Category: pyridazine

Pyridazines. XXXI. A facile synthesis of 3-pyridazinecarbonitriles via 2-(4-toluenesulfonyl)-2,3-dihydro-3-pyridazinecarbonitriles was written by Dostal, Wolfgang;Heinisch, Gottfried. And the article was included in Heterocycles in 1986.Category: pyridazine This article mentions the following:

Pyridazines I(R = R¹ = R² = H; R = R² = H, R¹ = Me; R = R¹ = H, R² = Me) reacted with Me₃SiCN/4-MeC₆H₄SO₂Cl to give dihydropyridazines II (R³ = tosyl) in 63-84% yields. II were converted to pyridazines I (R = cyano) in 71-99% yields by the action of DBU. In the experiment, the researchers used many compounds, for example, 4-Methylpyridazine-3-carbonitrile (cas: 106861-17-0Category: pyridazine).

4-Methylpyridazine-3-carbonitrile (cas: 106861-17-0) belongs to pyridazine derivatives. Pyridazines is a six-membered nitrogen-containing significant heterocycle. It has received considerable interest because of its useful applications as natural products, pharmaceuticals, and various bioactive molecules. In the past decade, X-ray data were reported with regard to the characterization and structural elucidation of a number of pyridazine-metal complexes, including pyridazine ligands with zinc, nickel, copper, cadmium and ruthenium.Category: pyridazine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Epigenetic drug screen identifies the histone deacetylase inhibitor NSC3852 as a potential novel drug for the treatment of pediatric acute myeloid leukemia was written by Wiggers, Caroline R. M.;Govers, Anita M. A. P.;Lelieveld, Daphne;Egan, David A.;Zwaan, C. Michel;Sonneveld, Edwin;Coffer, Paul J.;Bartels, Marije. And the article was included in Pediatric Blood & Cancer in 2019.Safety of Ethyl (3-methyl-6-(4-methyl-3-(methylsulfonamido)phenyl)-[1,2,4]triazolo[4,3-b]pyridazin-8-yl)carbamate This article mentions the following:

Acute myeloid leukemia (AML) is a heterogeneous disease regarding morphol., immunophenotyping, genetic abnormalities, and clin. behavior. The overall survival rate of pediatric AML is 60% to 70%, and has not significantly improved over the past two decades. Children with Down syndrome (DS) are at risk of developing acute megakaryoblastic leukemia (AMKL), which can be preceded by a transient myeloproliferative disorder during the neonatal period. Intensification of current treatment protocols is not feasible due to already high treatment-related morbidity and mortality. Instead, more targeted therapies with less severe side effects are highly needed. To identify potential novel therapeutic targets for myeloid disorders in children, including DS-AMKL and non-DS-AML, we performed an unbiased compound screen of 80 small mols. targeting epigenetic regulators in three pediatric AML cell lines that are representative for different subtypes of pediatric AML. Three candidate compounds were validated and further evaluated in normal myeloid precursor cells during neutrophil differentiation and in (pre-)leukemic pediatric patient cells. Candidate drugs LMK235, NSC3852, and bromosporine were effective in all tested pediatric AML cell lines with antiproliferative, proapoptotic, and differentiation effects. Out of these three compounds, the pan-histone deacetylase inhibitor NSC3852 specifically induced growth arrest and apoptosis in pediatric AML cells, without disrupting normal neutrophil differentiation. NSC3852 is a potential candidate drug for further preclin. testing in pediatric AML and DS-AMKL. In the experiment, the researchers used many compounds, for example, Ethyl (3-methyl-6-(4-methyl-3-(methylsulfonamido)phenyl)-[1,2,4]triazolo[4,3-b]pyridazin-8-yl)carbamate (cas: 1619994-69-2Safety of Ethyl (3-methyl-6-(4-methyl-3-(methylsulfonamido)phenyl)-[1,2,4]triazolo[4,3-b]pyridazin-8-yl)carbamate).

Ethyl (3-methyl-6-(4-methyl-3-(methylsulfonamido)phenyl)-[1,2,4]triazolo[4,3-b]pyridazin-8-yl)carbamate (cas: 1619994-69-2) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. Pyridazine is bioavailable (especially in the CNS) and can reduce toxicity. Pyridazine is a component of several drug molecules, and the pyridazine pharmacophore has contributed to a variety of pharmacologically active compounds.Safety of Ethyl (3-methyl-6-(4-methyl-3-(methylsulfonamido)phenyl)-[1,2,4]triazolo[4,3-b]pyridazin-8-yl)carbamate

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

3-Bromoimidazo[1,2-b]pyridazine-bromine and 3-bromo-6-chloroimidazo[1,2-b]pyridazine-bromine complexes: new brominating agents for organic compounds was written by Stanovnik, Branko;Tisler, Miha;Drnovsek, Iztok. And the article was included in Synthesis in 1981.Electric Literature of C6H3BrClN3 This article mentions the following:

Title compounds I.HBr.Br₂ (R = H or Cl) were prepared and used to brominate a variety of alkenes, ketones, 3-oxoalkanoic esters, and monocyclic and polycyclic N-heterocyclic compounds at room temperature or on gentle heating, monobrominated compounds are obtained in practically quant. yields. In the experiment, the researchers used many compounds, for example, 3-Bromo-6-chloroimidazo[1,2-b]pyridazine (cas: 13526-66-4Electric Literature of C6H3BrClN3).

3-Bromo-6-chloroimidazo[1,2-b]pyridazine (cas: 13526-66-4) belongs to pyridazine derivatives. The pyridazine structure is a popular pharmacophore which is found within a number of herbicides such as credazine, pyridafol and pyridate. Pyridazine compounds have attracted interest in various fields like medicinal, industrial, and agricultural research as they are used for numerous biological activities and other applications.Electric Literature of C6H3BrClN3

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Relations between structure and activity of maleic hydrazide analogs and related compounds was written by Parups, E.;Hoffman, I.;Morley, H. V.. And the article was included in Canadian Journal of Biochemistry and Physiology in 1962.Formula: C5H6N2O2 This article mentions the following:

The growth- inhibiting activities of a number of compounds structurally related to maleic hydrazide (I) were examined by the technique of bud-growth inhibition. The degree of inhibitory activity of I derivatives depended on tile ease with which the plant can split off substituents. Straight-chain compounds which partially resemble I were not as active as the parent compound, and ring closure was necessary for full activity. Residue data for some of the tested compounds showed that activity failure was not due to lack of uptake and translocation. The anal. procedure for I is shown to be valid for the quant. determination of hydroxymethyl-I and N-benzoyl-I. In the experiment, the researchers used many compounds, for example, 1,2-Dihydro-4-methyl-3,6-pyridazinedione (cas: 5754-18-7Formula: C5H6N2O2).

1,2-Dihydro-4-methyl-3,6-pyridazinedione (cas: 5754-18-7) belongs to pyridazine derivatives. The pyridazine structure is a popular pharmacophore which is found within a number of herbicides such as credazine, pyridafol and pyridate. In the past decade, X-ray data were reported with regard to the characterization and structural elucidation of a number of pyridazine-metal complexes, including pyridazine ligands with zinc, nickel, copper, cadmium and ruthenium.Formula: C5H6N2O2

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Pyridazines. XXI. Reaction of 1-methylpyridazinium salts with potassium cyanide was written by Kaneko, Chisato;Tsuchiya, Takashi;Igeta, Hiroshi. And the article was included in Chemical & Pharmaceutical Bulletin in 1973.Related Products of 19064-65-4 This article mentions the following:

The reaction of pyridazinium sulfates, prepared from the corresponding pyridazines and Me2SO4, with KCN was studied. The pyridazines (I, R = H, Me, MeO; R1 = R2 = H) gave dimers II and III and the pyridazinone IV. 3-Phenylpyridazines (I, R = Ph; R1 = R2 = H, Me) gave the 4-pyridazinenitriles (V) as the main product. Other pyridazines (e.g., I, R = R2 = H, R1 = Me; R = R2 = Me, R1 = H; R = MeO, R1 = H, R2 = Me) gave various cyano- and dicyanopyridazines. The mechanism of their formation were discussed. In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4Related Products of 19064-65-4).

3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. Pyridazine can act as a hydrogen bond acceptor to improve the physicochemical properties of drug molecules by increasing their water solubility, and has a high affinity for complexing with targets due to its dipole moment.Related Products of 19064-65-4

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Discovery of imidazopyridine derivatives as novel c-Met kinase inhibitors: Synthesis, SAR study, and biological activity was written by Yang, Yifei;Zhang, Yuan;Yang, Ling Yun;Zhao, Leilei;Si, Lianghui;Zhang, Huibin;Liu, Qingsong;Zhou, Jinpei. And the article was included in Bioorganic Chemistry in 2017.Related Products of 33050-32-7 This article mentions the following:

Receptor tyrosine kinase c-Met acts as an alternative angiogenic pathway in the process and contents of cancers. A series of imidazopyridine derivatives were designed and synthesized according to the established docking studies as possible c-Met inhibitors. Most of these imidazopyridine derivatives displayed nanomolar potency against c-Met in both biochem. enzymic screens and cellular pharmacol. studies. Especially, compound 7 g exhibited the most inhibitory activity against c-Met with IC₅₀ of 53.4 nM and 253 nM in enzymic and cellular level, resp. Following that, the compound 7 g was docked into the protein of c-Met and the structure-activity relationship was analyzed in detail. These findings indicated that the novel imidazopyridine derivative compound 7 g was a potential c-Met inhibitor deserving further investigation for cancer treatment. In the experiment, the researchers used many compounds, for example, 6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one (cas: 33050-32-7Related Products of 33050-32-7).

6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one (cas: 33050-32-7) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. Specifically, the pyridazine moiety is an important structural feature of various pharmacologically important compounds with activities like antimicrobial, analgesic, anti-inflammatory, antiplatelet, anticancer, antisecretory, antiulcer, antidepressant, cardiotonic, vasodilator, antiarrhythmic, and hypocholesterolaemic.Related Products of 33050-32-7

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Steric and electronic effects on the ¹H hyperpolarization of substituted pyridazines by signal amplification by reversible exchange was written by Rayner, Peter j.;Burns, Michael j.;Fear, Elizabeth j.;Duckett, Simon b.. And the article was included in Magnetic Resonance in Chemistry in 2021.Electric Literature of C5H6N2O This article mentions the following:

Utility of the pyridazine motif is growing in popularity as pharmaceutical and agrochem. agents. The detection and structural characterization of such materials is therefore imperative for the successful development of new products. Signal amplification by reversible exchange (SABRE) offers a route to dramatically improve the sensitivity of magnetic resonance methods, and we apply it here to the rapid and cost-effective hyperpolarization of substituted pyridazines. The 33 substrates investigated cover a range of steric and electronic properties and their capacity to perform highly effective SABRE is assessed. We find the method to be tolerant to a broad range of electron donating and withdrawing groups; however, good sensitivity is evident when steric bulk is added to the 3- and 6-positions of the pyridazine ring. We optimize the method by reference to a disubstituted ester that yields signal gains of >9000-fold at 9.4 T (>28% spin polarization). In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4Electric Literature of C5H6N2O).

3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. The pyridazine structure is also found within the structure of several drugs such as cefozopran, cadralazine, minaprine, pipofezine, and hydralazine. The unsubstituted pyridazines are more resistant to eletrophilic substitution due to the nature of withdrawal of electron density from the ring by two heteroatoms, while the related electron deficiency of the ring makes pyridazine more easily attacked by nucleophiles.Electric Literature of C5H6N2O

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Studies on diazepines. XIII. Photochemical behavior of pyrazine, pyrimidine, and pyridazine N-imides was written by Tsuchiya, Takashi;Kurita, Jyoji;Takayama, Kazuko. And the article was included in Chemical & Pharmaceutical Bulletin in 1980.Formula: C5H6N2O This article mentions the following:

Photolysis of various diazine N-ethoxycarbonylimides, I (R = H, Me; R¹, R² = H, Me, Ph), II, and III (R³ = R⁴ = H, Me; R³ = MeO, R⁴ = H) prepared from the corresponding diazines, gave the pyrazole derivatives, e.g. IV from pyrazine and pyridmidine N-imides, and the pyrrole derivatives from pyridazine N-imides. These photolyses may proceed by rearrangement to diaziridine intermediates, followed by ring expansion to the corresponding 1,2,5-, 1,2,4-, or 1,2,3-triazepines, which then undergo isomerization to the triazabicyclo[3.2.0]heptadienes, followed by elimination. In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4Formula: C5H6N2O).

3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. Pyridazines is a six-membered nitrogen-containing significant heterocycle. It has received considerable interest because of its useful applications as natural products, pharmaceuticals, and various bioactive molecules. Pyridazine compounds have attracted interest in various fields like medicinal, industrial, and agricultural research as they are used for numerous biological activities and other applications.Formula: C5H6N2O

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Synthesis and herbicidal activity of 3-aryloxy-6-chloro(or fluoro)pyridazines was written by Wang, Zhanping;Hu, Fangzhong;Zou, Xiaomao;Yang, Xiufeng;Yang, Huazheng. And the article was included in Nongyaoxue Xuebao in 2004.HPLC of Formula: 33097-39-1 This article mentions the following:

3-Aryloxy-6-chloro(or fluoro)pyridazines I (X = Cl, F; R = Me, NO₂, Cl, CF₃, NH₂, Br, OMe, COOEt, etc.) were prepared from the condensation of various substituted phenols with starting material 3, 6-dichloropyridazine and its fluorinated derivative, 3, 6-difluoropyridazine in high yields. All compounds were characterized by ¹H NMR and elemental analyses, and some of the compounds were confirmed by IR. Preliminary bioassay indicates that some of the title compounds showed herbicidal activity to some extents against Brassica napus and Echinochloa crus-galli, for example, at 100 μg/mL, the inhibition of compounds I (X = Cl, R = 3-Me, 3-NO₂ and X = F, R = 3-Me) against E. crus-gall are 95.7%, 96.1% and 91.2% , resp. In the experiment, the researchers used many compounds, for example, 3,6-Difluoropyridazine (cas: 33097-39-1HPLC of Formula: 33097-39-1).

3,6-Difluoropyridazine (cas: 33097-39-1) belongs to pyridazine derivatives. The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazine and derivatives coordinate readily with transition metals to form complexes and catalysts with synthetic utility.HPLC of Formula: 33097-39-1

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Study on the synthetic condition of aryloxypyridazinoxy lactates – effect of halides in 3,6-dihalide pyridazines on nucleophilic substitution reaction was written by Hu, Fang-Zhong;Wang, Xiang;Ren, Kang-Tai;Yang, Hua-Zheng. And the article was included in Youji Huaxue in 2002.Related Products of 33097-39-1 This article mentions the following:

The synthetic condition of aryloxypyridazinoxy lactates was studied. Aryloxypyridazinoxy lactates can be obtained by two methods. The effect of halides in 3,6-dihalide pyridazines on nucleophilic substitution reaction was studied, too. Calculation of mol. mechanics and quantum chem. indicated that 3,6-difluoropyridazine had an advantage over other 3,6-dihalide pyridazines when it was treated with nucleophilic reagents and confirmed by the exptl. results. In the experiment, the researchers used many compounds, for example, 3,6-Difluoropyridazine (cas: 33097-39-1Related Products of 33097-39-1).

3,6-Difluoropyridazine (cas: 33097-39-1) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. The unsubstituted pyridazines are more resistant to eletrophilic substitution due to the nature of withdrawal of electron density from the ring by two heteroatoms, while the related electron deficiency of the ring makes pyridazine more easily attacked by nucleophiles.Related Products of 33097-39-1

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem