Category: 84956-71-8

84956-71-8,84956-71-8, 2-(tert-Butyl)-4,5-dichloropyridazin-3(2H)-one is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A solution of the substituted pyridazinone and either a benzylic alcohol or benzylic bromide in dimethylformamide was treated with cesium carbonate then optionally heated to 55-80 C. After cooling to ambient temperature, the crude product was isolated as a solution in ethyl acetate, washed with water and aqueous sodium chloride then dried, filtered and concentrated. Subsequent purification by chromatography on silica afforded the title compound.

84956-71-8 2-(tert-Butyl)-4,5-dichloropyridazin-3(2H)-one 2782225, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; Lantheus Medical Imaging, Inc.; Cesati, Richard R.; Radeke, Heike S.; Pandey, Suresh K.; Purohit, Ajay; Robinson, Simon P.; US2015/196672; (2015); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

84956-71-8, 2-(tert-Butyl)-4,5-dichloropyridazin-3(2H)-one is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

84956-71-8, Preparation Example 23 Preparation of 2-t-butyl-4-chloro-5[{6-(4-fluorobenzyloxy)-3-pyridyl}-methyloxy]-3(2H)-pyridazinone (Compound No. 1011) To a solution of 2.3 g of 6-(4-fluorobenzyloxy)-3-pyridine methanol in 20 ml of N,N-dimethylformamide was added under stirring at 0C 0.5 g of 55% sodium hydride (in mineral oil). After stirring for 30 minutes at room temperature, thereto was added 2.2 g of 2-t-butyl-4,5-dichloro-3(2H)-pyridazinone. The reaction mixture was stirred at room temperature for additional 8 hours, poured into 50 ml of ice water and extracted twice with 50 ml of benzene. The organic layer was washed with water, dried over anhydrous sodium sulfate and then freed of solvent by distillation under reduced pressure to give 4.1 g of a crude product. The crude product was added with isopropyl ether and recrystallized therefrom to obtain 3.2 g of 2-t-butyl-4-chloro-5-[{6-(4-fluorobenzyloxy)-3-pyridyl}-methyloxy]-3(2H)-pyridazinone, m.p. 121.0 124.0C.

84956-71-8 2-(tert-Butyl)-4,5-dichloropyridazin-3(2H)-one 2782225, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; NISSAN CHEMICAL INDUSTRIES LTD.; EP199281; (1991); B1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.84956-71-8,2-(tert-Butyl)-4,5-dichloropyridazin-3(2H)-one,as a common compound, the synthetic route is as follows.

84956-71-8, General procedure: A solution of the substituted pyridazinone and either a benzylic alcohol or benzylic bromide in dimethylformamide was treated with cesium carbonate then optionally heated to 55-80 C. After cooling to ambient temperature, the crude product was isolated as a solution in ethyl acetate, washed with water and aqueous sodium chloride then dried, filtered and concentrated. Subsequent purification by chromatography on silica afforded the title compound.

As the paragraph descriping shows that 84956-71-8 is playing an increasingly important role.

Reference£º
Patent; Lantheus Medical Imaging, Inc.; Cesati, Richard R.; Radeke, Heike S.; Pandey, Suresh K.; Purohit, Ajay; Robinson, Simon P.; US2015/196672; (2015); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

84956-71-8, 2-(tert-Butyl)-4,5-dichloropyridazin-3(2H)-one is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

84956-71-8, Example 3 Synthesis of 2-tert-butyl-4-chloro-5-[2-(2-methyl-4-n-pentylphenoxy)ethylthio]-3(2H)-pyridazinone (Compound No. 12) In 20 ml of methanol were dissolved 1.8 g of 2-tert-butyl-4,5-dichloro-3(2H)-pyridazinone and 1.9 g of 2-(2-methyl-4-n-pentylphenoxy)ethylmercaptan, and then to the mixture was added dropwise a solution of 0.5 g of sodium methoxide dissolved in 5 ml of methanol. After dropwise addition, the mixture was stirred at room temperature for 1 hour to complete the reaction. Then, methanol was distilled off under reduced pressure, and an oily product which was separated by adding water was extracted with ethyl acetate The extract was washed with water, dried over anhydrous sodium sulfate, and then ethyl acetate was distilled off under reduced pressure. The oily product obtained was isolated by column chromatography (Wako Gel C-200, eluted with toluene: ethyl acetate = 9: 1) to give 2.8 g of the title compound as colorless oily liquid.

The synthetic route of 84956-71-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; UBE INDUSTRIES, LTD.; RIKAGAKU KENKYUSHO; EP283271; (1990); A3;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.84956-71-8,2-(tert-Butyl)-4,5-dichloropyridazin-3(2H)-one,as a common compound, the synthetic route is as follows.

84956-71-8, 2-(t-butyl)-4,5-dichloro-2-hydro-pyridazin-3-one (1.66 g, 7.50 mmol) and (4-(2-methyl-1,3-dioxolan-2-yl)phenyl) methanol (0.971g, 5.00mmol; for example, Takebayashi, S;. Dabral, N;. Miskolzie, M;.. Bergens, S.H.J.Am.Chem.Soc, 2011,133,25, 9666-9669, )solution in dry dimethylformamide (50.0 mL) to a it was treated at ambient temperature at a time by cesium carbonate (3.26g, 10.0mmol). Then, the resulting suspension was immersed in a preheated oil bath , and maintained at 65 C., with vigorous stirring, for 4 hours. After cooling to ambient temperature, the suspension was maintained for a further 12 hours,and then, is transferred to a separation funnel, and ethyl acetate (each 50 ml) and divided into water. Furthermore, these layers are separated, washed with ethyl acetate aqueous layer (2¡Á50mL). A saturated aqueous sodium chloride in combination with ethyl acetate (5¡Á50mL) washing and cleaning, then, dried with magnesium sulfate, filtering, in reduced pressure to concentrate the yellow solid. Subsequently, coarse material, 7:3 hydroxypentanoic/ethyl acetate is purified by using silica chromatography (40¡Á220mm). The main product is recovered at peak 400-700mL eluent, pools, in reduced pressure concd. white solid. Subsequently, the material is purified hot ethyl acetate/aminopentanenitrile by recrystallization from a colorless needle is obtained (1. 33g, 3. 51mmol; 70. 1%).1H NMR : (300MHz, DMSO-d6) delta8. 27 (1H, s), 7. 52-7. 36 (4H, m), 5. 44 (2H, s), 4. 07-3. 93 (2H, m), 3. 76-3. 60 (2H, m), 1. 57 (9H, s), 1. 55 (3H, s).13C NMR : (75MHz, DMSO-d6) delta157. 8,153. 9,143. 6,134. 9,127. 7,126. 2,125. 4,115. 5,107. 9, 71. 2, 65. 4, 64. 1, 27. 5, 27. 2. HRMS C19H2335ClN2O4to calculated value (M+H): 379. 1419 ; measured value: 379. 1416. TLC: Rf0. 39 (silica gel, 7:3 hydroxypentanoic/ethyl acetate, uv).

84956-71-8 2-(tert-Butyl)-4,5-dichloropyridazin-3(2H)-one 2782225, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; LANTHEUS MEDICAL IMAGING INCORPORATED; CESATI, RICHARD R; RADEKE, HEIKE S; PANDEY, SURESH K; PUROHIT, AJAY; ROBINSON, SIMON P; (297 pag.)JP2015/531760; (2015); A;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

84956-71-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.84956-71-8,2-(tert-Butyl)-4,5-dichloropyridazin-3(2H)-one,as a common compound, the synthetic route is as follows.

Example 39E; Synthesis of 2-(i-butyl)-4-chloro-5-[(4-(l,3-dioxolan-2-yl)phenyl)methoxy]-2- hydropyridazin-3-one (Compound 21); To a vessel charged with (4-(l,3-dioxolan-2-yl)phenyl)methanol (20 g, 110 mmol), benzyltriethylammonium chloride (2.27 g, 10 mmol), toluene (100 mL) and sodium hydroxide (50% in water, 22 mL, 420 mmol) was added a solution of 2-(?-butyl)- 4,5-dichloro-2-hydropyridazin-3-one (22.1 g, 100 mmol) in toluene (100 mL) over 5 min. A gradual and accelerating exotherm occurred with the final internal temperature reaching 39 C. After 2.5 h stirring was halted and MTBE (50 mL) and water (100 mL) added. The phases were split and the organic layer was washed with water (100 mL) and brine (100 mL). The organic extracts were dried (MgS04), filtered, and concentrated under vacuum to afford a tan solid (39 g). The solids were slurried in toluene/heptane (430 mL, 1 : 1) at 40 C for 2 h, cooled to ambient temperature, filtered and dried under vacuum at 40 C for 24 h (29.7 g, 69%).

The synthetic route of 84956-71-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; LANTHEUS MEDICAL IMAGING, INC.; CESATI, Richard, R.; CHEESMAN, Edward, H.; LAZEWATSKY, Joel; RADEKE, Heike, S.; CASTNER, James, F.; MONGEAU, Enrico; ZDANKIEWICZ, Dianne, D.; SIEGLER, Robert, Wilburn; DEVINE, Marybeth; WO2011/97649; (2011); A2;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

84956-71-8, 2-(tert-Butyl)-4,5-dichloropyridazin-3(2H)-one is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,84956-71-8

PREPARATION EXAMPLE 26 Preparation of 2-t-butyl-4-chloro-5-[{6-(2,2,2-trifluoroethoxy)-3-pyridyl}-methylthio]-3(2H)-pyridazinone (Compound No. 1055) In 40 ml of methanol were dissolved 2.2 g of 2-t-butyl-4,5-dichloro-3(2H)-pyridazinone and 2.4 g of 5-mercaptomethyl(2,2,2-trifluoro-ethoxy)-pyridine, and thereto was added 1.2 g of sodium carbonate. The reaction mixture was stirred overnight at room temperature and then poured into water. Then, procedures similar to those in Preparation Example 24 were conducted to obtain 3.6 g of 2-t-butyl-4-chloro-5-[{6-(2,2,2-trifluoroethoxy)-3-pyridyl}-methylthio]-3(2H)-pyridazinone, m.p. 109.0~110.0 C. NMR (CDCl3, delta, TMS): 1.61 (9H, s), 4.22 (2H, s), 4.73 (2H, q, J=9 Hz), 6.87 (1H, d, J=9 Hz), 7.62 (1H, s), 7.60~7.89 (1H, m), 8.15 (1H, d, J=2 Hz).

84956-71-8 2-(tert-Butyl)-4,5-dichloropyridazin-3(2H)-one 2782225, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; Nissan Chemical Industries, Ltd.; US4837217; (1989); A;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

84956-71-8, 2-(tert-Butyl)-4,5-dichloropyridazin-3(2H)-one is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

84956-71-8, Synthesis of 2-tert-butyl-4-chloro-5-(2-tert-butyldimethylsilyloxy-1-(4-tert-butylphenyl)-1-ethyl)oxy-3(2H)-pyridazinone To a solution of 2-tert-butyl-4,5-dichloro-3(2H)-pyridazinone (0.5 g, 2.27 mmol) in DMF (10 ml) were added anhydrous cesium carbonate (0.74 g, 2.27 mmol) and 1-tert-butyldimethylsilyloxy 2-hydroxy 2-(4-tertbutylphenyl) ethane (0.7 g, 2.27 mmol). The mixture is stirred for 2 hours at 70 C. and then cooled to room temperature and ethyl acetate is added to it. The solution is then washed with water, dried and concentrated and the residue subjected to purification by flash chromatography (silica gel; ethyl acetate/hexanes) to give the above compound.

84956-71-8 2-(tert-Butyl)-4,5-dichloropyridazin-3(2H)-one 2782225, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; Casebier, David S.; Robinson, Simon P.; Purohit, Ajay; Radeke, Heike S.; Azure, Michael T.; Dischino, Douglas D.; US2005/191238; (2005); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

84956-71-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.84956-71-8,2-(tert-Butyl)-4,5-dichloropyridazin-3(2H)-one,as a common compound, the synthetic route is as follows.

General procedure: A solution of the substituted pyridazinone and either a benzylic alcohol or benzylic bromide in dimethylformamide was treated with cesium carbonate then optionally heated to 55-80 C. After cooling to ambient temperature, the crude product was isolated as a solution in ethyl acetate, washed with water and aqueous sodium chloride then dried, filtered and concentrated. Subsequent purification by chromatography on silica afforded the title compound.

The synthetic route of 84956-71-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Lantheus Medical Imaging, Inc.; Cesati, Richard R.; Radeke, Heike S.; Pandey, Suresh K.; Purohit, Ajay; Robinson, Simon P.; US2015/196672; (2015); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

84956-71-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.84956-71-8,2-(tert-Butyl)-4,5-dichloropyridazin-3(2H)-one,as a common compound, the synthetic route is as follows.

EXAMPLE 8 Synthesis of 2-tert.-butyl-4-chloro-5-[4-(1,1,2-trifluoro-2-trifluoromethoxy-ethoxy)-benzyloxy]-3(2H)-pyridazinone [Compound (3)] 1.16 g of 4-(1,1,2-trifluoro-2-trifluoromethoxy-ethoxy)-benzyl alcohol (Example 3) and, 15 minutes later, 0.95 g of 2-tert.-butyl-4,5-dichloro-3(2H)-pyridazinone are added to a suspension of 0.2 g of sodium hydride at 50% in 10 cc of dimethylformamide. The resulting reaction mixture is stirred for 1 hour at room temperature, is diluted with ether, is washed with diluted HCl and brine; the washed solution is thoroughly dehydrated, the solvent is evaporated off and the so obtained raw reaction product is chromatographed on silica gel with 9/1 hexane/ethyl acetate. 1.3 g of pure product is obtained. Melting point 68-69 C.

84956-71-8 2-(tert-Butyl)-4,5-dichloropyridazin-3(2H)-one 2782225, apyridazine compound, is more and more widely used in various fields.

Reference£º
Patent; Presidenza del Consiglio dei Ministri-Ufficio del Ministro per il coordinamento delle iniziative per la ricerva Scientifica e Tecnologica; US5169848; (1992); A;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem