Category: pyridazine

Deyrup, J. A.; Gingrich, H. L. published the artcile< Cycloadditions of 4-oxazolin-2-ones>, Product Details of C4H5N3, the main research area is oxazolinone cycloaddition cyclopentadiene anthracene; chloranil cycloaddition oxazolinone; tetrazine pyridyl cycloaddition oxazolinone.

The 4-oxazolin-2-ones I (R = H, Ac, R1 = H; R = Ac, R1 = Ph) underwent cycloaddition reactions with a variety of cyclic unsaturated compounds, e.g. cyclopentadiene, o-chloranil, anthracene. E.g., I (R = Ac, R1 = H) with anthracene in o-xylene at 144° for 72 h gave 87% adduct II. Hydrolysis of II in refluxing alc. aqueous NaOH gave 74% amino alc. III.

Tetrahedron Letters published new progress about Cycloaddition reaction. 20744-39-2 belongs to class pyridazine, and the molecular formula is C4H5N3, Product Details of C4H5N3.

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Barlin, Gordon B. published the artcile< Methylation of aminopyridazines>, HPLC of Formula: 20744-39-2, the main research area is methylation aminopyridazine; pyridazine amino methylation; aminopyridazinium iodide UV NMR; acidity aminopyridazine.

Treatment of 3- and 4-amino- and 3,5-diaminopyridazine with MeI in MeOH gave mixtures of the corresponding 1- and 2-methyl iodides whereas 3,4-, 3,6-, and 4,5-diaminopyridazines gave only one methiodide, in the first case identified as 3,4-diamino-1-methylpyridazinium iodide. No ammonio compounds were detected. The ionization constants and uv and PMR spectra of the pyridazines, their methiodides, and related compounds were determined and discussed.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about Acidity. 20744-39-2 belongs to class pyridazine, and the molecular formula is C4H5N3, HPLC of Formula: 20744-39-2.

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Moriya, Koichi; Shibuya, Katsuhiko; Hattori, Yumi; Tsuboi, Shinichi; Shiokawa, Kozo; Kagabu, Shinzo published the artcile< Imidacloprid and analogous insecticides. IV. 1-Diazinylmethyl-2-nitromethylene- and 2-nitroimino-imidazolidines as new potential insecticides>, Synthetic Route of 120276-59-7, the main research area is diazinylmethyl imidazolidine insecticide.

Eight 1-diazinylmethylimidazolidines were prepared and their insecticidal activities were studied. 1-(2-Chloro-5-pyrimidinyl)methyl-2-(nitroimino)imidazolidine (I) was as effective as imidacloprid against green rice leafhoppers on rice seedlings in spray applications. Seven 1-(diazinylmethyl)-2-(nitromethylene)imidazolidines with or without a Cl or Me substituent on the diazine ring were less effective than I.

Nippon Noyaku Gakkaishi published new progress about Insecticides. 120276-59-7 belongs to class pyridazine, and the molecular formula is C5H4Cl2N2, Synthetic Route of 120276-59-7.

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Dong, Jianyang; Yue, Fuyang; Xu, Wentao; Song, Hongjian; Liu, Yuxiu; Wang, Qingmin published the artcile< Visible-light-mediated Minisci C-H alkylation of heteroarenes with 4-alkyl-1,4-dihydropyridines using O2 as an oxidant>, Computed Properties of 64067-99-8, the main research area is alkylated heteroarene green preparation; heteroarene alkyl dihydropyridine alkylation iridium photocatalyst.

A protocol for direct visible-light-mediated Minisci C-H alkylation reactions of N-heteroarenes with 4-alkyl-1,4-dihydropyridines for synthesis of alkylated N-heteroarenes such as I at room temperature with mol. oxygen as an oxidant was reported. The protocol permitted efficient functionalization of various N-heteroarenes with a broad range of cyclic and acyclic primary, secondary and tertiary alkyl groups and was scalable to the gram level. This mild protocol used an inexpensive, green oxidant and was suitable for late-stage C-H alkylation of complex nitrogen-containing mols. Its utility was demonstrated by preparing or functionalizing several pharmaceuticals and natural products.

Green Chemistry published new progress about Dihydropyridines Role: RCT (Reactant), RACT (Reactant or Reagent). 64067-99-8 belongs to class pyridazine, and the molecular formula is C9H8ClN3O2, Computed Properties of 64067-99-8.

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Lambert, William T.; Buysse, Ann M.; Wessels, Frank J. published the artcile< Discovery of novel insecticidal 3-aminopyridyl ureas>, Name: Pyridazin-4-amine, the main research area is aminopyridyl urea insecticidal synthesis activity; Bemisia tabaci; Myzus persicae; agrochemical discovery; commercial compounds; insecticidal spectrum; insecticide discovery; structure-activity relationship (SAR); urea.

Com. compound databases represent rich sources of potential starting points for pharmaceutical and agrochem. product development. Routine insecticidal screening of compounds ordered from these sources led to the identification of a 3-aminopyridyl urea with activity against Myzus persicae (Sulzer) (green peach aphid). Based on this activity and its structural novelty, further exploration of the chem. space around this hit was initiated. A series of ureas based on the structure of the initial hit were synthesized and screened for insecticidal activity. A broad range of tail groups derived from cyclic secondary amines were explored, and many of these compounds were found to be insecticidally active. However, only compounds featuring a 3-aminopyridine or 4-aminopyridazine head group exhibited significant insecticidal potency. Although activity against M. persicae was consistently observed, these ureas were largely inactive against another key sap-feeding insect pest, Bemisia tabaci (Glennadius) (sweetpotato whitefly). Follow-up of an insecticide hit identified from com. compound acquisition led to the discovery of a novel class of ureas with activity against M. persicae. Despite considerable effort to identify related compounds with addnl. insecticidal spectrum, however, activity on other important pests remains limited.

Pest Management Science published new progress about Bemisia tabaci. 20744-39-2 belongs to class pyridazine, and the molecular formula is C4H5N3, Name: Pyridazin-4-amine.

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Hamaguchi, Wataru; Masuda, Naoyuki; Isomura, Mai; Miyamoto, Satoshi; Kikuchi, Shigetoshi; Amano, Yasushi; Honbou, Kazuya; Mihara, Takuma; Watanabe, Toshihiro published the artcile< Design and synthesis of novel benzimidazole derivatives as phosphodiesterase 10A inhibitors with reduced CYP1A2 inhibition>, Recommanded Product: Pyridazin-4-amine, the main research area is benzimidazole derivative preparation phosphodiesterase 10A inhibitor; Benzimidazole; CYP1A2; PDE10A inhibitor; Schizophrenia.

A novel class of phosphodiesterase 10A (PDE10A) inhibitors with reduced CYP1A2 inhibition were designed and synthesized starting from 2-{[(1-phenyl-1H-benzimidazol-6-yl)oxy]methyl}quinoline I. Introduction of an iso-Pr group at the 2-position and a methoxy group at the 5-position of the benzimidazole ring of lead compound 1 resulted in the identification of 2-{[(2-isopropyl-5-methoxy-1-phenyl-1H-benzimidazol-6-yl)oxy]methyl}quinoline II, which exhibited potent PDE10A inhibitory activity with reduced CYP1A2 inhibitory activity compared to compound 1.

Bioorganic & Medicinal Chemistry published new progress about Benzimidazoles Role: SPN (Synthetic Preparation), PREP (Preparation). 20744-39-2 belongs to class pyridazine, and the molecular formula is C4H5N3, Recommanded Product: Pyridazin-4-amine.

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Jiang, Li-wen; Zheng, Bing-fu; Li, Bai-yu; Chen, Dong-ming published the artcile< Analysis of the volatile substances in Psophocarpus tetragonolobus D. C seeds>, Recommanded Product: Pyridazin-4-amine, the main research area is natural product Psophocarpus volatile substances gas chromatog mass spectrometry.

The aim was to analyze volatile substances from Psophocarpus tetragonolobus D. C seeds, so as to provide a basis for the better utilization of this resources. Volatile substances extracted from Psophocarpus tetragonolobus D. C seeds were identified by GC-MS, and their relative contents were determined by area normalization method. A total of 125 kinds of compounds were identified from 4 varies of P. tetragonolobus seeds, which belonged to alkanes, alkenes, acids, aromatic compounds, esters, ketones, ethers and heterocyclic compounds Moreover each variety of seeds had 42 volatile substances, which were mainly ketones, alc., esters and so on. There were no significant differences in the types and total amount of volatile substances from P. tetragonolobus seeds among different varieties, but their relative contents differed obviously. The differences of volatile substances formed their own characteristic flavors, which could contribute to products variation in the processing of P. tetragonolobus.

Medicinal Plant published new progress about Acids Role: ANT (Analyte), ANST (Analytical Study). 20744-39-2 belongs to class pyridazine, and the molecular formula is C4H5N3, Recommanded Product: Pyridazin-4-amine.

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Liu, Shaohua; He, Peixin; Tian, Zhaofu; Li, Xiaolan; Xu, Chunping published the artcile< Ultrasound-assisted extraction and characterization of pectic polysaccharide from oriental tobacco leaves>, Recommanded Product: Pyridazin-4-amine, the main research area is Nicotiana leaf pectic polysaccharide thermal stability antioxidant.

Ultrasound-assisted extraction (UAE) of pectic polysaccharide from oriental tobacco leaves was studied by orthogonal matrix method (L9(3)4). Furthermore, the crude polysaccharide was purified and two components (Fr-I and Fr-II) were obtained. FT-IR spectral anal. of the purified EPS revealed prominent characteristic groups. The monosaccharide composition anal. indicated the main composition between Fr-I and Fr-II was different. Furthermore, thermo gravimetric anal. (TGA) indicated the degradation temperature (Td) of the Fr-I (215 °C) was higher than those of Fr-II (162 °C). Detected by the pyrolysis GC/MS, though the main kinds of pyrolysis products from both Fr-I and Fr-II were similar, the larger amount of heterocycle and aromatic compounds liberated after hydrolysis of Fr-II. Finally, On the basis of the antioxidant activity test in vitro, Fr-II has stronger antioxidant activities than Fr-I. The thermal behavior and antioxidant activity might be attributed to the configuration of the sugar units and chem. compositions

Journal of the Chemical Society of Pakistan published new progress about Antioxidants. 20744-39-2 belongs to class pyridazine, and the molecular formula is C4H5N3, Recommanded Product: Pyridazin-4-amine.

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Mason, S. F. published the artcile< Frequencies and intensities of the NH stretching vibrations in primary amines>, Name: Pyridazin-4-amine, the main research area is .

The positions, extinction coefficients, and band half-widths of the symmetric and antisymmetric stretching vibration absorptions of the amide anion, and some monocyclic aliphatic, aromatic, and N-heteroaromatic primary amines were measured in the 3-μ region. Approx. values for the force constants, HHH bond angles, the “”s”” character of the hybrid orbitals bonding N to H, and the NH bond dipole gradients were calculated from the results. The force constant and the NH bond dipole gradient increase linearly with the amount of “”s”” character of the hybrid orbitals of the NH group, and in the aromatic series, these quantities increase as the π-electron charge d. on the N atom of the amino-group falls. Compound, solvent, symmetric, and antisymmetric frequency (in cm.-1) and force constant (in dyne/cm.) given: LiNH2, KBr, 3315, 3261, 5.99; cyclohexylamine, CCl4, 3381, 3316, 6.21; PhNH2, CCl4, 3481, 3395, 6.54; 2-aminopyridine (I), CCl4, 3509, 3410, 6.62; 3 analog of I, CCl4, 3481, 3396, 6.54; 4 analog of I, CCl4, 3505, 3413, 6.62; 2-aminopyrimidine (II), CCl4, 3540, 3425, 6.72; 4,6-Me2-II, CHCl3, 3533, 3422, 6.69; 4 analog of II, CCl4, 3536, 3421, 6.70; 5 analog of II, CCl4, 3485, 3399, 6.56; 2-aminopyrazine, CCl4, 3511, 3410, 6.62; 3-amino-6-methylpyridazine, CHCl3, 3509, 3407, 6.62; 4-aminopyridazine, 3514, 3415, 6.64; 3-amino-1,2,4-triazine (III), 3533, 3420, 6.70; 5,6-Me2-III, 3534, 3423, 6.68.

Journal of the Chemical Society published new progress about Amines. 20744-39-2 belongs to class pyridazine, and the molecular formula is C4H5N3, Name: Pyridazin-4-amine.

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Scholz, U.; Schlummer, B. published the artcile< Arylamines>, Application In Synthesis of 20744-39-2, the main research area is review arylamine preparation organic synthesis.

A review of methods to prepare arylamines.

Science of Synthesis published new progress about Aromatic amines Role: SPN (Synthetic Preparation), PREP (Preparation). 20744-39-2 belongs to class pyridazine, and the molecular formula is C4H5N3, Application In Synthesis of 20744-39-2.

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem