89203-22-5,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.89203-22-5,3-Aminopyridazine hydrochloride,as a common compound, the synthetic route is as follows.
2,8-dimethyl-6-(2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazine-3-carboxylic acid (150.0 mg, 0.45 mmol) was dissolved in DMF (2.4 mL). HATU (255.0 mg, 0.67 mmol) was added, followed by diisopropylethylamine (0.312 mL, 1.79 mmol). 3-aminopyridazine-HCl (59.0 mg, 0.45 mmol) was slurried in DMF (2.4 mL) and diisopropylethylamine (0.078 mL, 0.45 mmol) and added to the reaction mixture. This was warmed to 60 C and allowed to stir under nitrogen atmosphere for 3.5 h. The mixture was cooled to room temp, and saturated aqueous NaHCO3 was added (6 mL), then water was added (10 mL). This was extracted with EtOAc (3×20 mL) and the combined organics were washed with brine, dried with anhydrous Na2SO4, filtered, and concentrated. The crude product was purified by silica gel column chromatography using a gradient of 0 – 10% MeOH in CH2Cl2 to give 2,8-dimethyl-N-(pyridazin-3-yl)-6-(2-(trifluoromethyl)phenyl) imidazo[1,2-b]pyridazine-3-carboxamide (19.6 mg, 11%). MS (ESI) calcd for C20H15F3N6O: 412.13; found: 413.2 [M+H].
89203-22-5 3-Aminopyridazine hydrochloride 73994943, apyridazine compound, is more and more widely used in various.
Reference£º
Patent; GlaxoSmithKline LLC; CASAUBON, Rebecca, L.; NARAYAN, Radha; OALMANN, Christopher; VU, Chi, B.; (583 pag.)EP2768509; (2017); B1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem