Category: pyridazine

Dostal, Wolfgang’s team published research in Monatshefte fuer Chemie in 1988 | CAS: 1445-56-3

3-Chloropyridazine-4-carbonitrile(cas: 1445-56-3) belongs to pyridazine derivatives.The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazines are also important because of their utility in synthetic organic chemistry and in physical organic chemistry.There are reports available for the synthesis of pyridazine and their derivatives by using 2-oxoaldehyes.Name: 3-Chloropyridazine-4-carbonitrile

Dostal, Wolfgang; Heinisch, Gottfried; Loetsch, Gerhard published an article in Monatshefte fuer Chemie. The title of the article was 《Chemistry of pyridazines. XXXVI. Novel diaza-analogs of 10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-one》.Name: 3-Chloropyridazine-4-carbonitrile The author mentioned the following in the article:

Procedures for the preparation of the novel tricyclic ketones 10,11-dihydro-5H-benzo[4,5]cyclohepta[1,2-d]pyridazin-5-one (I), 5,6-dihydro-11H-benzo[4,5]cyclohepta[2,1-c]pyridazin-11-one, and 10,11-dihydro-5H-benzo[4,5]cyclohepta[1,2-c]pyridazin-5-one starting from a preformed 1,2-diazine system are proposed. The key intermediates, e.g., II (R = CO2Et) are prepared from (2-phenylethyl)pyridazines, e.g., II (R = H) by introduction of a carboxylic functionality via homolytic alkoxycarbonylation or via a sulfonyl Reissert-type reaction. The experimental process involved the reaction of 3-Chloropyridazine-4-carbonitrile(cas: 1445-56-3Name: 3-Chloropyridazine-4-carbonitrile)

3-Chloropyridazine-4-carbonitrile(cas: 1445-56-3) belongs to pyridazine derivatives.The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazines are also important because of their utility in synthetic organic chemistry and in physical organic chemistry.There are reports available for the synthesis of pyridazine and their derivatives by using 2-oxoaldehyes.Name: 3-Chloropyridazine-4-carbonitrile

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

 

Czech, Karin’s team published research in Monatshefte fuer Chemie in 1991 | CAS: 1445-56-3

3-Chloropyridazine-4-carbonitrile(cas: 1445-56-3) belongs to pyridazine derivatives.The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazines are also important because of their utility in synthetic organic chemistry and in physical organic chemistry.There are reports available for the synthesis of pyridazine and their derivatives by using 2-oxoaldehyes.Safety of 3-Chloropyridazine-4-carbonitrile

Safety of 3-Chloropyridazine-4-carbonitrileOn May 31, 1991, Czech, Karin; Haider, Norbert; Heinisch, Gottfried published an article in Monatshefte fuer Chemie. The article was 《Pyridazines. LIV. The synthesis of pyridazine-fused S-heterocycles: thieno[2,3-c]pyridazine, pyrimido[4′,5′:4,5]thieno[2,3-c]pyridazine, and pyridazino[3,4-b][1,4]benzothiazine》. The article mentions the following:

Starting from 3-chloro-4-pyridazinecarbonitrile (I), the thienopyridazine derivatives II (R = OMe; R1 = OMe, NH2) were prepared Condensation of II (R = NH2) with (EtO3)CH afforded the novel tricyclic system III. Reaction of I (R = R1 = NH2) with 2-H2NC6H4SH, followed by treatment with NaH/DMSO gave pyridazinobenzothiazine IV instead of the expected condensed thiazepine. In the experiment, the researchers used many compounds, for example, 3-Chloropyridazine-4-carbonitrile(cas: 1445-56-3Safety of 3-Chloropyridazine-4-carbonitrile)

3-Chloropyridazine-4-carbonitrile(cas: 1445-56-3) belongs to pyridazine derivatives.The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazines are also important because of their utility in synthetic organic chemistry and in physical organic chemistry.There are reports available for the synthesis of pyridazine and their derivatives by using 2-oxoaldehyes.Safety of 3-Chloropyridazine-4-carbonitrile

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

 

Landvoigt, Werner’s team published research in Mikrochimica Acta in 1982 | CAS: 40020-05-1

4,6-Dichloro-3-phenylpyridazine(cas: 40020-05-1) belongs to pyridazine. The pyridazine moiety is an important structural feature of various pharmacologically important compounds with activities like antimicrobial, cardiotonic, vasodilator, analgesic, anti-inflammatory, antiplatelet, anticancer, antisecretory, antiulcer, antidepressant, neuroleptic, sedative-hypnotic, anticonvulsant, immunosuppressant, antiarrhythmic, and hypocholesterolaemic. Recommanded Product: 4,6-Dichloro-3-phenylpyridazine

《Formation of a 3-phenyl-4-hydroxy-6-chloropyridazine derivative for GC with ECD and MS detection and its application to trace analysis》 was published in Mikrochimica Acta in 1982. These research results belong to Landvoigt, Werner; Malissa, Hans Jr.; Winsauer, Karl. Recommanded Product: 4,6-Dichloro-3-phenylpyridazine The article mentions the following:

The determination of Pyridate (I) [55512-33-9] and the metabolite CL 9673 (II, 6-chloro-4-hydroxy-3-phenylpyridazine) [40020-01-7] is described. The method permits the determination of both compounds sep. and is applicable to corn and rape crops. The reaction of pentafluorobenzoyl chloride  [2251-50-5] with II, important in the assay, is described. The product 6-chloro-4-pentafluorobenzoyl-3-phenylpyridazine  [83607-25-4] is unstable; when the reaction is run in dioxan or THF solvent, 4,6-dichloro-3-phenylpyridazine  [40020-05-1], a stable compound, is formed. This chloro derivative is easily determined by TLC, with detection limits of ∼1 μg/mL. Trace amounts are determined by an alternate method wherein, following separation of I and II by chromatog., II is brominated with POBr3, and determined by capillary gas chromatog. coupled with mass spectrometry. I is determined by saponification to II, and then determined as the brominated derivative as described. Detection limits are 10 ng/g.4,6-Dichloro-3-phenylpyridazine(cas: 40020-05-1Recommanded Product: 4,6-Dichloro-3-phenylpyridazine) was used in this study.

4,6-Dichloro-3-phenylpyridazine(cas: 40020-05-1) belongs to pyridazine. The pyridazine moiety is an important structural feature of various pharmacologically important compounds with activities like antimicrobial, cardiotonic, vasodilator, analgesic, anti-inflammatory, antiplatelet, anticancer, antisecretory, antiulcer, antidepressant, neuroleptic, sedative-hypnotic, anticonvulsant, immunosuppressant, antiarrhythmic, and hypocholesterolaemic. Recommanded Product: 4,6-Dichloro-3-phenylpyridazine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

 

Blagoeva, I.’s team published research in Izvestiya po Khimiya in 1988 | CAS: 40020-05-1

4,6-Dichloro-3-phenylpyridazine(cas: 40020-05-1) belongs to pyridazine. The pyridazine moiety is an important structural feature of various pharmacologically important compounds with activities like antimicrobial, sedative-hypnotic, anticonvulsant, analgesic, anti-inflammatory, antiplatelet, anticancer, antisecretory, antiulcer, antidepressant, neuroleptic, immunosuppressant, cardiotonic, vasodilator, antiarrhythmic, and hypocholesterolaemic. Safety of 4,6-Dichloro-3-phenylpyridazine

《Effect of a neighboring methyl group on the acid- and base-catalyzed cyclizations of 2-ureidobenzoic acids》 was published in Izvestiya po Khimiya in 1988. These research results belong to Blagoeva, I.; Koedzhikov, A.; Pozharliev, I.. Safety of 4,6-Dichloro-3-phenylpyridazine The article mentions the following:

The cyclization of title compound I (R = H) in acid is 1.6 times slower than that of I (R = Me); in base, however, I (R = H) cyclizes 16 times faster than I (R = Me). The rates are interpreted in terms of resonance stabilization of CO2H but not CO2- and steric hindrance in the transition state. In the base-catalyzed process, a change in rate-determining step occurs as the alkalinity is increased. In the experiment, the researchers used 4,6-Dichloro-3-phenylpyridazine(cas: 40020-05-1Safety of 4,6-Dichloro-3-phenylpyridazine)

4,6-Dichloro-3-phenylpyridazine(cas: 40020-05-1) belongs to pyridazine. The pyridazine moiety is an important structural feature of various pharmacologically important compounds with activities like antimicrobial, sedative-hypnotic, anticonvulsant, analgesic, anti-inflammatory, antiplatelet, anticancer, antisecretory, antiulcer, antidepressant, neuroleptic, immunosuppressant, cardiotonic, vasodilator, antiarrhythmic, and hypocholesterolaemic. Safety of 4,6-Dichloro-3-phenylpyridazine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

 

Donohoe, Timothy J.’s team published research in Tetrahedron in 2009 | CAS: 62567-44-6

3-Ethoxypyridazine(cas: 62567-44-6) belongs to pyridazine derivatives.The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazines are also important because of their utility in synthetic organic chemistry and in physical organic chemistry.There are reports available for the synthesis of pyridazine and their derivatives by using 2-oxoaldehyes.Application of 62567-44-6

Application of 62567-44-6On October 31, 2009 ,《Ring-closing metathesis for the synthesis of heteroaromatics: evaluating routes to pyridines and pyridazines》 appeared in Tetrahedron. The author of the article were Donohoe, Timothy J.; Bower, John F.; Basutto, Jose A.; Fishlock, Lisa P.; Procopiou, Panayiotis A.; Callens, Cedric K. A.. The article conveys some information:

Ring-closing olefin metathesis (RCM) has been applied to the efficient synthesis of densely and diversely substituted pyridine and pyridazine frameworks. Routes to suitable metathesis precursors have been investigated and the scope of the metathesis step has been probed. The metathesis products function as precursors to the target heteroaromatic structures via elimination of a suitable leaving group, which also facilitates earlier steps by serving as a protecting group at nitrogen. Further functionalization of the metathesis products is possible both prior to and after aromatization. The net result is a powerful strategy for the de novo synthesis of highly substituted heteroaromatic scaffolds. In the experiment, the researchers used 3-Ethoxypyridazine(cas: 62567-44-6Application of 62567-44-6)

3-Ethoxypyridazine(cas: 62567-44-6) belongs to pyridazine derivatives.The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazines are also important because of their utility in synthetic organic chemistry and in physical organic chemistry.There are reports available for the synthesis of pyridazine and their derivatives by using 2-oxoaldehyes.Application of 62567-44-6

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

 

Haider, N.’s team published research in Science of Synthesis in 2004 | CAS: 62567-44-6

3-Ethoxypyridazine(cas: 62567-44-6) belongs to pyridazine derivatives.The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazines are also important because of their utility in synthetic organic chemistry and in physical organic chemistry.There are reports available for the synthesis of pyridazine and their derivatives by using 2-oxoaldehyes.Category: pyridazine

《Product class 8: pyridazines》 was published in Science of Synthesis in 2004. These research results belong to Haider, N.; Holzer, W.. Category: pyridazine The article mentions the following:

A review. Methods of preparing pyridazines are reviewed including cyclization, ring transformation, aromatization, and substituent modification. The experimental process involved the reaction of 3-Ethoxypyridazine(cas: 62567-44-6Category: pyridazine)

3-Ethoxypyridazine(cas: 62567-44-6) belongs to pyridazine derivatives.The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazines are also important because of their utility in synthetic organic chemistry and in physical organic chemistry.There are reports available for the synthesis of pyridazine and their derivatives by using 2-oxoaldehyes.Category: pyridazine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

 

Stadlbauer, W.’s team published research in Synthesis in 1989 | CAS: 40020-05-1

4,6-Dichloro-3-phenylpyridazine(cas: 40020-05-1) belongs to pyridazine. The pyridazine moiety is an important structural feature of various pharmacologically important compounds with activities like antimicrobial, antiplatelet, anticancer, antisecretory, analgesic, anti-inflammatory, antiulcer, antidepressant, neuroleptic, sedative-hypnotic, anticonvulsant, immunosuppressant, cardiotonic, vasodilator, antiarrhythmic, and hypocholesterolaemic. HPLC of Formula: 40020-05-1

HPLC of Formula: 40020-05-1On October 31, 1989 ,《Organic azides in heterocyclic synthesis. Part 9. Ring closure of 4-azido-3-phenylpyridazines to pyridazino[4,3-b]indoles》 was published in Synthesis. The article was written by Stadlbauer, W.; Pfaffenschlager, A.; Kappe, T.. The article contains the following contents:

The cyclization of 4-azido-3-phenylpyridazines I (R = Cl, OH) and 7-azido-6-phenyltetrazolo[1,5-b]pyridazine II by heating with strong acids like MeSO3H affords 5H-pyridazino[4,3-b]indoles III or 10H-tetrazolo[1′,5′:1,6]pyridazino[4,3-b]indole IV, resp., whereas conventional photochem. and thermolytic methods fail. In the experiment, the researchers used many compounds, for example, 4,6-Dichloro-3-phenylpyridazine(cas: 40020-05-1HPLC of Formula: 40020-05-1)

4,6-Dichloro-3-phenylpyridazine(cas: 40020-05-1) belongs to pyridazine. The pyridazine moiety is an important structural feature of various pharmacologically important compounds with activities like antimicrobial, antiplatelet, anticancer, antisecretory, analgesic, anti-inflammatory, antiulcer, antidepressant, neuroleptic, sedative-hypnotic, anticonvulsant, immunosuppressant, cardiotonic, vasodilator, antiarrhythmic, and hypocholesterolaemic. HPLC of Formula: 40020-05-1

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

 

Kappe, T.’s team published research in Synthesis in 1989 | CAS: 40020-05-1

4,6-Dichloro-3-phenylpyridazine(cas: 40020-05-1) belongs to pyridazine. The pyridazine moiety is an important structural feature of various pharmacologically important compounds with activities like antimicrobial, neuroleptic, sedative-hypnotic, analgesic, anti-inflammatory, antiplatelet, anticancer, antisecretory, antiulcer, antidepressant, anticonvulsant, immunosuppressant, cardiotonic, vasodilator, antiarrhythmic, and hypocholesterolaemic. Synthetic Route of C10H6Cl2N2

Synthetic Route of C10H6Cl2N2On September 30, 1989 ,《Organic azides in heterocyclic synthesis. 8. Synthesis of aminopyridazines from Azidopyridazines and tetrazolo[1,5-b]pyridazines》 was published in Synthesis. The article was written by Kappe, T.; Pfaffenschlager, A.; Stadlbauer, W.. The article contains the following contents:

Azidopyridazines and tetrazolo[1,5-b]pyridazines can be converted to the corresponding aminopyridazines, by reaction with triphenylphosphine via phosphazenes and subsequent hydrolysis (Staudinger reaction). In addition to this study using 4,6-Dichloro-3-phenylpyridazine, there are many other studies that have used 4,6-Dichloro-3-phenylpyridazine(cas: 40020-05-1Synthetic Route of C10H6Cl2N2) was used in this study.

4,6-Dichloro-3-phenylpyridazine(cas: 40020-05-1) belongs to pyridazine. The pyridazine moiety is an important structural feature of various pharmacologically important compounds with activities like antimicrobial, neuroleptic, sedative-hypnotic, analgesic, anti-inflammatory, antiplatelet, anticancer, antisecretory, antiulcer, antidepressant, anticonvulsant, immunosuppressant, cardiotonic, vasodilator, antiarrhythmic, and hypocholesterolaemic. Synthetic Route of C10H6Cl2N2

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

 

Luraschi, Elena’s team published research in Farmaco in 1997-04-30 | 64067-99-8

Farmaco published new progress about Analgesics. 64067-99-8 belongs to class pyridazine, and the molecular formula is C9H8ClN3O2, Recommanded Product: Ethyl 6-chloroimidazo[1,2-b]pyridazine-2-carboxylate.

Luraschi, Elena; Arena, Francesca; Sacchi, Antonia; Laneri, Sonia; Abignente, Enrico; Avallone, Lucia; D’amico, Michele; Berrino, Libero; Rossi, Francesco published the artcile< Research on heterocyclic compounds. XXXVIII. Synthesis and pharmacological activity of imidazo[1,2-b]pyridazine-2-carboxylic derivatives>, Recommanded Product: Ethyl 6-chloroimidazo[1,2-b]pyridazine-2-carboxylate, the main research area is imidazopyridinecarboxylic acid derivative preparation antiinflammatory structure.

A series of imidazo[1,2-b]pyridazine-2-carboxylic acids, esters and amides was synthesized and tested for antiinflammatory, analgesic and ulcerogenic activities. The Et esters were prepared by cyclocondensation of some 3-aminopyridazines with Et bromopyruvate, followed by hydrolysis or ammonolysis to obtain the corresponding acids and amides. The inhibitory activity on the carrageenan-induced edema in the rat paw and on writhes induced by acetic acid in mice was evaluated, as well as the ulcerogenic action on the rat gastric mucosa. The pharmacol. activity was discussed in terms of structure-activity relationships. In particular, the analgesic activity shown by these carboxylic derivatives was compared with that found in other series of imidazo[1,2-b]pyridazine analogs previously examined

Farmaco published new progress about Analgesics. 64067-99-8 belongs to class pyridazine, and the molecular formula is C9H8ClN3O2, Recommanded Product: Ethyl 6-chloroimidazo[1,2-b]pyridazine-2-carboxylate.

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

 

Plate, A F’s team published research in Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya in 1956 | 20744-39-2

Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya published new progress about Bond. 20744-39-2 belongs to class pyridazine, and the molecular formula is C4H5N3, SDS of cas: 20744-39-2.

Plate, A. F.; Belikova, N. A.; Egorov, Yu. P. published the artcile< Reaction of five- and six-membered silicohydrocarbons with an atom of silicon in the ring with concentrated sulfuric acid>, SDS of cas: 20744-39-2, the main research area is .

Concentrated H2SO4 caused a rupture of the C-Si bond in cyclic 5-6 membered silanes; the 5-membered ring was somewhat more stable. The method of West (C.A. 49, 14767b) gave 26.6% Si[(CH2)4]2, b750 173-4°, nD20 1.4863, d20 0.9043, m. -52°. This (4.3 g.) shaken 6 hrs. at room temperature with 11.7 g. concentrated H2SO4 gave 4 g. [Bu(CH2)4Si]2O, 90%, b751 293.5-94°, nD20 1.4670, d20 0.9125. Similarly [Et(CH2)4Si]2O in 10 hrs. gave 60% sym-tetraethyltetrabutylcyclotetrasiloxane, b10 194-6°, nD20 1.4422, d20 0.9286. To the Grignard reagent from 37 g. Mg and 161 g. (CH2)5Br2 was added at once at 5° 90 g. Me2SiCl2 in 1 l. Et2O and, after refluxing 15 hrs. and treatment with H2O, there was obtained after distillation and chromatographic purification on silica, 26.7% Me2Si(CH2)5, b740 131.2-1.3°, nD20 1.4428, d20 0.8111, Raman spectrum (cm.-1) 105(15), 146(30), 203(70), 238(18), 253(15), 334(25), 371(10), 482(10), 585(200), 632(5), 663(2), 694(15), 724(15), 741(5), 794(40), 833(3), 908(30), 950(3), 990(8), 1006(40), 1037(2), 1080(12), 1098(10), 1134(15), 1180(19), 1193(15), 1251(15), 1268(12), 1291(15), 1333(7), 1408(15), 1445(25), 1460(10), 2846(75), 2874(20), 2900(125), 2928(15), 2965(50). This shaken with H2SO4 13.5 hrs. gave some CH4 and 85% mixed disiloxanes (I), presumably sym-diamyltetramethyldisiloxane, sym-dimethylbispentamethylenedisiloxane, and AmMe2SiOSiMe(CH2)5. Presumably the cleavage of the rings took place through formation of intermediate sulfate ester of the resulting silanol, and with a 6-membered ring it could take place in 2 possible directions as shown. Si[(CH2)4]2 had Raman spectrum: 242(15), 305(60), 591(25), 618(55), 668(15), 726(10), 757(5), 782(5), 854(60), 946(30), 1026(35), 1068 (12), 1156(20), 1200(7), 1254(25), 1340(5), 1414(25), 1457(35), 2854(120), 2870(35). 2895(135), 2945(275). sym-Tetramethyldiamyldisiloxane has Raman spectrum: 170 (2) 200(4), 479(1), 540(6), 652(5), 682(5), 705(3), 763(1), 767(1), 838(0), 895(4), 922(1), 956(4), 1026(3), 1070(3), 1102(43), 1135(4), 1186(6), 1245(4), 1262(1), 1304(6), 1336(1), 1380(1), 1410(5), 1443(7), 1456(5), 2858(5), 2882(5), 2904(10), 2965(10). I, b. 245-52°, nD20 1.4430, d20 0.8681, was presumed to have the above indicated composition on the basis of elemental analysis and Raman spectrum.

Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya published new progress about Bond. 20744-39-2 belongs to class pyridazine, and the molecular formula is C4H5N3, SDS of cas: 20744-39-2.

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem