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Novel and highly selective postsynaptic alpha-adrenoreceptor antagonists: Synthesis and structure-activity relationships of alkane-bridged [4-(phenoxyethyl)-1-piperazinyl]-3(2H)-pyridazinones

The synthesis of selected 4-[4-(phenoxyethyl)-1-piperazinyl]-3(2H)-pyridazinones and alkane-bridged dimers of 4-, 5- and 6-[4-(phenoxyethyl)-1-piperazinyl]-3(2H)-pyridazinones is reported. The blocking activity of these compounds was deterrnined on the pre- and postsynaptic alpha-adrenoreceptors of isolated rat vas deferens.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2313 – PubChem

 

Brief introduction of 4,5-Dichloro-3(2H)-pyridazinone

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Reference of 932-22-9, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.932-22-9, Name is 4,5-Dichloro-3(2H)-pyridazinone, molecular formula is C4H2Cl2N2O. In a article£¬once mentioned of 932-22-9

Synthesis and Reactions of 1-(2-Oxopropyl)pyridazin-6-ones

Oxopropylation of 4,5-dihalopyridazin-6-ones with chloroacetone afforded the corresponding 1-(2-oxopropyl) derivatives. Reaction of title compound with nucleophiles such as amines, alkoxides were investigated. In addition, selective reduction of 3-nitro-1-(2-oxopropyl)pyridazin-6-ones with iron/ammonium chloride in two phase solutions or zinc in acetic acid gave the corresponding 3-amino or 3-hydroxyimino derivatives.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2308 – PubChem

 

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Reference of 932-22-9, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.932-22-9, Name is 4,5-Dichloro-3(2H)-pyridazinone, molecular formula is C4H2Cl2N2O. In a Article£¬once mentioned of 932-22-9

Synthesis of 1-[(pyrazol-3-yl)methyl]pyridazin-6-ones

This paper presents the synthesis of 1-[(pyrazol-3-yl)methyl]pyridazin-6-ones from ethyl 4-(4,5-dichloro-6-oxopyridazin-1-yl)-3-oxobutanoate.

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Pyridazine | C4H4N2310 – PubChem

 

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ALPHA-4 INTEGRIN MEDIATED CELL ADHESION INHIBITORS FOR THE TREATMENT OR PREVENTION OF INFLAMMATORY DISEASES

The present invention relates to novel compounds of formula (I), processes for their preparation, compositions comprising them and their use in the treatment or prevention of diseases capable of being modulated by the inhibition of cell adhesion.

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Pyridazine | C4H4N2277 – PubChem

 

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Retro-ene reactions. III. Alkylation of 4,5-dichloro-1-hydroxymethylpyridazin-6-ones: Synthesis of 4,5-dichloro-1-(omega-phthalimido and saccharin-2?-ylalkyl)pyridazin-6-ones

4,5-Dichloro-1-(omega-phthalimido and saccharinyl-2?-ylalkyl)pyridazin-6-ones were synthesized from 4,5-dichloro-1-hydroxymethylpyridazin-6-one and the corresponding N-(omega-haloalkyl)phthalimides and saccharins via a fragmentation of retro-ene type.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2334 – PubChem

 

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Studies on improved synthesis of 2?-deoxyribonucleosides of pyridazine derivatives

A number of 2?-deoxyribonucleosides of halogenated pyridazine derivatives were prepared by glycosylation of their respective potassium or DBU salts in acetone. The reaction yielded predominatly beta-anomers that could be purified by simple crystallization or column chromatography. Of the studied pyridazines and deoxynucleosides, only 4-bromo-6-chloro-pyridazin-3-one and 6-chloro-2-(2?-deoxyribofuranosyl)pyridazin-3-one showed modest inhibition of CK2 kinase.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2326 – PubChem

 

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IMIDAZOLES

The present invention relates to imidazole derivatives of the general formulawherein R1, R2, R3, and R4 are as defined in the specification and to pharmaceutically acceptable salts thereof. Compounds of formula I are metabotropic glutamate receptor antagonists. They can be used in the treatment or prevention of mGluR5 receptor mediated disorders.

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Reference of 932-22-9, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 932-22-9, molcular formula is C4H2Cl2N2O, introducing its new discovery.

DERIVATIVES OF 2H PYRIDAZIN-3-ONES, THEIR PREPARATION AND THEIR USE AS SCD-1 INHIBITORS

The present invention concerns compounds of general formula (I) characterized in that (formula 1) wherein, in particular: -R1 represents one or more groups such as: trifluoromethyl, halogen such as F, Cl, -when n=m=1, W represents CH then Y represents oxygen, -U represents: either – (C=O) CH2NH- and is branched at position 4 of pyridazinone, then R2 represents H, or -(C=O) NH- and U is branched at positions (4), (5) or (6) of pyridazinone, then R2 represents H, – R3 represents a hydrogen or methyl and the addition salts with pharmaceutically acceptable bases and acids and the different isomers, and their mixtures in any proportion for use as SCD-1 enzyme inhibitors for the treatment of obesity, type-2 diabetes and lipid disorders

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2243 – PubChem

 

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Application of 932-22-9, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.932-22-9, Name is 4,5-Dichloro-3(2H)-pyridazinone, molecular formula is C4H2Cl2N2O. In a article£¬once mentioned of 932-22-9

NOVEL NITROGEN-CONTAINING AROMATIC HETEROCYCLIC COMPOUND

A compound represented by general formula [1] wherein X represents N or the like, Y represents CH or the like; RA represents a cycloalkyl group which may be substituted or the like, R1 represents an alkyl group or the like, R2 represents an alkyl group which may be substituted or the like, R3 represents a hydrogen atom or an alkyl group, or a pharmaceutically acceptable salt thereof has an inhibitory activity on aldosterone synthetase, and is useful as a prophylactic and/or therapeutic agent for various diseases or symptoms associated with aldosterone.

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Pyridazine – Wikipedia,
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Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Computed Properties of C4H2Cl2N2O, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 932-22-9, in my other articles.

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BIARYL DERIVATIVE AND MEDICINE CONTAINING SAME

Provided is a compound showing excellent antifungal activity against Trichophyton fungus, which is a major causative microorganism of superficial mycosis, and high effectiveness on diseases caused by Trichophyton fungi. A biaryl derivative represented by the formula (I) or a salt thereof: wherein ring A is an optionally substituted phenyl, or an optionally substituted 5- or 6-membered ring heteroaryl (ring A may be further condensed to form an optionally substituted fused ring); Q is CH2, C=O, NH, O, S or the like; X1, X2 and X3 are CR1 or N; Y is CH or N; Z is CR2b or N; R2a and R2b are each a hydrogen atom, a halogen atom, an optionally substituted C1-C6 alkyl group, a C1-C6 haloalkyl group or the like; R2a and R2b may form, together with carbon atoms bonded thereto, an optionally substituted carbocycle, or an optionally substituted heterocycle.

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Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N2279 – PubChem