Category: pyridazine

Reaction of methoxy-N-heteroaromatics with phenylacetonitrile under basic conditions was written by Yamanaka, Hiroshi;Ohba, Setsuya. And the article was included in Heterocycles in 1990.COA of Formula: C5H6N2O This article mentions the following:

The monomethoxy derivatives (I) of various π-electron deficient N-heteroaromatics reacted with PhCH₂CN in THF in the presence of NaH to give α-phenyl-N-heteroareneacetonitriles in 45-78% yields. Other active methylene compounds, e.g., NCCH₂CO₂Et or NCCH₂CN were less reactive towards (I) under similar conditions. The synthesis of benzoyl-N-heteroaromatics by the air oxidation of α-phenyl-N-heteroareneacetonitriles is also described. In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4COA of Formula: C5H6N2O).

3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. The activity depends upon the changes of substituted groups in the pyridazine ring system resulting in different biological activities. In addition, the natural pyrimidine bases uracil, thymine, and cytosine, which are constituents of the nucleic acids, are found to be the most important naturally occurring diazines.COA of Formula: C5H6N2O

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

3-Benzyloxy-6-fluoropyridazine was written by Hu, Fang Zhong;Zhang, Min;Song, Hai Bin;Zou, Xiao Mao;Yang, Hua Zheng. And the article was included in Acta Crystallographica, Section E: Structure Reports Online in 2005.Name: 3,6-Difluoropyridazine This article mentions the following:

The title mol., C₁₁H₉FN₂O, was synthesized from 3,6-difluoropyridazine, benzyl alc. and NaOH in MeCN under reflux. Crystallog. data are given. The asym. unit contains two independent mols. with nearly identical geometry. In the crystal structure, the mols. are linked by weak intermol. C-H···F H bonds and C-H···π interactions. In the experiment, the researchers used many compounds, for example, 3,6-Difluoropyridazine (cas: 33097-39-1Name: 3,6-Difluoropyridazine).

3,6-Difluoropyridazine (cas: 33097-39-1) belongs to pyridazine derivatives. The pyridazine structure is also found within the structure of several drugs such as cefozopran, cadralazine, minaprine, pipofezine, and hydralazine. Pyridazine is bioavailable (especially in the CNS) and can reduce toxicity. Pyridazine is a component of several drug molecules, and the pyridazine pharmacophore has contributed to a variety of pharmacologically active compounds.Name: 3,6-Difluoropyridazine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Synthesis and herbicidal activity of 3-(substituted benzyloxy)-6-(substituted amino)pyridazines was written by Hu, Fang-Zhong;Zhang, Min;Zhu, You-Quan;Zou, Xiao-Mao;Liu, Bin;Yang, Hua-Zheng. And the article was included in Youji Huaxue in 2007.Quality Control of 3,6-Difluoropyridazine This article mentions the following:

A series of new 3-(substituted benzyloxy)-6-(substituted amino)pyridazines were synthesized through the reaction of 3-(substituted benzyloxy)-6-fluoropyridazines with the solution of dimethylamine, morpholine or piperidine. The title compounds were identified by IR, ¹H NMR spectra and elemental analyses. Preliminary bioassay showed that some of them had certain extent herbicidal activities, and the structure-activity relationship was also discussed. In the experiment, the researchers used many compounds, for example, 3,6-Difluoropyridazine (cas: 33097-39-1Quality Control of 3,6-Difluoropyridazine).

3,6-Difluoropyridazine (cas: 33097-39-1) belongs to pyridazine derivatives. Pyridazines is a six-membered nitrogen-containing significant heterocycle. It has received considerable interest because of its useful applications as natural products, pharmaceuticals, and various bioactive molecules. The unsubstituted pyridazines are more resistant to eletrophilic substitution due to the nature of withdrawal of electron density from the ring by two heteroatoms, while the related electron deficiency of the ring makes pyridazine more easily attacked by nucleophiles.Quality Control of 3,6-Difluoropyridazine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Synthesis and herbicidal activity of 3-(benzyloxy)-6-fluoropyridazine derivatives was written by Zhang, Min;Hu, Fang-Zhong;Zhu, You-Quan;Zou, Xiao-Mao;Liu, Bin;Yang, Hua-Zheng. And the article was included in Youji Huaxue in 2007.Product Details of 33097-39-1 This article mentions the following:

A series of novel 3-(un)substituted benzyloxy-6-fluoropyridazine derivatives was synthesized by a reaction of various benzyl alcs. with 3,6-difluoropyridazine in CH₃CN catalyzed by NaOH. Their structures were identified by ¹H NMR, IR spectra and elemental anal. Preliminary bioassay showed that all of them possessed herbicidal activity to some extent against Brassica napus (rape) and Echinochloa crus-galli (barnyard grass). Their structure-activity relationship was discussed. In the experiment, the researchers used many compounds, for example, 3,6-Difluoropyridazine (cas: 33097-39-1Product Details of 33097-39-1).

3,6-Difluoropyridazine (cas: 33097-39-1) belongs to pyridazine derivatives. Pyridazines are rare in nature, possibly reflecting the scarcity of naturally occurring hydrazines, common building blocks for the synthesis of these heterocycles. The unsubstituted pyridazines are more resistant to eletrophilic substitution due to the nature of withdrawal of electron density from the ring by two heteroatoms, while the related electron deficiency of the ring makes pyridazine more easily attacked by nucleophiles.Product Details of 33097-39-1

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Hydrophobicity parameter of diazines. 1. Analysis and prediction of partition coefficients of monosubstituted diazines was written by Yamagami, Chisako;Takao, Narao;Fujita, Toshio. And the article was included in Quantitative Structure-Activity Relationships in 1990.Formula: C5H6N2O This article mentions the following:

The octanol/water partition coefficient (P) of a number of monosubstituted diazines was measured. The composition of the π value of substituents, the increment in the log P value accompanying the introduction of substituents, was examined in terms of physicochem. substituent parameters and correlation anal. The diazine-π value of substituents was generally higher than the pyridine-π value of corresponding substituents, indicating that the intramol. electronic interactions between the ring-N atoms and substituent are more pronounced than those in substituted pyridines in governing the log P value of the mol. Except for 2-substituted pyrimidines, the π value of substituents in each series of monosubstituted diazines was in general nicely correlated with the π value of the corresponding substituents in substituted pyridines along with electronic parameter terms representing bidirectional electronic effects on the relative solvation of the ring-N atom(s) and the hydrogen-bondable substituents with partitioning solvents according to the procedure proposed previously for the anal. of the π value in disubstituted benzenes and monosubstituted pyridines. Keeping in mind that 2-pyrimidines substituted by hydrogen-bondable groups sometimes behave as outliers, the correlations were believed to be usable for prediction of log P values of monosubstituted diazines. In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4Formula: C5H6N2O).

3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. The pyridazine structure is also found within the structure of several drugs such as cefozopran, cadralazine, minaprine, pipofezine, and hydralazine. In the past decade, X-ray data were reported with regard to the characterization and structural elucidation of a number of pyridazine-metal complexes, including pyridazine ligands with zinc, nickel, copper, cadmium and ruthenium.Formula: C5H6N2O

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Identification of N-(1H-pyrazol-4-yl)carboxamide inhibitors of interleukin-1 receptor associated kinase 4: Bicyclic core modifications was written by Lim, Jongwon;Altman, Michael D.;Baker, James;Brubaker, Jason D.;Chen, Hongmin;Chen, Yiping;Kleinschek, Melanie A.;Li, Chaomin;Liu, Duan;MacLean, John K. F.;Mulrooney, Erin F.;Presland, Jeremy;Rakhilina, Larissa;Smith, Graham F.;Yang, Ruojing. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2015.Recommanded Product: 19064-65-4 This article mentions the following:

IRAK4 plays a critical role in the IL-1R and TLR signaling, and selective inhibition of the kinase activity of the protein represents an attractive target for the treatment of inflammatory diseases. A series of permeable N-(1H-pyrazol-4-yl)carboxamides was developed by introducing lipophilic bicyclic cores in place of the polar pyrazolopyrimidine core of 5-amino-N-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamides. Replacement of the pyrazolo[1,5-a]pyrimidine core with the pyrrolo[2,1-f][1,2,4]triazine, the pyrrolo[1,2-b]pyridazine, and thieno[2,3-b]pyrazine cores guided by c Log D led to the identification of highly permeable IRAK4 inhibitors with excellent potency and kinase selectivity. In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4Recommanded Product: 19064-65-4).

3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. Pyridazines are rare in nature, possibly reflecting the scarcity of naturally occurring hydrazines, common building blocks for the synthesis of these heterocycles. Pyridazine compounds have attracted interest in various fields like medicinal, industrial, and agricultural research as they are used for numerous biological activities and other applications.Recommanded Product: 19064-65-4

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Two-, three-, and four-bond N-F spin-spin coupling constants in fluoroazines was written by Del Bene, Janet E.;Alkorta, Ibon;Elguero, Jose. And the article was included in Molecular Physics in 2010.Quality Control of 3,6-Difluoropyridazine This article mentions the following:

Ab initio EOM-CCSD calculations were performed to investigate 2-, 3- and 4-bond ¹⁵N-¹⁹F coupling constants in mono-, di-, and trifluoroazines. ²J(N-F) values are neg. and are dominated by the Fermi-contact (FC) term. Absolute values of ²J(N-F) tend to decrease as the number of N atoms in the ring increases, and may also be influenced by the number and positions of C-F bonds. ³J(N-F) values are pos. with three exceptions, are usually dominated by the FC term, and also tend to decrease as the number of N atoms increases. The three mols. which have neg. values of ³J(N-F) have dominant neg. paramagnetic-spin orbit (PSO) terms, and are structurally similar insofar as they have an intervening C-F bond between the N and the coupled F. ⁴J(N-F) values are neg. because the PSO, FC, and spin-dipole (SD) terms are neg., with only one exception. Four mols. have significantly greater values of ⁴J(N-F). These are structurally similar with the coupled N bonded to two other N atoms. The computed EOM-CCSD ⁿJ(N-F) coupling constants are in good agreement with the few exptl. values that are available. In the experiment, the researchers used many compounds, for example, 3,6-Difluoropyridazine (cas: 33097-39-1Quality Control of 3,6-Difluoropyridazine).

3,6-Difluoropyridazine (cas: 33097-39-1) belongs to pyridazine derivatives. Pyridazine and phthalazine have quite different spectroscopic properties compared with their isomers, pyrazine and quinoxaline. Pyridazine is bioavailable (especially in the CNS) and can reduce toxicity. Pyridazine is a component of several drug molecules, and the pyridazine pharmacophore has contributed to a variety of pharmacologically active compounds.Quality Control of 3,6-Difluoropyridazine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Chemical properties of ylidene derivatives of azines. 4. The structure of products resulting from the protonation and transformation of dihydroazinylidenecyanoacetic esters in concentrated sulfuric acid was written by Oleinik, I. V.;Zagulyaeva, O. A.;Denisov, A. Yu.;Mamaev, V. P.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1990.Recommanded Product: 3-Methoxypyridazine This article mentions the following:

In concentrated H₂SO₄, azinylidene derivatives I (X = CH, N) have an aromatic structure, whereas several others, e.g., II, retain the ylidene structure. On standing in 95% H₂SO₄, I are converted to amide esters (III), whereas others are converted to 2-(azinyl)acetamides and amide esters. In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4Recommanded Product: 3-Methoxypyridazine).

3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. The pyridazine structure is also found within the structure of several drugs such as cefozopran, cadralazine, minaprine, pipofezine, and hydralazine. Pyridazine compounds have attracted interest in various fields like medicinal, industrial, and agricultural research as they are used for numerous biological activities and other applications.Recommanded Product: 3-Methoxypyridazine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Electronic spectra of N-heteroaromatic systems. II. Substituted monocyclic azines was written by Mason, S. F.. And the article was included in Journal of the Chemical Society in 1959.Recommanded Product: 3-Methoxypyridazine This article mentions the following:

The visible and ultraviolet absorption spectra of the monocyclic azines and some derivatives have been measured in polar and nonpolar solvents. The n → π bands of the azines are shifted towards the blue region by electron-donating and towards the red region by electron-accepting substituents, while the π → π bands undergo bathochromic shifts with both types of substituent. The shift of the n → π band of an azine on substitution is due primarily to the effect of the substituent on the energy of the lowest unoccupied benzene-like π orbital of the azine. The solvent λ_maximum and ε_maximum for the n-π band, λ_maximum and ψ_maximum for the π → π band are given for pyridine, 2-cyano-, 3-cyano-, 4-cyano-, and 2,6-dicyanopyridine, pyrazine, 2-methyl-, 2,5-dimethyl-, 2,3-dimethoxycarbonyl-, 2,3-dicarboxy, and 2-methoxypyrazine, pyridazine, 3-methyl-, 4-methyl-, 3-methoxy-, 4-methoxy-, 3,6-dimethoxy-, and 4,5-dicarboxy-pyridazine, pyrimidine, 2-methoxy-, 4-methoxy-, 5-hydroxy-, 2-methoxycarbonyl-, 2-carboxy-, 4-carboxy-, and 5-carboxypyrimidine, 3,5,6-trimethyl-1,2,4-triazine, 3-amino-1,2,4-triazine, sym-tetrazine, 1,4-dimethyl-, and 1,4-dicarboxy-sym-tetrazine; each in 1 or more solvents, at various pH values. In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4Recommanded Product: 3-Methoxypyridazine).

3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. The pyridazine structure is also found within the structure of several drugs such as cefozopran, cadralazine, minaprine, pipofezine, and hydralazine. The unsubstituted pyridazines are more resistant to eletrophilic substitution due to the nature of withdrawal of electron density from the ring by two heteroatoms, while the related electron deficiency of the ring makes pyridazine more easily attacked by nucleophiles.Recommanded Product: 3-Methoxypyridazine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Mass spectra of pyridazines and their N-oxides was written by Ogura, Haruo;Sugimoto, Shingo;Igeta, Hiroshi;Tsuchiya, Takashi. And the article was included in Journal of Heterocyclic Chemistry in 1971.Application In Synthesis of 3-Methoxypyridazine This article mentions the following:

The mass spectra of pyridazines and their N-oxides is reported. Previous electron impact studies on aromatic amine N-oxides reported the appearance of M-16 and (or) M-17 ion peaks as the usual feature of the fragmentations. In these experiments, the representative fragmentation of the pyridazine N-oxides involves formation of a M-30 (M-NO) ion. The fragmentation patterns substantiated by extensive high resolution studies and anal. of the appropriate metastable ions. In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4Application In Synthesis of 3-Methoxypyridazine).

3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazine can act as a hydrogen bond acceptor to improve the physicochemical properties of drug molecules by increasing their water solubility, and has a high affinity for complexing with targets due to its dipole moment.Application In Synthesis of 3-Methoxypyridazine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem