Category: pyridazine

Berlin, Michael’s team published research in Bioorganic & Medicinal Chemistry Letters in 20 | CAS: 50901-42-3

Bioorganic & Medicinal Chemistry Letters published new progress about 50901-42-3. 50901-42-3 belongs to pyridazine, auxiliary class Pyridazine,Aldehyde, name is Pyridazine-4-carbaldehyde, and the molecular formula is C5H4N2O, Application of Pyridazine-4-carbaldehyde.

Berlin, Michael published the artcileReduction of hERG inhibitory activity in the 4-piperidinyl urea series of H3 antagonists, Application of Pyridazine-4-carbaldehyde, the publication is Bioorganic & Medicinal Chemistry Letters (2010), 20(7), 2359-2364, database is CAplus and MEDLINE.

Structural features of the substituted 4-piperidinyl urea analogs, e.g., I, responsible for the H3 antagonist activity, have been identified. Structure-activity relationship of the H3 receptor affinity, hERG ion channel inhibitory activity and their separation is described. Preliminary pharmacokinetic evaluation of some of the compounds of the series is addressed.

Bioorganic & Medicinal Chemistry Letters published new progress about 50901-42-3. 50901-42-3 belongs to pyridazine, auxiliary class Pyridazine,Aldehyde, name is Pyridazine-4-carbaldehyde, and the molecular formula is C5H4N2O, Application of Pyridazine-4-carbaldehyde.

Referemce:
https://en.wikipedia.org/wiki/Pyridazine,
Pyridazine | C4H4N2 – PubChem

 

Piras, Sandra’s team published research in Farmaco in 48 | CAS: 89532-79-6

Farmaco published new progress about 89532-79-6. 89532-79-6 belongs to pyridazine, auxiliary class Pyridazine,Alcohol,Ether, name is (6-Methoxypyridazin-3-yl)methanol, and the molecular formula is C6H8N2O2, Safety of (6-Methoxypyridazin-3-yl)methanol.

Piras, Sandra published the artcileSynthesis and evaluation of gastroprotective activity of omeprazole-related benzimidazole, imidazo[4,5-b]pyridine and quinoxaline 2-substituted derivatives, Safety of (6-Methoxypyridazin-3-yl)methanol, the publication is Farmaco (1993), 48(9), 1249-59, database is CAplus and MEDLINE.

Twenty title compounds, bearing either a substituted arylmethylmercapto group or an arylmethylsulfinyl group in position 2, were prepared (general methods given) in order to evaluate their antiulcer and gastroprotective activity in rats with a ligated pylorus, in comparison with omeprazole (50 mg/kg, i.m.). Approx. one-third of these compounds had a moderate activity, being about half as potent as omeprazole. Some structure-activity parameters are briefly discussed.

Farmaco published new progress about 89532-79-6. 89532-79-6 belongs to pyridazine, auxiliary class Pyridazine,Alcohol,Ether, name is (6-Methoxypyridazin-3-yl)methanol, and the molecular formula is C6H8N2O2, Safety of (6-Methoxypyridazin-3-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Pyridazine,
Pyridazine | C4H4N2 – PubChem

 

Heinisch, G.’s team published research in Monatshefte fuer Chemie in 105 | CAS: 50901-42-3

Monatshefte fuer Chemie published new progress about 50901-42-3. 50901-42-3 belongs to pyridazine, auxiliary class Pyridazine,Aldehyde, name is Pyridazine-4-carbaldehyde, and the molecular formula is C5H4N2O, Safety of Pyridazine-4-carbaldehyde.

Heinisch, G. published the artcileSyntheses and reactions of pyridazine derivatives. V. Thermal disproportionation of pyridazinyl-4-carbinols, Safety of Pyridazine-4-carbaldehyde, the publication is Monatshefte fuer Chemie (1974), 105(4), 763-71, database is CAplus.

Pyridazinecarbinols I (R1 = Me, Ph, 4-pyridazinylmethyl) disproportionated at 120° into the ketones II and alkanes III. The mechanism of the disproportionation was discussed. I (R1 = 4-pyridazinylmethyl) was prepared by treating 4-methylpyridazine with Et 4-pyridazinecarboxylate and Me3COK and reducing II (R1 = 4-pyridazinylmethyl). SeO2 oxidation of III (R1 = 4-pyridazinylmethyl) gave trans-1,2-bis(4-pyridazinyl)ethene. Condensation of 4-formylpyridazine with acetone gave 1-(4-pyridazinyl)-1,3-butanedione.

Monatshefte fuer Chemie published new progress about 50901-42-3. 50901-42-3 belongs to pyridazine, auxiliary class Pyridazine,Aldehyde, name is Pyridazine-4-carbaldehyde, and the molecular formula is C5H4N2O, Safety of Pyridazine-4-carbaldehyde.

Referemce:
https://en.wikipedia.org/wiki/Pyridazine,
Pyridazine | C4H4N2 – PubChem

 

Heinisch, G.’s team published research in Monatsh. Chem. in 104 | CAS: 50901-42-3

Monatsh. Chem. published new progress about 50901-42-3. 50901-42-3 belongs to pyridazine, auxiliary class Pyridazine,Aldehyde, name is Pyridazine-4-carbaldehyde, and the molecular formula is C5H4N2O, Computed Properties of 50901-42-3.

Heinisch, G. published the artcileSyntheses and reactions of pyridazine derivatives. 3. Pyridazine-4-carboxaldehyde, Computed Properties of 50901-42-3, the publication is Monatsh. Chem. (1973), 104(5), 1372-82, database is CAplus.

4-Pyridazine-carboxaldehyde (I) was prepared by treating 4-methylpyridazine with PhCHO and OsO4 oxidation of the resulting 4-styrylpyridazine. I underwent a variety of reactions with amines and CH-acids, as well as the Cannizzaro reaction.

Monatsh. Chem. published new progress about 50901-42-3. 50901-42-3 belongs to pyridazine, auxiliary class Pyridazine,Aldehyde, name is Pyridazine-4-carbaldehyde, and the molecular formula is C5H4N2O, Computed Properties of 50901-42-3.

Referemce:
https://en.wikipedia.org/wiki/Pyridazine,
Pyridazine | C4H4N2 – PubChem

 

Cookson, R. F.’s team published research in Journal of the Chemical Society, Perkin Transactions 10: Physical Organic Chemistry in 1972 | CAS: 7145-60-0

Journal of the Chemical Society, Perkin Transactions 10: Physical Organic Chemistry published new progress about Ionization. 7145-60-0 belongs to class pyridazine, name is 6-Chloro-N,N-dimethylpyridazin-3-amine, and the molecular formula is C6H8ClN3, Formula: C6H8ClN3.

Cookson, R. F. published the artcileBasicities of pyridazine derivatives, Formula: C6H8ClN3, the main research area is Hammett basicity pyridazine; pyridazone oxygen protonation Hammett; protonation pyridazine mechanism.

The Hammett free-energy relation was used to correlate the differences in basicity of six 3-(dimethylamino)pyridazines, five 3-chloropyridazines, and seven 3-pyridazones with substituent constants; protonation occurred meta to the Me2N group of the (dimethylamino)-pyridazines, ortho to the Cl of the chloropyridazines, and on the exocyclic O of the pyridazones.

Journal of the Chemical Society, Perkin Transactions 10: Physical Organic Chemistry published new progress about Ionization. 7145-60-0 belongs to class pyridazine, name is 6-Chloro-N,N-dimethylpyridazin-3-amine, and the molecular formula is C6H8ClN3, Formula: C6H8ClN3.

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

 

Crossland, Ingolf’s team published research in Acta Chemica Scandinavica (1947-1973) in 1967 | CAS: 7145-60-0

Acta Chemica Scandinavica (1947-1973) published new progress about Amination. 7145-60-0 belongs to class pyridazine, name is 6-Chloro-N,N-dimethylpyridazin-3-amine, and the molecular formula is C6H8ClN3, Product Details of C6H8ClN3.

Crossland, Ingolf published the artcileDimethylamination of chloropyridazines, Product Details of C6H8ClN3, the main research area is PYRIDAZINES CHLORO AMINATION.

3,6-Dichloropyridazine, 4-methyl-3,6-dichloropyridazine, the 2 trichloropyridazines, and tetrachloropyridazine are treated with aqueous Me2NH in EtOH at reflux temperature In no case is more than 1 dimethylamino group introduced, the 4- (or 5-) position being substituted in the tri- and tetra-chlorinated pyridazines. The reaction products are reductively dehalogenated and subsequently identified by N.M.R. anal. The Cl atoms ortho to the dimethylamino group are preferentially eliminated by hydrogenolysis.

Acta Chemica Scandinavica (1947-1973) published new progress about Amination. 7145-60-0 belongs to class pyridazine, name is 6-Chloro-N,N-dimethylpyridazin-3-amine, and the molecular formula is C6H8ClN3, Product Details of C6H8ClN3.

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

 

Matsumoto, Kiyoshi’s team published research in Synthetic Communications in 1992-03-31 | CAS: 7145-60-0

Synthetic Communications published new progress about Amination. 7145-60-0 belongs to class pyridazine, name is 6-Chloro-N,N-dimethylpyridazin-3-amine, and the molecular formula is C6H8ClN3, Safety of 6-Chloro-N,N-dimethylpyridazin-3-amine.

Matsumoto, Kiyoshi published the artcileSelectivity in consecutive SNAr-dequaternization reactions of chlorodiazines with tertiary amines, Safety of 6-Chloro-N,N-dimethylpyridazin-3-amine, the main research area is dequaternization reaction chloropyrimidine tertiary amine; chloropyrimidine amination tertiary amine; dealkylation tertiary amine amination chlorodiazine; alkylmethylaminodiazine; diazine alkylmethylamino.

Consecutive SNAr-dealkylation reactions of chlorodiazines, such as, 2-chloropyrimidine (I) and 3,6-dichloropyridazine, with tertiary amines took place in a highly selective fashion. Thus, I was treated with Me2N(CH2)7Me in THF at 100° under 8 kbar pressure to give 97% 2-(methyloctylamino)pyrimidine (II) and 2% 2-(dimethylamino)pyrimidine (III).

Synthetic Communications published new progress about Amination. 7145-60-0 belongs to class pyridazine, name is 6-Chloro-N,N-dimethylpyridazin-3-amine, and the molecular formula is C6H8ClN3, Safety of 6-Chloro-N,N-dimethylpyridazin-3-amine.

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

 

Cookson, R. F.’s team published research in Journal of the Chemical Society, Perkin Transactions 9: Physical Organic Chemistry in 1972 | CAS: 7145-60-0

Journal of the Chemical Society, Perkin Transactions 9: Physical Organic Chemistry published new progress about Hammett basicity pyridazine; pyridazone oxygen protonation Hammett; protonation pyridazine mechanism. 7145-60-0 belongs to class pyridazine, name is 6-Chloro-N,N-dimethylpyridazin-3-amine, and the molecular formula is C6H8ClN3, Application of 6-Chloro-N,N-dimethylpyridazin-3-amine.

Cookson, R. F. published the artcileBasicities of pyridazine derivatives, Application of 6-Chloro-N,N-dimethylpyridazin-3-amine, the main research area is Hammett basicity pyridazine; pyridazone oxygen protonation Hammett; protonation pyridazine mechanism.

The Hammett free-energy relation was used to correlate the differences in basicity of six 3-(dimethylamino)pyridazines, five 3-chloropyridazines, and seven 3-pyridazones with substituent constants; protonation occurred ortho to the Me2N group of the (dimethylamino)pyridazines, meta to the Cl of the chloropyridazines, and on the exocyclic O of the pyridazones.

Journal of the Chemical Society, Perkin Transactions 9: Physical Organic Chemistry published new progress about Hammett basicity pyridazine; pyridazone oxygen protonation Hammett; protonation pyridazine mechanism. 7145-60-0 belongs to class pyridazine, name is 6-Chloro-N,N-dimethylpyridazin-3-amine, and the molecular formula is C6H8ClN3, Application of 6-Chloro-N,N-dimethylpyridazin-3-amine.

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

 

Assandri, A.’s team published research in Xenobiotica in 1985-12-31 | CAS: 17259-32-4

Xenobiotica published new progress about MDL 899 metabolism; pyrrolylpyridazinamine metabolism. 17259-32-4 belongs to class pyridazine, name is 4-(6-Chloropyridazin-3-yl)morpholine, and the molecular formula is C8H10ClN3O, Quality Control of 17259-32-4.

Assandri, A. published the artcileMetabolic pathways of the antihypertensive agent, N-(2,5-dimethyl-1H-pyrrol-1-yl)-6-(4-morpholinyl)-3-pyridazinamine hydrochloride. I. Studies in the rat, Quality Control of 17259-32-4, the main research area is MDL 899 metabolism; pyrrolylpyridazinamine metabolism.

The metabolic fate of a new antihypertensive, MDL 899 (I) [86703-02-8] was studied in rats after both oral and i.v. administration (1 mg/kg). The compound underwent rapid metabolism, disappearing from the central compartment with a half-life of about 0.5 h. Plasma concentration of the parent drug and its major metabolite II  [100499-32-9] following i.v. and oral administration suggest a route-dependent first-pass metabolism Ten metabolites were isolated from the urine and identified by u.v., i.r., mass and 1H NMR spectroscopy. The structure of some was confirmed by 13C NMR and chem. synthesis. All biotransformations are restricted to the pyrrole ring which undergoes oxidative cleavage followed by a series of chem. rearrangements. A minor pathway leads to the formation of Me sulphinyl and Me sulfonyl pyrroles. It is suggested that, as with natural indoles, the pyrrole might be oxidized by a 2,3-dioxygenase. All metabolites tested (3 major and 2 minor) failed to showed antihypertensive activity in spontaneously hypertensive rats.

Xenobiotica published new progress about MDL 899 metabolism; pyrrolylpyridazinamine metabolism. 17259-32-4 belongs to class pyridazine, name is 4-(6-Chloropyridazin-3-yl)morpholine, and the molecular formula is C8H10ClN3O, Quality Control of 17259-32-4.

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

 

Crossland, Ingolf’s team published research in Acta Chemica Scandinavica (1947-1973) in 1972 | CAS: 7145-60-0

Acta Chemica Scandinavica (1947-1973) published new progress about pyridazine Grignard adduct conformation. 7145-60-0 belongs to class pyridazine, name is 6-Chloro-N,N-dimethylpyridazin-3-amine, and the molecular formula is C6H8ClN3, Synthetic Route of 7145-60-0.

Crossland, Ingolf published the artcileDihydropyridazines. XII. Stereochemical course of protonation of pyridazine Grignard adducts, Synthetic Route of 7145-60-0, the main research area is pyridazine Grignard adduct conformation.

Three Grignard-pyridazine adducts (I,R = Me3C, R1 = MeO; R = Ph R1 = MeO; R = Me3C, R1 = Me2N) were prepared The chem. shifts and coupling constants of the 3 ring protons of I were determined and compared with the deuterated analogs. The results showed that the proton introduced during hydrolysis assumed a pseudoaxial position and thus was identical with the proton introduced by base-catalyzed exchange of II(R2 = Me3C and Ph).

Acta Chemica Scandinavica (1947-1973) published new progress about pyridazine Grignard adduct conformation. 7145-60-0 belongs to class pyridazine, name is 6-Chloro-N,N-dimethylpyridazin-3-amine, and the molecular formula is C6H8ClN3, Synthetic Route of 7145-60-0.

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem