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The present invention is directed to heteroarylpiperidine ether compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

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Pyridazine – Wikipedia,
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The present invention provides a hepatitis c inhibitor spiro compound and its use in medicine. The compound of formula (I) compound shown by the formula (I) as shown in the stereo isomers, geometric isomers, tautomers, nitrogen oxide, hydrate, solvate, metabolite, pharmaceutically acceptable salt or prodrug. In addition, the invention also provides a pharmaceutical composition, said compound and said pharmaceutical composition for inhibiting HCV replication and inhibit HCV virus protein function of at least one of the use, and the compounds and pharmaceutical composition useful for the prevention, treatment, treatment or alleviation of patient’s HCV infection or hepatitis c treatment of diseases. (by machine translation)

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The present invention provides substituted tetrahydroquinolinone and related compounds of formula (I), which are therapeutically useful as modulators of Retinoic acid receptor-related orphan receptors (RORs), more particularly as RORgamma modulators. These compounds are useful in the treatment and prevention of diseases and/or disorder, in particular their use in diseases and/or disorder mediated by RORgamma receptor. The present invention also provides preparation of the compounds and pharmaceutical formulations comprising at least one of the substituted tetrahydroquinolinone or related compounds of formula (I), together with a pharmaceutically acceptable carrier, diluent or excipient therefor.

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HETEROARYL PIPERIDINE ETHER ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR

The present invention is directed to heteroarylpiperidine ether compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

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The present invention provides a hepatitis c inhibitor spiro compound and its use in medicine. The compound of formula (I) compound shown by the formula (I) as shown in the stereo isomers, geometric isomers, tautomers, nitrogen oxide, hydrate, solvate, metabolite, pharmaceutically acceptable salt or prodrug. In addition, the invention also provides a pharmaceutical composition, said compound and said pharmaceutical composition for inhibiting HCV replication and inhibit HCV virus protein function of at least one of the use, and the compounds and pharmaceutical composition useful for the prevention, treatment, treatment or alleviation of patient’s HCV infection or hepatitis c treatment of diseases. (by machine translation)

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NBS (2.16 g, 12 mmol) and compound 29-1 (2.5 g, 10 mmol) were dissolved in CCl4(20 mL) and dibenzoylperoxide (0.24 g, 1.0 mmol) was slowly added dropwise at 0 C.After the addition was completed, the mixture was stirred at room temperature for 15minutes and refluxed for 7.0 hours. After the reaction is complete, CCl is removed 4Theresidue was dissolved in EtOAc (100 mL), washed with water (50 mL x 3) and brine, driedover anhydrous sodium sulfate and concentrated to give 3.2 g of crude product, which wasused directly in the next reaction.

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Reference£º
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Zhang Yingjun; Zhang Jiancun; Xie Hongming; Ren Qingyun; Hu Bolin; Wu Xiwei; Fu Changping; Li Shifeng; Wang Chaohe; Li Jing; (183 pag.)CN103880823; (2017); B;,
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Pyridazine | C4H4N2 – PubChem