Category: pyridazine

Recommanded Product: 3-Aminopyridazine, When developing chemical systems it’s of course important to gain a deep understanding of the chemical reaction process. 5469-70-5, Name is 3-Aminopyridazine, molecular formula is C4H5N3. In a Article，once mentioned of 5469-70-5

Synthetic methodology studies are reported towards the preparation of new propargylic ketones with CF2R side chains. These molecules are used for the synthesis of various types of five- or six-membered heterocycles with difluoroalkyl side chains.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N59 – PubChem

Healthcare careers for chemists are once again largely based in laboratories, although increasingly there is opportunity to work at the point of care, helping with patient investigation. Application of 135034-10-5

The present invention provides compounds of formula (I): their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N3038 – PubChem

Having gained chemical understanding at molecular level, chemistry graduates may choose to apply this knowledge in almost unlimited ways, as it can be used to analyze all matter and therefore our entire environment. Electric Literature of 51047-56-4

DMPP is a well-known nicotinic agonist that does not fit any proposed pharmacophore for nicotinic binding and represents a unique ligand among the hundreds of nicotinic agonists studied in the past decades. A systematic modulation of the chemical structure of DMPP, aimed to establish its structure-affinity relationships, is reported. The research has allowed to identify molecules such as 11c, 13c, 14c, and 28c, with affinities for alpha4beta2 receptors in the low nanomolar range, some 2 orders of magnitude lower than the lead compound. The agonistic properties of the most interesting compounds have been assessed by measuring their analgesic activity on mice (hot-plate test). Another result of the research was the identification of DMPP analogues, such as 3a (Ki = 90 nM) and 14b (Ki = 180 nM), that maintain affinity for the central nicotinic receptor when the ammonium function is changed into an aminic one and are therefore possible leads for drug development in neurodegenerative diseases.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2222 – PubChem

With the volume and accessibility of scientific research increasing across the world, it has never been more important to continue building the reputation for quality and ethical publishing we’ve spent the past two centuries establishing. Product Details of 55928-86-4

The present invention relates to the technical field of agricultural fungicide, in particular to a […] amine compounds and preparation method and its application, characterized in that the compound of the general formula (I) general formula the following is shown: In the formula: R substituent1 , R2 The same or different, are selected from hydrogen, halogen, cyano, nitro, C1 – C12 Alkyl, halogenated C1 – C12 Alkyl, C1 – C12 Alkoxy, halogenated C1 – C12 Alkoxy, C1 – C12 Alkylthio, C1 – C12 Alkyl sulfonyl, has effective control downy mildew pathogen, powdery mildew pathogen, rice blast pathogen, rust or the like caused by disease germs and the like. (by machine translation)

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Pyridazine – Wikipedia,
Pyridazine | C4H4N3242 – PubChem

Career opportunities within science and technology are seeing unprecedented growth across the world, and those who study chemistry or another natural science at university now have increasingly better career prospects. name: Methyl 6-chloropyridazine-3-carboxylate. Introducing a new discovery about 65202-50-8, Name is Methyl 6-chloropyridazine-3-carboxylate

The present invention provides certain compounds according to formula (I) which are inhibitors of SSAO activity wherein V, W, X, Y, Z, R1 and R2 are as defined in the specification.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2410 – PubChem

Electric Literature of 1121-79-5, As a society publisher, everything we do is to support the scientific community – so you can trust us to always act in your best interests, and get your work the international recognition that it deserves. 1121-79-5, Name is 3-Chloro-6-methylpyridazine, molecular formula is C5H5ClN2. In a Article，once mentioned of 1121-79-5

1H, 13C, and 15N NMR chemical shifts for pyridazines 4-22 were measured using 1D and 2D NMR spectroscopic methods including 1H-1H gDQCOSY,1H-13C gHMQC,1H-13C gHMBC,and1H-15N CIGAR-HMBC experiments. (0 2010 John Wiley & Sons, Ltd.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N668 – PubChem

Electric Literature of 5096-73-1, The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research.

The induction of micronucleated liver cells (MN-liver cell) was examined with halogenated and hydroxylated quinolines using partially hepatectomized mice. Among the chloroquinolines, 8-chloroquinoline demonstrated a significantly higher level of induction than the control. All the fluorinated derivatives examined, except for 6-fluoroquinoline, induced significantly higher levels, and there were no appreciable differences in MN-liver cell induction among the fluorinated quinolines, regardless of their mutagenic potencies in the Ames test. Of the hydroxylated quinolines examined, 2- and 4-isomers, which are not mutagenic, induced MN-liver cells to the same extent as a mutagenic isomer, 8-hydroxyquinoline. It seems that clastogenicity was not satisfactorily correlated with mutagenicity in the Ames test as far as this class of compounds is concerned.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2064 – PubChem

Product Details of 141-30-0, Researchers are common within chemical engineering and are often tasked with creating and developing new chemical techniques, frequently combining other advanced and emerging scientific areas. 141-30-0, Name is 3,6-Dichloropyridazine, molecular formula is C4H2Cl2N2. In a article，once mentioned of 141-30-0

From an MCR fragment library, two novel chemical series have been developed as inhibitors of RET, which is a kinase involved in the pathology of medullary thyroid cancer (MTC). Structure activity relationship studies (SAR) identified two sub-micromolar tractable leads, 6g and 13g. 6g was confirmed to be a Type-II RET inhibitor. 13g and 6g inhibited RET in cells transformed by RET/C634. A RET DFG-out homology model was established and utilized to predict Type-II inhibitor binding modes.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1694 – PubChem

Chemical engineers work across a number of sectors, processes differ within each of these areas, but chemistry and chemical engineering roles are directly involved in the design, creation and manufacturing process of chemical products and materials. Safety of 3,6-Dichloropyridazine

The invention relates to 3,4-dihydro-1H-benzo[c][1,2]oxaboric acid compounds or pharmaceutically acceptable salts thereof, a preparation method of the compounds and application of the compounds and the salts. Concretely, the invention relates to the compound with the general formula (I) and the pharmaceutically acceptable salts, and the preparation method of the compounds. The invention also relates to a pharmaceutical composition containing the compounds or the pharmaceutically acceptable salts as a receptor tyrosine kinase inhibitor, especially as a c-Met inhibitor. The invention also relates to application of the compounds or the pharmaceutical composition to prepare medicines for preventing and/or treating diseases related to c-Met abnormity. The compounds have obvious propagation inhibition activity on SNU-5 cells, and have obvious inhibition effect on c-Met kinases activity.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N1528 – PubChem

Modeling chemical reactions helps engineers virtually understand the chemistry, optimal size and design of the system, and how it interacts with other physics that may come into play. Application of 17321-35-6

Some novel 3-halo-6-(4-substituted-phenoxy)pyridazines and 3,6-di-(4- substituted-phenoxy)pyridazines were synthesized from 3,6-dichloropyridazine or 3,6-diiodopyridazine. 3,6-Diiodopyridazine was prepared from 3,6- dichloropyridazine using hydriodic acid/iodine monochloride.

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. A catalyst does not appear in the overall stoichiometry of the reaction it catalyzes. “Application of 17321-35-6

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N3029 – PubChem