Category: 73963-42-5

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 73963-42-5, Name is 5-(4-Chlorobutyl)-1-cyclohexyl-1H-tetrazole, molecular formula is C11H19ClN4, belongs to pyridazines compound. In a document, author is Bulychev, V. P., introduce the new discover, SDS of cas: 73963-42-5.

Calculation of Vibrational Parameters of an Electride-Like Molecule Li4C4H2N2 and the Pyridazine Molecule C4H4N2

The frequencies and intensities are calculated for fundamental transitions between vibrational states of an electride-like molecule Li4C4H2N2 that can be obtained from the pyridazine molecule C4H4N2 by replacing two hydrogen atoms by lithium atoms and adding two other lithium atoms to nitrogen atoms. Spectral parameters of Li4C4H2N2 are calculated in the harmonic and anharmonic approximations using the MP2, CCSD, and QCISD methods with the sets of atomic functions aug-cc-pVDZ and aug-cc-pVTZ. For comparison the absorption spectrum of a pyridazine molecule was calculated in the same approximations. The calculations showed that, upon introducing lithium atoms into the pyridazine molecule, new intense bands appear and the spectral parameters of the bands present in the pyridazine spectrum are significantly changed. The results obtained may be useful for spectroscopic observation and identification of the new compound.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 73963-42-5. SDS of cas: 73963-42-5.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 73963-42-5, Name is 5-(4-Chlorobutyl)-1-cyclohexyl-1H-tetrazole, molecular formula is C11H19ClN4. In an article, author is Delaye, Pierre-Olivier,once mentioned of 73963-42-5, COA of Formula: C11H19ClN4.

Natural Deep Eutectic Solvents as Sustainable Solvents for Suzuki-Miyaura Cross-Coupling Reactions Applied to Imidazo-Fused Heterocycles

Herein, we present the first Suzuki-Miyaura cross-coupling in a sustainable natural deep eutectic solvent (NaDES) applied to biologically relevant imidazo-fused scaffolds imidazo[1,2-a]pyridine and imidazo[1,2-b]pyridazine. The choline chloride/glycerol (1:2, mol/mol) NaDES allowed the functionalisation of diverse positions on the heterocycles with various boronic acids, by using 2.5 mol% of readily available Pd(OAc)(2). Notably, the catalytic system proceeds without any ligands or additives, without protection from the atmosphere.

Interested yet? Keep reading other articles of 73963-42-5, you can contact me at any time and look forward to more communication. COA of Formula: C11H19ClN4.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Reference of 73963-42-5, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 73963-42-5, Name is 5-(4-Chlorobutyl)-1-cyclohexyl-1H-tetrazole, SMILES is ClCCCCC1=NN=NN1C2CCCCC2, belongs to pyridazines compound. In a article, author is Nahle, Ayssar, introduce new discover of the category.

Effect of substituted methyl group by phenyl group in pyridazine ring on the corrosion inhibition of mild steel in 1.0 M HCl

Purpose – The purpose of this paper is to study the inhibition effect of (6-phenyl-3-oxopyridazin-2-yl) acetohydrazide (GP4) on the corrosion of mild steel in acidic medium by gravimetric measurements, potentiodynamic polarization, and electrochemical impedance spectroscopy (EIS). Design/methodology/approach – Weight loss measurements, potentiodynamic tests and EIS were performed during this study. Findings -(6-phenyl-3-oxopyridazin-2-yl) acetohydrazide (GP4) was found to be a very efficient inhibitor for mild steel in 1.0 M HCl solution, reaching about 85 per cent with inhibitor concentration 1.0 x 10-3 M at 303 K. Practical implications -(6-phenyl-3-oxopyridazin-2-yl) acetohydrazide (GP4) was found to play an important role in the corrosion inhibition of mild steel in acidic solution. Originality/value – This paper is intended to be added to the family of pyridazine derivatives which are highly efficient inhibitors and can be used in the area of corrosion prevention and control.

Reference of 73963-42-5, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 73963-42-5 is helpful to your research.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Electric Literature of 73963-42-5, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 73963-42-5, Name is 5-(4-Chlorobutyl)-1-cyclohexyl-1H-tetrazole, SMILES is ClCCCCC1=NN=NN1C2CCCCC2, belongs to pyridazines compound. In a article, author is Iali, Wissam, introduce new discover of the category.

Achieving High Levels of NMR-Hyperpolarization in Aqueous Media With Minimal Catalyst Contamination Using SABRE

Signal amplification by reversible exchange (SABRE) is shown to allow access to strongly enhanced H-1 NMR signals in a range of substrates in aqueous media. To achieve this outcome, phase-transfer catalysis is exploited, which leads to less than 1.5 V 10(-6) mol dm(-3) of the iridium catalyst in the aqueous phase. These observations reflect a compelling route to produce a saline-based hyperpolarized bolus in just a few seconds for subsequent in vivo MRI monitoring. The new process has been called catalyst separated hyperpolarization through signal amplification by reversible exchange or CASH-SABRE. We illustrate this method for the substrates pyrazine, 5-methylpyrimidine, 4,6-d(2)-methyl nicotinate, 4,6-d(2)-nicotinamide and pyridazine achieving 1H signal gains of approximately 790-, 340-, 3000-, 260- and 380-fold per proton at 9.4 T at the time point at which phase separation is complete.

Electric Literature of 73963-42-5, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 73963-42-5 is helpful to your research.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 73963-42-5, Name is 5-(4-Chlorobutyl)-1-cyclohexyl-1H-tetrazole, molecular formula is C11H19ClN4. In an article, author is Buysse, Ann M.,once mentioned of 73963-42-5, SDS of cas: 73963-42-5.

Synthesis and biological activity of pyridazine amides, hydrazones and hydrazides

BACKGROUNDOptimization studies on compounds initially designed to be herbicides led to the discovery of a series of [6-(3-pyridyl)pyridazin-3-yl]amides exhibiting aphicidal properties. Systematic modifications of the amide moiety as well as the pyridine and pyridazine rings were carried out to determine if these changes could improve insecticidal potency. RESULTSStructure-activity relationship (SAR) studies showed that changes to the pyridine and pyridazine rings generally resulted in a significant loss of insecticidal potency against green peach aphids [Myzus persicae (Sulzer)] and cotton aphids [(Aphis gossypii (Glover)]. However, replacement of the amide moiety with hydrazines, hydrazones, or hydrazides appeared to be tolerated, with small aliphatic substituents being especially potent. CONCLUSIONSA series of aphicidal [6-(3-pyridyl)pyridazin-3-yl]amides were discovered as a result of random screening of compounds that were intially investigated as herbicides. Follow-up studies of the structure-activity relationship of these [6-(3-pyridyl)pyridazin-3-yl]amides showed that biosteric replacement of the amide moiety was widely tolerated suggesting that further opportunities for exploitation may exist for this new area of insecticidal chemistry. Insecticidal efficacy from the original hit, compound 1, to the efficacy of compound 14 produced greater than 10-fold potency improvement against Aphis gossypii and greater than 14-fold potency improvement against Myzus persicae. (c) 2016 Society of Chemical Industry

Interested yet? Keep reading other articles of 73963-42-5, you can contact me at any time and look forward to more communication. SDS of cas: 73963-42-5.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Reference of 73963-42-5, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 73963-42-5, Name is 5-(4-Chlorobutyl)-1-cyclohexyl-1H-tetrazole, SMILES is ClCCCCC1=NN=NN1C2CCCCC2, belongs to pyridazines compound. In a article, author is Chmovzh, Timofey N., introduce new discover of the category.

Safe Synthesis of 4,7-Dibromo[1,2,5]thiadiazolo[3,4-d]pyridazine and Its SNAr Reactions

A safe and efficient synthesis of 4,7-dibromo[1,2,5]thiadiazolo[3,4-d]pyridazine from the commercial diaminomaleonitrile is reported. Conditions for selective aromatic nucleophilic substitution of one or two bromine atoms by oxygen and nitrogen nucleophiles are found, whereas thiols formed the bis-derivatives only. Buchwald-Hartwig or Ullmann techniques are successful for incorporation of a weak nitrogen base, such as carbazole, into the [1,2,5]thiadiazolo[3,4-d]pyridazine core. The formation of rather stable S … eta(2)-(N=N) bound chains in 4,7-bis(alkylthio)-[1,2,5]thiadiazolo[3,4-d]pyridines makes these compounds promising for the design of liquid crystals.

Reference of 73963-42-5, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 73963-42-5.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Synthetic Route of 73963-42-5, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 73963-42-5, Name is 5-(4-Chlorobutyl)-1-cyclohexyl-1H-tetrazole, SMILES is ClCCCCC1=NN=NN1C2CCCCC2, belongs to pyridazines compound. In a article, author is Porter, Jacob D., introduce new discover of the category.

An anthrone-based Kv7.2/7.3 channel blocker with improved properties for the investigation of psychiatric and neurodegenerative disorders

A set of novel Kv7.2/7.3 (KCNQ2/3) channel blockers was synthesized to address several liabilities of the known compounds XE991 (metabolic instability and CYP inhibition) and the clinical compound DMP 543 (acid instability, insolubility, and lipophilicity). Using the anthrone scaffold of the prior channel blockers, alternative heteroarylmethyl substituents were installed via enolate alkylation reactions. Incorporation of a pyridazine and a fluorinated pyridine gave an analog (compound 18, JDP-107) with a promising combination of potency (IC50=0.16 mu M in a Kv7.2 thallium flux assay), efficacy in a Kv7.2/7.3 patch clamp assay, and drug-like properties.

Synthetic Route of 73963-42-5, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 73963-42-5.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 73963-42-5, Name is 5-(4-Chlorobutyl)-1-cyclohexyl-1H-tetrazole, SMILES is ClCCCCC1=NN=NN1C2CCCCC2, belongs to pyridazines compound. In a document, author is Dampc, Marcin, introduce the new discover, Quality Control of 5-(4-Chlorobutyl)-1-cyclohexyl-1H-tetrazole.

Electron impact ionization and cationic fragmentation of the pyridazine molecules

Electron impact mass spectroscopy was used to investigate ionization and cationic fragmentation of the pyridazine (1,2 diazine), C4H4N2, molecules in the gas phase. The mass spectra were measured and the observed mass peaks assigned to the corresponding cations. The appearance energies of most of the cationic fragments were determined and the possible fragmentation processes are discussed. The total cross section for electron impact ionization of pyridazine was calculated using the binary-encounter-Bethe (BEB) model. The calculated cross section was applied to normalize the measured cation yield curves and total and partial cross sections for ionization and cationic fragmentation were obtained over the energy range from the respective ionization thresholds to 140 eV.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 73963-42-5 is helpful to your research. Quality Control of 5-(4-Chlorobutyl)-1-cyclohexyl-1H-tetrazole.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 73963-42-5, Name is 5-(4-Chlorobutyl)-1-cyclohexyl-1H-tetrazole, SMILES is ClCCCCC1=NN=NN1C2CCCCC2, in an article , author is Abd El-Azim, Mohamed H. M., once mentioned of 73963-42-5, HPLC of Formula: C11H19ClN4.

Cyclization of thiosemicarbazide derivative: As a source of novel synthesis of some azoles and azines

In our study, we aimed to synthesize novel, some biologically active compounds, Azoles and Azines derivatives, that to be nitrogen-containing heterocycles, and have their diverse therapeutic values. Thiosemicarbazide, 2, was obtained from the attack of nitrogen of hydrazine to the carbon of heteroallene function of compound 1. Triazolotriazole derivative, 4, was obtained from the reaction of 2 with diethyl malonate. Cyclization of thiourea unit of compound 2 with heteroallene, 1, gave trazine, 6. Benzolyation of 2 using benzoyl chloride formed triazole derivative, 8. Reaction of 2 and maleic anhydride gave furothiadazine, 10. Cyclohexanopyrimidinthione, 12, was obtained from cyclocondensation of cyclohexanone with 2. Triazole, 14, was obtained from 2 and ammonium isothiocynate under thermal condition. Reaction of 2 with ethyl bromoacetate gave thiazole derivative, 16. [2+3] Cyclocondensation of acetyl acetone with 2 provided pyrazole, 18. Triazolotriazole, 20, was obtained from formalin and 2. Compound 2 suffers intramolecular base mediated cyclization affording pyrazole, 21. Keeping 2 and propinaldehyde under reflux provided triazolotriazole, 24. Acylation of 2 by succinic acid formed pyridazine derivative, 27.

Interested yet? Read on for other articles about 73963-42-5, you can contact me at any time and look forward to more communication. HPLC of Formula: C11H19ClN4.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem

 

Electric Literature of 73963-42-5, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 73963-42-5, Name is 5-(4-Chlorobutyl)-1-cyclohexyl-1H-tetrazole, SMILES is ClCCCCC1=NN=NN1C2CCCCC2, belongs to pyridazines compound. In a article, author is Wang Shuqin, introduce new discover of the category.

Synthesis and Bioactive Evaluation of Pyridazino-[6,1-b]quinazolinones Derivatives

Novel nitrogen-containing heterocyclic scaffold pyridazino[6,1-b]quinazolinones were designed by the combination of two privileged structure units. Then a scheme for the synthesis of pyridazino[6,1-b]quinazolinone derivatives in 4 steps starting from methyl 2-aminobenzoate was developed in which the intramolecular condensation of acylhydrazone with ester was a key step transformation. 14 pyridazino[6,1-b]quinazolinone derivatives were synthesized and their structures were characterized and comfirmed by H-1 NMR, C-13 NMR and HRMS. Their in vitro cytotoxic activities against a panel of human tumor cell lines (SK-OV-3, CNE-2, MGC-803, NCI-H460) and nomal liver cell LO2 were evaluated via methyl thiazolyl tetrazolium (MTT) assay. The result indicated that 2-(4-bromophenyl)-4-hydroxy-10H-pyridazino[6,1-b]quinazolin-10-one (4b) and 2-(3-chlorophenyl)-4-hydroxy-10H-pyridazino [6,1-b]quinazolin-10-one (4d) exhibted very potent cytotoxic activity. The IC50 value of 4b against CNE-2 and 4d against NCI-H460 cell line lowed to 0.85 and 2.31 mu mol/L, respectively, far potent than the positive control cisplatin and almost equivalent to the natrual anticancer medicine camptothecin. Ultraviolet spectrometry and fluorescence titration assay were carried out to evaluate the ability of the compound to interact with DNA. The result indicated that they were able to intercalate in to DNA. Compound 4d, which demonstrated potent antitumor activity while less cytotoxicity against the normal liver cell LO2, could arrest cell, cycle at G1 phase and significantly induce apoptosis on NCI-H460 cell in a dose-dependent manner, while 4b which exhibit potent cytotoxicity against LO2, could result in significant DNA double strand break when treated with the cell.

Electric Literature of 73963-42-5, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 73963-42-5.

Reference:
Pyridazine – Wikipedia,
,Pyridazine | C4H4N2 – PubChem