (39 mg, 0.19 mmol) as a brown oil in a yield of 94%., 5469-70-5

The synthetic route of 5469-70-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Cheng, Cang; Ge, Luo; Lu, Xuehe; Huang, Jianping; Huang, Haocheng; Chen, Jie; Cao, Weiguo; Wu, Xiaoyu; Tetrahedron; vol. 72; 43; (2016); p. 6866 – 6874;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

20744-39-2, Pyridazin-4-amine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Aniline (62mul, 0.68 mmol), 2,4-dichloropyridine (100 mg, 0.68 mmol), cesium carbonate (442 mg, 1.36 mmol), xantphos (47 mg, 0.08 mmol) and Pd(OAc)2 (12 mg, 0.05 mmol) were combined in a microwave tube, sealed and purged with nitrogen. Dioxane (3 mL) was then added and the reaction solution degassed with nitrogen prior to heating at 100C for 30 minutes. The reaction mixture was then filtered and the filtrate was purified by reverse phase chromatography, utilizing a 20-65% gradient over 9 mins, with 0.5% ammonia as modifier to afford 4-chloro-N-phenyl-pyridin-2-amine, 20744-39-2

As the paragraph descriping shows that 20744-39-2 is playing an increasingly important role.

Reference£º
Article; Burton, Rebecca J.; Crowther, Mandy L.; Fazakerley, Neal M.; Fillery, Shaun M.; Hayter, Barry M.; Kettle, Jason G.; McMillan, Caroline A.; Perkins, Paula; Robins, Peter; Smith, Peter M.; Williams, Emma J.; Wrigley, Gail L.; Tetrahedron Letters; vol. 54; 50; (2013); p. 6900 – 6904;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5788-58-9,4,5-Dibromopyridazin-3(2H)-one,as a common compound, the synthetic route is as follows.

5788-58-9, A mixture of 25 g (0.1 mol) of 4,5-dibromo-3 (2H) -pyridazinone, 93 g (0.5 mol) of tributylamine,(HFC-23) at room temperature, and the mixture was stirred at 80 C, and the reaction was carried out. After the reaction was followed by thin layer chromatography, the reaction mixture was cooled with 10 ml of methylene chloride And purified by column chromatography (the stationary phase was silica gel GF254, eluent ethyl acetate / petroleum ether V / V = 1: 1) to give 17.2 g of a white solid product as a white powder,Yield 90%.

As the paragraph descriping shows that 5788-58-9 is playing an increasingly important role.

Reference£º
Patent; Pei, Qing; (6 pag.)CN106083731; (2016); A;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

51355-94-3, 6-Bromopyridazin-3(2H)-one is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a 250-mL round-bottom flask was placed a solution of 2- chloro-N-[4-(trifluoromethyl)phenyl]propanamide (3 g, 11.92 mmol, as prepared in Example 1, step A) in acetone (120 mL) then K2CO3 (4.93 g, 35.67 mmol) and 6-bromo-2,3-dihydropyridazin-3-one (2.48 g, 14.17 mmol) were added. The reaction was heated to reflux for 16 h then the solids were filtered out and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography eluting with EtOAc/petroleum ether (1:20 up to 1: 1) affording 3.8 g (82%) of the title compound as a white solid. Mass Spectrum (LCMS, ESI pos): Calcd. for Ci4Hi2BrF3N302+: 390.0 (M+H); Found: 390.0., 51355-94-3

The synthetic route of 51355-94-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PROTEOSTASIS THERAPEUTICS, INC.; PARKS, Daniel; MUNOZ, Benito; (66 pag.)WO2018/81378; (2018); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem