Category: 825633-94-1

Application of 825633-94-1, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 825633-94-1, 5-Iodo-2,3-dihydropyridazin-3-one, introducing its new discovery.

Diamino-pyridine, pyrimidine and pyridazine compounds which may be used as H4 receptor modulators, and in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application of 825633-94-1. In my other articles, you can also check out more blogs about 825633-94-1

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2979 – PubChem

 

Chemistry is traditionally divided into organic and inorganic chemistry. Quality Control of 5-Iodo-2,3-dihydropyridazin-3-one, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 825633-94-1

The present invention provides a compound of general Formula (I) having histone deacetylase (HDAC) and/or Cyclin-dependent kinase (CDK) inhibitory activity, a pharmaceutical composition comprising the compound, and a method useful to treat diseases using the compound

If you are interested in 825633-94-1, you can contact me at any time and look forward to more communication. Quality Control of 5-Iodo-2,3-dihydropyridazin-3-one

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2980 – PubChem

 

Synthetic Route of 825633-94-1, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.825633-94-1, Name is 5-Iodo-2,3-dihydropyridazin-3-one, molecular formula is C4H3IN2O. In a Article，once mentioned of 825633-94-1

Design, synthesis, and structure-activity relationships of a novel series of 5-alkylidenepyridazin-3(2H)-ones with a non-cAMP-based antiplatelet activity

5-Alkylidenepyridazin-3-ones with four points of diversity (R2, R6, X, Y) have been synthesized and evaluated as platelet aggregation inhibitors. Several derivatives eliciting antiplatelet activity in the low micromolar range (e.g., 14e, 14k, 14p, 14v, IC50 ? 1 mu M) were identified. Structure-activity relationships studies on these compounds revealed the key molecular determinants of this new family of antiplatelet agents: (a) two ester groups in the alkoxy moieties; (b) lipophilic substituents at the N2 position of the pyridazin-3-one. The preliminary results of a pharmacological study aimed at determining the mechanism of action of a set of representative compounds revealed that, unlike other pyridazinones, the documented antiplatelet effect is not a consequence of a PDE-III inhibitory activity.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 825633-94-1

Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2986 – PubChem

 

Application of 825633-94-1, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.825633-94-1, Name is 5-Iodo-2,3-dihydropyridazin-3-one, molecular formula is C4H3IN2O. In a Patent£¬once mentioned of 825633-94-1

PYRIDAZINONE DERIVATIVES AS PHOSHOINOSITIDE 3-KINASES INHIBITORS

Compounds of formula (I) described herein inhibit phosphoinositide 3-kinases (PI3K) and useful for the treatment of disorders associated with PI3K enzymes.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 825633-94-1, and how the biochemistry of the body works.Application of 825633-94-1

Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N2976 – PubChem

 

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 825633-94-1, name is 5-Iodo-2,3-dihydropyridazin-3-one, introducing its new discovery. name: 5-Iodo-2,3-dihydropyridazin-3-one

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 825633-94-1, and how the biochemistry of the body works.name: 5-Iodo-2,3-dihydropyridazin-3-one

Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N2981 – PubChem

 

Application of 825633-94-1, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.825633-94-1, Name is 5-Iodo-2,3-dihydropyridazin-3-one, molecular formula is C4H3IN2O. In a Patent£¬once mentioned of 825633-94-1

SERINE/THREONINE KINASE INHIBITORS

Compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such diseases, or associated pathological conditions are disclosed.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 825633-94-1

Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N2978 – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, name: 5-Iodo-2,3-dihydropyridazin-3-one, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 825633-94-1, Name is 5-Iodo-2,3-dihydropyridazin-3-one, molecular formula is C4H3IN2O

Synthesis and evaluation of 4- and 5-pyridazin-3-one phenoxypropylamine analogues as histamine-3 receptor antagonists

A novel series of 4-pyridazin-3-one and 5-pyridazin-3-one analogues were designed and synthesized as H3R antagonists. Structure-activity relationship revealed the 5-pyridazin-3-ones 8a and S-methyl 8b had excellent human and rat H3R affinities, and acceptable pharmacokinetic properties. In vivo evaluation of 8a showed potent activity in the rat dipsogenia model and robust wake-promoting activity in the rat EEG/EMG model.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. name: 5-Iodo-2,3-dihydropyridazin-3-one, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 825633-94-1, in my other articles.

Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N2985 – PubChem

 

Application of 825633-94-1, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 825633-94-1, 5-Iodo-2,3-dihydropyridazin-3-one, introducing its new discovery.

PYRIDIZINONE DERIVATIVES

The present invention provides compounds of formula (I*): their use as H3 inhibitors, processes for their preparation, and pharmaceutical compositions thereof.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application of 825633-94-1. In my other articles, you can also check out more blogs about 825633-94-1

Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N2982 – PubChem

 

Application of 825633-94-1, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.825633-94-1, Name is 5-Iodo-2,3-dihydropyridazin-3-one, molecular formula is C4H3IN2O. In a Patent£¬once mentioned of 825633-94-1

AZA PYRIDONE ANALOGS USEFUL AS MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS

MCHR1 antagonists are provided having the following Formula (I): A 1 and A 2 are independently C or N, E is C or N, Q 1 , Q 2 , and Q 3 are independently C or N provided that at least one of Q 1 , Q 2 , and Q 3 is N but not more than one of Q 1 , Q 2 , and Q 3 is N, D 1 is a bond, -CR 8 R 9 X-, -XCR 8 R 9 -, -CHR 8 CHR 9 -, -CR 10 =CR 10′ -, -C-C-, or 1,2-cyclopropyl; X is O, S or NR 11, R 1 , R 2 , and R 3 are ,independently selected from the group consisting of hydrogen, halogen, lower alkyl, lower cycloalkyl, -CF 3 , -OCF 3 , -OR 12 and -SR 12, G is O, S or -NR 15, D 2 is lower alkyl, lower cycloalkyl, lower alkylcycloalkyl, lower cycloalkylalkyl, lower cycloalkoxyalkyl or lower alkylcycloalkoxy or when G is NR 15 , G and D 2 together may optionally form an azetidine, pyrrolidine or piperidine ring; Z 1 and Z 2 are independently hydrogen, lower alkyl, lower cycloalkyl, lower alkoxy, lower cycloalkoxy, halo, -CF 3 , -OCONR 14 R 14′ , -CN, -CONR 14 R 14′ , -SOR 12 , -SO 2 R 12 , -NR 14 COR 14′ , -NR 14 CO 2 R 14′ , -CO 2 R 12 , NR 14 SO 2 R 12 or COR 12 ; R 5 , R 6 , and R 7 are independently selected from the group consisting of hydrogen lower alkyl, lower cycloalkyl, -CF 3 , -SR 12 , lower alkoxy, lower cycloalkoxy, -CN, -CONR 14 R 14′ , SOR 12 , SO 2 R 12 , NR 14 COR 14′ , NR 14 CO 2 R 12 , CO 2 R 12 , NR 14 SO 2 R 12 and -COR 12 ; R 8 , R 9 , R 10 , R 10′ , R 11 are independently hydrogen or lower alkyl; R 12 is lower alkyl or lower cycloalkyl; R 14 and R 14′ are independently H, lower alkyl, lower cycloalkyl or R 14 and R 14′ together with the N to which they are attached form a ring having 4 to 7 atoms; and R 15 is independently selected from the group consisting of hydrogen and lower alkyl. Such compounds are useful for the treatment of MCHR1 mediated diseases, such as obesity, diabetes, IBD, depression, and anxiety

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 825633-94-1, and how the biochemistry of the body works.Application of 825633-94-1

Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N2972 – PubChem

 

Reference of 825633-94-1, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 825633-94-1, Name is 5-Iodo-2,3-dihydropyridazin-3-one,introducing its new discovery.

Pyridazine derivatives. Part 39: Reactivity of 5-iodopyridazin-3(2H)-ones in palladium-catalysed reactions

In the search for novel antiplatelet agents, convenient and efficient methods for the preparation of 2,5-disubstituted pyridazin-3(2H)-ones are reported that utilise palladium-catalysed cross-coupling reactions. A post-coupling base-promoted isomerisation has been observed during Sonogashira alkynylation of 5-iodopyridazin-3(2H)-ones (3) with 1-phenyl-2-propyn-1-ol. Variable amounts of phthalazinones were isolated as by-products during the Heck alkenylation of 3. The usefulness of the hydroxymethyl fragment as a protecting group during the synthesis of 5-substituted pyridazin-3(2H)-ones has been validated. Graphical Abstract

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 825633-94-1, and how the biochemistry of the body works.Reference of 825633-94-1

Reference£º
Pyridazine – Wikipedia,
Pyridazine | C4H4N2987 – PubChem