Category: 89466-38-6

Analyzing the synthesis route of 89466-38-6

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89466-38-6,89466-38-6, 6-Chloro-3-methoxy-4-methylpyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation of tert-butyl 4-((6-methoxy-5-methylpyridazin-3- yl)oxy)piperidine- 1 -carboxylate. To a solution of tert-butyl 4-hydroxy-4-methylpiperidine-l- carboxylate (761 mg, 3.78 mmol) in DMF (7.9 mL) was added sodium hydride (60% w/w, 164 mg, 4.10 mmol). The reaction was stirred for 5 min at ambient temperature. Then 6-chloro-3- methoxy-4-methylpyridazine (500 mg, 3.15 mmol) was added and reaction stirred overnight at 95C. The reaction was cooled to ambient temperature and diluted with water and extracted with EtOAc. Combined organics were washed with saturated NaHC03(aq), water, and brine. The combined organic extracts were dried over anhydrous Na2S04(S), filtered and concentrated in vacuo to afford the title compound (assumed quantative yield, 1.019 g) in sufficient purity for step 2. MS (apci) m/z = 324.1 (M+H).

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Reference£º
Patent; ANDREWS, Steven W.; ARONOW, Sean; BLAKE, James F.; BRANDHUBER, Barbara J.; COLLIER, James; COOK, Adam; HAAS, Julia; JIANG, Yutong; KOLAKOWSKI, Gabrielle R.; MCFADDIN, Elizabeth A.; MCKENNEY, Megan L.; MCNULTY, Oren T.; METCALF, Andrew T.; MORENO, David A.; RAMANN, Ginelle A.; TANG, Tony P.; REN, Li; WALLS, Shane M.; (946 pag.)WO2018/71454; (2018); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

 

Some tips on 89466-38-6

The synthetic route of 89466-38-6 has been constantly updated, and we look forward to future research findings.

89466-38-6, 6-Chloro-3-methoxy-4-methylpyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 6- chloro-3-methoxy-4-methylpyridazine (3.31 g, 20.9 mmol) in 4:1 dioxane: water (100 mL) was treated with 12.0 M HC1(aq) (1.91 mL, 23.0 mmol) and stirred for 60 h at 60 C. The reaction mixture was concentrated under vacuum, and the resulting crude residue was purified by silica chromatography (1-30% DCMIMeOH with 2% NH4OH as the gradient eluent) to afford the title compound (2.99 g, 99% yield). ?HNMR(400 IVIFIz, DMSO-d6) 13.03 (s, 1H), 7.44 (s, 1H), 2.05 (s, 3H).

The synthetic route of 89466-38-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ARRAY BIOPHARMA, INC.; ANDREWS, Steven W.; BLAKE, James F.; COOK, Adam; GUNAWARDANA, Indrani W.; HUNT, Kevin W.; METCALF, Andrew T.; MORENO, David; REN, Li; TANG, Tony P.; (263 pag.)WO2017/70708; (2017); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem