Category: 766-55-2

Manual and automated Cu-mediated radiosynthesis of the PARP inhibitor [¹⁸F]olaparib was written by Guibbal, Florian;Isenegger, Patrick G.;Wilson, Thomas C.;Pacelli, Anna;Mahaut, Damien;Sap, Jeroen B. I.;Taylor, Nicholas J.;Verhoog, Stefan;Preshlock, Sean;Hueting, Rebekka;Cornelissen, Bart;Gouverneur, Veronique. And the article was included in Nature Protocols in 2020.Category: pyridazine This article mentions the following:

Abstract: PET is a diagnostic nuclear imaging modality that relies on automated protocols to prepare agents labeled with a positron-emitting radionuclide (e.g., ¹⁸F). In recent years, new reactions have appeared for the ¹⁸F-labeling of agents that are difficult to access by applying traditional radiochem., for example those requiring ¹⁸F incorporation into unactivated (hetero)arenes. However, automation of these new methods for translation to the clinic has progressed slowly because extensive modification of manual protocols is typically required when implementing novel ¹⁸F-labeling methodologies within automated modules. Here, we describe the workflow that led to the automated radiosynthesis of the poly(ADP-ribose) polymerase (PARP) inhibitor [¹⁸F]olaparib. First, we established a robust manual protocol to prepare [¹⁸F]olaparib from the protected N-[2-(trimethylsilyl)ethoxy]methyl (SEM) arylboronate ester precursor in a 17% ± 5% (n = 15; synthesis time, 135 min) non-decay-corrected (NDC) activity yield, with molar activity (A_m) up to 34.6 GBq/μmol. Automation of the process, consisting of copper-mediated ¹⁸F-fluorodeboronation followed by deprotection, was achieved on an Eckert & Ziegler Modular-Lab radiosynthesis platform, affording [¹⁸F]olaparib in a 6% ± 5% (n = 3; synthesis time, 120 min) NDC activity yield with A_m up to 319 GBq/μmol. In the experiment, the researchers used many compounds, for example, Imidazo[1,2-b]pyridazine (cas: 766-55-2Category: pyridazine).

Imidazo[1,2-b]pyridazine (cas: 766-55-2) belongs to pyridazine derivatives. The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Specifically, the pyridazine moiety is an important structural feature of various pharmacologically important compounds with activities like antimicrobial, analgesic, anti-inflammatory, antiplatelet, anticancer, antisecretory, antiulcer, antidepressant, cardiotonic, vasodilator, antiarrhythmic, and hypocholesterolaemic.Category: pyridazine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Synthesis of pyridazine derivatives. XVI. Methyl-substituted imidazo[1,2-b]pyridazines by synthesis and homolytic methylation was written by Pollak, Alfred;Stanovnik, B.;Tisler, Miha. And the article was included in Tetrahedron in 1968.Computed Properties of C6H5N3 This article mentions the following:

Several Me substituted imidazo[1,2-b]pyridazines such as I, were synthesized and N.M.R. data for some of them are included and discussed. Homolytic methylation of imidazo[1,2-b]pyridazine revealed a marked selectivity and afforded a mixture of 7-methyl-, 8-methyl-, and 7,8-dimethylimidazo[1,2-b]pyridazine which could be separated by gas chromatog. 27 references. In the experiment, the researchers used many compounds, for example, Imidazo[1,2-b]pyridazine (cas: 766-55-2Computed Properties of C6H5N3).

Imidazo[1,2-b]pyridazine (cas: 766-55-2) belongs to pyridazine derivatives. The pyridazine structure is also found within the structure of several drugs such as cefozopran, cadralazine, minaprine, pipofezine, and hydralazine. In the past decade, X-ray data were reported with regard to the characterization and structural elucidation of a number of pyridazine-metal complexes, including pyridazine ligands with zinc, nickel, copper, cadmium and ruthenium.Computed Properties of C6H5N3

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Application of aza-transfer to organic compounds. Reactions between heterocyclic diazo compounds and hydrazines was written by Dezman, L.;Janezic, D.;Kokalj, M.;Kozak, E.;Primc, J.;Stanovnik, B.;Tisler, M.;Zaplotnik-Naglic, O.. And the article was included in Tetrahedron in 1977.Reference of 766-55-2 This article mentions the following:

Aza transfer reactions between heterocyclic hydrazines and diazonium salts or between heterocyclic diazo compounds and substituted hydrazines were studied. The reaction proceeds via intermediate tetrazenes and labeled compounds were used to elucidate the reaction mechanism. In the experiment, the researchers used many compounds, for example, Imidazo[1,2-b]pyridazine (cas: 766-55-2Reference of 766-55-2).

Imidazo[1,2-b]pyridazine (cas: 766-55-2) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. Pyridazine is bioavailable (especially in the CNS) and can reduce toxicity. Pyridazine is a component of several drug molecules, and the pyridazine pharmacophore has contributed to a variety of pharmacologically active compounds.Reference of 766-55-2

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Pyridazines. LXV. Reactions of some 1-phenacylazolopyridazinium halides with 2,3-diphenylcyclopropenone, -thione, or hydrazine was written by Koren, B.;Stanovnik, B.;Tisler, M.. And the article was included in Journal of Heterocyclic Chemistry in 1974.Quality Control of Imidazo[1,2-b]pyridazine This article mentions the following:

1-Phenacylazolo-pyridazinium bromides I (R = H, Cl, X = CH; R = H, X = N) reacted with 2,3-diphenylcyclopropenone or -thione in the presence of Et3N to give the pyrones II (X1 = O, S) and the azolopyridazines III. I (R = H, Cl, X = CH) reacted with N2H4 to give either 3,6-diphenylpyridazine and III (R = H, NHNH2, X = CH) or by ring opening of the azine part to give 1-methyl-2-(5-pyrazolyl)imidazole. In the experiment, the researchers used many compounds, for example, Imidazo[1,2-b]pyridazine (cas: 766-55-2Quality Control of Imidazo[1,2-b]pyridazine).

Imidazo[1,2-b]pyridazine (cas: 766-55-2) belongs to pyridazine derivatives. The pyridazine structure is a popular pharmacophore which is found within a number of herbicides such as credazine, pyridafol and pyridate. Pyridazine can act as a hydrogen bond acceptor to improve the physicochemical properties of drug molecules by increasing their water solubility, and has a high affinity for complexing with targets due to its dipole moment.Quality Control of Imidazo[1,2-b]pyridazine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Pyridazines. 67. Homolytic phenylation of some azolopyridazines was written by Furlan, A.;Furlan, M.;Stanovnik, B.;Tisler, M.. And the article was included in Monatshefte fuer Chemie in 1974.Synthetic Route of C6H5N3 This article mentions the following:

Homolytic phenylation of imidazopyridazines I (R = H, Ph, R1 = H; R = H, Ph, Me, R1 = Cl), triazolopyridazines II (R = H, Me, Ph, R1 = H, Cl), and III (R1 = H, Cl) with Bz2O, with or without PhCl, occurred preferentially at the 8-position. I also yielded 3-Ph derivatives II (R = H) also gave 8-Ph and 3-Ph derivatives, whereas II (R = Me, Ph) was substituted at the 8-position and then at the 7-position. III were phenylated only at the 8- and 7-positions. In the experiment, the researchers used many compounds, for example, Imidazo[1,2-b]pyridazine (cas: 766-55-2Synthetic Route of C6H5N3).

Imidazo[1,2-b]pyridazine (cas: 766-55-2) belongs to pyridazine derivatives. Pyridazines is a six-membered nitrogen-containing significant heterocycle. It has received considerable interest because of its useful applications as natural products, pharmaceuticals, and various bioactive molecules. Pyridazine compounds have attracted interest in various fields like medicinal, industrial, and agricultural research as they are used for numerous biological activities and other applications.Synthetic Route of C6H5N3

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Synthesis of imidazo[1,2-b]pyridazine was written by Lu, Hongguo;Xu, Yungen;Ren, Dong;Zhou, Bin. And the article was included in Zhongguo Yiyao Gongye Zazhi in 2006.COA of Formula: C6H5N3 This article mentions the following:

A method for the synthesis of the title compound is reported here. This compound is an intermediate for cefozopran [i.e., 1-[[(6R,7R)-7-[[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]imidazo[1,2-b]pyridazinium inner salt]. Imidazo[1,2-b]pyridazine was synthesized from 3,6-dichloropyridazine by ammonolysis to give 3-amino-6-chloropyridazine, which was subjected to condensation and cyclization followed by catalytic hydrogenolysis (overall yield 85.4%). In the experiment, the researchers used many compounds, for example, Imidazo[1,2-b]pyridazine (cas: 766-55-2COA of Formula: C6H5N3).

Imidazo[1,2-b]pyridazine (cas: 766-55-2) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. The activity depends upon the changes of substituted groups in the pyridazine ring system resulting in different biological activities. In addition, the natural pyrimidine bases uracil, thymine, and cytosine, which are constituents of the nucleic acids, are found to be the most important naturally occurring diazines.COA of Formula: C6H5N3

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem