Category: 932-22-9

Synthetic Route of 932-22-9, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 932-22-9, Name is 4,5-Dichloro-3(2H)-pyridazinone,introducing its new discovery.

Lactam-lactim tautomeric structure of three hydroxypyridazine derivatives was investigated by infrared spectroscopy. The conclusion could be drawn that the molecules exist in oxo-enol tautomeric equilibrium in dioxane solution. The cyclic dimer intermolecular association of the molecules was supported by a charge distribution calculation.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2342 – PubChem

Related Products of 932-22-9, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.932-22-9, Name is 4,5-Dichloro-3(2H)-pyridazinone, molecular formula is C4H2Cl2N2O. In a article，once mentioned of 932-22-9

The lipid peroxidation inhibiting piperazine and homopiperazine derivatives of the general formula (I) and the pharmaceutically acceptable acid addition salts thereof, Lip stands for hydrogen; C15 20 alkyl; C10 20 alkanoyl or C10 20 alkenoyl; trityl optionally substituted by halogen; adamantyl; 1- or 2-naphthyloxy or oxo-substituted tetrahydronaphthyloxy; or an amine protective group commonly used e.g. in the peptide chemistry;, A¹ and A² are selected independently from the group consisting of a single bond and C2 3 alkylene optionally substituted by hydroxy or oxo;, n is 1 or 2; and, Het represents, a group of the general formula (a), wherein, R¹ is amino or 1-pyrrolidinyl;, or a 4-chloro-3-oxo-2,3-dihydro-5-pyridazinyl group of the formula (b); or a 4-amino-6,7-dimethoxy-2-quinazolinyl group of the formula (c); or a 4,7-diamino-6-phenyl-2-pteridinyl group of the formula (d); or a 2,7-diamino-6-phenyl-4-pteridinyl group of the formula (e); or a 2,4,7-triamino-6-pteridinylcarbonyl group of the formula (f); or a group of the general formula (g); wherein, X means oxygen, sulfur or nitrogen optionally substituted by lower alkyl,with the frist proviso that, when Het stands for a group of the general fromula (a) and both A¹ and A² mean single bonds then Lip may not be hydrogen;, with the second priviso that, when Lip is different from naphthyloxy or oxo-substituted tetrahydronaphthyloxy then A¹ means a single bond;, with the third proviso that, when Lip represents naphthyloxy or oxo-substituted tetrahydronaphthyloxy then A¹ may not be a single bond, as well as with the fourth proviso that, A¹ and A² cannot simultaneously stand for C2 3 alkylene optionally substituted by hydroxy or oxo.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2285 – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. Computed Properties of C4H2Cl2N2O, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 932-22-9

Melanin-concentrating hormone receptor antagonists containing thieno- and a benzopyridazinone cores were designed and tested as potential anorectic agents. These ligands showed high affinity for the receptor, potent functional activity in vitro, and good oral bioavailability in rats. The thiophene analogue exhibited low iv clearance, long half-life, and high brain penetration. In obese rats, the thienopyridazinone demonstrated a dose-dependent reduction in feeding and body weight with doses between 1 and 10 mg kg-1.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2314 – PubChem

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 932-22-9, name is 4,5-Dichloro-3(2H)-pyridazinone, introducing its new discovery. Recommanded Product: 932-22-9

The functionalization of 4,5-dichloropyridazin-3(2H)-one and 4,5-dichloro-2-methyl-6-nitropyridazin-3(2H)-one was reported. A mixture of 4,5-dichloropyridazin-3(2H)-one, potassium nitrate and conc-sulfuric acid was stirred for 5 hours at 110-120C. After cooling to room temperature, the solution was slowly poured into ice-water. The resulting yellow crystals was filtered, washed with water and dried in air to give the product. A mixture of 4,5-dichloro-6- nitropyridazin-3(2H)-one and POCl3 was refluxed for 24 hours. After cooling to room temperature, the solution was evaporated under reduced pressure. The resulting residue was slowly poured into ice-water (300 mL). Chlorination of compound 4,5-dichloro-6- nitropyridazin-3(2H)-one with phosphorus oxychloride also gave 3,4,5-trichloro-6-nitropyridazine in 72% yield. Three proton signals were also detected at d 9.0 (1H), 8.64 (1H) and 6.20 (2H) ppm in the spectrum of 1H NMR.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2365 – PubChem

932-22-9, Name is 4,5-Dichloro-3(2H)-pyridazinone, belongs to pyridazine compound, is a common compound. COA of Formula: C4H2Cl2N2OIn an article, once mentioned the new application about 932-22-9.

In continuing our search for selective alpha(1)-adrenoceptor (AR) antagonists, we have synthesized new alkoxyarylpiperazinylalkylpyridazinone derivatives. The new compounds were tested for their affinity toward alpha(1)- and alpha(2)-AR and toward the 5-HT(1A) receptor. alpha(1)-AR affinity data are in the subnanomolar range, with 3 showing an affinity of 0.052 nM, about 5-fold higher than prazosin. None of the studied compounds was found to be alpha(1)/alpha(2) selective, but 8 showed an interesting 5-HT(1A)/alpha(1) affinity ratio of 119.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2294 – PubChem

Synthetic Route of 932-22-9, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 932-22-9, 4,5-Dichloro-3(2H)-pyridazinone, introducing its new discovery.

Aziridine-(iso)quinoline hybrid systems were prepared as novel synthetic intermediates en route to functionalized (iso)quinolines with potential antimalarial activity. Various quinolinecarboxaldehydes were converted into quinoline-aziridine-pyrazole, -pyridazinone or -pyrimidinone hybrids, and the three-membered azaheterocyclic moiety in these compounds was finally subjected to ring opening by either methanol or water to provide the corresponding functionalized quinolines. In addition, 5-hydroxyisoquinoline was used for the preparation of isoquinoline-aziridine chimeras, which were further transformed into a variety of functionalized isoquinolines via regioselective aziridine ring opening by various nucleophiles. Antiplasmodial evaluation of these new aziridine-(iso)quinoline hybrids and their ring-opening products revealed micromolar potency (0.22-30 muM) for all representatives against a chloroquine-sensitive strain of the malaria parasite Plasmodium falciparum. The six most potent compounds also showed micromolar activity against a chloroquine-resistant strain of P. falciparum with IC50-values ranging between 1.02 and 17.58 muM.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Synthetic Route of 932-22-9. In my other articles, you can also check out more blogs about 932-22-9

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2369 – PubChem

932-22-9, Name is 4,5-Dichloro-3(2H)-pyridazinone, belongs to pyridazine compound, is a common compound. Formula: C4H2Cl2N2OIn an article, once mentioned the new application about 932-22-9.

A compound represented by the formula (I) or a salt thereof: wherein a ring Z is a 5 to 6-membered heteroaromatic ring having one or two heteroatoms in the ring; X1 is a hydrogen atom, a hydroxy group, a hydroxy C1-6 alkyl group, ?B(OH)2, a boronate ester group, a cyclic boronate ester group, a boranyl group, a cyclic boranyl group, ?BF3Mn1, ?Sn(R12)(R13)(R14), a leaving group, a carboxy group, a formyl group, or ?NR16R17; and X2 is a hydrogen atom or ?CO2R18.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2274 – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. SDS of cas: 932-22-9, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 932-22-9

Abstract: A series of novel monocyclic cis-beta-lactams were prepared from phenoxyacetic acid as ketene source and imines derived from 1-chloro-3,4-dihydronaphthalene-2-carbaldehyde and respective amine using ethyl 4,5-dichloro-6-oxopyridazine-1(6H)-carboxylate (or 2-ethoxy carbonyl DCPN) as a carboxylic acid activator.This is the first time 2-ethoxy carbonyl DCPN has been used as an acid activator in synthesis of beta-lactams. The reaction was entirely diastereoselective leading to the formation cis-beta-lactam derivatives.These newly synthesized cis-beta-lactam were fully characterized by FT-IR, 1H NMR, 13C NMR, HRMS, CHNS and X-ray crystallography study. All this novel compound was also evaluated for their antibacterial and antifungal activities against certain strains of Gram-positive bacteria, Gram-negative bacteria and fungi. These compounds displayed moderate activity against using bacterial and fungal strains. Graphic abstract: [Figure not available: see fulltext.].

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2343 – PubChem

Related Products of 932-22-9, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.932-22-9, Name is 4,5-Dichloro-3(2H)-pyridazinone, molecular formula is C4H2Cl2N2O. In a Patent，once mentioned of 932-22-9

The present invention relates to compounds of Formula (I), or an agronomically acceptable salt of said compounds wherein X1, R1, R2, R3, R5, G and n are as defined herein. The invention further relates to herbicidal compositions which comprise a compound of Formula (I), and to their use for controlling weeds, in particular in crops of useful plants.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2234 – PubChem

932-22-9, Name is 4,5-Dichloro-3(2H)-pyridazinone, belongs to pyridazine compound, is a common compound. category: pyridazineIn an article, once mentioned the new application about 932-22-9.

We report the design and synthesis of a new class of piperazine- pyridazinone analogues. The arylpiperazine moiety, the length of the spacer, and the terminal molecular fragment were varied to evaluate their influence in determining the affinity of the new compounds toward the alpha1- adrenergic receptor (alpha1-AR), alpha2-adrenergic receptor (alpha2-AR), and the 5-HT1A serotoninergic receptor (5-HT1AR). Biological data showed that most of the compounds have an alpha1-AR affinity in the nanomolar or subnanomolar range, while affinity toward the other two receptors was lower in most cases. However, several of the tested compounds also showed very good (in the nanomolar range) or moderate affinity toward the 5-HT1AR subtype.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2297 – PubChem