Category: 914349-19-2

914349-19-2, Name is 4-(6-Chloropyridazin-3-yl)benzaldehyde, belongs to pyridazine compound, is a common compound. Recommanded Product: 914349-19-2In an article, once mentioned the new application about 914349-19-2.

Dipolar NLO Chromophores Bearing Diazine Rings as pi-Conjugated Linkers

The synthesis of a series of push-pull derivatives bearing triphenylamine electron-donating group, cyclopenta[c]thiophen-4,6-dione electron acceptor and various pi-linkers including (hetero)aromatic fragments is reported. All target chromophores with systematically varied pi-linker structure were further investigated by electrochemistry, absorption measurements, and EFISH experiments in conjunction with DFT calculations. Based on electrochemical and photophysical measurements, when a polarizable 2,5-thienylene moiety is embedded into the chromophore pi-backbone the highest intramolecular charge transfer (ICT) is observed. Benzene, pyrimidine, and pyridazine derivatives exhibit lower polarizability and extent of the ICT across these pi-linkers. The elongation of the pi-conjugated system via additional ethenylene linker results in a significant reduction of the HOMO-LUMO gap and an enhancement of the NLO response. Whereas it does not significantly influence electrochemical and linear optical properties, the orientation of the pyrimidine ring seems to be a key parameter on the mubeta value due to significant variation of the dipolar moment (mu) value. In 2a and 2c, pyrimidine is oriented to behave as an acceptor and thus generate dipolar molecule with mu above 5 D, whereas in 2b and 2d ground state dipole moment is significantly reduced. This study seems to indicate a high aromaticity of pyrimidine and pyridazine derivatives, close to the benzene analogues and significantly higher than thiophene analogues.

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2915 – PubChem

 

Application of 914349-19-2, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.914349-19-2, Name is 4-(6-Chloropyridazin-3-yl)benzaldehyde, molecular formula is C11H7ClN2O. In a article£¬once mentioned of 914349-19-2

Novel Triazolo Pyridazine Derivatives and Use Thereof

The present invention refers to novel triazolo pyridazine derivatives or therapeutic acceptable salt about number, including c-a Met tyrosine kinase-containing compositions and or more proliferative diseases (hyper proliferative disorder) number and number about number active billion for therapeutic composition for prevention or treatment of about number are disclosed. The present invention refers to c-a Met tyrosine kinase activity of a number of abnormal kinase activity number number efficiently billion by excessive cell proliferation and growth associated with various abnormal proliferative diseases, such as cancer, psoriasis, rheumatoid arthritis, diabetic retinopathy treatment of useful as number can be used. (by machine translation)

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 914349-19-2

Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N2914 – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, SDS of cas: 914349-19-2, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 914349-19-2, Name is 4-(6-Chloropyridazin-3-yl)benzaldehyde, molecular formula is C11H7ClN2O

Compounds for non-invasive measurement of aggregates of amyloid peptides

The invention relates to the provision of compounds, methods for producing them, and their use for imaging and quantification of aggregates of amyloid peptides in vivo. In a preferred aspect of the invention, a tracer is administered to humans and displays enrichment in the areas that are containing amyloid plaques. Tracers of the invention can be used for in vivo visualization and quantification of aggregates of amyloid peptides in patients affected diseases characterized in the generation of aggregates of amyloid peptides, for example familial or sporadic Alzheimer’s disease and type II diabetes. Tracers of the invention can be used for monitoring effects of amyloid-modulating therapies of patients affected with diseases characterized in the generation of aggregates of amyloid peptides, for example familial or sporadic Alzheimer’s disease and type II diabetes.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, SDS of cas: 914349-19-2, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 914349-19-2

Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N2913 – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.914349-19-2,4-(6-Chloropyridazin-3-yl)benzaldehyde,as a common compound, the synthetic route is as follows.

4- (6-chloropyridazin-3-yl) benzaldehyde (40 mg, 0.18 mmol)Was dissolved in methanol / dichloromethane (4: 1, 2 mL), sodium borohydride (NaBH4, 10 mg, 0.26 mmol) was gradually added at 0 C and the mixture was stirred at room temperature for 2 hours. After the reaction, ethyl acetate was added thereto, washed with brine, and the organic layer was dried over anhydrous sodium sulfate,Concentrated to give (4- (6-chloropyridazin-3-yl) phenyl) methanol(39 mg, 98%) as a yellow solid.

914349-19-2, The synthetic route of 914349-19-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Korea Research Institute of Chemical Technology; Handok Co., Ltd.; Jeong Hui-jeong; Kim Hyeong-rae; Ha Jae-du; Lee Jeong-ok; Cho Seong-yun; Choi Sang-un; Lee Jong-guk; Park Ji-hun; (45 pag.)KR101869534; (2018); B1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem