Category: 825633-94-1

Chemistry is traditionally divided into organic and inorganic chemistry. name: 5-Iodo-2,3-dihydropyridazin-3-one, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 825633-94-1

SRINE/THREONINE KINASE INHIBITORS

Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2977 – PubChem

 

825633-94-1, Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬Which mentioned a new discovery about 825633-94-1

PYRIDAZINONE DERIVATIVES AS PHOSHOINOSITIDE 3-KINASES INHIBITORS

Compounds of formula (I) described herein inhibit phosphoinositide 3-kinases (PI3K) and useful for the treatment of disorders associated with PI3K enzymes.

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Pyridazine – Wikipedia,
Pyridazine | C4H4N2976 – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.825633-94-1,5-Iodo-2,3-dihydropyridazin-3-one,as a common compound, the synthetic route is as follows.

5-Iodopyridazin-3 (2H) -one (200 mg, 0.90 mmol) , potassium carbonate (249 mg, 1.80 mmol) , and anhydrous acetonitrile (4.5 mL) were charged to a round-bottom flask equipped with a rubber septum and magnetic stirbar. Methyl iodide (62.0 muL, 0.991 mmol) was charged dropwise via syringe. The flask was then equipped with a reflux condenser and heated at reflux for 1 hour. The reaction mixture was filtered through. The filtrate was evaporated to give the crude product, which was purified by silica gel column chromatography (0-10 MeOH/DCM) to afford 5-iodo-2-methylpyridazin-3 (2H) -one. LC/MS: (M+1) +: 236.80., 825633-94-1

The synthetic route of 825633-94-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; PASTERNAK, Alexander; DONG, Shuzhi; GU, Xin; JIANG, Jinlong; SHI, Zhi-Cai; WALSH, Shawn P.; WU, Zhicai; YU, Yang; FERGUSON II, Ronald; GUO, Zhiqiang; FRIE, Jessica; SUZUKI, Takao; BLIZZARD, Timothy A.; FU, Qinghong; VANGELDER, Kelsey F.; (118 pag.)WO2016/65582; (2016); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem

 

825633-94-1, 5-Iodo-2,3-dihydropyridazin-3-one is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

825633-94-1, [00214] Step 4: To a solution of 5-iodopyridazin-3(2H)-one (5 g, 23 mmol) in NJV- dimethylformamide (45 mL, 23 mmol) was sequentially added l-(bromomethyl)-4- methoxybenzene (4.5 g, 23 mmol) and K2C03 (3.4 g, 25 mmol). The mixture was stirred at ambient temperature under N2 atmosphere. After 48 hours, additional 1 -(bromomethyl)-4- methoxybenzene (450 mg, 0.1 equivalent) was added, and the mixture was stirred at ambient temperature for 4 more hours. The mixture was poured into ice water (100 mL) and extracted with EtOAc (3 X 75 mL). The combined organic layers were washed with 2% HC1 followed by brine. The organic layer was dried (MgS04), filtered and concentrated in vacuo. The residue obtained was triturated with EtOAc rhexane to provide the first batch of the product. Mother liquor was concentrated and triturated with CH3CN to provide the second batch of the product. The combined batches gave 5-iodo-2-(4-methoxybenzyl)pyridazin-3(2H)-one (6.2 g, 80% yield) as a solid.

The synthetic route of 825633-94-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ARRAY BIOPHARMA INC.; GENENTECH, INC.; BLAKE, James, F.; COOK, Adam; GAUDINO, John; GUNAWARDANA, Indrani, W.; HICKEN, Erik, James; HUNT, Kevin, W.; LYON, Michael; METCALF, Andrew, T.; MOHR, Peter, J.; MORENO, David, A.; NEWHOUSE, Brad; REN, Li; SCHWARZ, Jacob; CHEN, Huifen; GAZZARD, Lewis; SCHMIDT, Jane; DO, Steve; WO2015/103137; (2015); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem