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QUINUCLIDINE DERIVATIVES AS MUSCARINIC M3 RECEPTOR ANTAGONISTS

The invention provides named compounds of formula (I), wherein R4 is a N-substituted quinuclidine (I) pharmaceutical compositions containing them and a process for preparing the pharmaceutical compositions. Their use in therapy for? the treatment of conditions mediated by M3 muscarinic receptors, such as chronic obstructive pulmonary disease is also disclosed.

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Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N2203 – PubChem

 

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Synthetic Route of 935777-24-5, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 935777-24-5, Name is 6-(Trifluoromethyl)pyridazin-3-amine, molecular formula is C5H4F3N3. In a Patent£¬once mentioned of 935777-24-5

HETERCYCLIC COMPOUNDS FOR THE TREATMENT OF DISEASE

Described herein are heterocyclic compounds, compositions, and methods for their use for treatment of disease.

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Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N2208 – PubChem

 

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GCN2 INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

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Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N2202 – PubChem